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Tag Content
UUCD2 ID IUUC-Ots-000050
Ensembl Protein ID
UniProt Accession Q9Y0T2; Q550Q0; Q9U9T1; Q9U9U5; FBXA_DICDI
Genbank Protein ID AAD40673.1; AAD37799.2; AAD37800.1; EAL68945.1
Protein Name F-box/WD repeat-containing protein A; Protein cheater A
Genbank Nucleotide ID AF151733; AF151111; AF151112; AAFI02000019
Gene Name fbxA; chtA; DDB_G0276887
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 14658498
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 14658498
Organism Dictyostelium discoideum
Functional Description
(View)

Functional Description



     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May target the cAMP phosphodiesterase regA for degradation leading to an increase in cAMP and PKA activity. Promotes development of prestalk cells as opposed to prespores within the developing fruiting body. Required for culmination and fruiting body development.
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May target the cAMP phosphodiesterase regA for degradation leading to an increase in cAMP and PKA activity. Promotes development of prestalk cells as opposed to prespores within the developing fruiting body. Required for culmination and fruiting body development.
Protein Sequence
(Fasta)
MQYVNGNDIS SQSIHEVLEL AFSTKIPWTK LEYESSEKHI IHSYSSHERG IYLSKGVAEF 60
NISPENMYEL LLDISSRSKW DFHCREAHII EEYDHLNHII HLNFTNPLIS NLDMNLYRSC 120
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Protein Fasta Sequence



>IUUC-Ots-000050|E3,F-box;E3,WD_repeat|Dictyostelium discoideum
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Sequence Source UniProt
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0293--Fruiting body
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR029058--AB_hydrolase
IPR011598--bHLH_dom
IPR001810--F-box_dom
IPR002469--Peptidase_S9B_N
IPR023393--START-like_dom
IPR002913--START_lipid-bd_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50848--START
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00646--F-box
PF00400--WD40

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0008289--F:lipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0099139--P:cheating during chimeric sorocarp development
GO:0031154--P:culmination involved in sorocarp development
GO:0007275--P:multicellular organism development
GO:0045595--P:regulation of cell differentiation
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG ddi:DDB_G0276887
Created Date 25-Jun-2017

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