PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P43254 Q94BM7 - 12887588 - X 2 Q94BM7 Q9FE25 two hybrid 23425305 direct interaction X 2 Q94BM7 Q39057-2 pull down 16854975 direct interaction X 2 Q94BM7 Q94BM7 pull down 18812498 direct interaction X 2 Q94BM7 Q94BM7 affinity chromatography technology 18812498 physical association X 2 B3H6I9 Q94BM7 pull down 20061554 direct interaction X 2 Q9ZTC3 Q94BM7 two hybrid 23425305 direct interaction X 2 P43254 Q94BM7 affinity chromatography technology 18812498 physical association X 2 P43254 Q94BM7 affinity chromatography technology 18812498 physical association X 2 Q9FN03 Q94BM7 affinity chromatography technology 24277841 physical association X 2 Q94BM7 Q9SYX2 pull down 18812498 direct interaction X 2 Q94BM7 Q9T014 pull down 18812498 direct interaction X 2 Q94BM7 pull down 18812498 direct interaction X 2 Q94BM7 Q9SYX2 pull down 18812498 direct interaction X 2 Q94BM7 Q9T014 pull down 18812498 direct interaction X 2 Q94BM7 pull down 18812498 direct interaction X 2 Q94BM7 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q94BM7 affinity chromatography technology 18812498 physical association X 2 Q94BM7 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q94BM7 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q94BM7 affinity chromatography technology 18812498 physical association X 2 Q94BM7 Q9SYX2 biochemical 18812498 colocalization X 2 Q94BM7 O49552 pull down 20061554 direct interaction X 2 Q94BM7 molecular sieving 18812498 association C 6 Q94BM7 O50055 anti tag coimmunoprecipitation 16854975 physical association X 2 Q94BM7 O50055 anti tag coimmunoprecipitation 18812498 physical association X 2 Q94BM7 Q94BM7 anti tag coimmunoprecipitation 18812498 physical association X 2 Q94BM7 O50055 anti tag coimmunoprecipitation 18812498 physical association X 2 Q94BM7 Q94BM7 anti tag coimmunoprecipitation 18812498 physical association X 2 Q94BM7 anti tag coimmunoprecipitation 18812498 association C 6 Q94BM7 anti tag coimmunoprecipitation 18812498 association C 6 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 5 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 5 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 5 Q94BM7 anti tag coimmunoprecipitation 18812498 association C 5 Q94BM7 anti tag coimmunoprecipitation 18812498 association C 5 Q94BM7 anti tag coimmunoprecipitation 18812498 association C 5 Q94BM7 anti tag coimmunoprecipitation 18812498 association C 5 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 5 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 3 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 3 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 3 Q94BM7 anti bait coimmunoprecipitation 18812498 association C 3 P43254 Q94BM7 two hybrid 12887588 physical association X 2 P43254 Q94BM7 anti tag coimmunoprecipitation 12887588 physical association X 2 P43254 Q94BM7 pull down 21798944 direct interaction X 2 P43254 Q94BM7 pull down 21798944 direct interaction X 2 P43254 Q94BM7 two hybrid array 21798944 physical association X 2 P43254 Q94BM7 two hybrid array 21798944 physical association X 2 Q94BM7 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q94BM7 Q9SYX2 confocal microscopy 18812498 colocalization X 2 Q94BM7 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9LJR3 Q94BM7 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9LJR3 Q94BM7 anti tag coimmunoprecipitation 18812498 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SPA4 MYB90 MI:0018(two hybrid) 23425305 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_17145 prey bait SPA4 SPA2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_1297|BIOGRID_1320|BIOGRID_1303 prey|bait|bait bait|prey|prey CO SPA4 MI:0096(pull down) 16854975 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_397 prey bait SPA4 SPA1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_11198|UniProt_11199|UniProt_11197|UniProt_11194|UniProt_11173|BIOGRID_1329|BIOGRID_1319|UniProt_11161|BIOGRID_1302|BIOGRID_1313|BIOGRID_1293|UniProt_11178|UniProt_11196 prey|bait|prey|neutral component|bait|prey|bait|prey|bait|prey|prey|neutral component|neutral component bait|prey|prey|neutral component|prey|bait|prey|bait|prey|bait|bait|neutral component|neutral component COP1 SPA4 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid) 12887588,18812498,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_11198|UniProt_11199|UniProt_11197|UniProt_11194|UniProt_11196|UniProt_7078|UniProt_2409|UniProt_17626|UniProt_8732|UniProt_8733|UniProt_17628 prey|prey|bait|neutral component|neutral component|prey|bait|prey|prey|bait|prey prey|bait|prey|neutral component|neutral component|bait|prey|bait|bait|prey|bait SPA4 UVR8 MI:0018(two hybrid) 24277841 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_20560 prey bait SPA4 SPA3 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_11196|UniProt_11171|BIOGRID_1317|BIOGRID_1301|BIOGRID_1304|BIOGRID_1321|UniProt_11169 neutral component|bait|prey|prey|bait|bait|prey neutral component|prey|bait|bait|prey|prey|bait COL1 SPA4 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16854975,18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_11196|UniProt_11172|UniProt_12446|UniProt_11165 neutral component|prey|prey|bait neutral component|bait|bait|prey SPA4 DDB1A MI:0401(biochemical) 20061554 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4066 prey bait DDB1B SPA4 MI:0401(biochemical) 20061554 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4071 bait prey

PPI - HINT Gene A Gene B PMID Method Quality COL1 SPA4 18812498,18812498,18812498 0007,0006,0071 LC COP1 SPA4 12887588,12887588,21798944,12887588,21798944 0018,0019,0096,0007,0397 LC,HT SPA4 MYB75 23425305 0018 LC SPA4 SPA1 18812498,18812498,18812498,18812498,18812498,18812498 0096,0663,0006,0007,0401,0004 LC SPA4 MYB90 23425305 0018 LC DDB1B SPA4 20061554 0096 LC COL1 SPA4 18812498,16854975,18812498,18812498 0007,0007,0006,0071 LC COP1 SPA4 12887588,12887588,21798944,12887588,18812498,18812498,18812498,21798944 0018,0019,0096,0007,0006,0007,0004,0397 LC CO SPA4 16854975 0096 LC SPA4 SPA4 18812498,18812498,18812498 0096,0007,0004 LC SPA4 UVR8 24277841 0004 LC SPA4 SPA3 18812498,18812498,18812498 0096,0007,0004 LC SPA4 DDB1A 20061554 0096 LC SPA4 SPA1 18812498,18812498,18812498,18812498,18812498,18812498 0096,0663,0006,0007,0401,0004 LC SPA4 SPA2 18812498,18812498 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q94BM7 O49552 SPA4 DDB1B 0.309 20061554 Q9FN03 Q94BM7 UVR8 SPA4 0.21 24277841 Q9M0V3 Q94BM7 DDB1A SPA4 0.309 20061554 Q9ZTC3 Q94BM7 MYB90 SPA4 0.309 23425305 Q94BM7 O50055 SPA4 COL1 0.597 16854975,18812498 Q94BM7 Q94BM7 SPA4 SPA4 0.436 18812498 Q9LJR3 Q94BM7 SPA3 SPA4 0.659 18812498 Q94BM7 P43254 SPA4 COP1 0.858 12887588,18812498,21798944 Q9SYX2 Q94BM7 SPA1 SPA4 0.78 18812498 Q94BM7 Q39057 SPA4 CO 0.309 16854975 Q9FE25 Q94BM7 MYB75 SPA4 0.309 23425305 Q9T014 Q94BM7 SPA2 SPA4 0.416 18812498