PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P43254 - 12887588 - X 2 P43254 Q9SID1 - 11226162 - X 2 P43254 Q96288 - 11226162 - X 2 P43254 O24646 - 9659918 - X 2 P43254 O24646 - 11226162 - X 2 P43254 Q0WNL1 - 11877375 - X 2 P43254 Q94BM7 - 12887588 - X 2 P43254 F4IBY7 - 11226162 - X 2 P43254 G4WTR2 - 11509693 - X 2 P43254 - 7753789 - X 2 P43254 O80386 - 9668129 - X 2 P43254 P43254 - 9755158 - X 2 Q9FE22 P43254 - 15620659 - X 2 Q9SPL2 P43254 - 10488108 - X 2 P43254 O24646 pull down 22692212 direct interaction X 2 P43254 Q39057-2 affinity chromatography technology 18388858 physical association X 2 P43254 O24646 two hybrid 23425305 direct interaction X 2 P43254 O49552 affinity chromatography technology 24067658 physical association X 2 P43254 affinity chromatography technology 24067658 physical association X 2 P43254 affinity chromatography technology 24067658 physical association X 2 P43254 P14712-2 pull down 15031264 direct interaction X 2 P43254 P14712-2 enzymatic study 15031264 direct interaction X 2 P43254 O24646 enzymatic study 14597662 direct interaction X 2 P43254 Q43125 two hybrid 11752373 direct interaction X 2 P43254 Q43125 pull down 11752373 direct interaction X 2 P43254 Q43125 affinity chromatography technology 11752373 physical association X 2 P43254 O24646 pull down 10990463 direct interaction X 2 P43254 O24646 two hybrid 10990463 direct interaction X 2 P43254 pull down 7753789 direct interaction X 2 P43254 Q39057-2 two hybrid 18296627 direct interaction X 2 P43254 Q39057-2 pull down 18296627 direct interaction X 2 P43254 Q39057-2 fluorescent resonance energy transfer 18296627 direct interaction X 2 P43254 Q39057-2 enzymatic study 18296627 direct interaction X 2 P43254 Q43125 two hybrid 18252844 direct interaction X 2 P43254 Q9SID1 fluorescent resonance energy transfer 16925598 direct interaction X 2 P43254 B9DGC9 two hybrid 16844902 direct interaction X 2 P43254 Q9SID1 fluorescent resonance energy transfer 18796637 direct interaction X 2 P43254 Q9SID1 enzymatic study 18796637 direct interaction X 2 P43254 P14712-2 affinity chromatography technology 18722184 physical association X 2 P43254 affinity chromatography technology 18812498 physical association X 2 P43254 affinity chromatography technology 18812498 physical association X 2 P43254 O82804 two hybrid 19061637 direct interaction X 2 P43254 O82804 affinity chromatography technology 19061637 physical association X 2 P43254 O82804 affinity chromatography technology 19061637 physical association X 2 P43254 O82804 enzymatic study 19061637 direct interaction X 2 P43254 O82804 protein complementation assay 19061637 direct interaction X 2 P43254 B9DGC9 affinity chromatography technology 15342494 physical association X 2 P43254 B9DGC9 two hybrid 11877375 direct interaction X 2 P43254 O24646 two hybrid 9755158 direct interaction X 2 P43254 O24646 two hybrid 11226162 direct interaction X 2 P43254 Q96288 two hybrid 11226162 direct interaction X 2 P43254 Q9SID1 two hybrid 11226162 direct interaction X 2 P43254 O24646 two hybrid 9659918 direct interaction X 2 P43254 O24646 pull down 9659918 direct interaction X 2 P43254 B3H6I9 pull down 20061554 direct interaction X 2 P43254 O49552 pull down 20061554 direct interaction X 2 P43254 O49552 affinity chromatography technology 20061554 physical association X 2 P43254 B9DGC9 affinity chromatography technology 20061554 physical association X 2 P43254 P14714 pull down 20605855 direct interaction X 2 P43254 P14714 enzymatic study 20605855 direct interaction X 2 P43254 O24646 two hybrid 21097709 direct interaction X 2 P43254 P14712-2 pull down 15031264 direct interaction X 2 P43254 Q6AWX6 pull down 21972261 direct interaction X 2 P43254 Q6AWX6 affinity chromatography technology 21972261 physical association X 2 P43254 P14712-2 two hybrid 22498774 direct interaction X 2 P43254 P14712-2 affinity chromatography technology 22498774 physical association X 2 P43254 pull down 22535582 direct interaction X 2 Q9FN03 P43254 two hybrid 19165148 direct interaction X 2 Q9FN03 P43254 affinity chromatography technology 19165148 physical association X 2 Q9FN03 P43254 two hybrid 22988111 direct interaction X 2 Q9FN03 P43254 affinity chromatography technology 23277547 physical association X 2 Q9FN03 P43254 two hybrid 23653191 direct interaction X 2 Q9FN03 P43254 two hybrid 24277841 direct interaction X 2 Q9FN03 P43254 affinity chromatography technology 24277841 physical association X 2 Q9FN03 P43254 affinity chromatography technology 24277841 physical association X 2 P48732 P43254 biochemical 20061554 colocalization X 2 P43254 Q8W4J9 protein complementation assay 20624951 direct interaction X 2 P43254 Q8W4J9 affinity chromatography technology 20624951 physical association X 2 P43254 P93025-2 affinity chromatography technology 20624951 physical association X 2 P43254 Q9FE25 affinity chromatography technology 23425305 physical association X 2 P43254 F4KH76 two hybrid 23573936 direct interaction X 2 P43254 F4KH76 two hybrid 23573936 direct interaction X 2 P43254 F4KH76 affinity chromatography technology 23573936 physical association X 2 P43254 F4KH76 protein complementation assay 23573936 direct interaction X 2 P43254 Q8LGH4 affinity chromatography technology 24067658 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 24067658 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 24067658 physical association X 2 P43254 enzymatic study 24838976 direct interaction X 2 P43254 Q9SYX2 biochemical 14597662 colocalization X 2 P43254 Q9SYX2 affinity chromatography technology 14597662 physical association X 2 P43254 Q9M0K4 pull down 12827204 direct interaction X 2 P43254 Q9M0K4 enzymatic study 12827204 direct interaction X 2 P43254 P28769 two hybrid 11752373 direct interaction X 2 P43254 P14713 two hybrid 11752373 direct interaction X 2 P43254 P28769 pull down 11752373 direct interaction X 2 P43254 Q9SYX2 two hybrid 11461903 direct interaction X 2 P43254 Q9SYX2 pull down 11461903 direct interaction X 2 P43254 Q9SYX2 pull down 11461903 direct interaction X 2 P43254 Q8LGH4 affinity chromatography technology 16844902 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18722184 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18722184 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 P43254 Q94BM7 affinity chromatography technology 18812498 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 P43254 Q9T014 affinity chromatography technology 18812498 physical association X 2 P43254 Q94BM7 affinity chromatography technology 18812498 physical association X 2 P43254 Q9SYX2 biochemical 18812498 colocalization X 2 P43254 Q9SQI2 protein complementation assay 19061637 direct interaction X 2 P43254 G4WTR2 two hybrid 11509693 direct interaction X 2 P43254 G4WTR2 affinity chromatography technology 11509693 physical association X 2 P43254 pull down 11226193 direct interaction X 2 P43254 P43254 affinity chromatography technology 11080276 physical association X 2 P43254 P43254 two hybrid 11080276 direct interaction X 2 P43254 P43254 fluorescent resonance energy transfer 15084749 direct interaction X 2 P43254 P43254 two hybrid 9755158 direct interaction X 2 P43254 O80386 pull down 9668129 direct interaction X 2 P43254 P43254 two hybrid 8837504 direct interaction X 2 P43254 A8MS70 two hybrid 12023303 direct interaction X 2 P43254 Q9SK53 two hybrid 16339850 direct interaction X 2 P43254 Q8LGH4 affinity chromatography technology 20061554 physical association X 2 P43254 P14713 pull down 20605855 direct interaction X 2 P43254 P14713 affinity chromatography technology 20605855 physical association X 2 P43254 P14713 enzymatic study 20605855 direct interaction X 2 P43254 P42497 pull down 20605855 direct interaction X 2 P43254 P42498 pull down 20605855 direct interaction X 2 P43254 P42497 enzymatic study 20605855 direct interaction X 2 P43254 P42498 enzymatic study 20605855 direct interaction X 2 P43254 Q9M0K4 biochemical 12827204 association X 2 P43254 G4WTR2 affinity chromatography technology 21514160 physical association X 2 P43254 F4II77 two hybrid 21525334 direct interaction X 2 P43254 F4II77 pull down 21525334 direct interaction X 2 P43254 F4II77 protein complementation assay 21525334 direct interaction X 2 P43254 F4II77 affinity chromatography technology 21525334 physical association X 2 Q9FE22 P43254 enzymatic study 17699755 direct interaction X 2 Q9FE22 P43254 two hybrid 15741320 direct interaction X 2 Q9FE22 P43254 pull down 15741320 direct interaction X 2 Q9FE22 P43254 affinity chromatography technology 15741320 physical association X 2 Q9FE22 P43254 enzymatic study 15741320 direct interaction X 2 Q9FE22 P43254 two hybrid 15620659 direct interaction X 2 Q9FE22 P43254 two hybrid 15620659 direct interaction X 2 Q9FE22 P43254 two hybrid 15705947 direct interaction X 2 Q9FE22 P43254 affinity chromatography technology 15705947 physical association X 2 Q9SPL2 P43254 pull down 12827204 direct interaction X 2 Q9SPL2 P43254 two hybrid 10488108 direct interaction X 2 Q9SPL2 P43254 pull down 10488108 direct interaction X 2 Q9SPL2 P43254 two hybrid 10488108 direct interaction X 2 Q9SPL2 P43254 pull down 12028569 direct interaction X 2 Q9SPL2 P43254 pull down 12028569 direct interaction X 2 Q9ZTC3 P43254 two hybrid 23425305 direct interaction X 2 Q9ZTC3 P43254 affinity chromatography technology 23425305 physical association X 2 P43254 P93025 bimolecular fluorescence complementation 20624951 direct interaction X 2 P43254 P93025 anti tag coimmunoprecipitation 20624951 direct interaction X 2 Q9FN03 P43254 anti tag coimmunoprecipitation 21041653 physical association X 2 P43254 G4WTR2 bimolecular fluorescence complementation 20624951 direct interaction X 2 P43254 P43254 bioluminescence resonance energy transfer 17551013 physical association Y 1 P43254 P43254 bioluminescence resonance energy transfer 17551013 physical association Y 1 P43254 Q8W4J9 anti tag coimmunoprecipitation 20624951 direct interaction X 2 P43254 Q8W4J9 bimolecular fluorescence complementation 20624951 direct interaction X 2 P43254 anti tag coimmunoprecipitation 18552200 association C 4 P43254 molecular sieving 18812498 association C 6 P43254 molecular sieving 14597662 physical association C 3 P43254 O24646 pull down 10990463 direct interaction X 2 P43254 O24646 two hybrid 10990463 physical association X 2 P43254 O24646 two hybrid 11226162 physical association X 2 P43254 O24646 two hybrid 11226162 physical association X 2 P43254 Q96288 two hybrid 11226162 physical association X 2 P43254 Q9SID1 two hybrid 11226162 physical association X 2 P43254 Q96288 two hybrid 11226162 physical association X 2 P43254 Q9SID1 two hybrid 11226162 physical association X 2 P43254 Q9SID1 two hybrid 11226162 physical association X 2 P43254 O24646 two hybrid 11226162 physical association X 2 P43254 Q43125 confocal microscopy 11509693 physical association X 2 P43254 Q43125 two hybrid 11752373 physical association X 2 P43254 Q43125 anti tag coimmunoprecipitation 11752373 direct interaction X 2 P43254 Q43125 anti tag coimmunoprecipitation 11752373 physical association X 2 P43254 Q0WNL1 two hybrid 11877375 physical association X 2 P43254 Q0WNL1 two hybrid 16844902 physical association X 2 P43254 Q9LQZ7 confocal microscopy 17965270 physical association X 2 P43254 Q9LQZ7 confocal microscopy 17965270 physical association X 2 P43254 Q39057 two hybrid 18296627 physical association X 2 P43254 Q39057 two hybrid 18296627 physical association X 2 P43254 Q39057 pull down 18296627 direct interaction X 2 P43254 Q39057 fluorescence microscopy 18296627 colocalization X 2 P43254 Q39057 fluorescent resonance energy transfer 18296627 physical association X 2 P43254 Q39057 anti tag coimmunoprecipitation 18388858 physical association X 2 P43254 Q39057 fluorescent resonance energy transfer 18388858 physical association X 2 P43254 Q39057 fluorescence microscopy 18388858 colocalization X 2 P43254 O24646 two hybrid array 21798944 physical association X 2 P43254 O24646 two hybrid 9659918 physical association X 2 P43254 O24646 pull down 9659918 direct interaction X 2 P43254 O24646 two hybrid 9755158 physical association X 2 Q9FN03 P43254 confocal microscopy 19165148 colocalization X 2 Q9FN03 P43254 bimolecular fluorescence complementation 19165148 physical association X 2 Q9FN03 P43254 anti tag coimmunoprecipitation 19165148 physical association X 2 Q9LJR3 P43254 two hybrid 12887588 physical association X 2 Q9LJR3 P43254 anti tag coimmunoprecipitation 12887588 physical association X 2 P43254 anti tag coimmunoprecipitation 18812498 association C 6 P43254 anti tag coimmunoprecipitation 18812498 association C 6 P43254 anti bait coimmunoprecipitation 18812498 association C 5 P43254 anti bait coimmunoprecipitation 18812498 association C 5 P43254 anti bait coimmunoprecipitation 18812498 association C 5 P43254 anti tag coimmunoprecipitation 18812498 association C 5 P43254 anti tag coimmunoprecipitation 18812498 association C 5 P43254 anti tag coimmunoprecipitation 18812498 association C 5 P43254 anti tag coimmunoprecipitation 18812498 association C 5 P43254 anti bait coimmunoprecipitation 18812498 association C 5 P43254 enzymatic study 15741320 ubiquitination reaction C 4 P43254 anti bait coimmunoprecipitation 18812498 association C 3 P43254 anti bait coimmunoprecipitation 18812498 association C 3 P43254 anti bait coimmunoprecipitation 18812498 association C 3 P43254 anti bait coimmunoprecipitation 18812498 association C 3 P43254 enzymatic study 18796637 ubiquitination reaction C 4 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 two hybrid 11461903 physical association X 2 P43254 G4WTR2 two hybrid 11509693 physical association X 2 P43254 G4WTR2 anti bait coimmunoprecipitation 11509693 physical association X 2 P43254 P14713 two hybrid 11752373 physical association X 2 P43254 Q8W191-2 two hybrid 12023303 physical association X 2 P43254 Q8W191-2 two hybrid 12023303 physical association X 2 P43254 Q8W191-2 fluorescent resonance energy transfer 12023303 physical association X 2 P43254 Q9M0K4 confocal microscopy 12827204 colocalization X 2 P43254 Q9SYX2 confocal microscopy 12827204 colocalization X 2 P43254 Q9M0K4 pull down 12827204 physical association X 2 P43254 Q9M0K4 pull down 12827204 physical association X 2 P43254 Q94BM7 two hybrid 12887588 physical association X 2 P43254 Q94BM7 anti tag coimmunoprecipitation 12887588 physical association X 2 P43254 Q9SYX2 molecular sieving 14597662 physical association X 2 P43254 Q9SYX2 two hybrid 14597662 physical association X 2 P43254 Q9SYX2 two hybrid 14597662 physical association X 2 P43254 P14712 pull down 15031264 physical association X 2 P43254 Q9SK53 two hybrid 16339850 physical association X 2 P43254 Q9SK53 fluorescent resonance energy transfer 16339850 direct interaction X 2 P43254 Q9SK53 two hybrid 16339850 physical association X 2 P43254 Q8LGH4 anti tag coimmunoprecipitation 16844902 physical association X 2 P43254 Q9SJL7 two hybrid 18397371 physical association X 2 P43254 Q9SJL7 bimolecular fluorescence complementation 18397371 physical association X 2 P43254 Q9SJL7 anti tag coimmunoprecipitation 18397371 physical association X 2 P43254 Q9SYM2 confocal microscopy 18796637 colocalization X 2 P43254 P43254 anti tag coimmunoprecipitation 18812498 physical association X 2 P43254 P43254 anti bait coimmunoprecipitation 18812498 physical association Y 1 P43254 Q94BM7 pull down 21798944 direct interaction X 2 P43254 Q94BM7 pull down 21798944 direct interaction X 2 P43254 Q94BM7 two hybrid array 21798944 physical association X 2 P43254 Q94BM7 two hybrid array 21798944 physical association X 2 P43254 Q38843 lambda phage display 7753789 physical association X 2 P43254 Q38843 lambda phage display 7753789 physical association X 2 P43254 Q38843 far western blotting 7753789 physical association X 2 P43254 P43254 two hybrid 9755158 physical association X 2 P43254 P43254 cross-linking study 9755158 direct interaction Y 1 P43254 P43254 molecular sieving 9755158 physical association Y 1 Q9FE22 P43254 confocal microscopy 15741320 colocalization X 2 Q9FE22 P43254 two hybrid 15741320 physical association X 2 Q9FE22 P43254 pull down 15741320 physical association X 2 Q9FE22 P43254 anti tag coimmunoprecipitation 15741320 physical association X 2 Q9FE22 P43254 pull down 17699755 physical association X 2 Q9SPL2 P43254 two hybrid 10488108 physical association X 2 Q9SPL2 P43254 two hybrid 10488108 physical association X 2 Q9SPL2 P43254 two hybrid 10488108 physical association X 2 Q9SPL2 P43254 pull down 10488108 physical association X 2 Q9SPL2 P43254 pull down 12028569 physical association X 2 Q9SPL2 P43254 pull down 12827204 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B COP1 UVR8 MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy) 19165148 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_11612|UniProt_11614|UniProt_11613 neutral component|bait|neutral component neutral component|prey|neutral component COP1 CIP8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0663(confocal microscopy)|MI:0018(two hybrid) 10488108,12028569,12827204 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_17545|UniProt_17546|UniProt_17547|UniProt_16032|UniProt_16362|UniProt_17544 bait|prey|bait|prey|bait|bait prey|bait|prey|bait|prey|prey COP1 uniprotkb:(gene name) MI:0066(lambda phage display)|MI:0066(lambda phage display)|MI:0066(lambda phage display) 7753789 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_8033|UniProt_8031|UniProt_8032 bait|bait|bait prey|prey|prey COP1 CRY1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11509693,11752373 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_17724|UniProt_17723|UniProt_17721|UniProt_16248 bait|prey|prey|neutral component prey|bait|bait|neutral component COP1 At5g11260 MI:0397(two hybrid array) 21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_2699 prey bait HY5 COP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0030(cross-linking study)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 10990463,11226162,9659918,9755158 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_8763|UniProt_8764|UniProt_17829|UniProt_8113|UniProt_16704|UniProt_16705|UniProt_17834|UniProt_17833 prey|bait|bait|bait|bait|prey|bait|bait bait|prey|prey|prey|prey|bait|prey|prey COP1 COP1 MI:0007(anti tag coimmunoprecipitation)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0007(anti tag coimmunoprecipitation) 18812498,9755158 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_11183|UniProt_8112|UniProt_8110|UniProt_8111|UniProt_11195 bait|prey|neutral component|neutral component|neutral component bait|prey|neutral component|neutral component|neutral component PHYB COP1 MI:0018(two hybrid) 11752373 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_17722 bait prey PHYA COP1 MI:0096(pull down) 15031264 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_17826 prey bait COP1 At1g78600 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18796637 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction)|MI:0403(colocalization) (intact)|(intact)|(intact) UniProt_200927|UniProt_10843|UniProt_10842 neutral component|neutral component|neutral component neutral component|neutral component|neutral component COP1 SPA4 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid) 12887588,18812498,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_11198|UniProt_11199|UniProt_11197|UniProt_11194|UniProt_11196|UniProt_7078|UniProt_2409|UniProt_17626|UniProt_8732|UniProt_8733|UniProt_17628 prey|prey|bait|neutral component|neutral component|prey|bait|prey|prey|bait|prey prey|bait|prey|neutral component|neutral component|bait|prey|bait|bait|prey|bait COP1 At1g75540 MI:0018(two hybrid)|MI:0018(two hybrid) 17965270 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_15296|UniProt_15297 neutral component|neutral component neutral component|neutral component COP1 CUL4 MI:0018(two hybrid) 16844902 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_12775 prey bait COP1 CO MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18296627,18388858 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_15818|UniProt_15817|UniProt_15020|UniProt_15021|UniProt_15819|UniProt_15019|UniProt_15017|UniProt_15018 fluorescence donor|bait|neutral component|fluorescence donor|neutral component|bait|prey|prey fluorescence accept|prey|neutral component|fluorescence accept|neutral component|prey|bait|bait COP1 STO MI:0018(two hybrid)|MI:0018(two hybrid) 11226162 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_17830|UniProt_17827 prey|bait null|null COP1 LAF1 MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy) 12827204 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_16359|UniProt_16361|UniProt_16363 neutral component|bait|prey neutral component|prey|bait COP1 HFR1 MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0096(pull down) 15741320,17699755 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_12194|UniProt_80372|UniProt_12193|UniProt_12192|UniProt_12191|UniProt_12190|UniProt_14093 neutral component|neutral component|bait|bait|prey|neutral component|prey neutral component|neutral component|prey|prey|bait|neutral component|bait COP1 HYH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12023303 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_17818|UniProt_17819|UniProt_17820 bait|bait|neutral component null|null|null COP1 CRY2 MI:0018(two hybrid)|MI:0018(two hybrid) 11509693 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_16246|UniProt_16247 prey|prey bait|bait COP1 STH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11226162 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_17828|UniProt_17832|UniProt_17831 bait|prey|prey prey|bait|bait COP1 COL3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16339850 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_12390|UniProt_12391|UniProt_12392 bait|fluorescence accept|bait prey|fluorescence donor|prey COP1 RAX2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18397371 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_15795|UniProt_15796|UniProt_15797 bait|neutral component|bait prey|neutral component|prey COP1 SPA3 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 12887588,18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_11196|UniProt_17625|UniProt_17627 neutral component|prey|prey neutral component|bait|bait COP1 COP10 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11877375,16844902,18552200 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_10848|UniProt_12768|UniProt_17661 prey|prey|prey bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality BBX19 COP1 25841036,25841036 0055,0018 LC CIP1 COP1 7753789,7753789,7753789 0084,0096,0047 LC HY5 COP1 14597662,9659918,9755158,24858936,11226162,24858936,10990463,10990463,9659918,23425305,21097709,21798944,9659918 0415,0096,0018,0415,0018,0096,0018,0096,0018,0018,0018,0397,0004 LC,HT COL1 COP1 18812498,18812498 0071,0006 LC CIP7 COP1 9668129,9668129,9668129 0096,0084,0004 LC ELF3 COP1 19061637,19061637,19061637,19061637 0004,0090,0415,0018 LC PHYA COP1 15031264,15031264,22498774,22498774,25627066 0415,0096,0018,0004,0018 LC PHYB COP1 11752373,20605855,20605855,20605855 0018,0096,0004,0415 LC PHYC COP1 20605855,20605855 0096,0415 LC CCT1 COP1 11752373,11752373 0018,0096 LC PHYD COP1 20605855,20605855 0096,0415 LC PHYE COP1 20605855,20605855 0096,0415 LC COP1 COP1 11080276,9755158,9755158,8837504,9755158,24858936,11080276,17551013,15084749,21153370,25817546 0018,0030,0071,0018,0018,0415,0004,0012,0055,0055,0018 LC COP1 CSN1 19175768,19175768,19175768,19175768,19175768 0004,0018,0428,0401,0096 LC COP1 DET1 20061554 0401 LC COP1 PHOT2 20624951,20624951,20624951 0809,0004,0007 LC COP1 Q38843 7753789,7753789 0047,0066 LC COP1 CO 18388858,18296627,18296627,18388858,18296627,18296627,18388858,18296627,18388858 0007,0416,0096,0004,0055,0415,0055,0018,0416 LC COP1 CRY1 11752373,11752373,11752373,11509693,11509693,18252844,11752373,11752373 0018,0019,0007,0019,0663,0018,0096,0004 LC COP1 PIF1 24858936,24858936 0004,0018 LC COP1 CSN4 19175768 0401 LC COP1 CSN5B 19175768 0401 LC COP1 CSN6A 14597662 0071 LC COP1 RPP8 20624951,20624951,20624951,20624951 0809,0004,0007,0090 LC COP1 CSN3 14597662 0071 LC COP1 SPA4 12887588,12887588,21798944,12887588,21798944 0018,0019,0096,0007,0397 LC,HT COP1 CRY2 11509693,20624951,11509693,11509693,11509693 0006,0809,0019,0018,0004 LC COP1 HFR1 17699755,15741320,15741320,15741320,15741320,15741320,15620659,15705947,17699755,15705947,15741320 0096,0004,0415,0018,0007,0096,0018,0004,0415,0018,0663 LC COP1 BIN4 23573936,23573936,23573936 0004,0018,0090 LC COP1 UVR8 24277841,19165148,25817546,19165148,24651064,25627067,24651064,22988111,19165148,23653191,19165148,25627067,19165148,24277841,19165148 0004,0004,0018,0018,0018,0018,0004,0018,0007,0018,0416,0004,0809,0018,0663 LC COP1 CNGC19 12023303,12023303 0018,0055 LC COP1 COP10 16844902,11877375 0018,0018 LC COP1 SPA3 12887588,12887588,12887588 0018,0019,0007 LC COP1 Q9LNE3 11226162 0018 LC COP1 BBX21 17965270,17965270 0055,0663 LC COP1 LAF1 12827204,12827204,12827204,12827204 0663,0401,0415,0096 LC COP1 BBX25 11226162,18796637,16925598,18796637 0018,0055,0055,0415 LC COP1 RAX2 18397371,18397371,18397371,18397371,18397371 0018,0007,0428,0004,0809 LC COP1 COL3 16339850,16339850 0055,0018 LC COP1 JAR1 21525334,21525334,21525334,21525334 0096,0090,0004,0018 LC COP1 CIP8 10488108,10488108,10488108 0004,0018,0096 LC COP1 GI 19061637 0090 LC COP1 T25B24.3 24838976 0415 LC COP1 BBX22 18796637,18796637 0663,0415 LC COP1 SPA1 11461903,14597662,14597662,11461903,14597662,11461903,18812498,14597662,25744387,25744387,18812498,18812498,14597662,18812498 0018,0004,0401,0007,0071,0096,0006,0007,0004,0018,0004,0007,0018,0401 LC COP1 MYB90 23425305,23425305 0004,0018 LC CIP1 COP1 7753789,7753789,7753789 0084,0096,0047 LC ELF4 COP1 26545401 0004 LC HY5 COP1 24610722,9659918,19802365,24858936,22692212,24858936,10990463,10990463,9659918,9659918 0096,0096,0096,0415,0096,0096,0018,0096,0018,0004 LC DDB1B COP1 20061554,20061554,24067658 0096,0004,0004 LC COL1 COP1 18812498,18812498 0071,0006 LC CIP7 COP1 9668129,9668129,9668129 0096,0084,0004 LC ELF3 COP1 26545401,19061637,19061637,19061637,19061637 0004,0004,0090,0415,0018 LC PHYA COP1 18722184,15031264,15031264,22498774,22498774 0004,0415,0096,0018,0004 LC PHYB COP1 20605855,20605855,20605855 0096,0004,0415 LC PHYC COP1 20605855,20605855 0096,0415 LC CCT1 COP1 11752373,11752373 0018,0096 LC PHYD COP1 20605855,20605855 0096,0415 LC PHYE COP1 20605855,20605855 0096,0415 LC COP1 COP1 11080276,19802365,11080276,24554768,18812498,18812498 0018,0096,0004,0428,0007,0006 LC COP1 CSN1 19175768,19175768,19175768,19175768,19175768 0004,0018,0428,0401,0096 LC COP1 DET1 20061554 0401 LC COP1 PHOT2 20624951,20624951,20624951 0809,0004,0007 LC COP1 BBX20 22535582 0096 LC COP1 CO 18388858,18296627,18296627,18388858,18296627,24554768,18296627,18388858,18296627,18388858 0007,0416,0096,0004,0055,0428,0415,0055,0018,0416 LC COP1 CRY1 11752373,11752373,24554768,11752373,11509693,24554768,11509693,11752373,11752373 0018,0019,0004,0007,0019,0428,0663,0096,0004 LC COP1 SCAR1 21972261,21972261 0004,0096 LC COP1 Q84V03 26839287 0004 LC COP1 PIF1 24858936,24858936 0004,0018 LC COP1 CSN4 19175768 0401 LC COP1 CSN5B 19175768 0401 LC COP1 CUL4 16844902,16844902,20061554,24067658 0004,0007,0004,0004 LC COP1 RPP8 20624951,20624951,20624951,20624951 0809,0004,0007,0090 LC COP1 TMN1 26378254 0004 LC COP1 SPA4 12887588,12887588,21798944,12887588,18812498,18812498,18812498,21798944 0018,0019,0096,0007,0006,0007,0004,0397 LC COP1 CRY2 11509693,11509693,11509693,24554768,21514160,11509693 0006,0019,0018,0428,0004,0004 LC COP1 HFR1 17699755,15741320,15741320,15741320,19802365,24554768,15741320,15741320,15705947,17699755,15705947,15741320 0096,0004,0415,0018,0096,0428,0007,0096,0004,0415,0018,0663 LC COP1 MYB75 23425305 0004 LC COP1 CIP4 11226193 0096 LC COP1 BIN4 23573936,23573936,23573936 0004,0018,0090 LC COP1 UVR8 24277841,24554768,19165148,19165148,24651064,25627067,24651064,23277547,24554768,19165148,19165148,25627067,21041653,19165148,24277841,19165148 0004,0004,0004,0018,0018,0018,0004,0004,0428,0007,0416,0004,0007,0809,0018,0663 LC COP1 CNGC19 19802365 0096 LC COP1 COP10 15342494,20061554,18552200 0004,0004,0007 LC COP1 SPA3 12887588,12887588,12887588,18812498,18812498,18812498,24067658 0018,0019,0007,0006,0007,0004,0004 LC COP1 BBX21 17965270,17965270 0055,0663 LC COP1 LAF1 12827204,12827204,12827204,12827204 0663,0401,0415,0096 LC COP1 DDB1A 20061554 0096 LC COP1 RAX2 18397371,18397371,18397371,18397371,18397371 0018,0007,0428,0004,0809 LC COP1 JAR1 21525334,21525334,21525334,21525334 0096,0090,0004,0018 LC COP1 CIP8 10488108,10488108,10488108,12028569,12827204 0004,0018,0096,0096,0096 LC COP1 GRF8 21094157 0004 HT COP1 BBX22 18796637,18796637 0663,0415 LC COP1 SPA1 11461903,18722184,14597662,14597662,11461903,14597662,11461903,19802365,18812498,14597662,25744387,12827204,25744387,18812498,18812498,24067658,21511872,14597662,18812498 0018,0004,0004,0401,0007,0071,0096,0096,0006,0007,0004,0663,0018,0004,0007,0004,0004,0018,0401 LC COP1 SPA2 18812498 0004 LC COP1 MYB90 23425305,23425305 0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q1H5E5 P43254 Q1H5E5 COP1 0.126 21798944 Q9M0V3 P43254 DDB1A COP1 0.309 20061554 Q84V03 P43254 Q84V03 COP1 0.21 26839287 Q9ZTC3 P43254 MYB90 COP1 0.454 23425305 Q9M0K4 P43254 LAF1 COP1 0.794 12827204 Q9SID1 P43254 STH COP1 0.843 18796637,11226162 P43254 C0SVM5 COP1 BBX19 {ECO:0000303|PUBMED:19920209} 0.523 25841036 P43254 P42498 COP1 PHYE 0.523 20605855 P43254 P42497 COP1 PHYD 0.523 20605855 P43254 P14714 COP1 PHYC 0.523 20605855 P43254 P28769 COP1 CCT1 0.523 11752373 Q9LJD7 P43254 COP10 COP1 0.888 15342494,16844902,20061554,11877375,18552200 Q9FN03 P43254 UVR8 COP1 0.991 23277547,24651064,24554768,23653191,25627067,25817546,22988111,19165148,24277841 Q8GZM7 P43254 PIF1 COP1 0.454 24858936 P43254 O82804 COP1 ELF3 0.837 19061637,26545401 P43254 O49552 COP1 DDB1B 0.569 20061554,24067658 P43254 P14712 COP1 PHYA 0.922 22498774,18722184,25627066,15031264 Q43125 P43254 CRY1 COP1 0.953 11752373,18252844,24554768,11509693 Q96524 P43254 CRY2 COP1 0.82 21514160,24554768,11509693 Q9LJR3 P43254 SPA3 COP1 0.801 12887588,18812498,24067658 Q9FE22 P43254 HFR1 COP1 0.992 17699755,24554768,15741320,15705947,15620659,19802365 Q9SKE2 P43254 JAR1 COP1 0.74 21525334 Q8LGH4 P43254 CUL4 COP1 0.61 24067658,16844902,20061554 Q8W191 P43254 HYH COP1 0.74 12023303,19802365 Q94BM7 P43254 SPA4 COP1 0.858 12887588,18812498,21798944 Q9SPL2 P43254 CIP8 COP1 0.963 12827204,12028569,10488108 Q39057 P43254 CO COP1 0.972 18388858,18296627,24554768 P43254 O24646 COP1 HY5 0.999 14597662,9755158,22692212,9659918,10990463,24858936,19802365,24610722,11226162,23425305,21097709 Q9SYX2 P43254 SPA1 COP1 0.999 12827204,14597662,11461903,21511872,18812498,18722184,19802365,25744387,24067658 P43254 P43254 COP1 COP1 0.994 9755158,8837504,11080276,25817546,21153370,19802365,24858936,18812498,15084749,24554768 Q8W4J9 P43254 RPP8 COP1 0.454 20624951 Q940G0 P43254 TMN1 {ECO:0000303|PUBMED:20681974} COP1 0.21 26378254 Q96288 P43254 STO COP1 0.671 11226162 Q9FE25 P43254 MYB75 COP1 0.21 23425305 Q9SYM2 P43254 Q9SYM2 COP1 0.155 18796637 P45432 P43254 CSN1 COP1 0.74 19175768 Q9SK53 P43254 COL3 COP1 0.772 16339850 P48348 P43254 GRF8 COP1 0.126 21094157 P48732 P43254 DET1 COP1 0.126 20061554 Q0IGM7 P43254 BBX20 COP1 0.309 22535582 P43254 P14713 COP1 PHYB 0.82 11752373,20605855 P93025 P43254 PHOT2 COP1 0.21 20624951 P62837 P43254 UBE2D2 COP1 0.033 15741320 P43254 O50055 COP1 COL1 0.332 18812498 Q9LQZ7 P43254 Q9LQZ7 COP1 0.569 17965270 Q38843 P43254 Q38843 COP1 0.376 7753789 Q29504 P43254 UBA1 COP1 0.033 15741320 Q6AWX6 P43254 SCAR1 COP1 0.454 21972261 Q8W575 P43254 CSN3 COP1 0.21 14597662 Q8L5U0 P43254 CSN4 COP1 0.21 19175768 Q8W206 P43254 CSN6A COP1 0.21 14597662 Q8LAZ7 P43254 CSN5B COP1 0.21 19175768 Q96RU8 P43254 TRIB1 COP1 0.309 27041596 Q9FLU1 P43254 BIN4 COP1 0.74 23573936 Q9SQI2 P43254 GI COP1 0.309 19061637 Q9SJL7 P43254 RAX2 COP1 0.794 18397371 Q9T014 P43254 SPA2 COP1 0.126 18812498 P43254 O04211 COP1 ELF4 0.21 26545401