PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O49484 O04197 - 14749489 - X 2 O65674 O04197 - 14749489 - X 2 O04197 Q9FHW7 - 14749489 - X 2 O04197 Q39255 - 14749489 - X 2 Q8W4J8-2 O04197 two hybrid 18547396 direct interaction X 2 Q8W4J8-2 O04197 two hybrid 18547396 direct interaction X 2 Q8W4J8-2 O04197 pull down 18547396 direct interaction X 2 Q8W4J8-2 O04197 two hybrid 21205029 direct interaction X 2 O49484 O04197 two hybrid 14749489 direct interaction X 2 O49484 O04197 two hybrid 14749489 direct interaction X 2 O65674 O04197 two hybrid 14749489 direct interaction X 2 O65674 O04197 two hybrid 14749489 direct interaction X 2 F4J6F9 O04197 two hybrid 18547396 direct interaction X 2 F4J6F9 O04197 pull down 17637675 direct interaction X 2 F4J6F9 O04197 pull down 17637675 direct interaction X 2 F4J6F9 O04197 pull down 20525008 direct interaction X 2 F4J6F9 O04197 two hybrid 20525008 direct interaction X 2 Q9LMA8 O04197 two hybrid 18547396 direct interaction X 2 Q9LMA8 O04197 two hybrid 18547396 direct interaction X 2 Q9LMA8 O04197 two hybrid 17637677 direct interaction X 2 Q9LMA8 O04197 two hybrid 17637677 direct interaction X 2 Q9LMA8 O04197 pull down 19717617 direct interaction X 2 Q9LMA8 O04197 biochemical 20360743 association X 2 O04197 Q9FHW7 two hybrid 14749489 direct interaction X 2 O04197 Q9FHW7 two hybrid 14749489 direct interaction X 2 O04197 Q9FHW7 two hybrid 12172031 direct interaction X 2 O04197 Q9FHW7 affinity chromatography technology 12172031 physical association X 2 O04197 Q9FHW7 affinity chromatography technology 12172031 physical association X 2 O04197 O22446 affinity chromatography technology 12445118 physical association X 2 O04197 Q9FHW7 two hybrid 12445118 direct interaction X 2 Q93ZM9-3 O04197 pull down 20525008 direct interaction X 2 O04197 two hybrid 12445118 direct interaction X 2 Q9FML2 O04197 two hybrid 12445118 direct interaction X 2 Q9S7M2 O04197 pull down 20525008 direct interaction X 2 Q9S7M2 O04197 two hybrid 20525008 direct interaction X 2 B9DGE3 O04197 affinity chromatography technology 15860010 physical association X 2 B9DGE3 O04197 affinity chromatography technology 12172031 physical association X 2 B9DGE3 O04197 affinity chromatography technology 12445118 physical association X 2 B9DGE3 O04197 pull down 14675533 direct interaction X 2 O04197 two hybrid 12445118 direct interaction X 2 O04197 Q39255 two hybrid 14749489 direct interaction X 2 O04197 Q39255 two hybrid 12172031 direct interaction X 2 O04197 Q39255 affinity chromatography technology 12172031 physical association X 2 O04197 F4K5K1 affinity chromatography technology 12172031 physical association X 2 O04197 Q39255 affinity chromatography technology 12445118 physical association X 2 O04197 Q39255 pull down 14675533 direct interaction X 2 Q9LMA8 O04197 two hybrid 20927106 direct interaction X 2 Q9LMA8 O04197 two hybrid 17637677 direct interaction X 2 Q9LMA8 O04197 tandem affinity purification 20360743 direct interaction X 2 Q9LMA8 O04197 pull down 17637675 direct interaction X 2 Q9LMA8 O04197 pull down 20927106 direct interaction X 2 Q8W4J8 O04197 two hybrid 23169619 direct interaction X 2 O04197 x-ray crystallography 20927106 physical association C 3 O04197 tandem affinity purification 20360743 - C 5 Q9LVI4 O04197 pull down 17637675 direct interaction X 2 Q9LVI4 O04197 pull down 17637675 direct interaction X 2 O04197 Q39255 mass spectrometry studies of complexes 20927106 direct interaction X 2 O04197 Q39255 molecular sieving 20927106 direct interaction X 2 O04197 Q39255 pull down 20927106 direct interaction X 2 O04197 anti tag coimmunoprecipitation 12724535 association C 6 O04197 anti tag coimmunoprecipitation 12724535 association C 6 O04197 anti bait coimmunoprecipitation 12172031 association C 4 O49484 O04197 two hybrid 14749489 physical association X 2 O49484 O04197 two hybrid 14749489 physical association X 2 O65674 O04197 two hybrid 14749489 physical association X 2 O65674 O04197 two hybrid 14749489 physical association X 2 Q9LMA8 O04197 two hybrid 17637677 physical association X 2 Q9LMA8 O04197 two hybrid 18547396 physical association X 2 Q9LMA8 O04197 two hybrid 18547396 physical association X 2 Q9LMA8 O04197 two hybrid 18547396 physical association X 2 Q9LMA8 O04197 two hybrid 18547396 physical association X 2 P43292 O04197 two hybrid 14749489 physical association X 2 O04197 Q9FHW7 two hybrid 12172031 physical association X 2 O04197 Q9FHW7 anti bait coimmunoprecipitation 12172031 physical association X 2 O04197 Q9FHW7 anti bait coimmunoprecipitation 12172031 physical association X 2 O04197 Q9FHW7 two hybrid 12445118 physical association X 2 O04197 Q9FHW7 two hybrid 12445118 physical association X 2 O04197 Q9FHW7 two hybrid 14749489 physical association X 2 Q8W4J8 O04197 two hybrid 18547396 physical association X 2 Q8W4J8 O04197 two hybrid 18547396 physical association X 2 Q8W4J8 O04197 pull down 18547396 physical association X 2 Q8W4J8 O04197 two hybrid 18547396 physical association X 2 Q8W4J8 O04197 two hybrid 18547396 physical association X 2 O04197 anti bait coimmunoprecipitation 12724535 association C 4 O04197 anti bait coimmunoprecipitation 12724535 association C 4 Q9LVI4 O04197 pull down 17637675 direct interaction X 2 Q9LVI4 O04197 pull down 17637675 direct interaction X 2 Q9LVI4 O04197 two hybrid 18547396 physical association X 2 Q9LVI4 O04197 two hybrid 18547396 physical association X 2 Q9LVI4 O04197 two hybrid 19309455 physical association X 2 Q9LVI4 O04197 pull down 19309455 physical association X 2 Q9FML2 O04197 two hybrid 12445118 physical association X 2 Q9FML2 O04197 anti tag coimmunoprecipitation 12445118 physical association X 2 Q9FML2 O04197 two hybrid 12445118 physical association X 2 Q9S7M2 O04197 two hybrid 18547396 physical association X 2 B9DGE3 O04197 anti bait coimmunoprecipitation 12172031 physical association X 2 B9DGE3 O04197 anti tag coimmunoprecipitation 12445118 physical association X 2 B9DGE3 O04197 molecular sieving 12724535 physical association X 2 O04197 Q39255 anti bait coimmunoprecipitation 12172031 physical association X 2 O04197 Q39255 two hybrid 12172031 physical association X 2 O04197 Q39255 two hybrid 12445118 physical association X 2 O04197 Q39255 two hybrid 12445118 physical association X 2 O04197 Q39255 anti tag coimmunoprecipitation 12445118 physical association X 2 O04197 Q39255 two hybrid 14749489 physical association X 2 O04197 Q39255 two hybrid array 21798944 physical association X 2 P10798 O04197 two hybrid 12445118 physical association X 2 P10798 O04197 two hybrid 12445118 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B COI1 RBCS-3B MI:0018(two hybrid)|MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_16722|UniProt_16717 bait|bait prey|prey COI1 TIFY10A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 17637677,18547396,19717617,20360743 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_1210|UniProt_11470|UniProt_11482|BIOGRID_2911|UniProt_11480|BIOGRID_4211|UniProt_11474|BIOGRID_2910|BIOGRID_1207|UniProt_13993|BIOGRID_3831 prey|bait|bait|bait|bait|prey|bait|prey|bait|bait|prey bait|prey|prey|prey|prey|bait|prey|bait|prey|prey|bait COI1 HDA6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_6895|UniProt_16723|UniProt_16718|UniProt_16727 bait|bait|bait|bait prey|prey|prey|prey COI1 HDA19 MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_2151 bait prey COI1 CIP1 MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_2147 bait prey COI1 TIFY7 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18547396,21205029 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(intact) BIOGRID_1211|BIOGRID_1212|UniProt_11483|BIOGRID_6495|UniProt_11481|UniProt_11472|UniProt_11473|BIOGRID_1209|UniProt_11478 prey|prey|bait|bait|bait|bait|bait|bait|prey bait|bait|prey|prey|prey|prey|prey|prey|bait COI1 ASK12 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14749489 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_290|BIOGRID_245|UniProt_17416|UniProt_17381 prey|bait|prey|bait bait|prey|bait|prey COI1 SKP1A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid) 12172031,12445118,14675533,14749489,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(biogrid) BIOGRID_2101|BIOGRID_2103|UniProt_17378|BIOGRID_246|UniProt_16719|UniProt_16726|UniProt_16715|BIOGRID_2150|UniProt_16069|UniProt_1694|UniProt_16067|BIOGRID_2457 bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey COI1 CUL1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid) 12172031,12445118,12724535 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_16404|UniProt_16403|UniProt_16406|UniProt_16725|UniProt_16071|UniProt_16405|UniProt_16073 prey|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey COI1 SRK2G MI:0018(two hybrid)|MI:0018(two hybrid) 12172031,14749489 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (intact)|(intact) UniProt_17414|UniProt_16073 prey|bait bait|prey COI1 CIP4 MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_2148 bait prey COI1 SKP1B MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12172031,12445118,14749489 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact) UniProt_16720|BIOGRID_282|BIOGRID_6894|UniProt_17379|BIOGRID_2102|UniProt_16072|BIOGRID_247|BIOGRID_2104|BIOGRID_2107|UniProt_16070|UniProt_16716|UniProt_16068 bait|prey|bait|bait|bait|prey|bait|bait|prey|bait|bait|bait prey|bait|prey|prey|prey|bait|prey|prey|bait|prey|prey|prey COI1 ASK11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14749489 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(biogrid) BIOGRID_244|UniProt_17380|UniProt_17415|BIOGRID_287 bait|bait|prey|prey prey|prey|bait|bait COI1 TIFY6B MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 17637675,18547396,19309455,20525008 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(biogrid) BIOGRID_4835|UniProt_15002|BIOGRID_2914|UniProt_10781|UniProt_11471|BIOGRID_2915|UniProt_10806|UniProt_15001|BIOGRID_1208|UniProt_11475|BIOGRID_4837 prey|prey|bait|prey|bait|prey|prey|bait|bait|bait|prey bait|bait|prey|bait|prey|bait|bait|prey|prey|prey|bait COI1 TIFY9 MI:0096(pull down) 20525008 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4833 prey bait COI1 RBX1A MI:0018(two hybrid) 12172031 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_2105 bait prey COI1 TIFY10B MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down) 18547396,20525008 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(biogrid) BIOGRID_4834|UniProt_11484|BIOGRID_4836 prey|bait|prey bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality CIP1 COI1 12445118 0018 LC COI1 ASK11 14749489 0018 LC COI1 ASK12 14749489 0018 LC COI1 RBCS-3B 12445118 0018 LC COI1 SRK2G 14749489 0018 LC COI1 SKP1A 12172031,20927106,12445118,12445118,18762895,20927106,12445118,12172031,18762895,12172031,20927106,21798944,14749489 0004,0071,0018,0007,0004,0096,0004,0018,0018,0006,0069,0397,0018 LC,HT COI1 TIFY7 23169619,26320228,18547396,21205029,18547396 0018,0018,0096,0018,0018 LC COI1 CUL1 12724535,12724535,12724535 0006,0071,0007 LC COI1 TIFY3B 26320228,26320228 0018,0004 LC COI1 Q9FGK0 24833385 0090 HT COI1 CIP4 12445118 0018 LC COI1 SKP1B 12172031,12445118,14749489,12172031,12172031 0004,0018,0018,0006,0018 LC COI1 HDA6 12445118,12445118 0018,0007 LC COI1 TIFY10A 20927106,17637677,20927106,20360743,20360743,18547396 0018,0018,0096,0676,0401,0018 LC COI1 TIFY6B 19309455,19309455,20525008,20525008,18547396 0096,0018,0096,0018,0018 LC COI1 TIFY10B 20525008,20525008,18547396 0096,0018,0018 LC COI1 COI1 12724535 0007 LC COI1 HDA19 12445118 0004 LC COI1 CSN8 12724535 0007 LC COI1 SRK2A 12172031 0006 LC COI1 SRK2G 12172031 0006 LC COI1 SKP1A 12172031,20927106,12445118,12445118,18762895,20927106,12445118,12172031,18762895,14675533,12172031,26320228,20927106 0004,0071,0018,0007,0004,0096,0004,0018,0018,0096,0006,0004,0069 LC COI1 CSN4 12724535,12724535 0006,0007 LC COI1 TIFY7 18547396,26198069,18547396 0096,0004,0018 LC COI1 CSN3 12724535,12724535 0006,0007 LC COI1 TIFY9 20525008 0096 LC COI1 RBX1A 12172031 0004 LC COI1 CUL1 12172031,12445118,26320228,12724535,12724535,12724535,12445118,14675533,12172031,15860010 0004,0007,0004,0006,0071,0007,0004,0096,0006,0004 LC COI1 TIFY3B 26320228,26320228 0018,0004 LC COI1 SKP1B 12172031,12172031,26320228,12172031 0004,0006,0004,0018 LC COI1 HDA6 12445118,12445118 0018,0007 LC COI1 TIFY10A 20927106,20927106,17637675,20360743,19717617,20360743 0018,0096,0096,0676,0096,0401 LC COI1 TIFY6B 19309455,19309455,17637675,20525008,20525008 0096,0018,0096,0096,0018 LC COI1 TIFY10B 20525008,20525008 0096,0018 LC COI1 AFPH2 26320228 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8L5U0 O04197 CSN4 COI1 0.507 12724535 O49484 O04197 ASK11 COI1 0.454 14749489 Q9FML2 O04197 HDA6 COI1 0.74 12445118 P10798 O04197 RBCS-3B COI1 0.309 12445118 P43292 O04197 SRK2G COI1 0.354 14749489,12172031 O65674 O04197 ASK12 COI1 0.554 14749489 Q8W575 O04197 CSN3 COI1 0.376 12724535 Q9LMA8 O04197 TIFY10A COI1 0.959 18547396,20360743,19717617,17637677 Q94AH6 O04197 CUL1 COI1 0.934 12172031,14675533,15860010,26320228,12724535,12445118 Q8W4J8 O04197 TIFY7 COI1 0.968 26198069,26320228,21205029,26258305,18547396 Q9LVI4 O04197 TIFY6B COI1 0.964 19309455,17637675,20525008,18547396 Q39255 O04197 SKP1A COI1 0.978 14749489,12172031,21798944,14675533,18762895,12445118,26320228 Q9FHW7 O04197 SKP1B COI1 0.962 12445118,14749489,12172031,26320228 Q93ZM9 O04197 TIFY9 COI1 0.309 20525008 Q9C5K8 O04197 TIFY3B COI1 0.569 26320228 Q9FGK0 O04197 Q9FGK0 COI1 0.183 24833385 O04197 O04197 COI1 COI1 0.236 12724535 O22446 O04197 HDA19 COI1 0.21 12445118 P43255 O04197 CSN8 COI1 0.21 12724535 P43291 O04197 SRK2A COI1 0.21 12172031 Q940X7 O04197 RBX1A COI1 0.21 12172031 Q9S7M2 O04197 TIFY10B COI1 0.671 18547396,20525008 Q9SV55 O04197 AFPH2 COI1 0.21 26320228