PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9SYX2 pull down 18812498 direct interaction X 2 Q9SYX2 pull down 18812498 direct interaction X 2 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q9SYX2 biochemical 18812498 colocalization X 2 Q9SYX2 Q9FE25 two hybrid 23425305 direct interaction X 2 Q9SYX2 Q9FE25 affinity chromatography technology 23425305 physical association X 2 Q9SYX2 Q39057-2 pull down 16854975 direct interaction X 2 Q9SYX2 Q39057-2 fluorescent resonance energy transfer 16854975 direct interaction X 2 Q9SYX2 Q9T014 pull down 18812498 direct interaction X 2 Q9SYX2 Q9T014 pull down 18812498 direct interaction X 2 Q9SYX2 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q9SYX2 Q9T014 biochemical 18812498 colocalization X 2 Q9SYX2 Q43125 two hybrid 21511871 direct interaction X 2 Q9SYX2 Q43125 affinity chromatography technology 21511871 physical association X 2 Q9SYX2 Q43125 two hybrid 22577138 direct interaction X 2 G4WTR2 Q9SYX2 fluorescent resonance energy transfer 22739826 direct interaction X 2 G4WTR2 Q9SYX2 two hybrid 21514160 direct interaction X 2 G4WTR2 Q9SYX2 affinity chromatography technology 21514160 physical association X 2 G4WTR2 Q9SYX2 two hybrid 22139370 direct interaction X 2 Q9ZTC3 Q9SYX2 two hybrid 23425305 direct interaction X 2 Q9ZTC3 Q9SYX2 affinity chromatography technology 23425305 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 24067658 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 24067658 physical association X 2 P43254 Q9SYX2 biochemical 14597662 colocalization X 2 P43254 Q9SYX2 affinity chromatography technology 14597662 physical association X 2 P43254 Q9SYX2 two hybrid 11461903 direct interaction X 2 P43254 Q9SYX2 pull down 11461903 direct interaction X 2 P43254 Q9SYX2 pull down 11461903 direct interaction X 2 P43254 Q9SYX2 affinity chromatography technology 18722184 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18722184 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 P43254 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 P43254 Q9SYX2 biochemical 18812498 colocalization X 2 Q9FN03 Q9SYX2 affinity chromatography technology 24277841 physical association X 2 Q9FN03 Q9SYX2 affinity chromatography technology 24277841 physical association X 2 Q94BM7 Q9SYX2 pull down 18812498 direct interaction X 2 Q94BM7 Q9SYX2 pull down 18812498 direct interaction X 2 Q94BM7 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q94BM7 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q94BM7 Q9SYX2 biochemical 18812498 colocalization X 2 P14713 Q9SYX2 affinity chromatography technology 23371951 physical association X 2 P14713 Q9SYX2 two hybrid 23371951 direct interaction X 2 Q9FE22 Q9SYX2 two hybrid 15960622 direct interaction X 2 Q9FE22 Q9SYX2 pull down 15960622 direct interaction X 2 B3H6I9 Q9SYX2 pull down 20061554 direct interaction X 2 Q9SYX2 O49552 affinity chromatography technology 24067658 physical association X 2 Q9SYX2 Q9SYX2 pull down 18812498 direct interaction X 2 Q9SYX2 Q9SYX2 protein complementation assay 18812498 direct interaction X 2 Q9SYX2 Q9SYX2 affinity chromatography technology 18812498 physical association X 2 Q9SYX2 O49552 pull down 20061554 direct interaction X 2 Q9SYX2 O49552 affinity chromatography technology 20061554 physical association X 2 G4WTR2 Q9SYX2 two hybrid 22139370 direct interaction X 2 Q9SYX2 molecular sieving 18812498 association C 6 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 6 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 6 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 6 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 6 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti tag coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 5 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 3 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 3 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 3 Q9SYX2 anti bait coimmunoprecipitation 18812498 association C 3 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 anti tag coimmunoprecipitation 11461903 physical association X 2 P43254 Q9SYX2 two hybrid 11461903 physical association X 2 P43254 Q9SYX2 confocal microscopy 12827204 colocalization X 2 P43254 Q9SYX2 molecular sieving 14597662 physical association X 2 P43254 Q9SYX2 two hybrid 14597662 physical association X 2 P43254 Q9SYX2 two hybrid 14597662 physical association X 2 Q94BM7 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q94BM7 Q9SYX2 confocal microscopy 18812498 colocalization X 2 Q94BM7 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9FE22 Q9SYX2 two hybrid 15960622 physical association X 2 Q9FE22 Q9SYX2 two hybrid 15960622 physical association X 2 Q9FE22 Q9SYX2 anti tag coimmunoprecipitation 15960622 direct interaction X 2 Q9LJR3 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9LJR3 Q9SYX2 confocal microscopy 18812498 colocalization X 2 Q9LJR3 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9SYX2 O24646 two hybrid 14597662 physical association X 2 Q9SYX2 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9SYX2 Q9SYX2 bimolecular fluorescence complementation 18812498 physical association X 2 Q9SYX2 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 Q9SYX2 Q9SYX2 confocal microscopy 18812498 colocalization X 2 O50055 Q9SYX2 anti tag coimmunoprecipitation 16854975 physical association X 2 O50055 Q9SYX2 fluorescent resonance energy transfer 16854975 direct interaction X 2 O50055 Q9SYX2 confocal microscopy 16854975 colocalization X 2 O50055 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 O50055 Q9SYX2 anti tag coimmunoprecipitation 18812498 physical association X 2 O50055 Q9SYX2 confocal microscopy 18812498 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HY5 SPA1 MI:0071(molecular sieving) 14597662 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_16784 prey bait SPA3 SPA1 MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization) (intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_11196|BIOGRID_1328|UniProt_11160|BIOGRID_1298|BIOGRID_1315|UniProt_11168|BIOGRID_1312|BIOGRID_1292|UniProt_11177 neutral component|prey|prey|bait|bait|bait|prey|prey|neutral component neutral component|bait|bait|prey|prey|prey|bait|bait|neutral component DDB1B SPA1 MI:0401(biochemical)|MI:0401(biochemical)|MI:0004(affinity chromatography technology) 20061554,24067658 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_4067|BIOGRID_4072|BIOGRID_20240 bait|bait|bait prey|prey|prey UVR8 SPA1 MI:0018(two hybrid)|MI:0018(two hybrid) 24277841 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_20557|BIOGRID_20562 bait|bait prey|prey DDB1A SPA1 MI:0401(biochemical) 20061554 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4062 bait prey HFR1 SPA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15960622 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_12704|UniProt_12705|UniProt_12703 bait|bait|bait prey|prey|prey COL1 SPA1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16854975,18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_11196|UniProt_11163|UniProt_12448|UniProt_12447|UniProt_11159|UniProt_12443|UniProt_11176 neutral component|bait|neutral component|neutral component|prey|prey|neutral component neutral component|prey|neutral component|neutral component|bait|bait|neutral component SPA4 SPA1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_11198|UniProt_11199|UniProt_11197|UniProt_11194|UniProt_11173|BIOGRID_1329|BIOGRID_1319|UniProt_11161|BIOGRID_1302|BIOGRID_1313|BIOGRID_1293|UniProt_11178|UniProt_11196 prey|bait|prey|neutral component|bait|prey|bait|prey|bait|prey|prey|neutral component|neutral component bait|prey|prey|neutral component|prey|bait|prey|bait|prey|bait|bait|neutral component|neutral component SPA1 MYB90 MI:0018(two hybrid)|MI:0018(two hybrid) 23425305 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_17152|BIOGRID_17143 prey|prey bait|bait CRY1 SPA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21511871,22577138 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_6753|BIOGRID_15695|BIOGRID_6752 bait|prey|bait prey|bait|prey SPA2 SPA1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_1327|BIOGRID_1294|BIOGRID_1311|BIOGRID_1291 prey|bait|prey|prey bait|prey|bait|bait CO SPA1 MI:0096(pull down)|MI:0096(pull down) 16854975 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_394|BIOGRID_398 prey|prey bait|bait PHYB SPA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23371951 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_17107|BIOGRID_17106 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality HY5 SPA1 14597662 0018 LC COL1 SPA1 18812498,16854975,18812498,16854975,18812498,18812498,16854975 0663,0663,0007,0007,0006,0071,0055 LC PHYA SPA1 25627066,25744387,25744387,25627066,25627066 0055,0090,0018,0004,0018 LC PHYB SPA1 23371951,25744387,25744387,26120968,23371951,25627066 0004,0090,0018,0018,0018,0018 LC COP1 SPA1 11461903,14597662,14597662,11461903,14597662,11461903,18812498,14597662,25744387,25744387,18812498,18812498,14597662,18812498 0018,0004,0401,0007,0071,0096,0006,0007,0004,0018,0004,0007,0018,0401 LC CO SPA1 16854975,16854975 0055,0096 LC CRY1 SPA1 22577138,21511871,21511872,21511871,21511872 0018,0004,0004,0018,0018 LC SPA4 SPA1 18812498,18812498,18812498,18812498,18812498,18812498 0096,0663,0006,0007,0401,0004 LC CRY2 SPA1 22139370,21514160,21514160,21511872,22739826 0018,0004,0018,0018,0055 LC HFR1 SPA1 15960622,15960622,15960622 0018,0096,0007 LC MYB75 SPA1 23425305,23425305 0004,0018 LC SPA3 SPA1 18812498,18812498,18812498,18812498,18812498 0096,0007,0401,0004,0663 LC SPA1 SPA1 18812498,18812498,18812498,18812498,18812498,18812498 0096,0663,0090,0007,0004,0809 LC SPA1 SPA2 18812498,18812498,18812498 0096,0401,0004 LC SPA1 MYB90 23425305,23425305 0004,0018 LC ELF4 SPA1 26545401 0004 LC DDB1B SPA1 20061554,20061554,24067658 0096,0004,0004 LC COL1 SPA1 18812498,16854975,18812498,16854975,18812498,18812498,16854975 0663,0663,0007,0007,0006,0071,0055 LC ELF3 SPA1 26545401 0004 LC PHYA SPA1 25627066,25627066,25627066 0055,0004,0018 LC PHYB SPA1 23371951,23371951 0004,0018 LC COP1 SPA1 11461903,18722184,14597662,14597662,11461903,14597662,11461903,19802365,18812498,14597662,25744387,12827204,25744387,18812498,18812498,24067658,21511872,14597662,18812498 0018,0004,0004,0401,0007,0071,0096,0096,0006,0007,0004,0663,0018,0004,0007,0004,0004,0018,0401 LC CO SPA1 16854975,16854975 0055,0096 LC CRY1 SPA1 21511871,21511872,21511871,21511872 0004,0004,0018,0018 LC Q84V03 SPA1 26839287 0004 LC PIF1 SPA1 24858936 0004 LC SPA4 SPA1 18812498,18812498,18812498,18812498,18812498,18812498 0096,0663,0006,0007,0401,0004 LC CRY2 SPA1 21514160,21514160 0004,0018 LC HFR1 SPA1 15960622,15960622,15960622 0018,0096,0007 LC MYB75 SPA1 23425305,23425305 0004,0018 LC UVR8 SPA1 24277841 0004 LC SPA3 SPA1 18812498,18812498,18812498,18812498,18812498 0096,0007,0401,0004,0663 LC DDB1A SPA1 20061554 0096 LC SPA1 SPA1 18812498,18812498,18812498,18812498,18812498,18812498 0096,0663,0090,0007,0004,0809 LC SPA1 SPA2 18812498,18812498,18812498 0096,0401,0004 LC SPA1 MYB90 23425305,23425305 0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9SYX2 Q9FN03 SPA1 UVR8 0.21 24277841 Q9SYX2 Q9M0V3 SPA1 DDB1A 0.309 20061554 Q9SYX2 O24646 SPA1 HY5 0.309 14597662 Q9SYX2 O82804 SPA1 ELF3 0.21 26545401 Q9SYX2 Q84V03 SPA1 Q84V03 0.21 26839287 Q9ZTC3 Q9SYX2 MYB90 SPA1 0.454 23425305 Q9SYX2 P14712 SPA1 PHYA 0.82 25744387,25627066 Q9SYX2 Q39057 SPA1 CO 0.523 16854975 Q9SYX2 Q9FE25 SPA1 MYB75 0.454 23425305 Q9SYX2 O49552 SPA1 DDB1B 0.569 20061554,24067658 Q9SYX2 O50055 SPA1 COL1 0.776 16854975,18812498 Q9SYX2 Q9LJR3 SPA1 SPA3 0.712 18812498 Q9SYX2 Q94BM7 SPA1 SPA4 0.78 18812498 Q9SYX2 Q9SYX2 SPA1 SPA1 0.717 18812498 Q9SYX2 P43254 SPA1 COP1 0.999 12827204,14597662,11461903,21511872,18812498,18722184,19802365,25744387,24067658 Q9SYX2 Q43125 SPA1 CRY1 0.794 21511872,21511871,22577138 Q9SYX2 Q8GZM7 SPA1 PIF1 0.21 24858936 Q9SYX2 Q96524 SPA1 CRY2 0.82 21514160,22139370,21511872,22739826 Q9SYX2 Q9FE22 SPA1 HFR1 0.772 15960622 Q9T014 Q9SYX2 SPA2 SPA1 0.463 18812498 Q9SYX2 P14713 SPA1 PHYB 0.876 25744387,25627066,26120968,23371951 Q9SYX2 O04211 SPA1 ELF4 0.21 26545401