PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P30183 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9FFV8 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9AR19 A8MRD5 pull down 11266554 direct interaction X 2 Q9AR19 Q9ATB4-3 pull down 11266554 direct interaction X 2 Q9AR19 P93835 pull down 11266554 direct interaction X 2 Q9AR19 Q9FFC0 enzymatic study 16648464 direct interaction X 2 Q9AR19 B9DGR9 enzymatic study 16648464 direct interaction X 2 Q9AR19 Q9ATB4-3 two hybrid 18498779 direct interaction X 2 Q9AR19 A8MRD5 two hybrid 18498779 direct interaction X 2 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9AR19 P93008 two hybrid 18498779 direct interaction X 2 Q9AR19 Q9SRR2 two hybrid 18498779 direct interaction X 2 Q9AR19 Q9LZD3 two hybrid 18498779 direct interaction X 2 Q9AR19 O22775 two hybrid 18498779 direct interaction X 2 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9ZVT0 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9LD55 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9SJC4 Q9AR19 two hybrid 18498779 direct interaction X 2 O49385 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9LR65 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9LR65 Q9AR19 pull down 18498779 direct interaction X 2 Q9LR65 Q9AR19 protein complementation assay 18498779 direct interaction X 2 Q9LR65 Q9AR19 enzymatic study 18498779 direct interaction X 2 Q8H1E5 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9AR19 O81826 enzymatic study 16648464 direct interaction X 2 Q9AR19 Q6A333-3 two hybrid 18498779 direct interaction X 2 Q9AR19 Q39067 two hybrid 18498779 direct interaction X 2 Q9AR19 Q0WNJ6 two hybrid 18498779 direct interaction X 2 Q9AR19 Q94K05 two hybrid 18498779 direct interaction X 2 Q38953 Q9AR19 two hybrid 18498779 direct interaction X 2 Q9SFD5 Q9AR19 two hybrid 16603259 physical association X 2 Q9SFD5 Q9AR19 two hybrid 16603259 physical association X 2 Q9AR19 P93835 two hybrid 16603259 physical association X 2 Q9ATB4 Q9AR19 two hybrid 16603259 physical association X 2 Q9ATB4 Q9AR19 enzymatic study 16603259 acetylation reaction X 2 Q9ATB4 Q9AR19 pull down 21798944 direct interaction X 2 Q9ATB4 Q9AR19 pull down 21798944 direct interaction X 2 Q9ATB4 Q9AR19 two hybrid array 21798944 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B At4g32190 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6466 prey bait HAG1 PPC6-6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_6472|BIOGRID_6473|BIOGRID_6474|BIOGRID_6457 prey|prey|prey|bait bait|bait|bait|prey At4g27230 HAG1 MI:0415(enzymatic study) 16648464 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_5868 prey bait RH21 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6458 prey bait CHC1 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6462 prey bait HAG1 ADA2A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 11266554,16603259,18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid) UniProt_13515|UniProt_13514|BIOGRID_1999|BIOGRID_6450 bait|bait|bait|bait prey|prey|prey|prey CYCB1-1 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6456 prey bait HTR4 HAG1 MI:0415(enzymatic study) 16648464 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_5870 prey bait HAG1 MYB106 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6454 bait prey GT2 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6468 prey bait HAG1 TIF3A1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6460 bait prey F10N7.120 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6467 prey bait DREB1B HAG1 MI:0096(pull down)|MI:0018(two hybrid) 11266554,16603259 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_2003|UniProt_13513 bait|prey prey|bait HAG1 COI MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:838603() MI:0407(direct interaction) (biogrid) BIOGRID_6470 bait prey HAG1 NUDT6 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6452 bait prey HAG1 At5g22880 MI:0415(enzymatic study) 16648464 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_5869 bait prey HAG1 At5g38640/MBB18.19 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6461 bait prey HAG1 ADA2B MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0397(two hybrid array) 11266554,16603259,18498779,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0192(acetylation reaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact) BIOGRID_6449|UniProt_8745|UniProt_8746|UniProt_13516|UniProt_13517|BIOGRID_2000|UniProt_7266 bait|bait|prey|bait|unspecified role|bait|bait prey|prey|bait|prey|unspecified role|prey|prey ALY2 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6453 prey bait CYCB1-2 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6455 prey bait HAG1 At5g08630 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6469 bait prey HAG1 F12E4_320 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6464 bait prey HAG1 At5g51850 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6471 bait prey HAG1 FH10 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6463 bait prey At3g26560 HAG1 MI:0018(two hybrid) 18498779 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_6459 prey bait

PPI - HINT Gene A Gene B PMID Method Quality CHR5 HAG1 18498779 0018 LC MYB106 HAG1 18498779 0018 LC F4KB54 HAG1 18498779 0018 LC XXT2 HAG1 18498779 0018 LC F10N7.120 HAG1 18498779 0018 LC O81826 HAG1 16648464 0415 LC CYCB1-1 HAG1 18498779 0018 LC HTR4|HTR5|HTR8 HAG1 16648464 0415 LC RH21 HAG1 18498779 0018 LC DREB1B HAG1 16603259 0018 LC CHC1 HAG1 18498779 0018 LC Q38953 HAG1 18498779 0018 LC CYCB1-2 HAG1 18498779 0018 LC ALY2 HAG1 18498779 0018 LC Q8H1E5 HAG1 18498779 0018 LC CCT8 HAG1 18498779 0018 LC HAG1 ADA2B 16603259,21798944,16603259,18498779,21798944 0415,0096,0018,0018,0397 LC,HT HAG1 Q9FFC0 16648464 0415 LC HAG1 Q9FFV8 18498779 0018 LC HAG1 Q9FLH6 18498779 0018 LC HAG1 TIF3A1 18498779 0018 LC HAG1 PPC6-6 18498779,18498779,18498779,18498779 0090,0415,0018,0096 LC HAG1 EXO70A1 18498779 0018 LC HAG1 F14O23.11 17151888,17151888 0018,0096 LC HAG1 ADA2A 16603259,18498779,16603259 0415,0018,0018 LC HAG1 NUDT6 18498779 0018 LC HAG1 FH10 18498779 0018 LC HAG1 F15K9.11 18498779 0018 LC DREB1B HAG1 11266554 0096 LC HAG1 ADA2B 21798944,11266554,21798944 0096,0096,0397 LC HAG1 PPC6-6 18498779,18498779,18498779,18498779 0090,0415,0018,0096 LC HAG1 F14O23.11 17151888,17151888 0018,0096 LC HAG1 ADA2A 11266554 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9SFD5 Q9AR19 ADA2A HAG1 0.891 16603259,11266554,18498779 Q9AR19 P93835 HAG1 DREB1B 0.523 16603259,11266554 Q9ATB4 Q9AR19 ADA2B HAG1 0.891 11266554,18498779,21798944,16603259 Q9AR19 F4IV99 HAG1 CHR5 {ECO:0000303|PUBMED:16547115} 0.309 18498779 Q9AR19 O22775 HAG1 GT2 0.309 18498779 Q9AR19 O81826 HAG1 O81826 0.309 16648464 Q9AR19 P30183 HAG1 CYCB1-1 0.309 18498779 Q9AR19 P59169 HAG1 HTR8 0.309 16648464 Q9AR19 P93008 HAG1 RH21 0.309 18498779 Q9AR19 Q0WNJ6 HAG1 CHC1 0.309 18498779 Q9AR19 Q38953 HAG1 Q38953 0.309 18498779 Q9AR19 Q39067 HAG1 CYCB1-2 0.309 18498779 Q9AR19 Q6A333 HAG1 ALY2 0.309 18498779 Q9AR19 Q94K05 HAG1 T11I18.7 0.309 18498779 Q9FFC0 Q9AR19 Q9FFC0 HAG1 0.309 16648464 Q9LD55 Q9AR19 TIF3A1 HAG1 0.309 18498779 Q9LR65 Q9AR19 PPC6-6 HAG1 0.772 18498779 Q9LZD3 Q9AR19 EXO70A1 HAG1 0.309 18498779 Q9SJC4 Q9AR19 NUDT6 HAG1 0.309 18498779 Q9SRR2 Q9AR19 FH10 HAG1 0.309 18498779