PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q570C0 - 10398681,11713520 - C 3 O49484 Q570C0 - 12795696 - X 2 Q570C0 - 10398681 - X 2 Q570C0 Q9FHW7 - 12795696 - X 2 Q570C0 Q39255 - 12795696 - X 2 Q570C0 Q39255 - 10398681 - X 2 Q570C0 Q9FHW7 - 10398681 - X 2 Q570C0 - 10398681,11713520 - C 3 Q38825 Q570C0 - 15917798 - X 2 Q38825 Q570C0 - 15917797 - X 2 Q38830 Q570C0 - 15992545 - X 2 Q9LSX9 Q570C0 - 12795696 - X 2 P93830 Q570C0 - 11713520 - X 2 Q38832 Q570C0 pull down 15295098 direct interaction X 2 Q570C0 two hybrid 12445118 direct interaction X 2 O49484 Q570C0 two hybrid 12795696 direct interaction X 2 O49484 Q570C0 two hybrid 12795696 direct interaction X 2 B9DGE3 Q570C0 biochemical 18550827 colocalization X 2 B9DGE3 Q570C0 affinity chromatography technology 16045473 physical association X 2 B9DGE3 Q570C0 affinity chromatography technology 12782725 physical association X 2 B9DGE3 Q570C0 affinity chromatography technology 10398681 physical association X 2 Q38822 Q570C0 pull down 14617065 direct interaction X 2 Q38822 Q570C0 pull down 22171938 direct interaction X 2 Q38822 Q570C0 two hybrid 22466420 direct interaction X 2 Q570C0 Q39255 x-ray crystallography 17410169 association X 2 Q570C0 Q39255 protein complementation assay 23226441 direct interaction X 2 Q570C0 Q39255 affinity chromatography technology 12782725 physical association X 2 Q570C0 Q39255 two hybrid 10398681 direct interaction X 2 Q570C0 Q9FHW7 two hybrid 10398681 direct interaction X 2 Q570C0 Q39255 affinity chromatography technology 10398681 physical association X 2 Q570C0 Q9FHW7 affinity chromatography technology 10398681 physical association X 2 Q570C0 Q39255 two hybrid 12795696 direct interaction X 2 Q570C0 Q9FHW7 two hybrid 12795696 direct interaction X 2 Q570C0 Q9FHW7 two hybrid 12445118 direct interaction X 2 Q570C0 Q39255 affinity chromatography technology 16045473 physical association X 2 Q570C0 Q9XFM0 two hybrid 22466420 direct interaction X 2 Q38825 Q570C0 x-ray crystallography 17410169 association X 2 Q38825 Q570C0 affinity chromatography technology 17410169 physical association X 2 Q38825 Q570C0 two hybrid 22912871 direct interaction X 2 Q38825 Q570C0 protein complementation assay 22912871 direct interaction X 2 Q38825 Q570C0 affinity chromatography technology 11713520 physical association X 2 Q38825 Q570C0 pull down 11713520 direct interaction X 2 Q38825 Q570C0 affinity chromatography technology 17942448 physical association X 2 Q38825 Q570C0 pull down 15917797 direct interaction X 2 Q38825 Q570C0 pull down 12932326 direct interaction X 2 Q38825 Q570C0 pull down 15992545 direct interaction X 2 Q38825 Q570C0 two hybrid 22171938 direct interaction X 2 Q38825 Q570C0 pull down 22476291 direct interaction X 2 Q38825 Q570C0 two hybrid 22466420 direct interaction X 2 F4I5P9 Q570C0 pull down 15992545 direct interaction X 2 Q9LSX9 Q570C0 protein complementation assay 23226441 direct interaction X 2 Q9LSX9 Q570C0 two hybrid 12795696 direct interaction X 2 P49677 Q570C0 pull down 15546359 direct interaction X 2 Q9LNT9 Q570C0 protein complementation assay 23226441 direct interaction X 2 P93830 Q570C0 two hybrid 22912871 direct interaction X 2 P93830 Q570C0 protein complementation assay 22912871 direct interaction X 2 P93830 Q570C0 pull down 12932326 direct interaction X 2 P93830 Q570C0 affinity chromatography technology 12782725 physical association X 2 Q570C0 F4IKE9 two hybrid 22912871 direct interaction X 2 Q570C0 F4IKE9 protein complementation assay 22912871 direct interaction X 2 Q570C0 F4IKE9 two hybrid 22466420 direct interaction X 2 Q9SL93 Q570C0 protein complementation assay 23226441 direct interaction X 2 Q9SDY5 Q570C0 pull down 12682009 direct interaction X 2 P33078 Q570C0 two hybrid 22466420 direct interaction X 2 Q38822 Q570C0 pull down 20018756 direct interaction X 2 Q570C0 Q39255 molecular sieving 17410169 direct interaction X 2 Q570C0 Q39255 x-ray crystallography 17410169 direct interaction X 2 Q570C0 Q39255 comigration in non denaturing gel electrophoresis 17410169 direct interaction X 2 Q570C0 Q39255 mass spectrometry studies of complexes 17410169 direct interaction X 2 Q570C0 molecular sieving 18550827 physical association C 4 Q570C0 pull down 24362628 - C 3 Q570C0 molecular sieving 18550827 physical association C 3 Q570C0 comigration in non denaturing gel electrophoresis 17410169 direct interaction C 3 Q570C0 x-ray crystallography 17410169 direct interaction C 3 Q38825 Q570C0 pull down 20018756 direct interaction X 2 Q38825 Q570C0 pull down 17410169 direct interaction X 2 O24409 Q570C0 pull down 24362628 physical association X 2 P43291 Q570C0 two hybrid 18948957 physical association X 2 Q570C0 pull down 11713520 association C 3 Q570C0 molecular sieving 18550827 physical association C 4 O49484 Q570C0 two hybrid 12795696 physical association X 2 O49484 Q570C0 two hybrid 12795696 physical association X 2 Q940X7 Q570C0 pull down 12215511 physical association X 2 Q38822 Q570C0 pull down 14617065 physical association X 2 P10798 Q570C0 two hybrid 12445118 physical association X 2 Q570C0 Q39255 two hybrid 10398681 physical association X 2 Q570C0 Q9FHW7 two hybrid 10398681 physical association X 2 Q570C0 Q9FHW7 two hybrid 10398681 physical association X 2 Q570C0 Q39255 anti tag coimmunoprecipitation 10398681 physical association X 2 Q570C0 Q9FHW7 anti tag coimmunoprecipitation 10398681 physical association X 2 Q570C0 Q39255 two hybrid 10398681 physical association X 2 Q570C0 Q39255 two hybrid 12795696 physical association X 2 Q570C0 Q9FHW7 two hybrid 12795696 physical association X 2 Q570C0 Q9XFM0 pull down 21734647 physical association X 2 Q38825 Q570C0 pull down 11713520 physical association X 2 Q38825 Q570C0 pull down 11713520 physical association X 2 Q38825 Q570C0 anti bait coimmunoprecipitation 11713520 physical association X 2 Q38830 Q570C0 pull down 15992545 physical association X 2 Q9LSX9 Q570C0 two hybrid 12795696 physical association X 2 Q9FML2 Q570C0 two hybrid 12445118 physical association X 2 P49677 Q570C0 pull down 15546359 physical association X 2 P43291 Q570C0 two hybrid 18948957 physical association X 2 P93830 Q570C0 pull down 11713520 physical association X 2 P93830 Q570C0 pull down 11713520 physical association X 2 Q9SDY5 Q570C0 pull down 12682009 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B IAA17 TIR1 MI:0018(two hybrid)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation) 11713520,12782725,12932326,22912871 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact) BIOGRID_16647|BIOGRID_1592|BIOGRID_1620|UniProt_15925|BIOGRID_16650|UniProt_15928 prey|bait|bait|bait|prey|bait bait|prey|prey|prey|bait|prey IAA3 TIR1 MI:0096(pull down) 14617065 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_16345 bait prey TIR1 ASK3 MI:0090(protein complementation assay) 23226441 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_16985 prey bait TIR1 RBX1A MI:0096(pull down) 12215511 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_17798 prey bait TIR1 SKP1B MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10398681,12445118,12795696 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(intact) BIOGRID_2110|UniProt_16039|BIOGRID_2112|UniProt_193343|UniProt_16990|BIOGRID_6896|UniProt_16043|BIOGRID_2340|UniProt_16041 bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey TIR1 CIP1 MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_2149 bait prey SRK2A TIR1 MI:0007(anti tag coimmunoprecipitation) 18948957 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_10679 prey bait TIR1 RCE1 MI:0096(pull down)|MI:0096(pull down) 12682009 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_2230|UniProt_17496 prey|prey bait|bait SKP1A TIR1 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0090(protein complementation assay)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 10398681,12782725,12795696,16045473,17410169,23226441 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid) BIOGRID_16464|BIOGRID_15025|UniProt_16974|UniProt_193327|BIOGRID_2111|UniProt_16038|BIOGRID_2109|BIOGRID_16984|BIOGRID_2287|UniProt_16040|UniProt_16042|BIOGRID_1619 prey|prey|prey|prey|prey|prey|prey|bait|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|prey|bait|bait|bait|bait RBCS-3B TIR1 MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_16724 prey bait TIR1 IAA5 MI:0018(two hybrid) 22466420 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_15536 bait prey TIR1 ASK9 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0090(protein complementation assay)|MI:0018(two hybrid) 12795696,23226441 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact) BIOGRID_2315|UniProt_193397|BIOGRID_16987|UniProt_17044 prey|prey|prey|prey bait|bait|bait|bait IAA7 TIR1 MI:0006(anti bait coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down) 11713520,12932326,15917797,15992545,17410169,17942448,22171938,22466420,22476291,22912871 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_15924|BIOGRID_16465|BIOGRID_15534|BIOGRID_16466|BIOGRID_15538|BIOGRID_14946|UniProt_15926|BIOGRID_1553|BIOGRID_629|UniProt_15927|BIOGRID_16648|BIOGRID_504|UniProt_15923|BIOGRID_505|BIOGRID_16645|BIOGRID_2738|BIOGRID_1591 bait|prey|bait|prey|prey|prey|bait|bait|bait|bait|prey|bait|bait|bait|prey|bait|bait prey|bait|prey|bait|bait|bait|prey|prey|prey|prey|bait|prey|prey|prey|bait|prey|prey TIR1 IAA3 MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down) 14617065,22171938,22466420 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_15535|BIOGRID_2426|BIOGRID_14944 bait|prey|prey prey|bait|bait IAA14 TIR1 MI:0096(pull down) 15295098 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1783 bait prey ASK11 TIR1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12795696 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(intact)|(intact)|(biogrid) UniProt_193363|UniProt_17011|BIOGRID_2339|UniProt_17010|UniProt_193364|BIOGRID_2298 prey|bait|prey|prey|bait|bait bait|prey|bait|bait|prey|prey TIR1 HDA6 MI:0018(two hybrid) 12445118 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_16721 bait prey IAA12 TIR1 MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation) 15992545 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_2741|UniProt_13438 bait|bait prey|prey IAA1 TIR1 MI:0096(pull down)|MI:0096(pull down) 15546359 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_15946|BIOGRID_2582 bait|bait prey|prey IAA8 TIR1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 22466420,22912871 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_16649|BIOGRID_15537|BIOGRID_16646 prey|prey|prey bait|bait|bait TIR1 IAA28 MI:0096(pull down)|MI:0018(two hybrid) 21734647,22466420 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_8180|BIOGRID_15546 prey|bait bait|prey TIR1 ASK4 MI:0090(protein complementation assay) 23226441 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_16986 prey bait

PPI - HINT Gene A Gene B PMID Method Quality CIP1 TIR1 12445118 0018 LC ASK11 TIR1 12795696,12711337 0018,0018 LC RBCS-3B TIR1 12445118 0018 LC IAA5 TIR1 26236497,22466420 0018,0018 LC ASK3 TIR1 23226441 0090 LC SRK2A TIR1 18948957 0018 LC IAA1 TIR1 25888615 0018 LC IAA17 TIR1 22912871,22912871,24591051 0090,0018,0018 LC IAA3 TIR1 26236497,24591051,22466420 0018,0018,0018 LC IAA7 TIR1 22912871,24591051,22171938,17410169,22466420,25758811,24591051,17410169,17410169,22912871 0018,0018,0018,0004,0018,0018,0096,0096,0114,0090 LC IAA8 TIR1 22912871,26236497,22466420,22912871 0018,0018,0018,0090 LC IAA12 TIR1 26236497 0018 LC ASK9 TIR1 12795696,23226441 0018,0090 LC SKP1A TIR1 17410169,12711337,17410169,17410169,10398681,12795696,10398681,10398681,18391211,10398681,17410169,23226441 0114,0018,0071,0069,0019,0018,0018,0007,0114,0004,0404,0090 LC TIR1 CAND1 18550827 0071 LC TIR1 CUL1 18550827 0401 LC TIR1 AUX1 23539280 0018 LC TIR1 SKP1B 12445118,12711337,10398681,12795696,10398681,10398681,10398681 0018,0018,0019,0018,0018,0007,0004 LC TIR1 HDA6 12445118 0018 LC TIR1 ASK4 23226441 0090 LC TIR1 IAA28 26236497,22466420 0018,0018 LC IAA19 TIR1 24362628 0096 LC IAA1 TIR1 15546359 0096 LC IAA17 TIR1 11713520,12932326,11713520,12782725 0004,0096,0096,0004 LC IAA3 TIR1 25758811,22171938,14617065,20018756 0096,0096,0096,0096 LC IAA7 TIR1 15992545,24591051,15992545,12932326,17410169,15917797,24591051,11713520,17942448,11713520,17410169,15917797,17410169,15917798,22476291,20018756,11713520 0004,0018,0096,0096,0004,0096,0096,0004,0004,0096,0096,0004,0114,0004,0096,0096,0006 LC IAA12 TIR1 15992545,15992545 0096,0004 LC IAA14 TIR1 15295098 0096 LC SKP1A TIR1 17410169,16045473,17410169,17410169,10398681,10398681,10398681,10398681,17410169,12782725 0114,0004,0071,0069,0019,0018,0007,0004,0404,0004 LC TIR1 RBX1A 12215511 0096 LC TIR1 CUL1 16045473,18550827,12782725,10398681 0004,0401,0004,0004 LC TIR1 SKP1B 10398681,10398681,10398681,10398681 0019,0018,0007,0004 LC TIR1 Q9LTX2 24313839 0096 LC TIR1 RCE1 12682009 0096 LC TIR1 IAA28 21734647 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q570C0 O49484 TIR1 ASK11 0.623 12795696,12711337 Q570C0 P10798 TIR1 RBCS-3B 0.309 12445118 Q570C0 P43291 TIR1 SRK2A 0.309 18948957 Q940X7 Q570C0 RBX1A TIR1 0.21 12215511 Q96247 Q570C0 AUX1 TIR1 0.309 23539280 Q9FML2 Q570C0 HDA6 TIR1 0.309 12445118 Q9LSX9 Q570C0 ASK9 TIR1 0.539 12795696,23226441 Q9LTX2 Q570C0 Q9LTX2 TIR1 0.309 24313839 Q8L5Y6 Q570C0 CAND1 TIR1 0.21 18550827 Q9LNT9 Q570C0 ASK4 TIR1 0.309 23226441 Q9XFM0 Q570C0 IAA28 TIR1 0.659 22466420,26236497,21734647 Q570C0 P33078 TIR1 IAA5 0.523 22466420,26236497 Q570C0 P93830 TIR1 IAA17 0.888 24591051,11713520,12932326,12782725,22912871 Q570C0 Q38822 TIR1 IAA3 0.941 22171938,25758811,24591051,22466420,26236497,14617065,20018756 Q9FHW7 Q570C0 SKP1B TIR1 0.905 12795696,12445118,12711337,10398681 Q570C0 Q38826 TIR1 IAA8 0.772 22466420,22912871,26236497 Q570C0 Q39255 TIR1 SKP1A 0.959 12795696,17410169,12711337,12782725,23226441,16045473,10398681 Q570C0 Q38825 TIR1 IAA7 0.999 17410169,24591051,20018756,11713520,15992545,12932326,22476291,22912871,15917797,22171938,25758811,22466420,17942448 Q94AH6 Q570C0 CUL1 TIR1 0.569 10398681,18550827,12782725,16045473 Q9SDY5 Q570C0 RCE1 TIR1 0.454 12682009 Q9SL93 Q570C0 ASK3 TIR1 0.309 23226441 Q570C0 P49677 TIR1 IAA1 0.623 25888615,15546359 Q570C0 Q38830 TIR1 IAA12 0.623 15992545,26236497 Q570C0 Q38832 TIR1 IAA14 0.309 15295098