PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9FE25 Q9T014 two hybrid 23425305 direct interaction X 2 Q9FN03 Q9T014 affinity chromatography technology 24277841 physical association X 2 Q39057-2 Q9T014 pull down 16854975 direct interaction X 2 O49552 Q9T014 pull down 20061554 direct interaction X 2 B3H6I9 Q9T014 pull down 20061554 direct interaction X 2 Q9T014 pull down 18812498 direct interaction X 2 Q9T014 pull down 18812498 direct interaction X 2 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q9SYX2 Q9T014 pull down 18812498 direct interaction X 2 Q9SYX2 Q9T014 pull down 18812498 direct interaction X 2 Q9SYX2 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q9SYX2 Q9T014 biochemical 18812498 colocalization X 2 P43254 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q94BM7 Q9T014 pull down 18812498 direct interaction X 2 Q94BM7 Q9T014 pull down 18812498 direct interaction X 2 Q94BM7 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q9T014 Q9T014 pull down 18812498 direct interaction X 2 Q9T014 Q9T014 affinity chromatography technology 18812498 physical association X 2 Q9ZTC3 Q9T014 two hybrid 23425305 direct interaction X 2 O50055 Q9T014 anti tag coimmunoprecipitation 16854975 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SPA4 SPA2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_1297|BIOGRID_1320|BIOGRID_1303 prey|bait|bait bait|prey|prey CO SPA2 MI:0096(pull down) 16854975 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_395 prey bait SPA3 SPA2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_1299|BIOGRID_1316|BIOGRID_1296 bait|bait|prey prey|prey|bait SPA2 MYB90 MI:0018(two hybrid) 23425305 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_17144 prey bait DDB1A SPA2 MI:0401(biochemical) 20061554 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4064 bait prey SPA2 SPA1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18812498 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_1327|BIOGRID_1294|BIOGRID_1311|BIOGRID_1291 prey|bait|prey|prey bait|prey|bait|bait COL1 SPA2 MI:0007(anti tag coimmunoprecipitation) 16854975 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_12444 prey bait DDB1B SPA2 MI:0401(biochemical) 20061554 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4069 bait prey UVR8 SPA2 MI:0018(two hybrid) 24277841 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_20558 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MYB75 SPA2 23425305 0018 LC SPA1 SPA2 18812498,18812498,18812498 0096,0401,0004 LC SPA2 MYB90 23425305 0018 LC DDB1B SPA2 20061554 0096 LC COL1 SPA2 16854975 0007 LC ELF3 SPA2 26545401 0004 LC COP1 SPA2 18812498 0004 LC CO SPA2 16854975 0096 LC SPA4 SPA2 18812498,18812498 0096,0004 LC UVR8 SPA2 24277841 0004 LC SPA3 SPA2 18812498,18812498 0096,0004 LC DDB1A SPA2 20061554 0096 LC SPA1 SPA2 18812498,18812498,18812498 0096,0401,0004 LC SPA2 SPA2 18812498,18812498 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9T014 O49552 SPA2 DDB1B 0.309 20061554 Q9T014 O50055 SPA2 COL1 0.21 16854975 Q9T014 Q9FN03 SPA2 UVR8 0.21 24277841 Q9T014 Q9M0V3 SPA2 DDB1A 0.309 20061554 Q9ZTC3 Q9T014 MYB90 SPA2 0.309 23425305 Q9T014 O82804 SPA2 ELF3 0.21 26545401 Q9T014 Q9T014 SPA2 SPA2 0.332 18812498 Q9T014 Q9FE25 SPA2 MYB75 0.309 23425305 Q9T014 Q39057 SPA2 CO 0.309 16854975 Q9T014 Q94BM7 SPA2 SPA4 0.416 18812498 Q9T014 Q9LJR3 SPA2 SPA3 0.416 18812498 Q9T014 Q9SYX2 SPA2 SPA1 0.463 18812498 Q9T014 P43254 SPA2 COP1 0.126 18812498