PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P30183 Q8VZS9 pull down 15970679 direct interaction X 2 Q8H1U5 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 O42839 pull down 15970679 direct interaction X 2 Q8VZS9 Q9C6Y3 pull down 15970679 direct interaction X 2 Q8VZS9 Q39067 pull down 15970679 direct interaction X 2 Q8VZS9 Q8LGU6 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 Q9STS3 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 O65418 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 Q8VY89-3 affinity chromatography technology 20706207 physical association X 2 Q9LY29 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 Q84WV1 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 Q8GXD2 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 Q94F20 affinity chromatography technology 20706207 physical association X 2 P28769 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q9M3D6 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q9ZPW2 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 P24100 Q8VZS9 affinity chromatography technology 15970679 physical association X 2 Q9M2R1 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q9SJJ5 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q9C504 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q9LH76 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 B3DNN5 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q8H1U4 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 Q9FVX0 pull down 15970679 direct interaction X 2 Q8VZS9 Q9LDM4 protein complementation assay 20407024 direct interaction X 2 Q8VZS9 Q9SF22 affinity chromatography technology 20706207 physical association X 2 Q9FFF9 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q93Y35 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q8L719 Q8VZS9 protein complementation assay 20706207 direct interaction X 2 Q8L719 Q8VZS9 affinity chromatography technology 20706207 physical association X 2 Q8VZS9 tandem affinity purification 20706207 association C 14 Q8VZS9 tandem affinity purification 20706207 physical association C 10 Q8VZS9 Q8LGU6 two hybrid 17944809 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CYCB1-2 FZR1 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1513 bait prey FZR1 F27M3_4 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5506 bait|bait prey|prey APC4 FZR1 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5493|UniProt_9105 prey|prey bait|bait APC5 FZR1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9105|BIOGRID_5494 prey|prey bait|bait FZR1 T10K17.70 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5491|UniProt_9105 bait|bait prey|prey FZR1 ABCG19 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5499 bait|bait prey|prey FZR1 APC6 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5490|UniProt_9105 bait|bait prey|prey CDKA-1 FZR1 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_1516 prey bait CCT1 FZR1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5507 prey|prey bait|bait APC7 FZR1 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5495|UniProt_9105 prey|prey bait|bait FZR1 ERF115 MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_5500 bait prey FZR1 APC1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9105|BIOGRID_5492 bait|bait prey|prey CDC27B FZR1 MI:0090(protein complementation assay)|MI:0018(two hybrid)|MI:0676(tandem affinity purification) 17944809,20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_5487|UniProt_13971|UniProt_9105 prey|prey|prey bait|bait|bait At4g24820 FZR1 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5498|UniProt_9183 prey|prey bait|bait FZR1 RHM3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5504 bait|bait prey|prey FZR1 CKS2 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5489|UniProt_9105 bait|bait prey|prey FZR1 CYCB2-3 MI:0055(fluorescent resonance energy transfer) 20407024 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4283 bait prey At5g25210/F21J6_105 FZR1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5503 prey|prey bait|bait APC2 FZR1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5497 prey|prey bait|bait At5g26360 FZR1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5501 prey|prey bait|bait CYCB1-1 FZR1 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1510 bait prey FZR1 CYCA1-1 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1504 prey bait At5g25460 FZR1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9183|BIOGRID_5508 prey|prey bait|bait FZR1 APC8 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5488|UniProt_9105 bait|bait prey|prey FZR1 CYCA1-2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1507 prey bait FZR1 At2g18290 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5496|UniProt_9183 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality ALY2 FZR1 20706207,20706207,20706207 0090,0004,0676 LC CDC27B FZR1 17944809 0018 LC FZR1 CYCB2-3 20407024 0090 LC APC6 FZR1 20706207,20706207 0004,0676 HT APC4 FZR1 20706207,20706207 0004,0676 HT CDKA-1 FZR1 15970679 0004 LC CCT1 FZR1 20706207,20706207 0004,0676 HT CYCB1-1 FZR1 15970679 0096 LC CYCB1-2 FZR1 15970679 0096 LC ALY2 FZR1 20706207,20706207,20706207 0090,0004,0676 HT CCT3 FZR1 20706207,20706207 0004,0676 HT Q8GXD2 FZR1 20706207,20706207 0004,0676 HT APC5 FZR1 20706207,20706207 0004,0676 HT APC2 FZR1 20706207,20706207 0004,0676 HT CDC27B FZR1 20706207,20706207 0004,0676 HT APC7 FZR1 20706207,20706207 0004,0676 HT FZR1 RPN7 20706207,20706207 0004,0676 HT FZR1 Q94F20 20706207,20706207 0004,0676 HT FZR1 F27M3_4 20706207,20706207 0004,0676 HT FZR1 CYCA1-1 15970679 0096 LC FZR1 APC1 20706207,20706207 0004,0676 HT FZR1 CYCA1-2 15970679 0096 LC FZR1 RHM3 20706207,20706207 0004,0676 HT FZR1 ERF115 20706207,20706207 0004,0676 HT FZR1 GIG1 20706207,20706207 0004,0676 HT FZR1 ABCG19 20706207,20706207 0004,0676 HT FZR1 F26K24.5 20706207,20706207 0004,0676 HT FZR1 CKS2 20706207,20706207 0004,0676 HT FZR1 APC8 20706207,20706207 0004,0676 HT FZR1 APC10 20706207,20706207 0004,0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8VZS9 Q8L719 FZR1 ALY2 0.376 20706207 Q8VZS9 Q8LGU6 FZR1 CDC27B 0.472 20706207,17944809 Q9FVX0 Q8VZS9 CYCA1-2 FZR1 0.309 15970679 Q8VZS9 B3DNN5 FZR1 APC6 0.236 20706207 Q8VZS9 O65418 FZR1 APC4 0.236 20706207 Q8VZS9 P28769 FZR1 CCT1 0.236 20706207 Q8VZS9 Q84WV1 FZR1 Q84WV1 0.236 20706207 Q8VZS9 Q8H1U4 FZR1 APC5 0.236 20706207 Q8VZS9 Q8H1U5 FZR1 APC2 0.236 20706207 Q8VZS9 Q8VY89 FZR1 APC7 0.236 20706207 Q93Y35 Q8VZS9 RPN7 FZR1 0.236 20706207 Q9LH76 Q8VZS9 RHM3 FZR1 0.236 20706207 Q9LY29 Q8VZS9 ERF115 FZR1 0.236 20706207 Q9M2R1 Q8VZS9 GIG1 FZR1 0.236 20706207 Q9M3D6 Q8VZS9 ABCG19 FZR1 0.236 20706207 Q9SJJ5 Q8VZS9 CKS2 FZR1 0.236 20706207 Q9STS3 Q8VZS9 APC8 FZR1 0.236 20706207 Q9ZPW2 Q8VZS9 APC10 FZR1 0.236 20706207 Q94F20 Q8VZS9 Q94F20 FZR1 0.126 20706207 Q8VZS9 Q8GXD2 FZR1 Q8GXD2 0.126 20706207 Q8VZS9 P24100 FZR1 CDKA-1 0.21 15970679 Q8VZS9 O42839 FZR1 CUT20 0.309 15970679 Q9LDM4 Q8VZS9 CYCB2-3 FZR1 0.183 20407024 Q9C504 Q8VZS9 F27M3_4 FZR1 0.126 20706207 Q9FFF9 Q8VZS9 APC1 FZR1 0.126 20706207 Q9SF22 Q8VZS9 F26K24.5 FZR1 0.126 20706207 Q8VZS9 P30183 FZR1 CYCB1-1 0.309 15970679 Q9C6Y3 Q8VZS9 CYCA1-1 FZR1 0.309 15970679 Q8VZS9 Q39067 FZR1 CYCB1-2 0.309 15970679