PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P30183 Q8L3Z8 pull down 15970679 direct interaction X 2 Q9LY29 Q8L3Z8 affinity chromatography technology 20706207 physical association X 2 F4IIP9 Q8L3Z8 affinity chromatography technology 20706207 physical association X 2 Q9M2R1 Q8L3Z8 two hybrid 22167058 direct interaction X 2 Q8L3Z8 Q39067 pull down 15970679 direct interaction X 2 Q8L3Z8 Q9STS3 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 O65418 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q84WV1 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q9SF16-2 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 F4K6W6 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q8VY89-3 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q8LGU6 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q93Y35 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q9SZA4 two hybrid 21687678 direct interaction X 2 Q8L3Z8 O48533 two hybrid 21798944 direct interaction X 2 Q8L3Z8 O48533 two hybrid 22167058 direct interaction X 2 Q8H1U5 Q8L3Z8 affinity chromatography technology 20706207 physical association X 2 Q8H1U4 Q8L3Z8 affinity chromatography technology 20706207 physical association X 2 P28769 Q8L3Z8 affinity chromatography technology 20706207 physical association X 2 P24100 Q8L3Z8 affinity chromatography technology 15970679 physical association X 2 Q8L3Z8 O42839 pull down 15970679 direct interaction X 2 Q8L3Z8 Q3ECW2-2 two hybrid 15970679 direct interaction X 2 Q8L3Z8 Q9C6Y3 pull down 15970679 direct interaction X 2 Q8L3Z8 Q9FVX0 pull down 15970679 direct interaction X 2 Q8L3Z8 Q9FFF9 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 F4ICX0 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 O49160 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q9M0I4 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 Q9S7I8 two hybrid 21687678 direct interaction X 2 Q8L719 Q8L3Z8 affinity chromatography technology 20706207 physical association X 2 Q8L3Z8 tandem affinity purification 20706207 physical association C 10 Q8L3Z8 Q8LGU6 two hybrid 17944809 physical association X 2 Q8L3Z8 O48533 two hybrid array 21798944 physical association X 2 Q8L3Z8 tandem affinity purification 20706207 association C 12

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FZR2 F17M5.30 MI:0018(two hybrid) 21687678 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_7345 prey bait FZR2 At2g28450 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5535|UniProt_9184 bait|bait prey|prey FZR2 T10K17.70 MI:0018(two hybrid) 22167058 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_14727 prey bait FZR2 APC8 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5518|UniProt_9104 bait|bait prey|prey FZR2 At4g24820 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5529|UniProt_9184 bait|bait prey|prey FZR2 CYCA1-2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1506 prey bait CYCB1-1 FZR2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1509 bait prey FZR2 APC1 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5519|UniProt_9104 bait|bait prey|prey At5g26360 FZR2 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5522|UniProt_9104 prey|prey bait|bait EMB1401 FZR2 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5524|UniProt_9104 prey|prey bait|bait FZR2 AT4g28230 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5533|UniProt_9184 bait|bait prey|prey FZR2 APC7 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5527|UniProt_9184 bait|bait prey|prey FZR2 CDC20-2 MI:0018(two hybrid) 21687678 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_7352 prey bait FZR2 CDC27B MI:0018(two hybrid)|MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 17944809,20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(intact) UniProt_13970|BIOGRID_5528|UniProt_9184 bait|bait|bait prey|prey|prey FZR2 ERF115 MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_5530 bait prey TIF3C1 FZR2 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5532|UniProt_9184 prey|prey bait|bait CCT1 FZR2 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5525|UniProt_9104 prey|prey bait|bait FZR2 F26K24.12 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5523|UniProt_9104 bait|bait prey|prey CYCA3-4 FZR2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1501 bait prey APC2 FZR2 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5526|UniProt_9184 prey|prey bait|bait CDKA-1 FZR2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_1515 prey bait APC5 FZR2 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9104|BIOGRID_5521 prey|prey bait|bait APC4 FZR2 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9104|BIOGRID_5520 prey|prey bait|bait CYCB1-2 FZR2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1512 bait prey FZR2 CYCA1-1 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1503 prey bait FZR2 At1g52360 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5531|UniProt_9184 bait|bait prey|prey UVI4 FZR2 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 21798944,22167058 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(biogrid) BIOGRID_13397|UniProt_1939|BIOGRID_14730 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PYM FZR2 22167058,21798944,21798944 0018,0018,0397 LC,HT CYCA3-4 FZR2 15970679 0018 LC FZR2 CDC27B 17944809 0018 LC FZR2 GIG1 22167058 0018 LC FZR2 CDC20-2 21687678 0018 LC FZR2 CDC20-1 21687678 0018 LC PDH-E1|ALPHA FZR2 20706207 0004 HT TIF3C1 FZR2 20706207,20706207 0004,0676 HT APC4 FZR2 20706207,20706207 0004,0676 HT CDKA-1 FZR2 15970679 0004 LC CCT1 FZR2 20706207,20706207 0004,0676 HT CYCB1-1 FZR2 15970679 0096 LC CYCB1-2 FZR2 15970679 0096 LC EMB1401 FZR2 20706207,20706207 0004,0676 HT ALY2 FZR2 20706207,20706207 0004,0676 HT CCT3 FZR2 20706207,20706207 0004,0676 HT RPN9B FZR2 20706207 0676 HT APC5 FZR2 20706207,20706207 0004,0676 HT APC2 FZR2 20706207,20706207 0004,0676 HT FZR2 Q8L7S3 20706207,20706207 0004,0676 HT FZR2 CDC27B 20706207,20706207 0004,0676 HT FZR2 APC7 20706207,20706207 0004,0676 HT FZR2 RPN7 20706207,20706207 0004,0676 HT FZR2 CYCA1-1 15970679 0096 LC FZR2 Q9C827 20706207,20706207 0004,0676 HT FZR2 CEL3 20706207 0676 HT FZR2 APC1 20706207,20706207 0004,0676 HT FZR2 CYCA1-2 15970679 0096 LC FZR2 ERF115 20706207,20706207 0004,0676 HT FZR2 Q9M0I4 20706207,20706207 0004,0676 HT FZR2 CCT7 20706207,20706207 0004,0676 HT FZR2 APC8 20706207,20706207 0004,0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8L3Z8 O42839 FZR2 CUT20 0.309 15970679 Q8L3Z8 O48533 FZR2 PYM 0.507 21798944,22167058 Q8L3Z8 P24100 FZR2 CDKA-1 0.21 15970679 Q8L3Z8 Q8GYA6 FZR2 RPN9B 0.126 20706207 Q9C9H5 Q8L3Z8 CEL3 FZR2 0.126 20706207 Q9FFF9 Q8L3Z8 APC1 FZR2 0.126 20706207 Q9M0I4 Q8L3Z8 Q9M0I4 FZR2 0.126 20706207 Q9FVX0 Q8L3Z8 CYCA1-2 FZR2 0.309 15970679 Q9M2R1 Q8L3Z8 GIG1 FZR2 0.309 22167058 Q8L3Z8 Q84WV1 FZR2 Q84WV1 0.236 20706207 Q8L3Z8 Q41969 FZR2 EMB1401 0.236 20706207 Q8L3Z8 O49160 FZR2 TIF3C1 0.236 20706207 Q8L3Z8 P28769 FZR2 CCT1 0.236 20706207 Q8L3Z8 O65418 FZR2 APC4 0.236 20706207 Q93Y35 Q8L3Z8 RPN7 FZR2 0.236 20706207 Q8L719 Q8L3Z8 ALY2 FZR2 0.236 20706207 Q8L3Z8 Q8H1U4 FZR2 APC5 0.236 20706207 Q8L3Z8 Q8H1U5 FZR2 APC2 0.236 20706207 Q8VY89 Q8L3Z8 APC7 FZR2 0.236 20706207 Q8L7S3 Q8L3Z8 Q8L7S3 FZR2 0.236 20706207 Q9SF16 Q8L3Z8 F26K24.12 FZR2 0.236 20706207 Q9C827 Q8L3Z8 Q9C827 FZR2 0.236 20706207 Q9LY29 Q8L3Z8 ERF115 FZR2 0.236 20706207 Q9STS3 Q8L3Z8 APC8 FZR2 0.236 20706207 Q8LGU6 Q8L3Z8 CDC27B FZR2 0.472 20706207,17944809 Q8L3Z8 P30183 FZR2 CYCB1-1 0.309 15970679 Q9C6Y3 Q8L3Z8 CYCA1-1 FZR2 0.309 15970679 Q9SZA4 Q8L3Z8 CDC20-1 FZR2 0.309 21687678 Q9S7I8 Q8L3Z8 CDC20-2 FZR2 0.309 21687678 Q8L3Z8 Q39067 FZR2 CYCB1-2 0.309 15970679 Q8L3Z8 Q3ECW2 FZR2 CYCA3-4 0.309 15970679