PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P30183 Q8LPL5 pull down 15970679 direct interaction X 2 Q8H1U5 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 P28769 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q9LJ50 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q9ZPW2 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 P24100 Q8LPL5 affinity chromatography technology 15970679 physical association X 2 Q9M2R1 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q9M2R1 Q8LPL5 two hybrid 22167058 direct interaction X 2 O23249 Q8LPL5 protein complementation assay 20407024 direct interaction X 2 O23249 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 O42839 pull down 15970679 direct interaction X 2 Q8LPL5 Q3ECW2-2 two hybrid 15970679 direct interaction X 2 Q8LPL5 Q9C6Y3 pull down 15970679 direct interaction X 2 Q8LPL5 Q9FVX0 pull down 15970679 direct interaction X 2 Q8LPL5 Q9LDM4 protein complementation assay 20407024 direct interaction X 2 Q8LPL5 O48533 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 O65418 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q8VY89-3 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q945K9 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 O80653 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 O49299 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 O48533 two hybrid 22167058 direct interaction X 2 Q8H1U4 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q8L9E3 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q39067 pull down 15970679 direct interaction X 2 Q8LPL5 Q9STS3 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q8LGU6 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q9FFF9 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 B3DNN5 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q84WV1 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 F4K6W6 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q8VYI4 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 Q94F20 affinity chromatography technology 20706207 physical association X 2 Q9SJJ5 Q8LPL5 protein complementation assay 20407024 direct interaction X 2 Q9SJJ5 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q8L719 Q8LPL5 affinity chromatography technology 20706207 physical association X 2 Q8LPL5 tandem affinity purification 20706207 association C 6 Q8LPL5 tandem affinity purification 20706207 association C 11 Q8LPL5 tandem affinity purification 20706207 physical association C 14 Q8LPL5 Q8LGU6 two hybrid 17944809 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APC5 FZR3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9106|BIOGRID_5650 prey|prey bait|bait CYCB1-2 FZR3 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1514 bait prey FZR3 APC6 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9106|BIOGRID_5653 bait|bait prey|prey CKS1 FZR3 MI:0090(protein complementation assay)|MI:0055(fluorescent resonance energy transfer)|MI:0676(tandem affinity purification) 20407024,20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid)|(intact) BIOGRID_5655|BIOGRID_4511|UniProt_9186 prey|bait|prey bait|prey|bait FZR3 CYCA1-1 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1505 prey bait FZR3 At5g25460 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5664|UniProt_9186 bait|bait prey|prey FZR3 T10K17.70 MI:0090(protein complementation assay)|MI:0018(two hybrid)|MI:0676(tandem affinity purification) 20706207,22167058 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_5646|BIOGRID_14728|UniProt_9106 bait|prey|bait prey|bait|prey FZR3 APC8 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5643|UniProt_9106 bait|bait prey|prey T14N5.5 FZR3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9186|BIOGRID_5657 prey|prey bait|bait At5g61220 FZR3 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5658|UniProt_9186 prey|prey bait|bait FZR3 APC1 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9106|BIOGRID_5648 bait|bait prey|prey CDC27B FZR3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay)|MI:0018(two hybrid) 17944809,20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_9106|BIOGRID_5647|UniProt_13972 prey|prey|prey bait|bait|bait CCT1 FZR3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9186|BIOGRID_5663 prey|prey bait|bait APC2 FZR3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9106|BIOGRID_5642 prey|prey bait|bait FZR3 APC7 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5651|UniProt_9106 bait|bait prey|prey APC4 FZR3 MI:0676(tandem affinity purification)|MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_9106|BIOGRID_5649 prey|prey bait|bait FZR3 At4g34150 MI:0090(protein complementation assay) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_5652 bait prey At1g23190 FZR3 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5660|UniProt_9186 prey|prey bait|bait At5g26360 FZR3 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_5654|UniProt_9106 prey|prey bait|bait CYCA3-4 FZR3 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1502 bait prey EMB1401 FZR3 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5659|UniProt_9186 prey|prey bait|bait FZR3 CYCA1-2 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1508 prey bait CDKA-1 FZR3 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_1517 prey bait CYCB1-1 FZR3 MI:0096(pull down) 15970679 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_1511 bait prey FZR3 CYCB2-3 MI:0055(fluorescent resonance energy transfer) 20407024 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_4284 bait prey FZR3 CKS2 MI:0055(fluorescent resonance energy transfer)|MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20407024,20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_4527|BIOGRID_5644|UniProt_9106 prey|bait|bait bait|prey|prey UVI4 FZR3 MI:0090(protein complementation assay)|MI:0018(two hybrid)|MI:0676(tandem affinity purification) 20706207,22167058 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_5645|BIOGRID_14731|UniProt_9106 prey|bait|prey bait|prey|bait FZR3 At2g18290 MI:0090(protein complementation assay)|MI:0676(tandem affinity purification) 20706207 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_5185|UniProt_9177 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality CKS1 FZR3 20407024 0090 LC PYM FZR3 22167058 0018 LC CYCA3-4 FZR3 15970679 0018 LC CDC27B FZR3 17944809 0018 LC FZR3 CYCB2-3 20407024 0090 LC FZR3 GIG1 22167058 0018 LC FZR3 CKS2 20407024 0090 LC APC6 FZR3 20706207,20706207 0004,0676 HT CKS1 FZR3 20706207,20706207 0004,0676 HT PDH-E1|ALPHA FZR3 20706207 0004 HT PYM FZR3 20706207,20706207 0004,0676 HT O49299 FZR3 20706207,20706207 0004,0676 HT O49490 FZR3 20706207 0676 HT APC4 FZR3 20706207,20706207 0004,0676 HT SKIP FZR3 20706207,20706207 0004,0676 HT CDKA-1 FZR3 15970679 0004 LC CCT1 FZR3 20706207,20706207 0004,0676 HT CYCB1-1 FZR3 15970679 0096 LC CYCB1-2 FZR3 15970679 0096 LC EMB1401 FZR3 20706207,20706207 0004,0676 HT ALY2 FZR3 20706207,20706207 0004,0676 HT CCT3 FZR3 20706207,20706207 0004,0676 HT APC5 FZR3 20706207,20706207 0004,0676 HT APC2 FZR3 20706207,20706207 0004,0676 HT Q8L9E3 FZR3 20706207,20706207 0004,0676 HT CDC27B FZR3 20706207,20706207 0004,0676 HT FZR3 APC7 20706207,20706207 0004,0676 HT FZR3 Q8VYI4 20706207,20706207 0004,0676 HT FZR3 Q945K9 20706207 0004 HT FZR3 Q94F20 20706207,20706207 0004,0676 HT FZR3 CYCA1-1 15970679 0096 LC FZR3 APC1 20706207,20706207 0004,0676 HT FZR3 CYCA1-2 15970679 0096 LC FZR3 Q9LJ50 20706207,20706207 0004,0676 HT FZR3 GIG1 20706207,20706207 0004,0676 HT FZR3 CKS2 20706207,20706207 0004,0676 HT FZR3 APC8 20706207,20706207 0004,0676 HT FZR3 APC10 20706207,20706207 0004,0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8LPL5 Q8LGU6 FZR3 CDC27B 0.472 20706207,17944809 Q8LPL5 O42839 FZR3 CUT20 0.309 15970679 Q8LPL5 O49490 FZR3 O49490 0.126 20706207 Q8LPL5 P24100 FZR3 CDKA-1 0.21 15970679 Q8LPL5 Q8L9E3 FZR3 Q8L9E3 0.126 20706207 Q8VYI4 Q8LPL5 Q8VYI4 FZR3 0.126 20706207 Q94F20 Q8LPL5 Q94F20 FZR3 0.126 20706207 Q9FFF9 Q8LPL5 APC1 FZR3 0.126 20706207 Q9LDM4 Q8LPL5 CYCB2-3 FZR3 0.183 20407024 Q9LJ50 Q8LPL5 Q9LJ50 FZR3 0.126 20706207 Q8LPL5 O48533 FZR3 PYM 0.472 20706207,22167058 Q9FVX0 Q8LPL5 CYCA1-2 FZR3 0.309 15970679 Q9M2R1 Q8LPL5 GIG1 FZR3 0.472 20706207,22167058 Q8LPL5 O23249 FZR3 CKS1 0.376 20706207,20407024 Q9ZPW2 Q8LPL5 APC10 FZR3 0.236 20706207 Q8VY89 Q8LPL5 APC7 FZR3 0.236 20706207 Q8LPL5 O80653 FZR3 SKIP 0.236 20706207 Q8LPL5 B3DNN5 FZR3 APC6 0.236 20706207 Q8LPL5 O65418 FZR3 APC4 0.236 20706207 Q8LPL5 O49299 FZR3 O49299 0.236 20706207 Q8LPL5 Q84WV1 FZR3 Q84WV1 0.236 20706207 Q8LPL5 P28769 FZR3 CCT1 0.236 20706207 Q8LPL5 Q41969 FZR3 EMB1401 0.236 20706207 Q8LPL5 Q8L719 FZR3 ALY2 0.236 20706207 Q8LPL5 Q8H1U4 FZR3 APC5 0.236 20706207 Q8LPL5 Q8H1U5 FZR3 APC2 0.236 20706207 Q9STS3 Q8LPL5 APC8 FZR3 0.236 20706207 Q8LPL5 P30183 FZR3 CYCB1-1 0.309 15970679 Q9C6Y3 Q8LPL5 CYCA1-1 FZR3 0.309 15970679 Q9SJJ5 Q8LPL5 CKS2 FZR3 0.376 20706207,20407024 Q8LPL5 Q39067 FZR3 CYCB1-2 0.309 15970679 Q8LPL5 Q3ECW2 FZR3 CYCA3-4 0.309 15970679