PTM - CPLM Gene Name UniProt ID Type Position Code MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 297 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 183 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 356 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 92 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 102 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 231 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 622 K MARK4; KIAA1860; MARKL1 Q96L34 Ubiquitination 67 K

PTM - dbPAF Gene Name UniProt ID Position Type Species MARK4; KIAA1860; MARKL1 Q96L34 15 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 17 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 2 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 20 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 214 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 218 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 23 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 26 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 27 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 391 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 393 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 394 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 404 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 423 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 438 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 440 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 441 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 442 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 45 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 48 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 495 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 496 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 497 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 504 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 507 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 511 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 543 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 545 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 546 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 563 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 564 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 567 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 568 T Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 594 S Homo sapiens(Human) MARK4; KIAA1860; MARKL1 Q96L34 64 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q96L34 R60-m1 Methylation QPHVGNYrLLRtIGK Q96L34 R561-m1 Methylation GERSRLArGstIRst Q96L34 S15-p Phosphorylation APGNDRNsDtHGtLG Q96L34 T17-p Phosphorylation GNDRNsDtHGtLGsG Q96L34 T20-p Phosphorylation RNsDtHGtLGsGRsS Q96L34 S23-p Phosphorylation DtHGtLGsGRsSDKG Q96L34 S26-p Phosphorylation GtLGsGRsSDKGPSW Q96L34 S45-p Phosphorylation LGARCRNsIAsCPEE Q96L34 S48-p Phosphorylation RCRNsIAsCPEEQPH Q96L34 T64-p Phosphorylation GNYrLLRtIGKGNFA Q96L34 T214-p Phosphorylation TLGSKLDtFCGsPPY Q96L34 S218-p Phosphorylation KLDtFCGsPPYAAPE Q96L34 S391-p Phosphorylation LARVRAPsDttNGTS Q96L34 T393-p Phosphorylation RVRAPsDttNGTSSS Q96L34 T394-p Phosphorylation VRAPsDttNGTSSSK Q96L34 S404-p Phosphorylation TSSSKGTsHSKGQRS Q96L34 S423-p Phosphorylation YHRQRRHsDFCGPSP Q96L34 S438-p Phosphorylation APLHPKRsPtstGEA Q96L34 T440-p Phosphorylation LHPKRsPtstGEAEL Q96L34 S441-p Phosphorylation HPKRsPtstGEAELK Q96L34 T442-p Phosphorylation PKRsPtstGEAELKE Q96L34 S458-p Phosphorylation RLPGRKAsCSTAGSG Q96L34 S496-p Phosphorylation ERRKDSTsTPNNLPP Q96L34 S504-p Phosphorylation TPNNLPPsMMtRRNt Q96L34 T507-p Phosphorylation NLPPsMMtRRNtYVC Q96L34 T511-p Phosphorylation sMMtRRNtYVCTERP Q96L34 S543-p Phosphorylation TPRVPPAsPssHSLA Q96L34 S545-p Phosphorylation RVPPAsPssHSLAPP Q96L34 S546-p Phosphorylation VPPAsPssHSLAPPS Q96L34 S563-p Phosphorylation RSRLArGstIRstFH Q96L34 T564-p Phosphorylation SRLArGstIRstFHG Q96L34 S567-p Phosphorylation ArGstIRstFHGGQV Q96L34 T568-p Phosphorylation rGstIRstFHGGQVR Q96L34 S594-p Phosphorylation VQNGPPAsPTLAHEA Q96L34 K183-ub Ubiquitination NIVHRDLkAENLLLD

PTM - dbPTM UniProt ID Position Code Type Resources References Q96L34 2 S Phosphorylation Swiss-Prot 1010711 19369195 Q96L34 17 T Phosphorylation Swiss-Prot 1010711 19369195 Q96L34 23 S Phosphorylation Swiss-Prot 1010711 19369195 Q96L34 26 S Phosphorylation Swiss-Prot 1010711 17192257;19369195 Q96L34 214 T Phosphorylation Swiss-Prot 1010711 14976552;17192257 Q96L34 423 S Phosphorylation Swiss-Prot 1010711 19369195 Q96L34 438 S Phosphorylation Swiss-Prot 1010711 19369195 Q96L34 545 S Phosphorylation Swiss-Prot 1010711 19369195 Q96L34 26 S Phosphorylation PhosphoELM.10011 17192257 Q96L34 218 S Phosphorylation PhosphoELM.10011 18669648 Q96L34 214 T Phosphorylation PhosphoELM.10011 17192257;14976552 Q96L34 183 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96L34 218 S Phosphorylation Phosphositeplus.1010730 18669648;18691976;19664994 Q96L34 26 S Phosphorylation Phosphositeplus.1010730 17192257;19369195 Q96L34 438 S Phosphorylation Phosphositeplus.1010730 19369195;21406692 Q96L34 214 T Phosphorylation Phosphositeplus.1010730 14976552;17192257;18691976;19276368;19362540;19369195;19664994;21406692;21659604 Q96L34 2 S Acetylation HPRD 9.0 19413330 Q96L34 218 S Phosphorylation HPRD 9.0 18669648 Q96L34 496 S Phosphorylation HPRD 9.0 19651622 Q96L34 504 S Phosphorylation HPRD 9.0 19651622 Q96L34 507 T Phosphorylation HPRD 9.0 19651622 Q96L34 26 S Phosphorylation (MARK4) HPRD 9.0 17192257 Q96L34 214 T Phosphorylation (MARK4) HPRD 9.0 17192257

PTM - HPRD Symbol Position Code Type References MARK4 2 S Acetylation 19413330 MARK4 214 T Phosphorylation 17192257 MARK4 218 S Phosphorylation 18669648 MARK4 26 S Phosphorylation 17192257 MARK4 496 S Phosphorylation 19651622 MARK4 504 S Phosphorylation 19651622 MARK4 507 T Phosphorylation 19651622

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q96L34 214 T 17192257 HTP Phosphorylation Q96L34 214 T 14976552 LKB1 LTP Phosphorylation Q96L34 26 S 17192257 HTP Phosphorylation Q96L34 218 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q96L34 214 Phosphothreonine; by LKB1 14976552 Q96L34 543 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type MARK4 IPI00064797 S 26 TLGSGRpSSDKGPS phosphorylation MARK4 IPI00064797 S 438 PLHPKRpSPTSTGE phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 57787 121760 - K Ubiquitination 18254724 57787 121760 - K Ubiquitination 21906983

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID MARK4 Homo sapiens (Human) 681; 180 "681,MMREIRKVLDANN; 180,IVHRDLKAENLLL" 681:22053931; 180:21906983 MARK4 Homo sapiens (Human) 183 "183,IVHRDLKAENLLL" 183:21906983 MARK4 Homo sapiens (Human) 183 "183,IVHRDLKAENLLL" 183:21906983 MARK4 Homo sapiens (Human) 184 "184,IVHRDLKAENLLL" 184:21906983