PTM - CPLM Gene Name UniProt ID Type Position Code FYN P06241 Ubiquitination 405 K FYN P06241 Ubiquitination 182 K FYN P06241 Ubiquitination 355 K

PTM - dbPAF Gene Name UniProt ID Position Type Species FYN P06241 12 T Homo sapiens(Human) FYN P06241 15 T Homo sapiens(Human) FYN P06241 178 S Homo sapiens(Human) FYN P06241 181 T Homo sapiens(Human) FYN P06241 185 Y Homo sapiens(Human) FYN P06241 186 S Homo sapiens(Human) FYN P06241 188 S Homo sapiens(Human) FYN P06241 21 S Homo sapiens(Human) FYN P06241 213 Y Homo sapiens(Human) FYN P06241 214 Y Homo sapiens(Human) FYN P06241 217 T Homo sapiens(Human) FYN P06241 25 S Homo sapiens(Human) FYN P06241 257 S Homo sapiens(Human) FYN P06241 26 S Homo sapiens(Human) FYN P06241 28 Y Homo sapiens(Human) FYN P06241 289 T Homo sapiens(Human) FYN P06241 294 T Homo sapiens(Human) FYN P06241 30 Y Homo sapiens(Human) FYN P06241 300 T Homo sapiens(Human) FYN P06241 307 S Homo sapiens(Human) FYN P06241 339 Y Homo sapiens(Human) FYN P06241 349 S Homo sapiens(Human) FYN P06241 39 Y Homo sapiens(Human) FYN P06241 420 Y Homo sapiens(Human) FYN P06241 421 T Homo sapiens(Human) FYN P06241 440 Y Homo sapiens(Human) FYN P06241 457 T Homo sapiens(Human) FYN P06241 483 Y Homo sapiens(Human) FYN P06241 512 T Homo sapiens(Human) FYN P06241 518 S Homo sapiens(Human) FYN P06241 525 T Homo sapiens(Human) FYN P06241 527 T Homo sapiens(Human) FYN P06241 531 Y Homo sapiens(Human) FYN P06241 91 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P06241 T12-p Phosphorylation QCKDKEAtKLTEERD P06241 S21-p Phosphorylation LTEERDGsLNQssGy P06241 S25-p Phosphorylation RDGsLNQssGyRyGT P06241 S26-p Phosphorylation DGsLNQssGyRyGTD P06241 Y28-p Phosphorylation sLNQssGyRyGTDPT P06241 Y30-p Phosphorylation NQssGyRyGTDPTPQ P06241 Y39-p Phosphorylation TDPTPQHyPSFGVTS P06241 Y91-p Phosphorylation VTLFVALyDYEARTE P06241 S178-p Phosphorylation GTFLIREsETtkGAy P06241 T181-p Phosphorylation LIREsETtkGAysLs P06241 Y185-p Phosphorylation sETtkGAysLsIRDW P06241 S186-p Phosphorylation ETtkGAysLsIRDWD P06241 S188-p Phosphorylation tkGAysLsIRDWDDM P06241 Y213-p Phosphorylation RKLDNGGyyITtRAQ P06241 Y214-p Phosphorylation KLDNGGyyITtRAQF P06241 T217-p Phosphorylation NGGyyITtRAQFETL P06241 S257-p Phosphorylation MPRLTDLsVKTKDVW P06241 T289-p Phosphorylation FGEVWMGtWNGNtKV P06241 T294-p Phosphorylation MGtWNGNtKVAIKtL P06241 T300-p Phosphorylation NtKVAIKtLKPGTMs P06241 S307-p Phosphorylation tLKPGTMsPESFLEE P06241 Y339-p Phosphorylation VVSEEPIyIVTEYMN P06241 S349-p Phosphorylation TEYMNKGsLLDFLKD P06241 Y420-p Phosphorylation RLIEDNEytARQGAK P06241 T421-p Phosphorylation LIEDNEytARQGAKF P06241 Y440-p Phosphorylation TAPEAALyGRFTIKS P06241 Y483-p Phosphorylation LEQVERGyRMPCPQD P06241 T525-p Phosphorylation SFLEDYFtAtEPQyQ P06241 T527-p Phosphorylation LEDYFtAtEPQyQPG P06241 Y531-p Phosphorylation FtAtEPQyQPGENL_ P06241 K182-ub Ubiquitination IREsETtkGAysLsI P06241 K405-ub Ubiquitination VGNGLICkIADFGLA P06241 K431-ub Ubiquitination QGAKFPIkWTAPEAA

PTM - dbPTM UniProt ID Position Code Type Resources References P06241 2 G Myristoylation Swiss-Prot 1010711 1699196 P06241 15 T Phosphorylation Swiss-Prot 1010711 19369195 P06241 21 S Phosphorylation Swiss-Prot 1010711 17192257;18088087;18669648;18691976;19007248;19369195 P06241 25 S Phosphorylation Swiss-Prot 1010711 18691976 P06241 213 Y Phosphorylation Swiss-Prot 1010711 18083107 P06241 214 Y Phosphorylation Swiss-Prot 1010711 18083107 P06241 257 S Phosphorylation Swiss-Prot 1010711 18691976 P06241 420 Y Phosphorylation Swiss-Prot 1010711 17192257;18083107;18088087;19690332 P06241 440 Y Phosphorylation Swiss-Prot 1010711 18083107 P06241 512 T Phosphorylation Swiss-Prot 1010711 19369195 P06241 531 Y Phosphorylation Swiss-Prot 1010711 1533589;1699196;18691976;19369195 P06241 21 S Phosphorylation PhosphoELM.10011 18669648;18088087;17192257 P06241 12 T Phosphorylation PhosphoELM.10011 15537652 P06241 213 Y Phosphorylation PhosphoELM.10011 18083107 P06241 214 Y Phosphorylation PhosphoELM.10011 18083107;16497976 P06241 440 Y Phosphorylation PhosphoELM.10011 18083107 P06241 531 Y Phosphorylation PhosphoELM.10011 1985196 P06241 30 Y Phosphorylation PhosphoELM.10011 9425276 P06241 39 Y Phosphorylation PhosphoELM.10011 9425276 P06241 420 Y Phosphorylation PhosphoELM.10011 18083107;18088087;17192257;1985196 P06241 28 Y Phosphorylation PhosphoELM.10011 9425276;9425276 P06241 186 S Phosphorylation Phosphositeplus.1010730 18691976 P06241 21 S Phosphorylation Phosphositeplus.1010730 17192257;18088087;18669648;18691976;19369195;20068231;20363803;20658524;21406692 P06241 25 S Phosphorylation Phosphositeplus.1010730 18691976 P06241 257 S Phosphorylation Phosphositeplus.1010730 18691976 P06241 12 T Phosphorylation Phosphositeplus.1010730 15537652;20068231 P06241 421 T Phosphorylation Phosphositeplus.1010730 17192257;22115753 P06241 185 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;18669648;19369195;20007894;20068231;20736484;21253578 P06241 213 Y Phosphorylation Phosphositeplus.1010730 17360941;17646646;18083107;18180459;19369195;19534553;19658100;20007894;20068231;20736484;21049007;21253578 P06241 214 Y Phosphorylation Phosphositeplus.1010730 16497976;17389760;18083107;18180459;19534553;19658100;20007894;20736484;21049007;21253578 P06241 28 Y Phosphorylation Phosphositeplus.1010730 18083107;9425276 P06241 30 Y Phosphorylation Phosphositeplus.1010730 9425276 P06241 339 Y Phosphorylation Phosphositeplus.1010730 20736484 P06241 39 Y Phosphorylation Phosphositeplus.1010730 9425276 P06241 420 Y Phosphorylation Phosphositeplus.1010730 11983687;12921535;15316024;15489898;15917250;16497976;17062641;17192257;17360941;17389760;18083107;18088087;18180459;18326860;18578522;18669648;18691976;18707149;18776048;19369195;19534553;19605366;19658100;19664994;19690332;1985196;19934324;20007894;20058876;20068231;20090780;20658524;20736484;20855525;21049007;21253578;21394647;21403953;21406692;21447384;21659604;22115753;22322096;9425276 P06241 440 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;19369195;19534553;19605366;20736484;21253578;21403953;21447384 P06241 531 Y Phosphorylation Phosphositeplus.1010730 11983687;12921535;1533589;15592455;15713745;1699196;17062641;17389760;18083107;18180459;18691976;19258392;19369195;1985196;20736484;21253578 P06241 420 Y Dephosphorylation HPRD 9.0 11158295 P06241 420 Y Dephosphorylation HPRD 9.0 11983687 P06241 531 Y Dephosphorylation HPRD 9.0 9535845,8980254,15588985 P06241 531 Y Dephosphorylation HPRD 9.0 9535845,8980254 P06241 2 G Myristoylation HPRD 9.0 11423543 P06241 3 C Palmitoylation HPRD 9.0 9060467 P06241 21 S Phosphorylation HPRD 9.0 18669648,18691976,19007248,18088087,20068231 P06241 25 S Phosphorylation HPRD 9.0 18691976 P06241 257 S Phosphorylation HPRD 9.0 18691976 P06241 12 T Phosphorylation HPRD 9.0 20068231 P06241 457 T Phosphorylation HPRD 9.0 20068231 P06241 512 T Phosphorylation HPRD 9.0 20068231 P06241 525 T Phosphorylation HPRD 9.0 18691976 P06241 185 Y Phosphorylation HPRD 9.0 20068231 P06241 213 Y Phosphorylation HPRD 9.0 16497976,20068231 P06241 214 Y Phosphorylation HPRD 9.0 18083107,16497976 P06241 531 Y Phosphorylation (CSK) HPRD 9.0 1985196,18691976 P06241 30 Y Phosphorylation (FYN) HPRD 9.0 9425276 P06241 39 Y Phosphorylation (FYN) HPRD 9.0 9425276 P06241 420 Y Phosphorylation (FYN) HPRD 9.0 1985196,16497976,20068231,20058876 P06241 28 Y Phosphorylation (PDGFRB) HPRD 9.0 9425276 P06241 19 D Proteolytic Cleavage HPRD 9.0 10435619 P06241 21 S Phosphorylation SysPTM 1.1 18669648;18691976;18088087 P06241 25 S Phosphorylation SysPTM 1.1 18691976 P06241 257 S Phosphorylation SysPTM 1.1 18691976 P06241 420 Y Phosphorylation SysPTM 1.1 18088087 P06241 531 Y Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References FYN 12 T Phosphorylation 20068231 FYN 185 Y Phosphorylation 20068231 FYN 19 D Proteolytic Cleavage 10435619 FYN 2 G Myristoylation 11423543 FYN 21 S Phosphorylation 18669648,18691976,19007248,18088087,20068231 FYN 213 Y Phosphorylation 16497976,20068231 FYN 214 Y Phosphorylation 18083107,16497976 FYN 25 S Phosphorylation 18691976 FYN 257 S Phosphorylation 18691976 FYN 28 Y Phosphorylation 9425276 FYN 3 C Palmitoylation 9060467 FYN 30 Y Phosphorylation 9425276 FYN 365 Y Dephosphorylation 11983687 FYN 365 Y Phosphorylation 1985196,16497976,20068231,20058876 FYN 39 Y Phosphorylation 9425276 FYN 417 Y Dephosphorylation 11983687 FYN 417 Y Phosphorylation 1985196,16497976,20068231,20058876 FYN 420 Y Dephosphorylation 11158295 FYN 420 Y Dephosphorylation 11983687 FYN 420 Y Phosphorylation 1985196,16497976,20068231,20058876 FYN 457 T Phosphorylation 20068231 FYN 470 T Phosphorylation 18691976 FYN 476 Y Dephosphorylation 9535845,8980254 FYN 476 Y Phosphorylation 1985196,18691976 FYN 509 T Phosphorylation 20068231 FYN 512 T Phosphorylation 20068231 FYN 522 T Phosphorylation 18691976 FYN 525 T Phosphorylation 18691976 FYN 528 Y Dephosphorylation 9535845,8980254 FYN 528 Y Phosphorylation 1985196,18691976 FYN 531 Y Dephosphorylation 9535845,8980254 FYN 531 Y Dephosphorylation 9535845,8980254,15588985 FYN 531 Y Phosphorylation 1985196,18691976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P06241 39 Y 9425276 Fyn LTP Phosphorylation P06241 420 Y 18083107 HTP Phosphorylation P06241 420 Y 18088087 HTP Phosphorylation P06241 420 Y 17192257 HTP Phosphorylation P06241 420 Y 1985196 Fyn LTP Phosphorylation P06241 12 T 15537652 LTP Phosphorylation P06241 213 Y 18083107 HTP Phosphorylation P06241 531 Y 1985196 Csk LTP Phosphorylation P06241 214 Y 18083107 HTP Phosphorylation P06241 214 Y 16497976 HTP Phosphorylation P06241 28 Y 9425276 Fyn LTP Phosphorylation P06241 28 Y 9425276 PDGFR_beta LTP Phosphorylation P06241 440 Y 18083107 HTP Phosphorylation P06241 30 Y 9425276 Fyn LTP Phosphorylation P06241 21 S 18669648 HTP Phosphorylation P06241 21 S 18088087 HTP Phosphorylation P06241 21 S 17192257 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P06241 12 Phosphothreonine; by PKC 15537652 P06241 21 Phosphoserine 18088087;18669648;18691976;19369195;20068231;23186163 P06241 26 Phosphoserine 23186163 P06241 531 Phosphotyrosine; by CSK 18691976;1699196

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type FYN IPI00166845 S 21 TEERDGpSLNQSSG phosphorylation FYN IPI00166845 Y 476 TATEPQpYQPGENL phosphorylation FYN IPI00219012 S 20 TEERDGpSLNQSSG phosphorylation FYN IPI00219012 S 24 DGSLNQpSSGYRYG phosphorylation FYN IPI00219012 S 256 PRLTDLpSVKTKDV phosphorylation FYN IPI00219012 Y 530 TATEPQpYQPGENL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 2534 108810 - K Ubiquitination 20584982 2534 108810 - K Ubiquitination 15208330 2534 108810 - K Ubiquitination 21139048 2534 108810 - K Ubiquitination 22447928 2534 108810 - K Ubiquitination 15190072 2534 108810 - K Ubiquitination 21890473 2534 108810 - K Ubiquitination 21963094 2534 108810 - K Ubiquitination 23000965

PTM - PhosphoBase Gene Name PB Accession PROT ID Serine Threonine Tyrosine Peptide FYN A045 Proto-oncogene tyrosine-protein kinase Fyn - - 419 [A045-A], 530 [A045-B] A045-B - TEPQYQPGE;!

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID FYN Homo sapiens (Human) 133; 379 "133,RESETTKGAYSLS; 379,GAKFPIKWTAPEA" 133:21890473; 379:21890473 FYN Homo sapiens (Human) 428; 182 "428,GAKFPIKWTAPEA; 182,RESETTKGAYSLS" 428:21890473; 182:21890473 FYN Homo sapiens (Human) 182; 376 "182,RESETTKGAYSLS; 376,GAKFPIKWTAPEA" 182:21890473; 376:21890473 FYN Homo sapiens (Human) 431; 182 "431,GAKFPIKWTAPEA; 182,RESETTKGAYSLS" 431:21890473; 182:21890473 FYN Homo sapiens (Human) 431; 182 "431,GAKFPIKWTAPEA; 182,RESETTKGAYSLS" 431:21890473; 182:21890473 FYN Homo sapiens (Human) 133; 379 "133,RESETTKGAYSLS; 379,GAKFPIKWTAPEA" 133:21890473; 379:21890473