PTM - CPLM Gene Name UniProt ID Type Position Code UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 821 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 822 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 994 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1255 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1187 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1687 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1718 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 104 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 255 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 789 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1044 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1599 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 48 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 779 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 27 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 284 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 443 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1496 K UBR2; C6orf133; KIAA0349 Q8IWV8 Ubiquitination 1352 K

PTM - dbPAF Gene Name UniProt ID Position Type Species UBR2; C6orf133; KIAA0349 Q8IWV8 1005 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1006 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1008 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1009 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1014 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1017 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1022 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1023 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1050 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 110 Y Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1266 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1312 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1339 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 141 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 142 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 143 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 154 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 1607 Y Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 170 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 171 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 224 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 263 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 274 Y Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 328 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 581 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 716 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 734 S Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 826 T Homo sapiens(Human) UBR2; C6orf133; KIAA0349 Q8IWV8 844 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IWV8 Y110-p Phosphorylation FKVGEPTySCRDCAV Q8IWV8 T141-p Phosphorylation RDHRYRMttsGGGGF Q8IWV8 T142-p Phosphorylation DHRYRMttsGGGGFC Q8IWV8 S143-p Phosphorylation HRYRMttsGGGGFCD Q8IWV8 T154-p Phosphorylation GFCDCGDtEAWKEGP Q8IWV8 S224-p Phosphorylation DLEMVEKsDTYYCML Q8IWV8 Y274-p Phosphorylation DGRRSVRyGDFQYCE Q8IWV8 S328-p Phosphorylation LGSIIGYsDGLRRIL Q8IWV8 T581-p Phosphorylation MQCHGGYtDGEQPIT Q8IWV8 T826-p Phosphorylation HFKKPGLtGRGMYEL Q8IWV8 Y844-p Phosphorylation CAKEFNLyFYHFSRA Q8IWV8 S1005-p Phosphorylation AVKKMREssPtsPVA Q8IWV8 S1006-p Phosphorylation VKKMREssPtsPVAE Q8IWV8 T1008-p Phosphorylation KMREssPtsPVAEtE Q8IWV8 S1009-p Phosphorylation MREssPtsPVAEtEG Q8IWV8 T1014-p Phosphorylation PtsPVAEtEGtIMEE Q8IWV8 T1017-p Phosphorylation PVAEtEGtIMEEsSR Q8IWV8 S1022-p Phosphorylation EGtIMEEsSRDKDKA Q8IWV8 S1050-p Phosphorylation EkIMAQMsEMQRHFI Q8IWV8 T1266-p Phosphorylation FLRKEEStPNNASTK Q8IWV8 T1312-p Phosphorylation LTTFGTAtYKVGLKV Q8IWV8 Y1607-p Phosphorylation LINLPEDySSLINQA Q8IWV8 K27-ub Ubiquitination SAEEIAGkWLQATDL Q8IWV8 K255-ub Ubiquitination KAVNCTQkEAIGFAT Q8IWV8 K443-ub Ubiquitination NLMSIIIkTFMDHLR Q8IWV8 K779-ub Ubiquitination VNATDEIkREIIHQL Q8IWV8 K994-ub Ubiquitination DMIRWILkTFNAVKK Q8IWV8 K1044-ub Ubiquitination IARLRREkIMAQMsE Q8IWV8 K1187-ub Ubiquitination YFDSVQAkEQRRQQR Q8IWV8 K1255-ub Ubiquitination RTISQQIkALQFLRK

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IWV8 1009 S Phosphorylation PhosphoELM.10011 18669648 Q8IWV8 1008 T Phosphorylation PhosphoELM.10011 18669648 Q8IWV8 1187 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWV8 1255 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IWV8 443 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWV8 779 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IWV8 994 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IWV8 1005 S Phosphorylation Phosphositeplus.1010730 20044836 Q8IWV8 1006 S Phosphorylation Phosphositeplus.1010730 20044836 Q8IWV8 1009 S Phosphorylation Phosphositeplus.1010730 19690332 Q8IWV8 1022 S Phosphorylation Phosphositeplus.1010730 20044836 Q8IWV8 1008 T Phosphorylation Phosphositeplus.1010730 19690332;20044836 Q8IWV8 1014 T Phosphorylation Phosphositeplus.1010730 20044836 Q8IWV8 1009 S Phosphorylation HPRD 9.0 18669648 Q8IWV8 263 T Phosphorylation HPRD 9.0 17081983 Q8IWV8 1008 T Phosphorylation HPRD 9.0 18669648

PTM - HPRD Symbol Position Code Type References UBR2 1008 T Phosphorylation 18669648 UBR2 1009 S Phosphorylation 18669648 UBR2 263 T Phosphorylation 17081983

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8IWV8 1009 S 18669648 HTP Phosphorylation Q8IWV8 1008 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8IWV8 2 N-acetylalanine 22223895;22814378

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type UBR2 IPI00217407 S 716 FLMIMLpSRFELYQ phosphorylation UBR2 IPI00217407 T 1339 WGSCAYpTIQSIER phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 23304 116896 - K Ubiquitination 21987572 23304 116896 - K Ubiquitination 21139048 23304 116896 - K Ubiquitination 21890473 23304 116896 - K Ubiquitination 21906983 23304 116896 - K Ubiquitination 22053931 23304 116896 - K Ubiquitination 22505724 23304 116896 - K Ubiquitination 21963094 23304 116896 - K Ubiquitination 23000965

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID UBR2 Homo sapiens (Human) 821; 1255; 822; 994 "821,EAVAHFKKPGLTG; 1255,TISQQIKALQFLR; 822,AVAHFKKPGLTGR; 994,MIRWILKTFNAVK" 821:21890473; 1255:21890473; 822:21890473; 994:21890473 UBR2 Homo sapiens (Human) 821; 1255; 822; 994 "821,EAVAHFKKPGLTG; 1255,TISQQIKALQFLR; 822,AVAHFKKPGLTGR; 994,MIRWILKTFNAVK" 821:21890473; 1255:21890473; 822:21890473; 994:21890473 UBR2 Homo sapiens (Human) 1187; 1352 "1187,FDSVQAKEQRRQQ; 1352,ILSDEDKPLFGPL" 1187:22053931; 1352:22053931 UBR2 Homo sapiens (Human) 821; 1187; 1255; 443; 822; 994; 779 "821,EAVAHFKKPGLTG; 1187,FDSVQAKEQRRQQ; 1255,TISQQIKALQFLR; 443,LMSIIIKTFMDHL; 822,AVAHFKKPGLTGR; 994,MIRWILKTFNAVK; 779,NATDEIKREIIHQ" 821:21890473; 1187:21906983; 1255:21890473; 443:21906983; 822:21890473; 994:21890473; 779:21906983 UBR2 Homo sapiens (Human) 821; 1187; 1255; 443; 822; 1352; 994; 779 "821,EAVAHFKKPGLTG; 1187,FDSVQAKEQRRQQ; 1255,TISQQIKALQFLR; 443,LMSIIIKTFMDHL; 822,AVAHFKKPGLTGR; 1352,ILSDEDKPLFGPL; 994,MIRWILKTFNAVK; 779,NATDEIKREIIHQ" "821:21890473; 1187:21906983,22053931; 1255:21890473; 443:21906983; 822:21890473; 1352:22053931; 994:21890473; 779:21906983" UBR2 Homo sapiens (Human) 326; 325; 283; 498 "326,AVAHFKKPGLTGR; 325,EAVAHFKKPGLTG; 283,NATDEIKREIIHQ; 498,MIRWILKTFNAVK" 326:21890473; 325:21890473; 283:21906983; 498:21890473