Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 16 75601962 75601962 + Nonsense_Mutation SNP C C T TCGA-FD-A6TG-01A-11D-A32B-08 TCGA-FD-A6TG-10A-01D-A329-08 g.chr16:75601962C>T c.118C>T c.(118-120)Cag>Tag p.Q40* COAD 16 75601996 75601996 + Missense_Mutation SNP T T C TCGA-AZ-4315-01A-01D-1408-10 TCGA-AZ-4315-10A-01D-1408-10 g.chr16:75601996T>C c.152T>C c.(151-153)gTt>gCt p.V51A COAD 16 75611211 75611211 + Missense_Mutation SNP G G T TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr16:75611211G>T c.298G>T c.(298-300)Gat>Tat p.D100Y COAD 16 75611250 75611250 + Missense_Mutation SNP A A G TCGA-G4-6586-01A-11D-1771-10 TCGA-G4-6586-10A-01D-1771-10 g.chr16:75611250A>G c.337A>G c.(337-339)Aac>Gac p.N113D COAD 16 75611250 75611251 + Missense_Mutation DNP AA AA GG TCGA-F4-6460-01A-11D-1771-10 TCGA-F4-6460-10B-01D-1771-10 g.chr16:75611250_75611251AA>GG c.337_338AA>GG c.(337-339)AAc>GGc p.N113G COAD 16 75611251 75611251 + Missense_Mutation SNP A A G TCGA-AZ-6608-01A-11D-1835-10 TCGA-AZ-6608-11A-01D-1835-10 g.chr16:75611251A>G c.338A>G c.(337-339)aAc>aGc p.N113S COADREAD 16 75601996 75601996 + Missense_Mutation SNP T T C TCGA-AZ-4315-01A-01D-1408-10 TCGA-AZ-4315-10A-01D-1408-10 g.chr16:75601996T>C c.152T>C c.(151-153)gTt>gCt p.V51A COADREAD 16 75611211 75611211 + Missense_Mutation SNP G G T TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr16:75611211G>T c.298G>T c.(298-300)Gat>Tat p.D100Y COADREAD 16 75611250 75611250 + Missense_Mutation SNP A A G TCGA-G4-6586-01A-11D-1771-10 TCGA-G4-6586-10A-01D-1771-10 g.chr16:75611250A>G c.337A>G c.(337-339)Aac>Gac p.N113D COADREAD 16 75611250 75611251 + Missense_Mutation DNP AA AA GG TCGA-F4-6460-01A-11D-1771-10 TCGA-F4-6460-10B-01D-1771-10 g.chr16:75611250_75611251AA>GG c.337_338AA>GG c.(337-339)AAc>GGc p.N113G COADREAD 16 75611251 75611251 + Missense_Mutation SNP A A G TCGA-AZ-6608-01A-11D-1835-10 TCGA-AZ-6608-11A-01D-1835-10 g.chr16:75611251A>G c.338A>G c.(337-339)aAc>aGc p.N113S HNSC 16 75601963 75601963 + Missense_Mutation SNP A A C TCGA-P3-A6T6-01A-11D-A34J-08 TCGA-P3-A6T6-10A-01D-A34M-08 g.chr16:75601963A>C c.119A>C c.(118-120)cAg>cCg p.Q40P HNSC 16 75602095 75602095 + Missense_Mutation SNP T T C TCGA-F7-A624-01A-22D-A30E-08 TCGA-F7-A624-10A-01D-A30H-08 g.chr16:75602095T>C c.251T>C c.(250-252)gTc>gCc p.V84A OV 16 75611250 75611250 + Missense_Mutation SNP A A G TCGA-04-1338-01A-01W-0484-10 TCGA-04-1338-11A-01W-0485-10 g.chr16:75611250A>G c.337A>G c.(337-339)Aac>Gac p.N113D PAAD 16 75600792 75600792 + Missense_Mutation SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr16:75600792C>T c.77C>T c.(76-78)cCc>cTc p.P26L SKCM 16 75601934 75601934 + Splice_Site SNP G G C TCGA-ER-A19P-06A-11D-A196-08 TCGA-ER-A19P-10A-01D-A198-08 g.chr16:75601934G>C c.e3-1

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BRCA-EU 16 75595484 75595484 single base substitution A G upstream_gene_variant BRCA-EU 16 75595970 75595970 single base substitution T A upstream_gene_variant BRCA-EU 16 75597854 75597854 single base substitution C A upstream_gene_variant BRCA-EU 16 75598160 75598160 single base substitution C T upstream_gene_variant BRCA-EU 16 75599446 75599446 single base substitution T A upstream_gene_variant BRCA-EU 16 75600188 75600188 single base substitution C T upstream_gene_variant BRCA-EU 16 75603565 75603565 single base substitution C T downstream_gene_variant BRCA-EU 16 75603565 75603565 single base substitution C T intron_variant BRCA-EU 16 75604484 75604484 single base substitution G A downstream_gene_variant BRCA-EU 16 75604484 75604484 single base substitution G A intron_variant BRCA-EU 16 75604777 75604777 single base substitution G T downstream_gene_variant BRCA-EU 16 75604777 75604777 single base substitution G T intron_variant BRCA-EU 16 75604777 75604777 single base substitution G T upstream_gene_variant BRCA-EU 16 75607675 75607675 single base substitution C A intron_variant BRCA-EU 16 75607675 75607675 single base substitution C A upstream_gene_variant BRCA-EU 16 75608042 75608042 single base substitution C T intron_variant BRCA-EU 16 75608042 75608042 single base substitution C T upstream_gene_variant BRCA-EU 16 75609734 75609734 single base substitution A C exon_variant BRCA-EU 16 75609734 75609734 single base substitution A C intron_variant BRCA-EU 16 75610360 75610360 single base substitution A G exon_variant BRCA-EU 16 75610360 75610360 single base substitution A G intron_variant BRCA-EU 16 75611316 75611316 single base substitution A G 3_prime_UTR_variant BRCA-EU 16 75611316 75611316 single base substitution A G exon_variant BRCA-EU 16 75611530 75611530 single base substitution G A 3_prime_UTR_variant BRCA-EU 16 75611530 75611530 single base substitution G A downstream_gene_variant BRCA-EU 16 75611530 75611530 single base substitution G A exon_variant BRCA-EU 16 75612852 75612852 single base substitution C A downstream_gene_variant BRCA-EU 16 75613260 75613260 single base substitution C G downstream_gene_variant BRCA-EU 16 75613359 75613359 single base substitution C G downstream_gene_variant BRCA-EU 16 75614615 75614615 single base substitution T C downstream_gene_variant BRCA-FR 16 75608042 75608042 single base substitution C T intron_variant BRCA-FR 16 75608042 75608042 single base substitution C T upstream_gene_variant BRCA-FR 16 75610360 75610360 single base substitution A G exon_variant BRCA-FR 16 75610360 75610360 single base substitution A G intron_variant BRCA-FR 16 75613260 75613260 single base substitution C G downstream_gene_variant CESC-US 16 75611123 75611123 single base substitution C G exon_variant CESC-US 16 75611123 75611123 single base substitution C G intron_variant COAD-US 16 75601996 75601996 single base substitution T C 5_prime_UTR_variant COAD-US 16 75601996 75601996 single base substitution T C intron_variant COAD-US 16 75601996 75601996 single base substitution T C missense_variant V51A 152T>C COAD-US 16 75611211 75611211 single base substitution G T exon_variant COAD-US 16 75611211 75611211 single base substitution G T missense_variant D100Y 298G>T COAD-US 16 75611211 75611211 single base substitution G T missense_variant D40Y 118G>T COAD-US 16 75611211 75611211 single base substitution G T missense_variant R42I 125G>T COCA-CN 16 75600749 75600749 single base substitution G T splice_acceptor_variant COCA-CN 16 75611204 75611204 single base substitution G A exon_variant COCA-CN 16 75611204 75611204 single base substitution G A missense_variant G40R 118G>A COCA-CN 16 75611204 75611204 single base substitution G A synonymous_variant K37K 111G>A COCA-CN 16 75611204 75611204 single base substitution G A synonymous_variant K97K 291G>A ESAD-UK 16 75597208 75597208 single base substitution G A upstream_gene_variant ESAD-UK 16 75598766 75598766 single base substitution C A upstream_gene_variant ESAD-UK 16 75600138 75600138 single base substitution C A upstream_gene_variant ESAD-UK 16 75603724 75603724 insertion of <=200bp - T downstream_gene_variant ESAD-UK 16 75603724 75603724 insertion of <=200bp - T intron_variant ESAD-UK 16 75608528 75608528 single base substitution G A intron_variant ESAD-UK 16 75608528 75608528 single base substitution G A upstream_gene_variant ESAD-UK 16 75608761 75608761 insertion of <=200bp - AAACAC intron_variant ESAD-UK 16 75608761 75608761 insertion of <=200bp - AAACAC upstream_gene_variant ESAD-UK 16 75611390 75611390 single base substitution T G 3_prime_UTR_variant ESAD-UK 16 75611390 75611390 single base substitution T G exon_variant ESAD-UK 16 75612514 75612514 single base substitution C A downstream_gene_variant ESAD-UK 16 75615428 75615428 single base substitution G A downstream_gene_variant LAML-KR 16 75615633 75615633 single base substitution C A downstream_gene_variant LICA-CN 16 75600389 75600389 single base substitution A T missense_variant K2M 5A>T LICA-CN 16 75600389 75600389 single base substitution A T upstream_gene_variant LINC-JP 16 75602643 75602643 single base substitution A G downstream_gene_variant LINC-JP 16 75602643 75602643 single base substitution A G intron_variant LIRI-JP 16 75598138 75598138 single base substitution T C upstream_gene_variant LIRI-JP 16 75599163 75599163 single base substitution T C upstream_gene_variant LIRI-JP 16 75599903 75599903 single base substitution G C upstream_gene_variant LIRI-JP 16 75603266 75603266 single base substitution G A downstream_gene_variant LIRI-JP 16 75603266 75603266 single base substitution G A intron_variant LIRI-JP 16 75603943 75603943 single base substitution G T downstream_gene_variant LIRI-JP 16 75603943 75603943 single base substitution G T intron_variant LIRI-JP 16 75607253 75607253 single base substitution C A downstream_gene_variant LIRI-JP 16 75607253 75607253 single base substitution C A intron_variant LIRI-JP 16 75607253 75607253 single base substitution C A upstream_gene_variant LIRI-JP 16 75609550 75609550 single base substitution G A exon_variant LIRI-JP 16 75609550 75609550 single base substitution G A intron_variant LIRI-JP 16 75609609 75609609 single base substitution A T exon_variant LIRI-JP 16 75609609 75609609 single base substitution A T intron_variant LIRI-JP 16 75610292 75610292 single base substitution C A exon_variant LIRI-JP 16 75610292 75610292 single base substitution C A intron_variant LUSC-KR 16 75597850 75597850 single base substitution A G upstream_gene_variant LUSC-KR 16 75598435 75598435 single base substitution G T upstream_gene_variant LUSC-KR 16 75598645 75598645 single base substitution C T upstream_gene_variant LUSC-KR 16 75600109 75600109 single base substitution C G upstream_gene_variant LUSC-KR 16 75600151 75600151 single base substitution C T upstream_gene_variant LUSC-KR 16 75605643 75605643 single base substitution C T downstream_gene_variant LUSC-KR 16 75605643 75605643 single base substitution C T intron_variant LUSC-KR 16 75605643 75605643 single base substitution C T upstream_gene_variant LUSC-KR 16 75616630 75616630 single base substitution C T downstream_gene_variant MALY-DE 16 75605521 75605521 single base substitution T G downstream_gene_variant MALY-DE 16 75605521 75605521 single base substitution T G intron_variant MALY-DE 16 75605521 75605521 single base substitution T G upstream_gene_variant MALY-DE 16 75608700 75608700 single base substitution C A intron_variant MALY-DE 16 75608700 75608700 single base substitution C A upstream_gene_variant MALY-DE 16 75615001 75615001 single base substitution T A downstream_gene_variant MELA-AU 16 75595276 75595276 single base substitution C T upstream_gene_variant MELA-AU 16 75595813 75595813 single base substitution G A upstream_gene_variant MELA-AU 16 75595833 75595833 single base substitution C T upstream_gene_variant MELA-AU 16 75595837 75595837 single base substitution T A upstream_gene_variant MELA-AU 16 75596109 75596109 single base substitution G A upstream_gene_variant MELA-AU 16 75596111 75596111 single base substitution C T upstream_gene_variant MELA-AU 16 75596187 75596187 single base substitution C T upstream_gene_variant MELA-AU 16 75596270 75596270 single base substitution C T upstream_gene_variant MELA-AU 16 75596893 75596893 single base substitution C T upstream_gene_variant MELA-AU 16 75596935 75596935 single base substitution G A upstream_gene_variant MELA-AU 16 75597253 75597253 single base substitution G A upstream_gene_variant MELA-AU 16 75597294 75597294 single base substitution G A upstream_gene_variant MELA-AU 16 75598675 75598675 single base substitution C T upstream_gene_variant MELA-AU 16 75599381 75599381 single base substitution C T upstream_gene_variant MELA-AU 16 75599887 75599887 single base substitution C T upstream_gene_variant MELA-AU 16 75600182 75600182 single base substitution C T upstream_gene_variant MELA-AU 16 75600191 75600191 single base substitution G A upstream_gene_variant MELA-AU 16 75600202 75600202 single base substitution C T upstream_gene_variant MELA-AU 16 75600204 75600204 single base substitution G A upstream_gene_variant MELA-AU 16 75600212 75600212 single base substitution G A upstream_gene_variant MELA-AU 16 75600793 75600793 single base substitution C T 5_prime_UTR_premature_start_codon_gain_variant MELA-AU 16 75600793 75600793 single base substitution C T synonymous_variant P26P 78C>T MELA-AU 16 75602241 75602241 single base substitution C T 3_prime_UTR_variant MELA-AU 16 75602241 75602241 single base substitution C T intron_variant MELA-AU 16 75602319 75602319 single base substitution T A downstream_gene_variant MELA-AU 16 75602319 75602319 single base substitution T A intron_variant MELA-AU 16 75603107 75603107 deletion of <=200bp T - downstream_gene_variant MELA-AU 16 75603107 75603107 deletion of <=200bp T - intron_variant MELA-AU 16 75603783 75603783 single base substitution C T downstream_gene_variant MELA-AU 16 75603783 75603783 single base substitution C T intron_variant MELA-AU 16 75604534 75604534 single base substitution C T downstream_gene_variant MELA-AU 16 75604534 75604534 single base substitution C T intron_variant MELA-AU 16 75604534 75604534 single base substitution C T upstream_gene_variant MELA-AU 16 75605225 75605225 single base substitution T C downstream_gene_variant MELA-AU 16 75605225 75605225 single base substitution T C intron_variant MELA-AU 16 75605225 75605225 single base substitution T C upstream_gene_variant MELA-AU 16 75606676 75606676 single base substitution G A downstream_gene_variant MELA-AU 16 75606676 75606676 single base substitution G A intron_variant MELA-AU 16 75606676 75606676 single base substitution G A upstream_gene_variant MELA-AU 16 75608456 75608457 multiple base substitution (>=2bp and <=200bp) GG AA intron_variant MELA-AU 16 75608456 75608457 multiple base substitution (>=2bp and <=200bp) GG AA upstream_gene_variant MELA-AU 16 75609590 75609590 single base substitution C T exon_variant MELA-AU 16 75609590 75609590 single base substitution C T intron_variant MELA-AU 16 75611443 75611443 single base substitution G A 3_prime_UTR_variant MELA-AU 16 75611443 75611443 single base substitution G A downstream_gene_variant MELA-AU 16 75611443 75611443 single base substitution G A exon_variant MELA-AU 16 75611696 75611696 single base substitution A G 3_prime_UTR_variant MELA-AU 16 75611696 75611696 single base substitution A G downstream_gene_variant MELA-AU 16 75611696 75611696 single base substitution A G exon_variant MELA-AU 16 75612380 75612380 single base substitution C G downstream_gene_variant MELA-AU 16 75613601 75613601 single base substitution C T downstream_gene_variant MELA-AU 16 75615181 75615181 insertion of <=200bp - A downstream_gene_variant MELA-AU 16 75615382 75615382 single base substitution C T downstream_gene_variant MELA-AU 16 75615997 75615997 single base substitution C T downstream_gene_variant ORCA-IN 16 75615639 75615639 insertion of <=200bp - G downstream_gene_variant OV-AU 16 75607091 75607091 single base substitution T G downstream_gene_variant OV-AU 16 75607091 75607091 single base substitution T G intron_variant OV-AU 16 75607091 75607091 single base substitution T G upstream_gene_variant OV-AU 16 75612528 75612528 single base substitution A T downstream_gene_variant OV-AU 16 75614016 75614016 single base substitution A T downstream_gene_variant PACA-AU 16 75595857 75595857 single base substitution C T upstream_gene_variant PACA-AU 16 75597366 75597366 single base substitution G A upstream_gene_variant PACA-AU 16 75601300 75601300 single base substitution C T intron_variant PACA-AU 16 75607580 75607580 single base substitution G A intron_variant PACA-AU 16 75607580 75607580 single base substitution G A upstream_gene_variant PACA-AU 16 75610594 75610594 single base substitution G T exon_variant PACA-AU 16 75610594 75610594 single base substitution G T intron_variant PACA-CA 16 75595834 75595834 single base substitution G A upstream_gene_variant PACA-CA 16 75596464 75596464 single base substitution G A upstream_gene_variant PACA-CA 16 75597830 75597830 single base substitution C T upstream_gene_variant PACA-CA 16 75597935 75597935 single base substitution A G upstream_gene_variant PACA-CA 16 75604118 75604118 single base substitution C T downstream_gene_variant PACA-CA 16 75604118 75604118 single base substitution C T intron_variant PACA-CA 16 75608986 75608986 single base substitution A T intron_variant PACA-CA 16 75608986 75608986 single base substitution A T upstream_gene_variant PACA-CA 16 75612448 75612448 single base substitution G A downstream_gene_variant PACA-CA 16 75615244 75615244 single base substitution T C downstream_gene_variant PACA-CA 16 75616422 75616422 single base substitution C T downstream_gene_variant PBCA-DE 16 75610470 75610470 single base substitution G A exon_variant PBCA-DE 16 75610470 75610470 single base substitution G A intron_variant READ-US 16 75602069 75602069 single base substitution G A intron_variant READ-US 16 75602069 75602069 single base substitution G A synonymous_variant A15A 45G>A READ-US 16 75602069 75602069 single base substitution G A synonymous_variant A75A 225G>A RECA-EU 16 75596196 75596196 single base substitution C T upstream_gene_variant RECA-EU 16 75597720 75597720 single base substitution C T upstream_gene_variant RECA-EU 16 75603080 75603080 single base substitution T G downstream_gene_variant RECA-EU 16 75603080 75603080 single base substitution T G intron_variant RECA-EU 16 75607799 75607799 single base substitution A G intron_variant RECA-EU 16 75607799 75607799 single base substitution A G upstream_gene_variant RECA-EU 16 75610338 75610338 single base substitution T C exon_variant RECA-EU 16 75610338 75610338 single base substitution T C intron_variant RECA-EU 16 75612844 75612844 single base substitution C T downstream_gene_variant RECA-EU 16 75613562 75613562 single base substitution A G downstream_gene_variant SKCA-BR 16 75600217 75600217 single base substitution G A upstream_gene_variant SKCA-BR 16 75600218 75600218 single base substitution G A upstream_gene_variant SKCA-BR 16 75600475 75600475 single base substitution T C intron_variant SKCA-BR 16 75600475 75600475 single base substitution T C upstream_gene_variant SKCA-BR 16 75609592 75609592 single base substitution A C exon_variant SKCA-BR 16 75609592 75609592 single base substitution A C intron_variant SKCA-BR 16 75614462 75614462 single base substitution G A downstream_gene_variant STAD-US 16 75602021 75602021 single base substitution G A 5_prime_UTR_variant STAD-US 16 75602021 75602021 single base substitution G A intron_variant STAD-US 16 75602021 75602021 single base substitution G A synonymous_variant Q59Q 177G>A STAD-US 16 75611253 75611253 single base substitution A C 3_prime_UTR_variant STAD-US 16 75611253 75611253 single base substitution A C exon_variant STAD-US 16 75611253 75611253 single base substitution A C missense_variant T114P 340A>C STAD-US 16 75611253 75611253 single base substitution A C missense_variant T54P 160A>C UCEC-US 16 75601985 75601985 single base substitution G A 5_prime_UTR_variant UCEC-US 16 75601985 75601985 single base substitution G A intron_variant UCEC-US 16 75601985 75601985 single base substitution G A synonymous_variant R47R 141G>A UCEC-US 16 75602094 75602094 single base substitution G T intron_variant UCEC-US 16 75602094 75602094 single base substitution G T missense_variant V24F 70G>T UCEC-US 16 75602094 75602094 single base substitution G T missense_variant V84F 250G>T UCEC-US 16 75611244 75611244 single base substitution G A 3_prime_UTR_variant UCEC-US 16 75611244 75611244 single base substitution G A exon_variant UCEC-US 16 75611244 75611244 single base substitution G A missense_variant G111R 331G>A UCEC-US 16 75611244 75611244 single base substitution G A missense_variant G51R 151G>A

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-AP-A051-01 COSM973750 c.250G>T p.V84F Substitution - Missense 16:75568196-75568196 + 10-P4110 COSM4579276 c.285C>T p.Y95Y Substitution - coding silent 16:75577300-75577300 + S01563 COSM311336 c.53C>A p.S18Y Substitution - Missense 16:75566870-75566870 + TCGA-AP-A056-01 COSM973751 c.331G>A p.G111R Substitution - Missense 16:75577346-75577346 + TCGA-EI-6882-01 COSM3421163 c.225G>A p.A75A Substitution - coding silent 16:75568171-75568171 + TCGA-04-1338-01 COSM77747 c.337A>G p.N113D Substitution - Missense 16:75577352-75577352 + sysucc-1370T COSM5470568 c.291G>A p.K97K Substitution - coding silent 16:75577306-75577306 + HCC063T COSM5812359 c.5A>T p.K2M Substitution - Missense 16:75566491-75566491 + TCGA-BR-6458-01 COSM4062859 c.177G>A p.Q59Q Substitution - coding silent 16:75568123-75568123 + ESCC_94 COSM5637379 c.139C>T p.R47W Substitution - Missense 16:75568085-75568085 + TCGA-BR-8680-01 COSM4062860 c.340A>C p.T114P Substitution - Missense 16:75577355-75577355 + TCGA-AP-A0LM-01 COSM973749 c.141G>A p.R47R Substitution - coding silent 16:75568087-75568087 + TCGA-AZ-4315-01 COSM1379814 c.152T>C p.V51A Substitution - Missense 16:75568098-75568098 + S01563 COSM311336 c.53C>A p.S18Y Substitution - Missense 16:75566870-75566870 + TCGA-CA-6717-01 COSM1379815 c.298G>T p.D100Y Substitution - Missense 16:75577313-75577313 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.461369;Hs.461372;Hs.461379 16q22.1 607452 1511750|dbSNP|BC005985|C/T|non-coding||69|Validated; 1511750|dbSNP|BC014594|C/T|non-coding||87|Validated; 1511750|dbSNP|BC029601|C/T|non-coding||118|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Missense p.N113D c.337A>G 16 75611250 OV C A Missense p.S18Y c.53C>A 16 75600768 SCLC G A IntronicSNV . c.264-707G>A 16 75610470 MB G A Synonymous p.Q59Q c.177G>A 16 75602021 STAD G C SpliceAcceptorSNV . c.91-1G>C 16 75601934 CM