PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CUL1 FBXO42 21145461,19509332 biogrid exp GP G G G G GP G G GP G GP GP GP G G GP GP G G G G G GP G GP G GP GP G FBXO42 SMURF1 21572392 biogrid exp G GP G G G GP G G GP G GP G GP G G G GP G G G G G G G G G G GP G SKP1 FBXO42 19509332 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP G G G G G GP G GP G GP GP G NEDD8 FBXO42 21145461 innatedb exp GP GP G G G GP G G GP G GP GP GP G G GP GP G G G G G GP G GP G GP GP G RBX1 FBXO42 19509332 biogrid exp G G G G G GP G G G G G G GP G G G GP G G G G G G G G G G GP G FBXO42 COPS6 21145461 biogrid exp GP GP G G G GP G G GP G GP G GP G G GP GP G G G G G GP G GP G GP GP G TP53 FBXO42 19509332 biogrid exp G G G G G G G G G G G G G G G GP G G G G G G G G GP G G GP G RBPJ FBXO42 26186194,25609649 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RHOB FBXO42 19637314 innatedb,intact exp G GP G G G GP G G G G G G GP G G G GP G G G G G G G G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A090N7U0 Q6P3S6 affinity chromatography technology 21145461 physical association X 2 A0A090N7U0 Q6P3S6 affinity chromatography technology 19509332 physical association X 2 P0CG48 Q6P3S6 affinity chromatography technology 20972266 physical association X 2 P0CG48 Q6P3S6 affinity chromatography technology 21906983 physical association X 2 Q6P3S6 Q15843 affinity chromatography technology 18247557 physical association X 2 Q6P3S6 affinity chromatography technology 21572392 physical association X 2 Q6P3S6 P04637-7 enzymatic study 19509332 direct interaction X 2 Q6P3S6 P62877 affinity chromatography technology 19509332 physical association X 2 Q6P3S6 P04637-7 affinity chromatography technology 19509332 physical association X 2 Q6P3S6 P04637-7 affinity chromatography technology 19509332 physical association X 2 Q6P3S6 P04637-7 pull down 19509332 direct interaction X 2 P63208 Q6P3S6 affinity chromatography technology 19509332 physical association X 2 Q6P3S6 Q7L5N1 affinity chromatography technology 21145461 physical association X 2 P62745 Q6P3S6 two hybrid 19637314 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B NRF1 FBXO42 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294995 bait prey FBXO42 SMURF1 MI:0004(affinity chromatography technology) 21572392 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_258614 prey bait RHOB FBXO42 MI:0018(two hybrid) 19637314 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100483 bait prey SKP1 FBXO42 MI:0004(affinity chromatography technology) 19509332 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_152841 prey bait NEDD8 FBXO42 MI:0004(affinity chromatography technology) 18247557 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_251578 bait prey p53 FBXO42 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19509332 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_152844|BIOGRID_152843|BIOGRID_152845|BIOGRID_152839 bait|prey|prey|prey prey|bait|bait|bait CUL1 FBXO42 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19509332,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_204502|BIOGRID_152840 bait|prey prey|bait FBXO42 COPS6 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205775 prey bait RBX1 FBXO42 MI:0004(affinity chromatography technology) 19509332 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_152842 prey bait UBC FBXO42 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20972266,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_177313|BIOGRID_164244 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality RBPJ FBXO42 26186194,25609649,25609649 0004,0676,0004 HT CUL1 FBXO42 19509332,21145461 0004,0004 LC,HT FBXO42 COPS6 21145461 0004 HT RBPJ FBXO42 26186194,25609649,25609649 0004,0676,0004 HT CUL1 FBXO42 21145461 0004 HT FBXO42 COPS6 21145461 0004 HT CUL1 FBXO42 19509332 0004 LC TP53 FBXO42 19509332,19509332,19509332 0004,0415,0096 LC RHOB FBXO42 19637314 0018 LC Q53GA5 FBXO42 19509332,19509332,19509332 0004,0415,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE7 Q6P3S6 SMURF1 FBXO42 0.21 21572392 Q7L5N1 Q6P3S6 COPS6 FBXO42 0.126 21145461 Q6P3S6 P62877 FBXO42 RBX1 0.21 19509332 Q6P3S6 P62745 FBXO42 RHOB 0.309 19637314 Q6P3S6 P04637 FBXO42 TP53 0.702 19509332 Q6P3S6 Q06330 FBXO42 RBPJ 0.416 25609649,26186194 Q6P3S6 Q13616 FBXO42 CUL1 0.309 19509332,21145461 Q6P3S6 P63208 FBXO42 SKP1 0.309 27705803,19509332

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CCDC85C FBXO42 MI:0362 inference MI:0461 interaction database TP53 FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database UBC FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database RHOB FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database SKP1 FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database RBPJ FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 FBXO42 MI:0045 experimental interaction detection MI:0461 interaction database FBXO42 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database FBXO42 ZDHHC23 MI:0362 inference MI:0461 interaction database FBXO42 PUS7 MI:0362 inference MI:0461 interaction database FBXO42 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database