PTM - dbPAF Gene Name UniProt ID Position Type Species TRIO O75962 116 S Homo sapiens(Human) TRIO O75962 1459 S Homo sapiens(Human) TRIO O75962 1515 S Homo sapiens(Human) TRIO O75962 1519 S Homo sapiens(Human) TRIO O75962 1545 T Homo sapiens(Human) TRIO O75962 1627 S Homo sapiens(Human) TRIO O75962 1700 T Homo sapiens(Human) TRIO O75962 1704 S Homo sapiens(Human) TRIO O75962 1721 S Homo sapiens(Human) TRIO O75962 1723 S Homo sapiens(Human) TRIO O75962 1724 S Homo sapiens(Human) TRIO O75962 1741 S Homo sapiens(Human) TRIO O75962 1745 S Homo sapiens(Human) TRIO O75962 1749 S Homo sapiens(Human) TRIO O75962 1752 S Homo sapiens(Human) TRIO O75962 1762 S Homo sapiens(Human) TRIO O75962 1763 S Homo sapiens(Human) TRIO O75962 1778 T Homo sapiens(Human) TRIO O75962 1779 S Homo sapiens(Human) TRIO O75962 1785 S Homo sapiens(Human) TRIO O75962 1786 S Homo sapiens(Human) TRIO O75962 1809 S Homo sapiens(Human) TRIO O75962 1814 S Homo sapiens(Human) TRIO O75962 1818 S Homo sapiens(Human) TRIO O75962 1821 S Homo sapiens(Human) TRIO O75962 1824 T Homo sapiens(Human) TRIO O75962 1847 S Homo sapiens(Human) TRIO O75962 1854 S Homo sapiens(Human) TRIO O75962 1899 T Homo sapiens(Human) TRIO O75962 1900 S Homo sapiens(Human) TRIO O75962 1901 S Homo sapiens(Human) TRIO O75962 1903 T Homo sapiens(Human) TRIO O75962 1905 S Homo sapiens(Human) TRIO O75962 1928 S Homo sapiens(Human) TRIO O75962 1951 S Homo sapiens(Human) TRIO O75962 1954 S Homo sapiens(Human) TRIO O75962 2058 Y Homo sapiens(Human) TRIO O75962 2075 Y Homo sapiens(Human) TRIO O75962 2208 S Homo sapiens(Human) TRIO O75962 2255 S Homo sapiens(Human) TRIO O75962 2281 T Homo sapiens(Human) TRIO O75962 2282 S Homo sapiens(Human) TRIO O75962 2286 Y Homo sapiens(Human) TRIO O75962 2299 S Homo sapiens(Human) TRIO O75962 2302 S Homo sapiens(Human) TRIO O75962 2326 S Homo sapiens(Human) TRIO O75962 2367 S Homo sapiens(Human) TRIO O75962 2369 T Homo sapiens(Human) TRIO O75962 2370 S Homo sapiens(Human) TRIO O75962 2371 T Homo sapiens(Human) TRIO O75962 2388 S Homo sapiens(Human) TRIO O75962 2391 S Homo sapiens(Human) TRIO O75962 2417 S Homo sapiens(Human) TRIO O75962 2426 S Homo sapiens(Human) TRIO O75962 2428 S Homo sapiens(Human) TRIO O75962 2429 S Homo sapiens(Human) TRIO O75962 2440 S Homo sapiens(Human) TRIO O75962 2455 S Homo sapiens(Human) TRIO O75962 2459 S Homo sapiens(Human) TRIO O75962 2462 S Homo sapiens(Human) TRIO O75962 2463 S Homo sapiens(Human) TRIO O75962 2467 S Homo sapiens(Human) TRIO O75962 2476 S Homo sapiens(Human) TRIO O75962 2477 S Homo sapiens(Human) TRIO O75962 2492 S Homo sapiens(Human) TRIO O75962 2495 S Homo sapiens(Human) TRIO O75962 2499 S Homo sapiens(Human) TRIO O75962 2508 S Homo sapiens(Human) TRIO O75962 2513 T Homo sapiens(Human) TRIO O75962 2625 T Homo sapiens(Human) TRIO O75962 2629 S Homo sapiens(Human) TRIO O75962 2631 S Homo sapiens(Human) TRIO O75962 2659 Y Homo sapiens(Human) TRIO O75962 2671 S Homo sapiens(Human) TRIO O75962 2773 S Homo sapiens(Human) TRIO O75962 2794 S Homo sapiens(Human) TRIO O75962 2796 Y Homo sapiens(Human) TRIO O75962 297 S Homo sapiens(Human) TRIO O75962 299 S Homo sapiens(Human) TRIO O75962 3084 S Homo sapiens(Human) TRIO O75962 517 T Homo sapiens(Human) TRIO O75962 724 T Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type TRIO rs55687522 ACG->ATG T->M 1637 T DGSSQPDTISIASRT 1627 Phosphorylation TypeII- TRIO rs55687522 ACG->ATG T->M 1639 S SSQPDTISIASRTSQ 1629 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O75962 K265-ac Acetylation EEHSQLKkKVIKAPI O75962 K681-ac Acetylation VSFHTHVkELWTWLE O75962 K1808-ac Acetylation KKSREVRksADAGsQ O75962 K2481-ac Acetylation PPssPLQkGGSFWSS O75962 K2640-ac Acetylation HtALRLRkKSEKKDK O75962 T89-p Phosphorylation KRGGPILtFPARSNH O75962 S116-p Phosphorylation SYLACIPsEEVCKRG O75962 S297-p Phosphorylation ESFPKKNsGsGNADL O75962 S299-p Phosphorylation FPKKNsGsGNADLQN O75962 T517-p Phosphorylation DKLQRPLtPGSSDsL O75962 S523-p Phosphorylation LtPGSSDsLTASANY O75962 T724-p Phosphorylation QQTTLQVtVNVIKEG O75962 S1258-p Phosphorylation DSNKSSKsLQLDIIP O75962 S1459-p Phosphorylation DGLEVMLsVPKRAND O75962 T1545-p Phosphorylation FTSELGVtEHVEGDP O75962 S1627-p Phosphorylation RDGEDLDsQGDGSSQ O75962 S1645-p Phosphorylation ISIASRTsQNTLDSD O75962 S1655-p Phosphorylation TLDSDKLsGGCELTV O75962 T1700-p Phosphorylation PDWCLVRtTDRsPAA O75962 S1704-p Phosphorylation LVRtTDRsPAAEGLV O75962 S1723-p Phosphorylation LCIAHSRssMEMEGI O75962 S1724-p Phosphorylation CIAHSRssMEMEGIF O75962 S1745-p Phosphorylation SVSSNDAsPPAsVAs O75962 S1749-p Phosphorylation NDAsPPAsVAsLQPH O75962 S1752-p Phosphorylation sPPAsVAsLQPHMIG O75962 T1778-p Phosphorylation NTLRKWLtsPVRRLs O75962 S1779-p Phosphorylation TLRKWLtsPVRRLss O75962 S1785-p Phosphorylation tsPVRRLssGKADGH O75962 S1786-p Phosphorylation sPVRRLssGKADGHV O75962 S1809-p Phosphorylation KSREVRksADAGsQK O75962 S1814-p Phosphorylation RksADAGsQKDsDDs O75962 S1818-p Phosphorylation DAGsQKDsDDsAAtP O75962 S1821-p Phosphorylation sQKDsDDsAAtPQDE O75962 T1824-p Phosphorylation DsDDsAAtPQDETVE O75962 T1843-p Phosphorylation NEGLSSGtLsKsSSS O75962 S1845-p Phosphorylation GLSSGtLsKsSSSGM O75962 S1847-p Phosphorylation SSGtLsKsSSSGMQs O75962 S1854-p Phosphorylation sSSSGMQsCGEEEGE O75962 T1899-p Phosphorylation SRLLVRPtssEtPSA O75962 S1900-p Phosphorylation RLLVRPtssEtPSAA O75962 S1901-p Phosphorylation LLVRPtssEtPSAAE O75962 T1903-p Phosphorylation VRPtssEtPSAAELV O75962 Y2058-p Phosphorylation HERRLHMyIAYCQNK O75962 Y2075-p Phosphorylation SEHIVSEyIDTFFED O75962 S2122-p Phosphorylation LKYSKKAsLDTSELE O75962 S2208-p Phosphorylation LDKKKGFsMPGFLFK O75962 S2255-p Phosphorylation TFILHSSsPSVRQTW O75962 S2282-p Phosphorylation NFLNALTsPIEyQRN O75962 Y2286-p Phosphorylation ALTsPIEyQRNHSGG O75962 S2302-p Phosphorylation GGGGSGGsGGGGGSG O75962 S2326-p Phosphorylation GHSGGPSsCGGAPST O75962 S2358-p Phosphorylation VLVSSAAsSQAEADK O75962 S2388-p Phosphorylation AAPEAGPsAPsRRPP O75962 S2391-p Phosphorylation EAGPsAPsRRPPGAD O75962 S2402-p Phosphorylation PGADAEGsEREAEPI O75962 S2417-p Phosphorylation PKMKVLEsPRKGAAN O75962 S2428-p Phosphorylation GAANASGssPDAPAK O75962 S2429-p Phosphorylation AANASGssPDAPAKD O75962 S2440-p Phosphorylation PAKDARAsLGtLPLG O75962 T2443-p Phosphorylation DARAsLGtLPLGKPR O75962 S2455-p Phosphorylation KPRAGAAsPLNsPLs O75962 S2459-p Phosphorylation GAAsPLNsPLsSAVP O75962 S2462-p Phosphorylation sPLNsPLsSAVPsLG O75962 S2467-p Phosphorylation PLsSAVPsLGKEPFP O75962 S2476-p Phosphorylation GKEPFPPssPLQkGG O75962 S2477-p Phosphorylation KEPFPPssPLQkGGS O75962 S2492-p Phosphorylation FWSSIPAsPAsRPGS O75962 S2495-p Phosphorylation SIPAsPAsRPGSFTF O75962 S2508-p Phosphorylation TFPGDSDsLQRQtPR O75962 T2513-p Phosphorylation SDsLQRQtPRHAAPG O75962 T2625-p Phosphorylation IVENPDGtLKKSTsW O75962 S2631-p Phosphorylation GtLKKSTsWHtALRL O75962 T2634-p Phosphorylation KKSTsWHtALRLRkK O75962 Y2659-p Phosphorylation EGKLENGyRKSREGL O75962 S2671-p Phosphorylation EGLSNKVsVKLLNPN O75962 S2794-p Phosphorylation TWKDNFDsFySEVAE O75962 Y2796-p Phosphorylation KDNFDsFySEVAELG O75962 S3068-p Phosphorylation LDTSRLTsFIERRKH O75962 K1131-ub Ubiquitination LHYWTMRkRRLDQCQ

PTM - dbPTM UniProt ID Position Code Type Resources References O75962 1545 T Phosphorylation Swiss-Prot 1010711 16094384 O75962 1903 T Phosphorylation Swiss-Prot 1010711 17081983 O75962 2282 S Phosphorylation Swiss-Prot 1010711 18669648 O75962 2455 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 O75962 2459 S Phosphorylation Swiss-Prot 1010711 19413330 O75962 2467 S Phosphorylation Swiss-Prot 1010711 18669648 O75962 1545 T Phosphorylation PhosphoELM.10011 16094384 O75962 1903 T Phosphorylation PhosphoELM.10011 17081983 O75962 2796 Y Phosphorylation PhosphoELM.10011 12551902 O75962 1779 S Phosphorylation Phosphositeplus.1010730 18220336;19276368;19664994 O75962 1785 S Phosphorylation Phosphositeplus.1010730 20736484;20815410 O75962 1786 S Phosphorylation Phosphositeplus.1010730 20736484;20815410 O75962 1901 S Phosphorylation Phosphositeplus.1010730 19276368 O75962 2282 S Phosphorylation Phosphositeplus.1010730 18669648 O75962 2417 S Phosphorylation Phosphositeplus.1010730 19664994 O75962 2429 S Phosphorylation Phosphositeplus.1010730 22115753 O75962 2455 S Phosphorylation Phosphositeplus.1010730 18669648;20058876;20068231;20363803;20815410;21406692;21659604;22115753 O75962 2459 S Phosphorylation Phosphositeplus.1010730 20068231;20363803;20815410;21406692;22115753 O75962 1545 T Phosphorylation Phosphositeplus.1010730 16094384 O75962 1903 T Phosphorylation Phosphositeplus.1010730 19690332 O75962 2796 Y Phosphorylation Phosphositeplus.1010730 12551902 O75962 1779 S Phosphorylation HPRD 9.0 19664994 O75962 2282 S Phosphorylation HPRD 9.0 18669648 O75962 2417 S Phosphorylation HPRD 9.0 19664994 O75962 2429 S Phosphorylation HPRD 9.0 19651622 O75962 2440 S Phosphorylation HPRD 9.0 20068231 O75962 2455 S Phosphorylation HPRD 9.0 18669648,19413330,19651622,18767875,20068231,20058876 O75962 2459 S Phosphorylation HPRD 9.0 19413330,19651622,18767875,20068231 O75962 2462 S Phosphorylation HPRD 9.0 19651622 O75962 2467 S Phosphorylation HPRD 9.0 18669648 O75962 1903 T Phosphorylation HPRD 9.0 17081983 O75962 2281 T Phosphorylation HPRD 9.0 20068231 O75962 2796 Y Phosphorylation (PTK2) HPRD 9.0 12551902 O75962 2455 S Phosphorylation SysPTM 1.1 18669648 O75962 2467 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References TRIO 1779 S Phosphorylation 19664994 TRIO 1903 T Phosphorylation 17081983 TRIO 2281 T Phosphorylation 20068231 TRIO 2282 S Phosphorylation 18669648 TRIO 2417 S Phosphorylation 19664994 TRIO 2429 S Phosphorylation 19651622 TRIO 2440 S Phosphorylation 20068231 TRIO 2455 S Phosphorylation 18669648,19413330,19651622,18767875,20068231,20058876 TRIO 2459 S Phosphorylation 19413330,19651622,18767875,20068231 TRIO 2462 S Phosphorylation 19651622 TRIO 2467 S Phosphorylation 18669648 TRIO 2796 Y Phosphorylation 12551902

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O75962 1844 T 17081983 HTP Phosphorylation O75962 1486 T 16094384 HTP Phosphorylation O75962 2737 Y 12551902 LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O75962 2282 Phosphoserine 18669648 O75962 2455 Phosphoserine 18669648;20068231;23186163 O75962 2459 Phosphoserine 20068231;23186163 O75962 2631 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TRIO IPI00479523 T 1844 RPTSSEpTPSAAEL phosphorylation TRIO IPI00657953 S 2455 PRAGAApSPLNSPL phosphorylation TRIO IPI00657953 S 2459 AASPLNpSPLSSAV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7204 113055 - K Ubiquitination 21139048