PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EPN3 TNKS2 26186194 biogrid exp G G G G GP G GP G G G G EPN3 RNF11 15231748 hprd,biogrid,i2d,mint,intact exp GP P P G G GP GP P P GP P GP P GP GP GP P GP P EPN2 EPN3 26186194 biogrid exp P P P P P P EPN3 ARIH1 26186194 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP P GP P UBB EPN3 26186194 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP P GP P CYHR1 EPN3 26186194 biogrid exp GP P G G GP GP P P GP P GP P GP GP GP P GP P MID1 EPN3 26186194 biogrid exp G P G G GP GP GP P GP P G G GP GP P VPS39 EPN3 26186194 biogrid exp G P G G G GP G G G G G G P CDC27 EPN3 26186194 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP P GP P HSPA1L EPN3 26186194 biogrid exp P G G P G G P PHGDH EPN3 26186194 biogrid exp G P P G G GP GP P P GP P GP P GP GP GP P GP P CASP2 EPN3 26186194 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP P GP P RALBP1 EPN3 20709745 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP P GP P TRIM32 EPN3 26186194 biogrid exp GP P G G GP GP P GP P GP P GP GP GP P GP P EPN3 FEM1B 26186194 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP GP P SHKBP1 EPN3 26186194 biogrid exp GP P P G GP GP P P GP P GP P GP G GP P GP P EPN3 KCTD3 26186194 biogrid exp GP P G G GP G GP P GP P GP GP GP GP P EPN3 MID2 26186194 biogrid exp GP P G G GP GP P P GP P GP P G GP GP GP P EPN3 EPN1 26186194,21115825 biogrid exp GP P G G GP GP GP P GP P GP GP GP GP P EPN3 KCTD10 26186194 biogrid exp GP P P G G GP GP P GP P GP P GP GP GP P GP P LAPTM5 EPN3 15231748 hprd,biogrid,i2d,mint,intact exp GP P P G G GP GP P P GP P GP GP GP GP P GP P BTBD1 EPN3 26186194 biogrid exp GP P P G G GP GP P P GP P G P GP GP GP P GP P TNKS EPN3 26186194 biogrid exp GP P P G G GP GP P P GP P GP P GP GP GP GP P EPN3 SMURF1 26186194 biogrid exp GP P P G G GP GP P G P G P G G G P G P BTBD9 EPN3 26186194 biogrid exp G P P G G GP G P G P GP G GP G P GP P EPN3 EHD2 21115825 biogrid exp, ortho G P G G GP P P G P G P G G P G P EPN3 EHD1 21115825 biogrid exp, ortho G P G G GP GP P G P G P G G G P G P EPS15 EPN3 21115825, 25402006 biogrid exp, pred GP P P G G GP GP P P GP P GP P GP GP GP P GP P AP2A2 EPN3 25402006 pred GP P P G G GP GP P P GP P GP P GP GP GP P GP P CLINT1 EPN3 23023127 pred GP P P G G GP GP P P GP P GP P GP GP GP P GP P REPS2 EPN3 25402006 pred G P P G GP GP P P GP P GP P GP G GP P GP P STAM EPN3 23023127 pred GP P P G G GP GP P P GP P GP P GP GP GP GP P EPN3 EPS15L1 25402006 pred GP P P G G GP GP P P GP P GP P GP GP GP P GP P EPN3 GGA2 25402006 pred GP P G G GP GP P P GP P GP P GP GP GP P GP P AP2A1 EPN3 25402006 pred GP P P G G GP GP P GP P GP P GP GP GP P GP P TOM1 EPN3 23023127 pred GP P P G G GP GP P P GP P GP P GP GP GP P GP P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9H201 B7Z240 affinity chromatography technology 21115825 physical association X 2 Q9H201 B2R5U3 affinity chromatography technology 21115825 physical association X 2 Q9H201 Q13571 two hybrid 15231748 direct interaction X 2 P0CG48 Q9H201 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9H201 affinity chromatography technology 21906983 physical association X 2 Q15311 Q9H201 affinity chromatography technology 20709745 physical association X 2 Q9Y3C5 Q9H201 two hybrid 15231748 direct interaction X 2 Q9H201 Q9Y6I3-1 imaging technique 21115825 colocalization X 2 A0A024R0S6 Q9H201 affinity chromatography technology 21115825 physical association X 2 Q9H201 Q13571 two hybrid 15231748 - X 2 Q9H201 Q13571 two hybrid 15231748 - X 2 Q9Y3C5 Q9H201 two hybrid 15231748 - X 2 Q9Y3C5 Q9H201 two hybrid 15231748 - X 2 Q9H201 Q13571 two hybrid 15231748 physical association X 2 Q9Y3C5 Q9H201 two hybrid 15231748 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EPN3 EHD2 MI:0428(imaging technique) 21115825 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199410 prey bait EPS15 EPN3 MI:0428(imaging technique) 21115825 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199408 bait prey NRF1 EPN3 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295321 bait prey UBC EPN3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21890473,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_263732|BIOGRID_181751 bait|bait prey|prey EPN3 RNF11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(intact) HPRD_37803|BIOGRID_259437|MINT_60219|MINT_31454|UniProt_78543 -|prey|prey|prey|prey -|bait|bait|bait|bait LAPTM5 EPN3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|(intact) MINT_61514|MINT_32666|BIOGRID_259141|HPRD_2802|UniProt_79180 bait|bait|bait|-|bait prey|prey|prey|-|prey EPN3 EPN1 MI:0428(imaging technique) 21115825 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_199404 prey bait EPN3 EHD1 MI:0428(imaging technique) 21115825 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199409 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MID1 EPN3 26186194 0004 HT PHGDH EPN3 26186194 0004 HT EPN2 EPN3 26186194 0004 HT TNKS EPN3 26186194 0004 HT UBB EPN3 26186194 0004 HT CDC27 EPN3 26186194 0004 HT HSPA1L EPN3 26186194 0004 HT CASP2 EPN3 26186194 0004 HT TRIM32 EPN3 26186194 0004 HT CYHR1 EPN3 26186194 0004 HT SHKBP1 EPN3 26186194 0004 HT VPS39 EPN3 26186194 0004 HT BTBD9 EPN3 26186194 0004 HT BTBD1 EPN3 26186194 0004 HT EPN3 TNKS2 26186194 0004 HT EPN3 KCTD10 26186194 0004 HT EPN3 SMURF1 26186194 0004 HT EPN3 MID2 26186194 0004 HT EPN3 FEM1B 26186194 0004 HT EPN3 ARIH1 26186194 0004 HT EPN3 KCTD3 26186194 0004 HT EPN3 EPN1 21115825,26186194 0428,0004 LC,HT MID1 EPN3 26186194 0004 HT PHGDH EPN3 26186194 0004 HT EPN2 EPN3 26186194 0004 HT TNKS EPN3 26186194 0004 HT UBB EPN3 26186194 0004 HT CDC27 EPN3 26186194 0004 HT HSPA1L EPN3 26186194 0004 HT CASP2 EPN3 26186194 0004 HT TRIM32 EPN3 26186194 0004 HT CYHR1 EPN3 26186194 0004 HT SHKBP1 EPN3 26186194 0004 HT VPS39 EPN3 26186194 0004 HT BTBD9 EPN3 26186194 0004 HT BTBD1 EPN3 26186194 0004 HT EPN3 TNKS2 26186194 0004 HT EPN3 KCTD10 26186194 0004 HT EPN3 SMURF1 26186194 0004 HT EPN3 MID2 26186194 0004 HT EPN3 FEM1B 26186194 0004 HT EPN3 ARIH1 26186194 0004 HT EPN3 KCTD3 26186194 0004 HT EPN3 EPN1 26186194 0004 HT EPN3 EPN1 21115825 0428 LC LAPTM5 EPN3 15231748 0018 HT EPN3 RNF11 15231748 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H4M9 Q9H201 EHD1 EPN3 0.21 21115825 Q9H201 Q8TBC3 EPN3 SHKBP1 0.126 26186194 Q9H201 Q6ZMK1 EPN3 CYHR1 0.126 26186194 Q9H201 O43175 EPN3 PHGDH 0.126 26186194 Q9H201 O15344 EPN3 MID1 0.126 26186194 Q9H201 Q13049 EPN3 TRIM32 0.126 26186194 Q9H201 P0CG47 EPN3 UBB 0.126 26186194 Q9H201 O95208 EPN3 EPN2 0.126 26186194 Q9H201 O95271 EPN3 TNKS 0.126 26186194 Q9H201 P42575 EPN3 CASP2 0.126 26186194 Q9H201 P30260 EPN3 CDC27 0.126 26186194 Q9H201 P34931 EPN3 HSPA1L 0.126 26186194 Q9HCE7 Q9H201 SMURF1 EPN3 0.126 26186194 Q9H201 Q96Q07 EPN3 BTBD9 0.126 26186194 Q9H201 Q96JC1 EPN3 VPS39 0.126 26186194 Q9H3F6 Q9H201 KCTD10 EPN3 0.126 26186194 Q9H201 Q9H0C5 EPN3 BTBD1 0.126 26186194 Q9H2K2 Q9H201 TNKS2 EPN3 0.126 26186194 Q9Y3C5 Q9H201 RNF11 EPN3 0.332 15231748 Q9UJV3 Q9H201 MID2 EPN3 0.126 26186194 Q9UK73 Q9H201 FEM1B EPN3 0.126 26186194 Q9Y6I3 Q9H201 EPN1 EPN3 0.236 21115825,26186194 Q9Y4X5 Q9H201 ARIH1 EPN3 0.126 26186194 Q9Y597 Q9H201 KCTD3 EPN3 0.126 26186194 Q9NZN4 Q9H201 EHD2 EPN3 0.21 21115825 Q9H201 Q13571 EPN3 LAPTM5 0.332 15231748 Q9H201 Q15311 EPN3 RALBP1 0.21 20709745 Q9H201 P42566 EPN3 EPS15 0.21 21115825

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MID1 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database PHGDH EPN3 MI:0045 experimental interaction detection MI:0461 interaction database EED EPN3 MI:0362 inference MI:0461 interaction database AP2A2 EPN3 MI:0362 inference MI:0461 interaction database EPN2 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database TNKS EPN3 MI:0045 experimental interaction detection MI:0461 interaction database AP2A1 EPN3 MI:0362 inference MI:0461 interaction database CLTA EPN3 MI:0362 inference MI:0461 interaction database UBB EPN3 MI:0045 experimental interaction detection MI:0461 interaction database UBC EPN3 MI:0045 experimental interaction detection MI:0461 interaction database CDC27 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L EPN3 MI:0045 experimental interaction detection MI:0461 interaction database FLT4 EPN3 MI:0362 inference MI:0461 interaction database EPS15 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database CASP2 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database AMPH EPN3 MI:0362 inference MI:0461 interaction database RPS27A EPN3 MI:0362 inference MI:0461 interaction database UBA52 EPN3 MI:0362 inference MI:0461 interaction database AP2B1 EPN3 MI:0362 inference MI:0461 interaction database TUBA1B EPN3 MI:0362 inference MI:0461 interaction database TUBA4A EPN3 MI:0362 inference MI:0461 interaction database CLTC EPN3 MI:0362 inference MI:0461 interaction database SLC6A3 EPN3 MI:0362 inference MI:0461 interaction database ZBTB16 EPN3 MI:0362 inference MI:0461 interaction database TRIM32 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 EPN3 MI:0362 inference MI:0461 interaction database LAPTM5 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database TUBA3C EPN3 MI:0362 inference MI:0461 interaction database RALBP1 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database ITSN1 EPN3 MI:0362 inference MI:0461 interaction database TUBA3E EPN3 MI:0362 inference MI:0461 interaction database CYHR1 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database TUBA1A EPN3 MI:0362 inference MI:0461 interaction database SHKBP1 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database USP9X EPN3 MI:0362 inference MI:0461 interaction database AP2M1 EPN3 MI:0362 inference MI:0461 interaction database VPS39 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database BTBD9 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database BTBD1 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 TNKS2 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 KCTD10 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 EHD1 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 NECAP2 MI:0362 inference MI:0461 interaction database EPN3 EHD2 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 EPS15L1 MI:0362 inference MI:0461 interaction database EPN3 MID2 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 FEM1B MI:0045 experimental interaction detection MI:0461 interaction database EPN3 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 ARIH1 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 KCTD3 MI:0045 experimental interaction detection MI:0461 interaction database EPN3 EPN1 MI:0045 experimental interaction detection MI:0461 interaction database