PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TNIP3 TBK1 19615732 intact exp P P P P P P P P P P P P P P P P P P P ALDH9A1 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P P PPP6R3 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P P KRTAP10-8 TNIP3 25416956 biogrid,intact exp CNKSR2 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P TNIP3 IKBKG 17485448 innatedb exp UBC TNIP3 18212736 biogrid exp P P P P P P P P P P P P P P P P P P P NFKB1 TNIP3 14743216 biogrid exp P P P P P P P P P P P YWHAB TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P TNIP3 FBXO3 19615732 intact exp ZBTB8A TNIP3 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P P KIF11 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P P KRTAP10-3 TNIP3 25416956 biogrid exp LRRC47 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P P TNIP3 TNIP3 25416956 intact exp P P P P P P P P P P P P P P P P P P P TNIP3 LZTS2 25416956 biogrid,intact exp P P P P P P P P P P P P P P MCM6 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P NDUFS1 TNIP3 19615732 intact exp TAX1BP1 TNIP3 25416956 biogrid,intact exp P P P P P P P P P P P P P P TNIP1 TNIP3 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P KRT40 TNIP3 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P GLDC TNIP3 19615732 intact exp P P P P P YWHAH TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P RNH1 TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P P NOTCH2NL TNIP3 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P P PPP2R1B TNIP3 19615732 intact exp P P P P P P P P P P P P P P P P P P P DAZAP2 TNIP3 25416956 biogrid,intact exp TNFAIP3 TNIP3 17088249,25416956 biogrid,intact exp, ortho P P P P P P P P P P P P P P P P P P P TNIP3 SAP30L 21836163 pred SMC5 TNIP3 21836163 pred P P P P P P P P P P P P P P P P P P P TNIP3 WBP11 21836163 pred P P P P P P P P P P P P P P P P P P P DEAF1 TNIP3 21836163 pred P P P P P P P P P P P P P P P P P P SP100 TNIP3 21836163 pred P P P P P P P P P P P P P P P P P P P TNIP3 21836163 pred TNIP3 SLC25A31 21836163 pred P P P P P P P P P P P CALCOCO2 TNIP3 21836163 pred P P P P P P P P P P P P P P P P P P P TNIP3 CBX8 21836163 pred P P P P P P P P P P P P P P P P P P P TNIP3 SENP7 21836163 pred P P P P P P P P P P P P P P P P P P P TNIP3 SENP1 21836163 pred P P P P P P P P P P P P P P P P P P P ZBTB14 TNIP3 21836163 pred P P P P P P P P P P P P P P P P P P USP7 TNIP3 21836163 pred P P P P P P P P P P P P P P P P P P P TNIP3 DAXX 21836163, 21836163, 21836163 pred P P P P P P P P P P P P P P P P P P P NFX1 TNIP3 21836163 pred HOXD12 TNIP3 21836163 pred P P P P P P P P P P P IL10 TNIP3 21836163 pred P P P P P P P P P P P P P TNIP3 TNPO3 21836163 pred P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96KP6 P60410 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 A0A024R110 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 Q7Z3S9 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 Q86VP1 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 P60410 two hybrid array 25416956 physical association X 2 Q96KP6 A0A024R110 two hybrid array 25416956 physical association X 2 Q96KP6 Q7Z3S9 two hybrid array 25416956 physical association X 2 Q96KP6 Q86VP1 two hybrid array 25416956 physical association X 2 Q96KP6 P60410 validated two hybrid 25416956 physical association X 2 Q96KP6 A0A024R110 validated two hybrid 25416956 physical association X 2 Q96KP6 Q7Z3S9 validated two hybrid 25416956 physical association X 2 Q96KP6 Q86VP1 validated two hybrid 25416956 physical association X 2 Q15025 Q96KP6 two hybrid prey pooling approach 25416956 physical association X 2 Q15025 Q96KP6 two hybrid array 25416956 physical association X 2 Q15025 Q96KP6 validated two hybrid 25416956 physical association X 2 Q96KP6 anti tag coimmunoprecipitation 19615732 physical association C 15 P21580 Q96KP6 two hybrid prey pooling approach 25416956 physical association X 2 P21580 Q96KP6 two hybrid array 25416956 physical association X 2 P21580 Q96KP6 validated two hybrid 25416956 physical association X 2 Q96KP6 Q6A162 mammalian protein protein interaction trap 25416956 physical association X 2 Q96KP6 Q6A162 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 Q96BR9 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 Q9BRK4 two hybrid prey pooling approach 25416956 physical association X 2 Q96KP6 Q6A162 two hybrid array 25416956 physical association X 2 Q96KP6 Q96BR9 two hybrid array 25416956 physical association X 2 Q96KP6 Q9BRK4 two hybrid array 25416956 physical association X 2 Q96KP6 Q6A162 validated two hybrid 25416956 physical association X 2 Q96KP6 Q96BR9 validated two hybrid 25416956 physical association X 2 Q96KP6 Q9BRK4 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality RNH1 TNIP3 19615732 0007 HT NFKB1 TNIP3 14743216 0004 HT GLDC TNIP3 19615732 0007 HT NDUFS1 TNIP3 19615732 0007 HT PPP2R1B TNIP3 19615732 0007 HT YWHAB TNIP3 19615732 0007 HT ALDH9A1 TNIP3 19615732 0007 HT KIF11 TNIP3 19615732 0007 HT YWHAH TNIP3 19615732 0007 HT MCM6 TNIP3 19615732 0007 HT PPP6R3 TNIP3 19615732 0007 HT LRRC47 TNIP3 19615732 0007 HT CNKSR2 TNIP3 19615732 0007 HT TNIP3 TBK1 19615732 0007 HT TNIP3 FBXO3 19615732 0007 HT RNH1 TNIP3 19615732 0007 HT NFKB1 TNIP3 14743216 0004 HT GLDC TNIP3 19615732 0007 HT NDUFS1 TNIP3 19615732 0007 HT PPP2R1B TNIP3 19615732 0007 HT YWHAB TNIP3 19615732 0007 HT ALDH9A1 TNIP3 19615732 0007 HT KIF11 TNIP3 19615732 0007 HT YWHAH TNIP3 19615732 0007 HT MCM6 TNIP3 19615732 0007 HT PPP6R3 TNIP3 19615732 0007 HT LRRC47 TNIP3 19615732 0007 HT CNKSR2 TNIP3 19615732 0007 HT TNIP3 TBK1 19615732 0007 HT TNIP3 FBXO3 19615732 0007 HT UBC TNIP3 18212736,18212736 0004,0018 LC TNFAIP3 TNIP3 25416956,25416956,25416956,25416956 0397,1112,0018,1356 HT KRTAP10-3 TNIP3 25416956 0018 HT KRTAP10-8 TNIP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TNIP1 TNIP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT DAZAP2 TNIP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KRT40 TNIP3 25416956,25416956,25416956,25416956,25416956 1112,0397,0018,0231,1356 HT NOTCH2NL TNIP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TAX1BP1 TNIP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB8A TNIP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TNIP3 LZTS2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96KP6 Q7Z3S9 TNIP3 NOTCH2NL 0.583 25416956,unassigned1304 Q9NRY6 Q96KP6 PLSCR3 TNIP3 0.236 unassigned1304 Q96KP6 P0CG48 TNIP3 UBC 0.454 18212736 Q96KP6 Q96BR9 TNIP3 ZBTB8A 0.454 25416956 Q96KP6 O00505 TNIP3 KPNA3 0.236 unassigned1304 Q96KP6 B8A4K4 TNIP3 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q96KP6 P43356 TNIP3 MAGEA2B 0.416 unassigned1304 Q96KP6 P48745 TNIP3 NOV 0.236 unassigned1304 Q96KP6 Q3B820 TNIP3 FAM161A 0.236 unassigned1304 Q96KP6 Q96HA8 TNIP3 WDYHV1 0.236 unassigned1304 Q9BZR9 Q96KP6 TRIM8 TNIP3 0.236 unassigned1304 Q99732 Q96KP6 LITAF TNIP3 0.236 unassigned1304 Q96KP6 A0A087WUI6 TNIP3 PIBF1 {ECO:0000313|ENSEMBL:ENSP00000478697} 0.236 unassigned1304 Q96KP6 Q6A162 TNIP3 KRT40 0.523 25416956 Q96KP6 Q5JR59 TNIP3 MTUS2 0.236 unassigned1304 Q96KP6 Q86VP1 TNIP3 TAX1BP1 0.583 25416956,unassigned1304 Q96KP6 Q15038 TNIP3 DAZAP2 0.583 25416956,unassigned1304 Q96KP6 P60410 TNIP3 KRTAP10-8 0.454 25416956 Q96KP6 P21580 TNIP3 TNFAIP3 0.569 25416956,17088249 Q9BRK4 Q96KP6 LZTS2 TNIP3 0.583 25416956,unassigned1304 Q96KP6 P13489 TNIP3 RNH1 0.126 19615732 Q96KP6 P23378 TNIP3 GLDC 0.126 19615732 Q96KP6 P28331 TNIP3 NDUFS1 0.126 19615732 Q96KP6 P30154 TNIP3 PPP2R1B 0.126 19615732 Q96KP6 P31946 TNIP3 YWHAB 0.126 19615732 Q96KP6 P49189 TNIP3 ALDH9A1 0.126 19615732 Q96KP6 P52732 TNIP3 KIF11 0.126 19615732 Q96KP6 P60369 TNIP3 KRTAP10-3 0.183 25416956 Q96KP6 Q04917 TNIP3 YWHAH 0.126 19615732 Q96KP6 Q14566 TNIP3 MCM6 0.126 19615732 Q96KP6 Q15025 TNIP3 TNIP1 0.583 25416956,unassigned1304 Q96KP6 Q5H9R7 TNIP3 PPP6R3 0.126 19615732 Q96KP6 Q8N1G4 TNIP3 LRRC47 0.126 19615732 Q96KP6 Q8WXI2 TNIP3 CNKSR2 0.126 19615732 Q9UHD2 Q96KP6 TBK1 TNIP3 0.126 19615732 Q9UK99 Q96KP6 FBXO3 TNIP3 0.126 19615732 Q96KP6 P19838 TNIP3 NFKB1 0.126 14743216

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MAP3K7 TNIP3 MI:0362 inference MI:0461 interaction database UBC TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database RNH1 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database NFKB1 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 TNIP3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database GLDC TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database NDUFS1 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R1B TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database YWHAB TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database ALDH9A1 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database KIF11 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-3 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-8 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database YWHAH TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database MCM6 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database TNIP1 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database DAZAP2 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database PPP6R3 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database KRT40 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH2NL TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database TAX1BP1 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database LRRC47 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database CNKSR2 TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB8A TNIP3 MI:0045 experimental interaction detection MI:0461 interaction database TNIP3 LZTS2 MI:0045 experimental interaction detection MI:0461 interaction database TNIP3 TBK1 MI:0045 experimental interaction detection MI:0461 interaction database TNIP3 FBXO3 MI:0045 experimental interaction detection MI:0461 interaction database