PTM - CPLM Gene Name UniProt ID Type Position Code BCAR1; CAS; CASS1; CRKAS P56945 Ubiquitination 702 K

PTM - dbPAF Gene Name UniProt ID Position Type Species BCAR1; CAS; CASS1; CRKAS P56945 113 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 115 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 12 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 128 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 134 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 139 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 165 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 179 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 18 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 184 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 192 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 222 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 224 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 234 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 249 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 260 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 262 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 267 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 269 T Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 287 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 292 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 300 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 306 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 311 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 313 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 326 T Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 327 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 355 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 362 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 372 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 385 T Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 387 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 407 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 410 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 428 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 430 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 431 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 432 T Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 434 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 435 T Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 437 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 438 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 440 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 639 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 653 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 664 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 666 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 67 Y Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 694 S Homo sapiens(Human) BCAR1; CAS; CASS1; CRKAS P56945 815 Y Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type BCAR1; CAS; CASS1; CRKAS rs17855755 AGC->AAC S->N 165 Y PSPATDLYQVPPGPG 165 Phosphorylation TypeIII- BCAR1; CAS; CASS1; CRKAS rs4990726 CCC->TCC P->S 165 Y PSPATDLYQVPPGPG 165 Phosphorylation TypeIII- BCAR1; CAS; CASS1; CRKAS rs61729593 CCG->CGG P->R 362 Y SPPAEDVYDVPPPAP 362 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P56945 K143-ac Acetylation QFQsPPAkQTSTFSK P56945 Y12-p Phosphorylation NVLAKALyDNVAEsP P56945 S18-p Phosphorylation LyDNVAEsPDELSFR P56945 Y67-p Phosphorylation LKILVGMyDKKPAGP P56945 S113-p Phosphorylation TYQPQPDsVyLVPTP P56945 Y115-p Phosphorylation QPQPDsVyLVPTPSK P56945 Y128-p Phosphorylation SKAQQGLyQVPGPsP P56945 S134-p Phosphorylation LyQVPGPsPQFQsPP P56945 S139-p Phosphorylation GPsPQFQsPPAkQTS P56945 Y165-p Phosphorylation PSPATDLyQVPPGPG P56945 Y179-p Phosphorylation GGPAQDIyQVPPsAG P56945 S184-p Phosphorylation DIyQVPPsAGMGHDI P56945 Y192-p Phosphorylation AGMGHDIyQVPPSMD P56945 S202-p Phosphorylation PPSMDTRsWEGTKPP P56945 Y222-p Phosphorylation PTRVGQGyVyEAAQP P56945 Y224-p Phosphorylation RVGQGyVyEAAQPEQ P56945 Y234-p Phosphorylation AQPEQDEyDIPRHLL P56945 Y249-p Phosphorylation APGPQDIyDVPPVRG P56945 S260-p Phosphorylation PVRGLLPsQyGQEVy P56945 Y262-p Phosphorylation RGLLPsQyGQEVyDt P56945 Y267-p Phosphorylation sQyGQEVyDtPPMAV P56945 T269-p Phosphorylation yGQEVyDtPPMAVKG P56945 Y287-p Phosphorylation RDPLLEVyDVPPsVE P56945 S292-p Phosphorylation EVyDVPPsVEKGLPP P56945 S300-p Phosphorylation VEKGLPPsNHHAVyD P56945 Y306-p Phosphorylation PsNHHAVyDVPPsVs P56945 S311-p Phosphorylation AVyDVPPsVsKDVPD P56945 S313-p Phosphorylation yDVPPsVsKDVPDGP P56945 T326-p Phosphorylation GPLLREEtyDVPPAF P56945 Y327-p Phosphorylation PLLREEtyDVPPAFA P56945 S355-p Phosphorylation LAAPPPDsPPAEDVy P56945 Y362-p Phosphorylation sPPAEDVyDVPPPAP P56945 Y372-p Phosphorylation PPPAPDLyDVPPGLR P56945 T385-p Phosphorylation LRRPGPGtLyDVPRE P56945 Y387-p Phosphorylation RPGPGtLyDVPRERV P56945 S407-p Phosphorylation ADGGVVDsGVyAVPP P56945 Y410-p Phosphorylation GVVDsGVyAVPPPAE P56945 S428-p Phosphorylation PAEGKRLsAsstGst P56945 S430-p Phosphorylation EGKRLsAsstGstRs P56945 S431-p Phosphorylation GKRLsAsstGstRss P56945 T432-p Phosphorylation KRLsAsstGstRssQ P56945 S434-p Phosphorylation LsAsstGstRssQsA P56945 T435-p Phosphorylation sAsstGstRssQsAS P56945 S437-p Phosphorylation sstGstRssQsASSL P56945 S438-p Phosphorylation stGstRssQsASSLE P56945 S440-p Phosphorylation GstRssQsASSLEVA P56945 S602-p Phosphorylation SFLHGNAsLLFRRTK P56945 S639-p Phosphorylation IQSRPLPsPPKFTSQ P56945 S648-p Phosphorylation PKFTSQDsPDGQyEN P56945 Y653-p Phosphorylation QDsPDGQyENSEGGW P56945 Y664-p Phosphorylation EGGWMEDyDyVHLQG P56945 Y666-p Phosphorylation GWMEDyDyVHLQGKE P56945 S694-p Phosphorylation SITRQGKsQLELQQL P56945 Y815-p Phosphorylation VRSQVTHySNLLCDL P56945 K702-ub Ubiquitination QLELQQLkQFERLEQ

PTM - dbPTM UniProt ID Position Code Type Resources References P56945 128 Y Phosphorylation Swiss-Prot 1010711 16212419;18083107;19534553 P56945 134 S Phosphorylation Swiss-Prot 1010711 18669648 P56945 139 S Phosphorylation Swiss-Prot 1010711 16964243;18669648 P56945 222 Y Phosphorylation Swiss-Prot 1010711 16212419 P56945 224 Y Phosphorylation Swiss-Prot 1010711 16212419 P56945 234 Y Phosphorylation Swiss-Prot 1010711 16212419;17389395;18083107;19534553 P56945 249 Y Phosphorylation Swiss-Prot 1010711 15951569;16212419;18083107;19534553 P56945 267 Y Phosphorylation Swiss-Prot 1010711 17389395;19534553 P56945 269 T Phosphorylation Swiss-Prot 1010711 18669648 P56945 287 Y Phosphorylation Swiss-Prot 1010711 19534553 P56945 292 S Phosphorylation Swiss-Prot 1010711 18669648 P56945 327 Y Phosphorylation Swiss-Prot 1010711 15592455;15951569;17389395;19534553 P56945 362 Y Phosphorylation Swiss-Prot 1010711 17389395 P56945 387 Y Phosphorylation Swiss-Prot 1010711 16212419;17389395;18083107;19534553 P56945 410 Y Phosphorylation Swiss-Prot 1010711 17389395 P56945 639 S Phosphorylation Swiss-Prot 1010711 17081983 P56945 1 M Acetylation Swiss-Prot 1010711 - P56945 134 S Phosphorylation PhosphoELM.10011 18669648 P56945 139 S Phosphorylation PhosphoELM.10011 18669648;16964243 P56945 292 S Phosphorylation PhosphoELM.10011 18669648 P56945 639 S Phosphorylation PhosphoELM.10011 17081983 P56945 269 T Phosphorylation PhosphoELM.10011 18669648 P56945 165 Y Phosphorylation PhosphoELM.10011 15817476 P56945 222 Y Phosphorylation PhosphoELM.10011 16212419 P56945 224 Y Phosphorylation PhosphoELM.10011 16212419 P56945 234 Y Phosphorylation PhosphoELM.10011 16212419;18083107 P56945 387 Y Phosphorylation PhosphoELM.10011 16212419;18083107;15316024 P56945 664 Y Phosphorylation PhosphoELM.10011 11604500;8621540 P56945 128 Y Phosphorylation PhosphoELM.10011 16212419;18083107;12601080 P56945 249 Y Phosphorylation PhosphoELM.10011 16212419;18083107;12601080 P56945 306 Y Phosphorylation PhosphoELM.10011 12601080 P56945 327 Y Phosphorylation PhosphoELM.10011 12601080 P56945 410 Y Phosphorylation PhosphoELM.10011 12601080 P56945 653 Y Phosphorylation PhosphoELM.10011 12480533;8670206;11604500 P56945 702 K Ubiquitylation Phosphositeplus.1010730 21890473 P56945 134 S Phosphorylation Phosphositeplus.1010730 18669648;20068231 P56945 139 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;19454314;20068231 P56945 292 S Phosphorylation Phosphositeplus.1010730 18669648 P56945 428 S Phosphorylation Phosphositeplus.1010730 20363803;21406692;22115753 P56945 431 S Phosphorylation Phosphositeplus.1010730 21406692 P56945 437 S Phosphorylation Phosphositeplus.1010730 19454314 P56945 639 S Phosphorylation Phosphositeplus.1010730 17081983;19454314 P56945 269 T Phosphorylation Phosphositeplus.1010730 18669648 P56945 12 Y Phosphorylation Phosphositeplus.1010730 21937722 P56945 128 Y Phosphorylation Phosphositeplus.1010730 12601080;16212419;17016520;18083107;18180459;19534553;19901323;20007894;20090780;20736484;21049007;21403953;21447384;22710723 P56945 165 Y Phosphorylation Phosphositeplus.1010730 15817476;20133777;20802517;22084245 P56945 192 Y Phosphorylation Phosphositeplus.1010730 20736484 P56945 222 Y Phosphorylation Phosphositeplus.1010730 16212419 P56945 224 Y Phosphorylation Phosphositeplus.1010730 16212419;18083107;18180459 P56945 234 Y Phosphorylation Phosphositeplus.1010730 16212419;17016520;17389395;18083107;18180459;19534553;20007894;20562096;20736484;21049007;21447384 P56945 249 Y Phosphorylation Phosphositeplus.1010730 12601080;15316024;15657067;15951569;16212419;17016520;18083107;18180459;18704117;18776048;19029090;19534553;19901323;20007894;20068231;20090780;20736484;21049007 P56945 267 Y Phosphorylation Phosphositeplus.1010730 17016520;17389395;18083107;18180459;19534553;20007894;20736484;21049007 P56945 287 Y Phosphorylation Phosphositeplus.1010730 17016520;18083107;18180459;19534553;20090780;20736484;21049007 P56945 306 Y Phosphorylation Phosphositeplus.1010730 12601080;15657067;18083107;18180459;20736484 P56945 327 Y Phosphorylation Phosphositeplus.1010730 12601080;15316024;15951569;17016520;17389395;17646646;18083107;18180459;19534553;20736484;21049007 P56945 362 Y Phosphorylation Phosphositeplus.1010730 15870699;17016520;17389395;18083107;18180459 P56945 372 Y Phosphorylation Phosphositeplus.1010730 17016520;18083107;18180459 P56945 387 Y Phosphorylation Phosphositeplus.1010730 15316024;15657067;16212419;17016520;17389395;18083107;18180459;18707149;18776048;19534553;19901323;20007894;20562096;20736484;21049007;21394647;21403953 P56945 410 Y Phosphorylation Phosphositeplus.1010730 12601080;15316024;17016520;17389395;18083107;20007894;20562096;21403953 P56945 664 Y Phosphorylation Phosphositeplus.1010730 15870699;20736484;22084245 P56945 666 Y Phosphorylation Phosphositeplus.1010730 20736484 P56945 134 S Phosphorylation HPRD 9.0 18669648,20068231 P56945 139 S Phosphorylation HPRD 9.0 18669648,16964243,20068231 P56945 292 S Phosphorylation HPRD 9.0 18669648 P56945 428 S Phosphorylation HPRD 9.0 20068231 P56945 639 S Phosphorylation HPRD 9.0 17081983 P56945 269 T Phosphorylation HPRD 9.0 18669648 P56945 128 Y Phosphorylation HPRD 9.0 12601080,17016520,19901323,20068231 P56945 222 Y Phosphorylation HPRD 9.0 16212419 P56945 224 Y Phosphorylation HPRD 9.0 16212419 P56945 249 Y Phosphorylation HPRD 9.0 12601080,17016520,19901323,20068231 P56945 306 Y Phosphorylation HPRD 9.0 12601080 P56945 327 Y Phosphorylation HPRD 9.0 12601080,17389395,17016520 P56945 372 Y Phosphorylation HPRD 9.0 17016520 P56945 410 Y Phosphorylation HPRD 9.0 12601080,17389395,17016520 P56945 664 Y Phosphorylation (PTK2) HPRD 9.0 9360983,12119061,9360968 P56945 666 Y Phosphorylation (PTK2) HPRD 9.0 9360983 P56945 115 Y Phosphorylation (SRC) HPRD 9.0 12972425 P56945 165 Y Phosphorylation (SRC) HPRD 9.0 12972425 P56945 179 Y Phosphorylation (SRC) HPRD 9.0 12972425 P56945 192 Y Phosphorylation (SRC) HPRD 9.0 12972425 P56945 234 Y Phosphorylation (SRC) HPRD 9.0 12972425,17389395,17016520 P56945 267 Y Phosphorylation (SRC) HPRD 9.0 12972425,17389395,17016520 P56945 287 Y Phosphorylation (SRC) HPRD 9.0 12972425,17016520 P56945 362 Y Phosphorylation (SRC) HPRD 9.0 12972425,17389395,17016520 P56945 387 Y Phosphorylation (SRC) HPRD 9.0 12972425,17389395,17016520,19901323 P56945 653 Y Phosphorylation (SRC) HPRD 9.0 12972425 P56945 318 D Proteolytic Cleavage HPRD 9.0 10712510 P56945 650 D Proteolytic Cleavage HPRD 9.0 10712510 P56945 249 Y Phosphorylation SysPTM 1.1 15657067

PTM - HPRD Symbol Position Code Type References BCAR1 115 Y Phosphorylation 12972425 BCAR1 128 Y Phosphorylation 12601080,17016520,19901323,20068231 BCAR1 134 S Phosphorylation 18669648,20068231 BCAR1 139 S Phosphorylation 18669648,16964243,20068231 BCAR1 165 Y Phosphorylation 12972425 BCAR1 179 Y Phosphorylation 12972425 BCAR1 192 Y Phosphorylation 12972425 BCAR1 222 Y Phosphorylation 16212419 BCAR1 224 Y Phosphorylation 16212419 BCAR1 234 Y Phosphorylation 12972425,17389395,17016520 BCAR1 249 Y Phosphorylation 12601080,17016520,19901323,20068231 BCAR1 267 Y Phosphorylation 12972425,17389395,17016520 BCAR1 269 T Phosphorylation 18669648 BCAR1 287 Y Phosphorylation 12972425,17016520 BCAR1 292 S Phosphorylation 18669648 BCAR1 306 Y Phosphorylation 12601080 BCAR1 318 D Proteolytic Cleavage 10712510 BCAR1 326 Y Phosphorylation 17016520 BCAR1 327 Y Phosphorylation 12601080,17389395,17016520 BCAR1 362 Y Phosphorylation 12972425,17389395,17016520 BCAR1 372 Y Phosphorylation 17016520 BCAR1 386 Y Phosphorylation 17016520 BCAR1 387 Y Phosphorylation 12972425,17389395,17016520,19901323 BCAR1 410 Y Phosphorylation 12601080,17389395,17016520 BCAR1 428 S Phosphorylation 20068231 BCAR1 639 S Phosphorylation 17081983 BCAR1 650 D Proteolytic Cleavage 10712510 BCAR1 653 Y Phosphorylation 12972425 BCAR1 664 Y Phosphorylation 9360983,12119061,9360968 BCAR1 666 Y Phosphorylation 9360983

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P56945 128 Y 16212419 HTP Phosphorylation P56945 128 Y 18083107 HTP Phosphorylation P56945 128 Y 12601080 FGFR1 LTP Phosphorylation P56945 224 Y 16212419 HTP Phosphorylation P56945 387 Y 16212419 HTP Phosphorylation P56945 387 Y 18083107 HTP Phosphorylation P56945 387 Y 15316024 LTP Phosphorylation P56945 292 S 18669648 HTP Phosphorylation P56945 165 Y 15817476 LTP Phosphorylation P56945 134 S 18669648 HTP Phosphorylation P56945 327 Y 12601080 FGFR1 LTP Phosphorylation P56945 234 Y 16212419 HTP Phosphorylation P56945 234 Y 18083107 HTP Phosphorylation P56945 139 S 18669648 HTP Phosphorylation P56945 139 S 16964243 HTP Phosphorylation P56945 653 Y 12480533 LTP Phosphorylation P56945 653 Y 8670206 LTP Phosphorylation P56945 653 Y 11604500 SRC LTP Phosphorylation P56945 269 T 18669648 HTP Phosphorylation P56945 306 Y 12601080 FGFR1 LTP Phosphorylation P56945 664 Y 11604500 LTP Phosphorylation P56945 664 Y 8621540 LTP Phosphorylation P56945 249 Y 16212419 HTP Phosphorylation P56945 249 Y 18083107 HTP Phosphorylation P56945 249 Y 12601080 FGFR1 LTP Phosphorylation P56945 410 Y 12601080 FGFR1 LTP Phosphorylation P56945 222 Y 16212419 HTP Phosphorylation P56945 639 S 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P56945 128 Phosphotyrosine; by SRC 22710723 P56945 134 Phosphoserine 18669648;20068231 P56945 139 Phosphoserine 18669648;20068231;23186163;19454314 P56945 269 Phosphothreonine 18669648 P56945 292 Phosphoserine 18669648 P56945 428 Phosphoserine 21406692 P56945 437 Phosphoserine 19454314 P56945 639 Phosphoserine 23186163;19454314

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type BCAR1 IPI00011998 S 134 YQVPGPpSPQFQSP phosphorylation BCAR1 IPI00011998 S 139 PSPQFQpSPPAKQT phosphorylation BCAR1 IPI00011998 S 657 QSRPLPpSPPKFTS phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9564 114934 - K Ubiquitination 21890473 9564 114934 - K Ubiquitination 23000965

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID BCAR1 Homo sapiens (Human) 720 "720,LELQQLKQFERLE" 720:21890473 BCAR1 Homo sapiens (Human) 748 "748,LELQQLKQFERLE" 748:21890473 BCAR1 Homo sapiens (Human) 702 "702,LELQQLKQFERLE" 702:21890473 BCAR1 Homo sapiens (Human) 720 "720,LELQQLKQFERLE" 720:21890473 BCAR1 Homo sapiens (Human) 492 "492,LELQQLKQFERLE" 492:21890473 BCAR1 Homo sapiens (Human) 492 "492,LELQQLKQFERLE" 492:21890473 BCAR1 Homo sapiens (Human) 748 "748,LELQQLKQFERLE" 748:21890473 BCAR1 Homo sapiens (Human) 492 "492,LELQQLKQFERLE" 492:21890473 BCAR1 Homo sapiens (Human) 720 "720,LELQQLKQFERLE" 720:21890473 BCAR1 Homo sapiens (Human) 702 "702,LELQQLKQFERLE" 702:21890473 BCAR1 Homo sapiens (Human) 702 "702,LELQQLKQFERLE" 702:21890473 BCAR1 Homo sapiens (Human) 492 "492,LELQQLKQFERLE" 492:21890473 BCAR1 Homo sapiens (Human) 702 "702,LELQQLKQFERLE" 702:21890473 BCAR1 Homo sapiens (Human) 720 "720,LELQQLKQFERLE" 720:21890473