PTM - CPLM Gene Name UniProt ID Type Position Code USP36; KIAA1453 Q9P275 Acetylation 230 K USP36; KIAA1453 Q9P275 Ubiquitination 338 K USP36; KIAA1453 Q9P275 Ubiquitination 230 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP36; KIAA1453 Q9P275 1021 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 1048 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 1051 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 1118 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 1119 Y Homo sapiens(Human) USP36; KIAA1453 Q9P275 18 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 268 Y Homo sapiens(Human) USP36; KIAA1453 Q9P275 295 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 300 Y Homo sapiens(Human) USP36; KIAA1453 Q9P275 31 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 321 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 325 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 429 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 439 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 440 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 447 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 453 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 463 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 464 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 467 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 494 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 50 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 511 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 513 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 515 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 519 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 521 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 523 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 546 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 557 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 559 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 562 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 580 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 581 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 582 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 60 Y Homo sapiens(Human) USP36; KIAA1453 Q9P275 602 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 610 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 611 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 612 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 613 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 614 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 618 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 620 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 621 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 629 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 632 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 640 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 651 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 653 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 656 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 667 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 671 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 673 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 674 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 675 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 679 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 680 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 682 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 692 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 698 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 703 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 713 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 715 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 716 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 742 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 748 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 756 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 760 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 763 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 764 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 765 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 807 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 825 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 871 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 874 Y Homo sapiens(Human) USP36; KIAA1453 Q9P275 89 T Homo sapiens(Human) USP36; KIAA1453 Q9P275 937 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 939 S Homo sapiens(Human) USP36; KIAA1453 Q9P275 952 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9P275 K230-ac Acetylation ACLNGCAkLDRQTQA Q9P275 K508-m2 Methylation QNGCIPPkLPSGsPs Q9P275 S18-p Phosphorylation LKPGRKDsADDGELG Q9P275 S31-p Phosphorylation LGKLLASsAKKVLLQ Q9P275 S50-p Phosphorylation EPASKSFsYQLEALK Q9P275 Y268-p Phosphorylation VSDTYDPyLDVALEI Q9P275 S429-p Phosphorylation RIPGSKksPEGLISR Q9P275 S439-p Phosphorylation GLISRTGsSSLPGRP Q9P275 S447-p Phosphorylation SSLPGRPsVIPDHsK Q9P275 S453-p Phosphorylation PsVIPDHsKKNIGNG Q9P275 S464-p Phosphorylation IGNGIISsPLtGKRQ Q9P275 T467-p Phosphorylation GIISsPLtGKRQDSG Q9P275 S494-p Phosphorylation VPISRNGsTLGLKSQ Q9P275 S513-p Phosphorylation PPkLPSGsPsPKLSQ Q9P275 S515-p Phosphorylation kLPSGsPsPKLSQtP Q9P275 T521-p Phosphorylation PsPKLSQtPtHMPTI Q9P275 T523-p Phosphorylation PKLSQtPtHMPTILD Q9P275 S546-p Phosphorylation PAPPQHFsPRTAQGL Q9P275 S580-p Phosphorylation DSRdVVLstsPKLLA Q9P275 T581-p Phosphorylation SRdVVLstsPKLLAT Q9P275 S582-p Phosphorylation RdVVLstsPKLLATA Q9P275 S602-p Phosphorylation GLKGNDEsAGLDRRG Q9P275 S610-p Phosphorylation AGLDRRGsSsssPEH Q9P275 S612-p Phosphorylation LDRRGsSsssPEHsA Q9P275 S613-p Phosphorylation DRRGsSsssPEHsAs Q9P275 S614-p Phosphorylation RRGsSsssPEHsAss Q9P275 S618-p Phosphorylation SsssPEHsAssDSTK Q9P275 S620-p Phosphorylation ssPEHsAssDSTKAP Q9P275 S621-p Phosphorylation sPEHsAssDSTKAPQ Q9P275 T629-p Phosphorylation DSTKAPQtPRsGAAH Q9P275 S632-p Phosphorylation KAPQtPRsGAAHLCD Q9P275 S640-p Phosphorylation GAAHLCDsQETNCST Q9P275 S651-p Phosphorylation NCSTAGHsKtPPsGA Q9P275 T653-p Phosphorylation STAGHsKtPPsGADS Q9P275 S656-p Phosphorylation GHsKtPPsGADSKTV Q9P275 S667-p Phosphorylation SKTVKLKsPVLsNTT Q9P275 S671-p Phosphorylation KLKsPVLsNTTTEPA Q9P275 S679-p Phosphorylation NTTTEPAstMsPPPA Q9P275 T680-p Phosphorylation TTTEPAstMsPPPAK Q9P275 S682-p Phosphorylation TEPAstMsPPPAKKL Q9P275 S692-p Phosphorylation PAKKLALsAKKASTL Q9P275 S713-p Phosphorylation DLRPPPPsPSSDLTH Q9P275 S742-p Phosphorylation VHRARAVsPAPQSsS Q9P275 S748-p Phosphorylation VsPAPQSsSRLQPPF Q9P275 S756-p Phosphorylation SRLQPPFsPHPtLLs Q9P275 T760-p Phosphorylation PPFsPHPtLLsstPK Q9P275 S763-p Phosphorylation sPHPtLLsstPKPPG Q9P275 S764-p Phosphorylation PHPtLLsstPKPPGT Q9P275 T765-p Phosphorylation HPtLLsstPKPPGTS Q9P275 S807-p Phosphorylation EASEPPQsPSEKRKK Q9P275 S825-p Phosphorylation GEPQRLGsETRLPQH Q9P275 S871-p Phosphorylation QTQRQPGsPMYRREG Q9P275 S937-p Phosphorylation HQDPLRHsCsPMGDG Q9P275 S939-p Phosphorylation DPLRHsCsPMGDGDP Q9P275 S952-p Phosphorylation DPEAMEEsPRKKKKR Q9P275 S1021-p Phosphorylation SWNGEREsDVVQELL Q9P275 S1051-p Phosphorylation DGKMSAVsQDAIEDS Q9P275 S1118-p Phosphorylation PAKAASLsyRR____ Q9P275 Y1119-p Phosphorylation AKAASLsyRR_____ Q9P275 K338-ub Ubiquitination FANFSGGkITkDVGY Q9P275 K341-ub Ubiquitination FSGGkITkDVGYPEF Q9P275 K428-ub Ubiquitination LRIPGSKksPEGLIS

PTM - dbPTM UniProt ID Position Code Type Resources References Q9P275 464 S Phosphorylation Swiss-Prot 1010711 18669648;19007248;19413330;19690332 Q9P275 494 S Phosphorylation Swiss-Prot 1010711 19007248 Q9P275 513 S Phosphorylation Swiss-Prot 1010711 19413330 Q9P275 515 S Phosphorylation Swiss-Prot 1010711 19413330 Q9P275 546 S Phosphorylation Swiss-Prot 1010711 18669648 Q9P275 582 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q9P275 613 S Phosphorylation Swiss-Prot 1010711 19413330 Q9P275 614 S Phosphorylation Swiss-Prot 1010711 19413330 Q9P275 653 T Phosphorylation Swiss-Prot 1010711 19413330 Q9P275 667 S Phosphorylation Swiss-Prot 1010711 18669648;19007248;19413330;19690332 Q9P275 680 T Phosphorylation Swiss-Prot 1010711 18669648 Q9P275 682 S Phosphorylation Swiss-Prot 1010711 19413330;19690332 Q9P275 713 S Phosphorylation Swiss-Prot 1010711 19007248 Q9P275 742 S Phosphorylation Swiss-Prot 1010711 16565220;17924679;18691976;19007248;19413330 Q9P275 874 Y Phosphorylation Swiss-Prot 1010711 17081983 Q9P275 952 S Phosphorylation Swiss-Prot 1010711 17081983 Q9P275 1048 S Phosphorylation Swiss-Prot 1010711 19007248 Q9P275 464 S Phosphorylation PhosphoELM.10011 18669648 Q9P275 546 S Phosphorylation PhosphoELM.10011 18669648 Q9P275 582 S Phosphorylation PhosphoELM.10011 18669648 Q9P275 667 S Phosphorylation PhosphoELM.10011 18669648 Q9P275 679 S Phosphorylation PhosphoELM.10011 18669648 Q9P275 682 S Phosphorylation PhosphoELM.10011 18669648 Q9P275 742 S Phosphorylation PhosphoELM.10011 16565220 Q9P275 675 T Phosphorylation PhosphoELM.10011 18669648 Q9P275 680 T Phosphorylation PhosphoELM.10011 18669648 Q9P275 576 D Caspase Phosphositeplus.1010730 18722006 Q9P275 338 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q9P275 1118 S Phosphorylation Phosphositeplus.1010730 20068231 Q9P275 429 S Phosphorylation Phosphositeplus.1010730 19691289 Q9P275 464 S Phosphorylation Phosphositeplus.1010730 18669648;19664995;19690332;19691289 Q9P275 494 S Phosphorylation Phosphositeplus.1010730 21406692 Q9P275 513 S Phosphorylation Phosphositeplus.1010730 19691289 Q9P275 546 S Phosphorylation Phosphositeplus.1010730 18669648 Q9P275 582 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;19691289;20068231 Q9P275 610 S Phosphorylation Phosphositeplus.1010730 21406692 Q9P275 667 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19690332;19691289;20068231;21406692;22115753 Q9P275 679 S Phosphorylation Phosphositeplus.1010730 19664995 Q9P275 682 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19664995;19690332;19691289 Q9P275 692 S Phosphorylation Phosphositeplus.1010730 20068231 Q9P275 713 S Phosphorylation Phosphositeplus.1010730 20068231;22115753 Q9P275 742 S Phosphorylation Phosphositeplus.1010730 16565220;18691976;19664995;19691289;20068231;20363803;21406692;22115753 Q9P275 871 S Phosphorylation Phosphositeplus.1010730 19691289;21406692 Q9P275 952 S Phosphorylation Phosphositeplus.1010730 19664995;20068231 Q9P275 680 T Phosphorylation Phosphositeplus.1010730 19664995 Q9P275 1119 Y Phosphorylation Phosphositeplus.1010730 20068231 Q9P275 300 Y Phosphorylation Phosphositeplus.1010730 18083107 Q9P275 321 S Phosphorylation HPRD 9.0 20068231 Q9P275 429 S Phosphorylation HPRD 9.0 19691289 Q9P275 464 S Phosphorylation HPRD 9.0 18669648,19413330,19007248,19664995,19691289,20068231 Q9P275 494 S Phosphorylation HPRD 9.0 19007248 Q9P275 513 S Phosphorylation HPRD 9.0 19413330,19691289 Q9P275 515 S Phosphorylation HPRD 9.0 19413330,19691289 Q9P275 546 S Phosphorylation HPRD 9.0 18669648 Q9P275 580 S Phosphorylation HPRD 9.0 18691976,19691289,20068231 Q9P275 582 S Phosphorylation HPRD 9.0 18669648,19691289,20068231 Q9P275 612 S Phosphorylation HPRD 9.0 20068231 Q9P275 613 S Phosphorylation HPRD 9.0 19413330 Q9P275 614 S Phosphorylation HPRD 9.0 19413330 Q9P275 667 S Phosphorylation HPRD 9.0 18669648,19007248,19691289,20068231 Q9P275 671 S Phosphorylation HPRD 9.0 20068231 Q9P275 679 S Phosphorylation HPRD 9.0 18669648,19664995 Q9P275 682 S Phosphorylation HPRD 9.0 18669648,19413330,19664995,19691289,20068231 Q9P275 692 S Phosphorylation HPRD 9.0 20068231 Q9P275 713 S Phosphorylation HPRD 9.0 19007248,19691289,20068231 Q9P275 742 S Phosphorylation HPRD 9.0 16565220,18691976,19007248,19664995,19651622,19691289,17924679,20068231 Q9P275 871 S Phosphorylation HPRD 9.0 19691289 Q9P275 952 S Phosphorylation HPRD 9.0 17081983,19664995,20068231 Q9P275 325 T Phosphorylation HPRD 9.0 20068231 Q9P275 467 T Phosphorylation HPRD 9.0 20068231 Q9P275 581 T Phosphorylation HPRD 9.0 17081983,19691289,20068231 Q9P275 653 T Phosphorylation HPRD 9.0 19413330 Q9P275 673 T Phosphorylation HPRD 9.0 20068231 Q9P275 675 T Phosphorylation HPRD 9.0 18669648 Q9P275 680 T Phosphorylation HPRD 9.0 18669648,19413330,19664995,20068231 Q9P275 874 Y Phosphorylation HPRD 9.0 17081983 Q9P275 464 S Phosphorylation SysPTM 1.1 18669648 Q9P275 546 S Phosphorylation SysPTM 1.1 18669648 Q9P275 582 S Phosphorylation SysPTM 1.1 18669648 Q9P275 667 S Phosphorylation SysPTM 1.1 18669648 Q9P275 742 S Phosphorylation SysPTM 1.1 18691976;16565220 Q9P275 952 S Phosphorylation SysPTM 1.1 17081983 Q9P275 581 T Phosphorylation SysPTM 1.1 17081983 Q9P275 680 T Phosphorylation SysPTM 1.1 18669648 Q9P275 874 Y Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References USP36 1050 S Phosphorylation 19007248 USP36 1053 S Phosphorylation 18077418 USP36 1120 S Phosphorylation 20068231 USP36 1121 Y Phosphorylation 20068231 USP36 321 S Phosphorylation 20068231 USP36 325 T Phosphorylation 20068231 USP36 429 S Phosphorylation 19691289 USP36 464 S Phosphorylation 18669648,19413330,19007248,19664995,19691289,20068231 USP36 467 T Phosphorylation 20068231 USP36 494 S Phosphorylation 19007248 USP36 513 S Phosphorylation 19413330,19691289 USP36 515 S Phosphorylation 19413330,19691289 USP36 546 S Phosphorylation 18669648 USP36 580 S Phosphorylation 18691976,19691289,20068231 USP36 581 T Phosphorylation 17081983,19691289,20068231 USP36 582 S Phosphorylation 18669648,19691289,20068231 USP36 612 S Phosphorylation 20068231 USP36 613 S Phosphorylation 19413330 USP36 614 S Phosphorylation 19413330 USP36 653 T Phosphorylation 19413330 USP36 667 S Phosphorylation 18669648,19007248,19691289,20068231 USP36 671 S Phosphorylation 20068231 USP36 673 T Phosphorylation 20068231 USP36 675 T Phosphorylation 18669648 USP36 679 S Phosphorylation 18669648,19664995 USP36 680 T Phosphorylation 18669648,19413330,19664995,20068231 USP36 682 S Phosphorylation 18669648,19413330,19664995,19691289,20068231 USP36 692 S Phosphorylation 20068231 USP36 713 S Phosphorylation 19007248,19691289,20068231 USP36 742 S Phosphorylation 16565220,18691976,19007248,19664995,19651622,19691289,17924679,20068231 USP36 871 S Phosphorylation 19691289 USP36 874 Y Phosphorylation 17081983 USP36 952 S Phosphorylation 17081983,19664995,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9P275 680 T 18669648 HTP Phosphorylation Q9P275 679 S 18669648 HTP Phosphorylation Q9P275 742 S 16565220 HTP Phosphorylation Q9P275 582 S 18669648 HTP Phosphorylation Q9P275 675 T 18669648 HTP Phosphorylation Q9P275 546 S 18669648 HTP Phosphorylation Q9P275 667 S 18669648 HTP Phosphorylation Q9P275 464 S 18669648 HTP Phosphorylation Q9P275 682 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9P275 429 Phosphoserine 23186163 Q9P275 464 Phosphoserine 18669648;23186163 Q9P275 546 Phosphoserine 23186163 Q9P275 582 Phosphoserine 18669648;20068231;23186163 Q9P275 667 Phosphoserine 18669648;19690332;23186163 Q9P275 682 Phosphoserine 19690332;23186163 Q9P275 713 Phosphoserine 20068231;23186163 Q9P275 742 Phosphoserine 20068231;21406692 Q9P275 952 Phosphoserine 17081983;20068231;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP36 IPI00001786 S 1120 AKAASLpSYRR___ phosphorylation USP36 IPI00001786 S 464 GNGIISpSPLTGKR phosphorylation USP36 IPI00001786 S 580 SRDVVLpSTSPKLL phosphorylation USP36 IPI00001786 S 582 DVVLSTpSPKLLAT phosphorylation USP36 IPI00001786 S 667 KTVKLKpSPVLSNT phosphorylation USP36 IPI00001786 S 682 EPASTMpSPPPAKK phosphorylation USP36 IPI00001786 S 692 AKKLALpSAKKAST phosphorylation USP36 IPI00001786 S 713 LRPPPPpSPSSDLT phosphorylation USP36 IPI00001786 S 742 HRARAVpSPAPQSS phosphorylation USP36 IPI00001786 S 952 PEAMEEpSPRKKKK phosphorylation USP36 IPI00001786 T 467 IISSPLpTGKRQDS phosphorylation USP36 IPI00001786 T 581 RDVVLSpTSPKLLA phosphorylation USP36 IPI00001786 T 680 TTEPASpTMSPPPA phosphorylation USP36 IPI00001786 Y 1121 KAASLSpYRR____ phosphorylation USP36 IPI00001786 Y 60 EALKSKpYVLLNPK phosphorylation USP36 IPI00001786 Y 874 QPGSPMpYRREGQA phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 57602 121651 - K Ubiquitination 15809067 57602 121651 - K Ubiquitination 22118674 57602 121651 - K Ubiquitination 21963094 57602 121651 - K Ubiquitination 21139048 57602 121651 - K Ubiquitination 21890473 57602 121651 - K Ubiquitination 21906983 57602 121651 - K Ubiquitination 22505724 57602 121651 - K Ubiquitination 23000965 57602 121651 - K Ubiquitination 25015289 57602 121651 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP36 Homo sapiens (Human) 338 "338,ANFSGGKITKDVG" "338:21906983,21890473" USP36 Homo sapiens (Human) 338 "338,ANFSGGKITKDVG" "338:21906983,21890473" USP36 Homo sapiens (Human) 38 "38,ANFSGGKITKDVG" 38:21890473