PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RNF4 RNF169 21252943 intact exp P P P P P P P RPA1 RNF4 22661229 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TDG 20696907 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G PARP1 RNF4 19779455 mint,intact exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G HMGA1 RNF4 10713105 hprd,bci exp GP G G G GP G GP GP G GP G G G G G GP P G G GP GP G G G G GP GP G RNF4 TRAIP 22493164 biogrid,intact exp P P P P P P P P P P P P GP RNF4 TARDBP 24882209 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 NFE2L2 23543742 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G APEX1 RNF4 20696907 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SKIL RNF4 15231748 biogrid,i2d,mint,intact exp GP G G G G GP G G GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 UEVLD 19549727 biogrid,intact exp GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G HNF4A RNF4 22505616 biogrid exp G G G G GP GP GP G G G G G G G GP G P P G CREB1 RNF4 20936779 i2d exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G ATXN1 RNF4 24882209 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G UBA1 RNF4 25260751 intact exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 NFATC2IP 17762865 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC RNF4 24714598 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 IKBKG 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 SRPK2 23602568 biogrid,intact exp GP G G G G GP G G GP G GP G G G G G GP G G G GP G G GP G G G GP G MECP2 RNF4 25355316 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G PML RNF4 19380586,24637324,24907272,23028697,18708055,15707587,22388745,21252943,18408734 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G SART1 RNF4 21252943 biogrid exp GP G G G G GP G G GP G GP G G G G GP G G G GP G G G G P GP G RNF4 MDC1 22661230 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 HIST2H3A, HIST2H3C, HIST2H3D 24714598 biogrid exp, ortho P P P P P P P P P P P P P RNF4 RNF4 15707587,21857666,24714598,24882209,24656128 biogrid,intact exp, ortho GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G GSC2 RNF4 10822263, 21836163 hprd exp, ortho, pred P P P P P P P P P P P P RNF4 TRPS1 12885770, 21836163 hprd,biogrid,mint,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AR RNF4 11719514,9710597,10617653, 25402006, 21836163 hprd,biogrid exp, ortho, pred GP G G G G G G G G G G G G G G G G G G G G G G G GP G RNF4 UBE2W 19549727,23560854,19690564, 25402006 biogrid,intact exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G UBE2E1 RNF4 19549727, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP G G GP G G GP GP G PGR RNF4 9710597, 21836163 biogrid exp, pred GP G P G G G G G G G P GP G P G G G G G G G ESR1 RNF4 9710597,11696545, 25402006, 21836163 hprd,biogrid,bci exp, pred GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 TCF20 10849425, 21836163 hprd,biogrid,bci exp, pred GP G G G G GP G G GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 UBE2E2 19549727, 23023127 biogrid,intact exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 PATZ1 11719514,10713105, 21836163 hprd,biogrid,i2d,bci exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G UBE2D3 RNF4 19549727,23560854,23530056,19690564, 25402006, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP G GP G G GP GP G UBE2N RNF4 25260751, 23023127 intact exp, pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G UBE2K RNF4 19549727, 23023127 biogrid,intact exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 UBE2V1 25260751, 23023127 intact exp, pred TBP RNF4 9710597,11696545, 25402006 hprd,biogrid exp, pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 UBE2T 19690564, 23023127 biogrid exp, pred G G G GP G GP P G GP GP P G G P GP G UBE2I RNF4 19549727,20936779, 25402006, 23023127 biogrid,i2d,intact exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G UBE2D2 RNF4 19549727,23560854,23530056,19690564, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP G GP G G GP GP G UBE2H RNF4 19549727, 25402006, 23023127 biogrid,intact exp, pred GP G G G G GP G GP G G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SP1 RNF4 21983342,10617653, 25402006 biogrid exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G UBE2L6 RNF4 19690564, 23023127 biogrid exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G UBE2D1 RNF4 19549727,21857666,24656128,23560854,19690564,23504328,24969970,24714598,18408734,24882209, 25402006, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP G GP G G GP GP G RNF4 UBE2E3 19549727, 25402006, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP G G GP G G GP GP G SUMO1 RNF4 24844634,24151981,15707587,23086935,24907272, 25402006 biogrid exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 UHRF1 21252943, 23023127 biogrid exp, pred G G G G G G G G G G G G G G G RNF4 TRIM28 24907272,21252943, 23023127 biogrid exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 UBE2D4 19549727,23560854,19690564, 25402006, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP G GP G G GP GP G SUMO2 RNF4 24844634,23086935,24151981,23560854,22661230,23530056,24969970,21252943,18408734,20943951, 25402006 biogrid exp, pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 RNF4 ortho P P P P P P P P P P P P P RNF4 HIST1H2AC ortho GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J RNF4 ortho P G G G P GP P P P P P GP GP GP G P P MYC RNF4 25402006 pred GP G G G P G GP GP GP G G G G G P GP G GP GP GP GP G G GP GP G RNF4 NCOA2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RARA RNF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CDC27 RNF4 23023127 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 PSMD2 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF126 25402006 pred GP G G G G GP G G GP G GP G G G G G GP GP G GP GP G G G G GP GP G GNB1 RNF4 21836163 pred G G G G G GP G GP GP G GP G G G G G GP GP G G G G GP G G G GP GP G TUBB RNF4 23023127, 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G BRCA1 RNF4 25402006, 23023127 pred P G G P P P P G P P P P P P P GP TGFB1I1 RNF4 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP G GP GP G G GP GP G AHRR RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP P G G GP GP G RNF4 NCOA4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD11 RNF4 23023127 pred G G G G G GP G GP GP G GP G G G G G GP G G G GP G G G G G G GP G RNF4 RNF151 23023127 pred P G G G GP GP GP GP G G GP G G P GP G G GP RNF4 CUL1 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G DNMT1 RNF4 23023127 pred G G G G G G G G GP G G G G G G G G G G G GP G G G G G GP GP G RNF4 MAEA 21836163 pred GP G G G G GP G G G G G G G G G G GP G G G G G GP GP G G G GP G RNF4 RFWD3 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G RNF4 H3F3A, H3F3B 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G CNOT4 RNF4 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G CENPF RNF4 23023127 pred GP G G G P G GP GP P G G P GP G GP P GP GP G G GP GP RNF4 SBDS 23023127 pred P P P P P P P P P P P P P BTF3 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 PWP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 SRA1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF26 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP G G G G GP GP G PIAS1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 NCOA6 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G YWHAB RNF4 21836163 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 CENPE 23023127 pred P G G P P P P P P P P P P GP BHLHE40 RNF4 25402006 pred G G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP G G G GP GP G RNF4 RNF115 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PXN RNF4 23023127 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G G GP G RNF4 GABPB1 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 PDLIM5 23023127 pred GP G P G GP GP GP G G G G G P GP G GP GP GP GP G G GP P G RNF4 BIRC3 25402006 pred GP G G G G GP P G G G G G G G P G GP G G GP GP RNF4 TRIM39 25402006 pred P P P P P P P NCOR1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 RPL24 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G PIK3R1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G TUBG1 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RELA 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RAG1 RNF4 23023127 pred RNF4 FKBP4 23023127 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 DDX54 25402006 pred G G G G G GP G G GP G GP G G G G G GP G G G GP G G GP G G GP GP G RNF4 UBE2F 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G SRF RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G GP GP GP GP G G GP GP G SOX10 RNF4 25402006 pred G G GP G GP GP G G G GP P G G G GP G G G G RNF4 ANAPC10 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G G GP GP GP G G GP GP G BUB1B RNF4 23023127 pred P G G P GP GP P G G P GP GP P P P G GP GP G WWP2 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 ANAPC2 23023127 pred GP G G G G GP G G GP G GP G G G G G GP G G G GP GP GP G G G GP GP G RNF4 CAP1 21836163 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 TRAF6 25402006, 23023127 pred GP G G G G G G GP GP G GP G G G G G G GP G G GP GP GP G G G GP GP G UBOX5 RNF4 25402006 pred GP G G G G GP G GP P G G G G G G GP G G G G G GP P G G GP G G UBE2G2 RNF4 23023127 pred GP G G G G GP G G GP G GP G G G G G GP G G G GP GP G G G G GP GP G ATF4 RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 ASF1B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2AFZ RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF31 23023127 pred P G G G GP P P G GP G G G GP P G G GP P P GP G G P GP TRIM21 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SRP19 RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SNRPB RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 SP3 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G GTF2F1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 SMAD3 25402006 pred GP G G G G GP G G G G G G G G G G GP G G G GP G G G G G G G G CALM1, CALM2, CALM3 RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G UBE2A RNF4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MSX1 RNF4 25402006 pred GP G G GP G GP GP G GP G G G G GP GP G G GP GP P GP G G GP P G PSMA2 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 SRY 25402006 pred P P P P G RNF4 SMAD4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 UXT 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TAF11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 MAPRE1 21836163 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 PSMD13 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF103 RNF4 23023127 pred G G G G G GP G G GP G GP G G G G G GP GP G G G GP G G G G GP GP G RNF4 FBXO5 23023127 pred P G G P P GP P G P GP P P P P G G P P RNF4 ADNP 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 AP3S1 21836163 pred GP G G G G GP G GP G G GP G G G G G GP G G G G G GP G G G G GP G PPP1CC RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 HDAC6 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 DNMT3B 23023127 pred GP G G G GP G GP P GP G G G G GP GP G G GP P GP GP G G GP GP EIF4A3 RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G MID1 RNF4 23023127 pred G G G GP G GP GP G GP G G G G G GP G G G GP G G GP G G GP GP G MITF RNF4 25402006 pred G G G G G G G GP G G GP G G G G G G G G G G G G G G G G G G RNF4 RNF14 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF13 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G ARIH2 RNF4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PARK2 RNF4 23023127 pred P G G GP G GP GP G GP G GP GP G P GP GP G P GP G EGFR RNF4 25402006 pred GP G G GP G G GP G GP G G G G G GP G G G GP GP G GP G G GP GP G RNF4 CREBBP 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 ARIH1 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 ZNRF1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 GATA6 23023127 pred GP G P GP GP P G G G G G P GP G GP GP P P G G GP GP G RNF4 RNF125 25402006 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP GP G G GP P G RNF4 RCHY1 25402006, 23023127 pred G G G G G GP G GP GP G GP G G G G G GP G G G G G GP G G G GP G G UBE2C RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 DZIP3 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G P GP GP GP G G GP GP G COX7A2 RNF4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CLTA RNF4 21836163 pred GP G G G G GP G G GP G GP G G G G G GP G G G GP GP GP G G G GP GP G CDK7 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 PTGES3 25402006 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G ARF6 RNF4 23023127 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G AURKA RNF4 23023127 pred G G P G G G G G G P G G G G G GP TGFB1 RNF4 23023127 pred G G G G G G G G G G G G G G G G G G G G GP G G G G GP G G RNF4 NHLRC1 23023127 pred TTC3 RNF4 23023127 pred P P RNF4 PELP1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G GP GP GP GP G G GP GP G RNF4 ITCH 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 DTX3L 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP G GP GP G G GP GP G RNF4 KAT5 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RBX1 RNF4 23023127 pred G G G G G GP G GP G G G G G G G G GP G G G GP GP G G G G G GP G NEDD4 RNF4 25402006, 23023127 pred GP G G G P G GP GP GP G G G G G GP GP G G GP GP GP GP G G GP P G GCH1 RNF4 21836163 pred GP G G G G GP GP G GP G G G G G G P G G GP G GP GP G G GP GP G RNF4 RAD54L2 25402006 pred G G G G G G G G PIAS2 RNF4 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TCF3 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF111 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TRIM25 25402006 pred G G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 JARID2 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 KMT2A 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SMARCA4 RNF4 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 HDAC1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 SNAPC2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 ATG5 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 BRF1 25402006 pred G G G G G G G G G G G G G RNF4 HAUS1 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RB1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TAF9 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 DTX2 25402006 pred GP P GP GP P G G G G P G G G G G GP GP G GP GP G RNF4 UBE4A 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 ATG3 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP G G G GP GP G RNF4 FHL2 25402006, 23023127 pred GP G G G G GP G GP GP GP G G G G G GP GP G G GP GP G GP G G GP GP G GTF2E1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G GTF2A1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G RNF4 UHRF2 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 DRAP1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G MAPK1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G CCT3 RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SSR2 RNF4 21836163 pred G G G G G GP G GP GP G GP G G G G G GP G G G G G GP G G G GP GP G RNF4 SKA1 23023127 pred P P P P P P P P P P P P P RNF4 HELLS 23023127 pred P G G P G G P P G GP GP RNF4 FOXO1 25402006 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G PSMA1 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TAF2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 TRIM17 23023127 pred P P P P P P P P P P P P GP NEK2 RNF4 23023127 pred G G P P GP P G P P P G P P G P GP CCNB1 RNF4 23023127 pred P G G G G G G GP G P G G G G G G GP G P G GP GP RNF4 RNF43 25402006 pred P G P P GP GP G G G P GP G G GP GP GP P G GP GP G RNF4 TRAF7 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G G G GP GP G G GP GP G SIAH2 RNF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G ETS1 RNF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTCF RNF4 23023127, 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G MED24 RNF4 25402006 pred GP G G G G GP G GP GP G G G G G G G GP G G G G G G G G G G GP G RNF4 HJURP 23023127 pred P G G P GP GP P G G P G P P GP P G GP GP PSMA4 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 SIAH1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G UBE2L3 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G G G GP GP G G GP GP G RNF4 MDM2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF135 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 TPX2 23023127 pred GP G G P G G GP P G G G G GP G G G GP GP G G GP GP G RNF4 TRAF2 23023127 pred P P P P P P P P P P P G GP P RNF4 CENPH 23023127 pred G G P P P P G P GP P P P GP G RNF4 UBE2V2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 ESR2 25402006 pred GP G G G GP G GP GP GP G G G G GP GP G G GP P GP GP G G GP GP RNF4 NCOA1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 BTRC 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF25 25402006 pred G P P P P P P P G P P RNF4 TOPORS 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G GTF2H1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G FAM193A RNF4 21836163 pred GP G G G G GP G G GP G GP G G G G G GP G G G GP G G G G G GP GP G JUN RNF4 25402006 pred GP G G G G GP G G GP G GP G G G G G GP G G G GP G GP G G G GP G G GTF2E2 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TRIM68 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 SPC25 23023127 pred P G G P P G P G P P RNF4 EP300 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 BARD1 25402006, 23023127 pred G G P P GP P G G G P G P GP P GP G GP GP G RNF4 XIAP 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G G G G GP GP G G G GP GP G RNF4 RNF5 25402006, 23023127 pred GP G G G G GP G G GP G GP G G G G G GP G G G GP GP GP GP G G GP GP G RNF4 HNRNPD 25402006 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 NCOA3 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G DHX15 RNF4 21836163 pred G G G G G GP G G GP G GP G G G G G GP GP G G GP G G G G G GP GP G RNF4 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 LRSAM1 23023127 pred P G G GP G P GP G GP G G GP GP G G P GP P P G P P G RNF4 HIST1H2BH 23023127 pred G G G G G G G G G RNF4 LIMA1 23023127 pred GP G G G G G G G GP G GP G G G G G G G G G GP GP GP GP G G GP GP G POU3F2 RNF4 25402006 pred G G G G G G G G RNF4 UBE2NL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G1 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G TTK RNF4 23023127 pred P G G P P GP P G P P P P P P G GP GP HSP90AA1 RNF4 25402006 pred GP G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G NRIP1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G CBX4 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G DNAJA1 RNF4 23023127, 21836163 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G TP53 RNF4 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G GP G TOP1 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G TRIM13 RNF4 23023127 pred GP G G G G GP G G GP G G G G G G G GP G G G G GP G GP G G GP GP G TAF6 RNF4 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 UBE2R2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G G RNF4 TRIM54 23023127 pred P GP P G P GP G P P RAN RNF4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 RUVBL1 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP G G G GP GP G TRIM16 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF2 25402006 pred P P GP P P P P P P RNF4 UBE3A 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 UBE2S 23023127 pred G G G G G G G G GP G G G G G G G G G G G G G G G GP G CENPA RNF4 23023127 pred GP G G G G GP G G GP G GP G G G G G GP GP G G GP G G GP G G GP GP G ROCK2 RNF4 23023127 pred GP G G G G GP G GP GP G G G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RBM4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G EEF1B2 RNF4 21836163 pred P P P P P P P P P P P RNF4 TERF2 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 SMAD1 25402006 pred G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G GATA4 RNF4 23023127 pred P P GP P P G G P GP G GP P P P G GP GP HIST1H1T RNF4 23023127 pred G G G SMARCA2 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 GTF2B 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF133 23023127 pred P P P P P P GP CDC34 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 STUB1 25402006, 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G SSR4 RNF4 21836163 pred GP G G G G GP G G GP G G G G G G G GP G G G GP GP GP G G G GP GP G RNF4 AMFR 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF11 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 RNF144B 23023127 pred G G G G G GP G GP GP G GP G G G G G GP GP G G GP G G G G G G GP G RNF4 ANAPC11 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G CKS2 RNF4 23023127 pred GP G G G P G GP GP GP G G G G G P GP GP GP P P G G GP GP G RNF4 DAXX 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 TUBB1 23023127 pred GP G G P G GP P P P G P P P G P GP RNF4 FBLIM1 23023127 pred G G G G G GP G GP GP G GP G G G G G GP G G G G G G GP G G G G G RNF4 RNF19A 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 NR0B2 25402006 pred G G G G G G G G G G G G G G G G UBE2B RNF4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPL29 RNF4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 TACC3 23023127 pred P G G P GP P G G P P P P P G G GP GP WT1 RNF4 25402006 pred G P GP P GP P GP GP P P G P GP G RNF4 RNF6 25402006, 23023127 pred G G G G G GP G G GP G GP G G G G G GP G G G GP G G G G G GP GP G SRC RNF4 25402006 pred GP G G GP GP G G GP G G G G G GP G G G GP GP G G G GP GP G RNF4 GMEB1 25402006 pred GP G G P P P P G G G P GP GP P P P G G GP GP CDC42 RNF4 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G RNF4 FOXP3 23023127 pred G G G G G G P RNF4 MED17 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 RNF220 23023127 pred G G G G G GP G G GP G GP G G G G G GP G G G GP GP GP GP G G GP G G YWHAQ RNF4 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP G G G GP GP G GTF2A2 RNF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF4 SET 21836163 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P78317 - 10713105 - X 2 P78317 - 15231748 - X 2 P78317 - 10713105 - X 2 P78317 A0A024R1M5 - 10713105 - X 2 P78317 A0A024R1M5 - 10713105 - X 2 P78317 - 10713105 - X 2 Q9UHF7-2 P78317 affinity chromatography technology 12885770 physical association X 2 Q13569 P78317 affinity chromatography technology 20696907 physical association X 2 Q13569 P78317 affinity chromatography technology 20696907 physical association X 2 Q96FF1 P78317 imaging technique 24882209 colocalization X 2 Q96FF1 P78317 enzymatic study 24882209 direct interaction X 2 P27694 P78317 affinity chromatography technology 22661229 physical association X 2 Q969T4 P78317 two hybrid 19549727 direct interaction X 2 Q96T88-2 P78317 affinity chromatography technology 21252943 physical association X 2 P0CG48 P78317 affinity chromatography technology 18408734 physical association X 2 P0CG48 P78317 affinity chromatography technology 22505724 physical association X 2 P0CG48 P78317 affinity chromatography technology 21963094 physical association X 2 P0CG48 P78317 affinity chromatography technology 23000965 physical association X 2 P0CG48 P78317 enzymatic study 24714598 direct interaction X 2 P0CG48 P78317 pull down 24882209 direct interaction X 2 P0CG48 P78317 affinity chromatography technology 14987998 physical association X 2 P78317 A0A024R3Z2 pull down 15707587 direct interaction X 2 P78317 P78317 enzymatic study 15707587 direct interaction X 2 P78317 P29590-5 affinity chromatography technology 15707587 physical association X 2 P78317 P29590-5 fluorescent resonance energy transfer 19380586 direct interaction X 2 P78317 P29590-5 enzymatic study 18408734 direct interaction X 2 P78317 P29590-5 fluorescent resonance energy transfer 23028697 direct interaction X 2 P78317 P29590-5 affinity chromatography technology 23028697 physical association X 2 P78317 A0A024R3Z2 pull down 23086935 direct interaction X 2 P78317 A0A024RA90 pull down 23560854 direct interaction X 2 P78317 Q96FI0 pull down 23560854 direct interaction X 2 P78317 Q9BWF2 two hybrid 22493164 direct interaction X 2 P78317 F1D8T0 pull down 22505616 direct interaction X 2 P78317 F1D8T0 enzymatic study 22505616 direct interaction X 2 P78317 P78362-2 enzymatic study 23602568 direct interaction X 2 P78317 A0A024R3Z2 pull down 24151981 direct interaction X 2 P78317 P29590-5 affinity chromatography technology 22388745 physical association X 2 P78317 P78317 enzymatic study 24656128 direct interaction X 2 P78317 P78317 affinity chromatography technology 24656128 physical association X 2 P78317 P78317 fluorescent resonance energy transfer 24656128 direct interaction X 2 P78317 A0A024R3Z2 x-ray crystallography 24844634 association X 2 P78317 P78317 enzymatic study 24882209 direct interaction X 2 P78317 P29590-5 affinity chromatography technology 24907272 physical association X 2 P78317 P29590-5 pull down 24907272 direct interaction X 2 P78317 A0A024R3Z2 protein complementation assay 24907272 direct interaction X 2 P78317 P29590-5 enzymatic study 18708055 direct interaction X 2 P78317 two hybrid 9710597 direct interaction X 2 P78317 P20226 pull down 9710597 direct interaction X 2 P78317 P08047 affinity chromatography technology 10617653 physical association X 2 P78317 A0A024RA90 two hybrid 19690564 direct interaction X 2 P78317 Q96FI0 two hybrid 19690564 direct interaction X 2 P78317 A0A024RA90 two hybrid 19549727 direct interaction X 2 P78317 A0A024R2K3 two hybrid 19549727 direct interaction X 2 P78317 Q96FI0 two hybrid 19549727 direct interaction X 2 P78317 A0A024R2Q2 two hybrid 19549727 direct interaction X 2 P78317 two hybrid 20211142 direct interaction X 2 P78317 P78317 x-ray crystallography 21857666 association X 2 P78317 P78317 fluorescent resonance energy transfer 21857666 direct interaction X 2 P78317 P08047 affinity chromatography technology 21983342 physical association X 2 P78317 P08047 pull down 21983342 direct interaction X 2 P78317 P08047 enzymatic study 21983342 direct interaction X 2 P78317 P29590-5 affinity chromatography technology 21252943 physical association X 2 P78317 O43290 affinity chromatography technology 21252943 physical association X 2 P78317 Q14676 affinity chromatography technology 22661230 physical association X 2 P63279 P78317 two hybrid 19549727 direct interaction X 2 P63279 P78317 two hybrid 20936779 direct interaction X 2 Q13263 P78317 affinity chromatography technology 24907272 physical association X 2 Q13263 P78317 affinity chromatography technology 24907272 physical association X 2 Q13263 P78317 pull down 24907272 direct interaction X 2 Q13263 P78317 protein complementation assay 24907272 direct interaction X 2 Q13263 P78317 affinity chromatography technology 21252943 physical association X 2 P27695 P78317 affinity chromatography technology 20696907 physical association X 2 P27695 P78317 affinity chromatography technology 20696907 physical association X 2 A0A024R4E2 P78317 imaging technique 24882209 colocalization X 2 P78317 affinity chromatography technology 23504328 physical association X 2 P78317 affinity chromatography technology 23504328 physical association X 2 P78317 enzymatic study 23504328 direct interaction X 2 P61086 P78317 two hybrid 19549727 direct interaction X 2 Q16236-3 P78317 affinity chromatography technology 23543742 physical association X 2 P78317 P61956-2 affinity chromatography technology 18408734 physical association X 2 P78317 P61956-2 enzymatic study 18408734 direct interaction X 2 P78317 A0A087WW00 pull down 18408734 direct interaction X 2 P78317 P61956-2 pull down 23086935 direct interaction X 2 P78317 P12757-5 two hybrid 15231748 direct interaction X 2 P78317 A0A024R1M5 two hybrid 10713105 direct interaction X 2 P78317 P61956-2 enzymatic study 23560854 direct interaction X 2 P78317 A0A087WW00 pull down 23560854 direct interaction X 2 P78317 P62837 pull down 23560854 direct interaction X 2 P78317 P61077-3 pull down 23560854 direct interaction X 2 P78317 A0A087WW00 pull down 23504328 direct interaction X 2 P78317 P61956-2 enzymatic study 23530056 direct interaction X 2 P78317 P62837 pull down 23530056 direct interaction X 2 P78317 P61077-3 pull down 23530056 direct interaction X 2 P78317 P61956-2 pull down 24151981 direct interaction X 2 P78317 A0A087WW00 pull down 24714598 direct interaction X 2 P78317 A0A087WW00 pull down 24656128 direct interaction X 2 P78317 P61956-2 x-ray crystallography 24844634 association X 2 P78317 P61956-2 pull down 24844634 direct interaction X 2 P78317 A0A087WW00 pull down 24882209 direct interaction X 2 P78317 P51608-2 enzymatic study 25355316 direct interaction X 2 P78317 P61956-2 pull down 22661230 direct interaction X 2 P78317 Q9UGU0 two hybrid 10849425 direct interaction X 2 P78317 Q9UGU0 pull down 10849425 direct interaction X 2 P78317 A0A024R1M5 pull down 10713105 direct interaction X 2 P78317 A0A024R1M5 affinity chromatography technology 10713105 physical association X 2 P78317 pull down 9710597 direct interaction X 2 P78317 two hybrid 9710597 direct interaction X 2 P78317 affinity chromatography technology 9710597 physical association X 2 P78317 A0A024R1M5 affinity chromatography technology 11719514 physical association X 2 P78317 A0A024R1M5 affinity chromatography technology 11719514 physical association X 2 P78317 affinity chromatography technology 11719514 physical association X 2 P78317 affinity chromatography technology 11719514 physical association X 2 P78317 pull down 10617653 direct interaction X 2 P78317 A0A087WW00 two hybrid 19690564 direct interaction X 2 P78317 P62837 two hybrid 19690564 direct interaction X 2 P78317 P61077-3 two hybrid 19690564 direct interaction X 2 P78317 O14933-2 two hybrid 19690564 direct interaction X 2 P78317 A0A024R9A9 two hybrid 19690564 direct interaction X 2 P78317 Q8IX04-2 two hybrid 19549727 direct interaction X 2 P78317 A0A087WW00 two hybrid 19549727 direct interaction X 2 P78317 P62837 two hybrid 19549727 direct interaction X 2 P78317 P61077-3 two hybrid 19549727 direct interaction X 2 P78317 two hybrid 19549727 direct interaction X 2 P78317 A0A087WW00 affinity chromatography technology 21857666 physical association X 2 P78317 A0A087WW00 pull down 21857666 direct interaction X 2 P78317 two hybrid 9710597 direct interaction X 2 P78317 two hybrid 10617653 direct interaction X 2 P78317 P61956-2 fluorescent resonance energy transfer 20943951 direct interaction X 2 P78317 P61956-2 affinity chromatography technology 21252943 physical association X 2 P78317 P61956-2 affinity chromatography technology 21252943 physical association X 2 P78317 P61956-2 pull down 21252943 direct interaction X 2 Q71DI3 P78317 enzymatic study 24714598 direct interaction X 2 G4XH65 P78317 in vivo 11696545 - X 2 G4XH65 P78317 in vitro 11696545 - X 2 G4XH65 P78317 in vitro 11696545 - X 2 G4XH65 P78317 in vivo 11696545 - X 2 Q9UHF7-2 P78317 two hybrid 12885770 - X 2 Q9UHF7-2 P78317 in vitro 12885770 - X 2 Q9UHF7-2 P78317 in vivo 12885770 - X 2 Q9UHF7-2 P78317 in vitro 12885770 - X 2 Q9UHF7-2 P78317 in vivo 12885770 - X 2 Q9UHF7-2 P78317 two hybrid 12885770 - X 2 P78317 P20226 in vitro 11696545 - X 2 P78317 P20226 in vitro 11696545 - X 2 F1D8N5 P78317 in vivo 10617653,11719514,9710597 - X 2 F1D8N5 P78317 in vitro 10617653,11719514,9710597 - X 2 F1D8N5 P78317 two hybrid 10617653,11719514,9710597 - X 2 F1D8N5 P78317 two hybrid 10617653,11719514,9710597 - X 2 F1D8N5 P78317 in vivo 10617653,11719514,9710597 - X 2 F1D8N5 P78317 in vitro 10617653,11719514,9710597 - X 2 O15499 P78317 two hybrid 10822263 - X 2 O15499 P78317 in vivo 10822263 - X 2 O15499 P78317 in vitro 10822263 - X 2 O15499 P78317 in vivo 10822263 - X 2 O15499 P78317 in vitro 10822263 - X 2 O15499 P78317 two hybrid 10822263 - X 2 Q9HBE1-4 P78317 two hybrid 10713105,11719514 - X 2 Q9HBE1-4 P78317 in vitro 10713105,11719514 - X 2 Q9HBE1-4 P78317 in vivo 10713105,11719514 - X 2 Q9HBE1-4 P78317 in vitro 10713105,11719514 - X 2 Q9HBE1-4 P78317 in vivo 10713105,11719514 - X 2 Q9HBE1-4 P78317 two hybrid 10713105,11719514 - X 2 P78317 P17096 two hybrid 10713105 - X 2 P78317 P17096 in vitro 10713105 - X 2 P78317 P17096 two hybrid 10713105 - X 2 P78317 P17096 in vitro 10713105 - X 2 Q9UGU0-2 P78317 in vitro 10849425 - X 2 Q9UGU0-2 P78317 two hybrid 10849425 - X 2 Q9UGU0-2 P78317 in vitro 10849425 - X 2 Q9UGU0-2 P78317 two hybrid 10849425 - X 2 P78317 pull down 21252943 association C 31 A0A024QZJ2 P78317 two hybrid array 19549727 physical association X 2 Q969T4 P78317 two hybrid array 19549727 physical association X 2 P78317 Q8NCF5 anti tag coimmunoprecipitation 17762865 physical association X 2 P78317 Q8IX04 two hybrid array 19549727 physical association X 2 P78317 A0A024RDH2 two hybrid array 19549727 physical association X 2 P78317 A0A024R2K3 two hybrid array 19549727 physical association X 2 P78317 A0A024R2Q2 two hybrid array 19549727 physical association X 2 P78317 A4D1L5 two hybrid array 19549727 physical association X 2 P78317 A0A024RA90 two hybrid array 19549727 physical association X 2 P78317 Q5NHX5 two hybrid pooling approach 20711500 physical association X 2 P78317 Q9BWF2 two hybrid array 22493164 physical association X 2 P78317 A0A024R704 protein kinase assay 23602568 phosphorylation reaction X 2 P78317 P78317 x ray scattering 24714598 direct interaction Y 1 P78317 P78317 x-ray crystallography 24714598 direct interaction Y 1 P12757 P78317 two hybrid 15231748 physical association X 2 P63279 P78317 two hybrid array 19549727 physical association X 2 P63279 P78317 two hybrid pooling approach 20936779 physical association X 2 P78317 ubiquitinase assay 25260751 ubiquitination reaction C 4 A0A024R3T8 P78317 pull down 19779455 direct interaction X 2 Q9UHF7 P78317 coimmunoprecipitation 12885770 physical association X 2 Q9UHF7 P78317 coimmunoprecipitation 12885770 physical association X 2 Q9UHF7 P78317 two hybrid 12885770 physical association X 2 P78317 P62837 two hybrid array 19549727 physical association X 2 B3KSH4 P78317 two hybrid array 19549727 physical association X 2 Q96B02 P78317 two hybrid array 19549727 physical association X 2 P78317 A0A024R1M5 copurification 10713105 - X 2 P78317 A0A024R1M5 copurification 10713105 - X 2 P78317 A0A024R1M5 coimmunoprecipitation 10713105 - X 2 P78317 P17096 two hybrid 10713105 - X 2 P78317 P17096 copurification 10713105 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2H RNF4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101335|BIOGRID_124275 bait|bait prey|prey UBC RNF4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14987998,18408734,21963094,22505724,23000965,24714598 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_266511|BIOGRID_224774|BIOGRID_200695|BIOGRID_310102|BIOGRID_131984|BIOGRID_270473 bait|bait|prey|prey|bait|bait prey|prey|bait|bait|prey|prey RNF4 MDC1 MI:0428(imaging technique)|MI:0428(imaging technique) 22661230 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_186214|BIOGRID_186216 bait|bait prey|prey HMGA1 RNF4 MI:0492(in vitro) 10713105 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_7579 - - RNF4 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101192 prey bait RNF4 UHRF1 MI:0004(affinity chromatography technology) 21252943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_183696 bait prey RNF4 NFATC2IP MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 17762865 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint) MINT_60675|UniProt_94209|MINT_31854 prey|prey|prey bait|bait|bait RNF4 IKBKG MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128655 bait prey RNF4 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study) 19549727,19690564,23560854 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_101443|BIOGRID_124272|BIOGRID_123530|BIOGRID_272399 prey|prey|prey|bait bait|bait|bait|prey RNF4 NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296753 prey bait RNF4 NFE2L2 MI:0055(fluorescent resonance energy transfer) 23543742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_272236 bait prey RPA1 RNF4 MI:0004(affinity chromatography technology) 22661229 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186223 prey bait PARP1 RNF4 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10,19779455 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_46850|UniProt_103890|MINT_78615 prey|prey|prey bait|bait|bait RNF4 TCF20 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 10849425 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_11564|BIOGRID_99026|BIOGRID_99027 -|prey|prey -|bait|bait RNF4 TRPS1 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 12885770 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact) HPRD_11565|MINT_80757|MINT_48982|UniProt_73124|BIOGRID_214201|MINT_80756|MINT_48981|MINT_80758|MINT_48983|UniProt_73125|UniProt_73126 -|prey|prey|prey|bait|prey|prey|prey|prey|prey|prey -|bait|bait|bait|prey|bait|bait|bait|bait|bait|bait HNF4A RNF4 MI:0415(enzymatic study)|MI:0415(enzymatic study) 22505616 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_290237|BIOGRID_290236 prey|prey bait|bait RNF4 SRPK2 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 23602568 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0217(phosphorylation reaction) (biogrid)|(intact) BIOGRID_291385|UniProt_128904 prey|neutral component bait|neutral component RNF4 UBE2T MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123638 prey bait UBE2D3 RNF4 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study) 19549727,19690564,23530056,23560854 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_101273|BIOGRID_272823|BIOGRID_124271|BIOGRID_123498|BIOGRID_272398 bait|prey|bait|bait|prey prey|bait|prey|prey|bait SUMO1 RNF4 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 15707587,23086935,24151981 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_198033|BIOGRID_296991|BIOGRID_247377 bait|prey|prey prey|bait|bait SART1 RNF4 MI:0004(affinity chromatography technology) 21252943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_183695 prey bait RNF4 TRAIP MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283962|UniProt_122490 bait|prey prey|bait AR RNF4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10617653,11719514,9710597 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_77636|BIOGRID_77637|BIOGRID_107743|BIOGRID_107741|BIOGRID_107731|BIOGRID_107734|HPRD_5956|BIOGRID_107739 bait|bait|prey|prey|bait|prey|-|bait prey|prey|bait|bait|prey|bait|-|prey RNF4 UEVLD MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124037|UniProt_101177 prey|prey bait|bait PML RNF4 MI:0004(affinity chromatography technology)|MI:0055(fluorescent resonance energy transfer)|MI:0055(fluorescent resonance energy transfer)|MI:0004(affinity chromatography technology)|MI:0055(fluorescent resonance energy transfer)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 15707587,18408734,19380586,21252943,22388745,23028697 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_307807|BIOGRID_217295|BIOGRID_217294|BIOGRID_183694|BIOGRID_199867|BIOGRID_198039|BIOGRID_200696 prey|prey|bait|prey|bait|prey|prey bait|bait|prey|bait|prey|bait|bait UBE2L6 RNF4 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123604 bait prey UBE2E1 RNF4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101297|BIOGRID_124273 bait|bait prey|prey UBE2K RNF4 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124277 bait prey PGR RNF4 MI:0018(two hybrid) 9710597 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_107733 prey bait RNF4 TRIM28 MI:0004(affinity chromatography technology) 21252943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_183693 bait prey GSC2 RNF4 MI:0493(in vivo) 10822263 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_9940 - - SUMO2 RNF4 MI:0055(fluorescent resonance energy transfer)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 18408734,20943951,21252943,23086935,23530056,23560854,24151981 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_150503|BIOGRID_200693|BIOGRID_272395|BIOGRID_186207|BIOGRID_183692|BIOGRID_296992|BIOGRID_200694|BIOGRID_183913|BIOGRID_247376|BIOGRID_272821 prey|prey|prey|prey|prey|prey|prey|bait|prey|prey bait|bait|bait|bait|bait|bait|bait|prey|bait|bait ESR1 RNF4 MI:0018(two hybrid)|MI:0493(in vivo) 11696545,9710597 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_107732|HPRD_24541 prey|- bait|- UBE2D1 RNF4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 18408734,19549727,19690564,21857666,23504328,23560854,24656128,24714598 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid) BIOGRID_225877|BIOGRID_272576|BIOGRID_141765|BIOGRID_141764|BIOGRID_124269|BIOGRID_123433|UniProt_101226|BIOGRID_310103|BIOGRID_310249|BIOGRID_272396 prey|prey|prey|prey|bait|bait|bait|prey|prey|prey bait|bait|bait|bait|prey|prey|prey|bait|bait|bait RNF4 UBE2W MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,19690564,23560854 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_124278|BIOGRID_272400|BIOGRID_123707|UniProt_101474 prey|bait|prey|prey bait|prey|bait|bait RNF4 PATZ1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 10713105,11719514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_77891|HPRD_11566|BIOGRID_107736|BIOGRID_107738|BIOGRID_104806|BIOGRID_104805 bait|-|bait|prey|prey|bait prey|-|prey|bait|bait|prey RNF4 UBE2E2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124279|UniProt_101320 prey|prey bait|bait SKIL RNF4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid) MINT_60563|MINT_31779|UniProt_78669|BIOGRID_258947 bait|bait|bait|bait prey|prey|prey|prey SP1 RNF4 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10617653,21983342 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_107742|BIOGRID_153363|BIOGRID_153364|BIOGRID_153366 prey|bait|bait|prey bait|prey|prey|bait APEX1 RNF4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20696907 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_199929|BIOGRID_199927 bait|prey prey|bait RNF4 TDG MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20696907 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_199926|BIOGRID_199928 bait|prey prey|bait UBE2D2 RNF4 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid) 19549727,19690564,23530056,23560854 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_123465|BIOGRID_272822|BIOGRID_124270|BIOGRID_272397|UniProt_101248 bait|prey|bait|prey|bait prey|bait|prey|bait|prey RNF4 HIST2H3A; MI:0415(enzymatic study) 24714598 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_310104 bait prey RNF4 UBE2E3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124274|UniProt_101423 prey|prey bait|bait TBP RNF4 MI:0493(in vivo)|MI:0018(two hybrid) 11696545,9710597 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_25300|BIOGRID_107735 -|prey -|bait UBE2I RNF4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 19549727,20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_126800|BIOGRID_124276|UniProt_101363|UniProt_110792 bait|bait|bait|bait prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality SP1 RNF4 21983342,10617653,21983342,26511642,21983342 0096,0004,0415,0004,0004 LC AR RNF4 9710597,9710597,10617653,11719514,11719514,10617653,9710597 0018,0004,0018,0018,0004,0096,0096 LC PML RNF4 24907272,23028697,21252943,22388745,24907272,15707587,23028697 0096,0004,0004,0004,0004,0004,0055 LC UBE2D1 RNF4 23504328,21857666,24714598,26950370,18408734,24969970,21857666,23560854,24882209,24656128 0096,0004,0096,0096,0096,0096,0096,0096,0096,0096 LC UBE2D3 RNF4 23560854,23530056 0096,0096 LC SUMO2 RNF4 24151981,23086935,24844634,25533185,24969970,18408734,18408734,24969970,24844634,22661230,21252943,21252943 0096,0096,0114,0004,0415,0415,0096,0096,0096,0096,0004,0096 LC UBE2D2 RNF4 25960396,23530056,23560854 0096,0096,0096 LC SUMO1 RNF4 24151981,23086935,15707587 0096,0096,0096 LC RNF4 RNF4 24656128,24656128,24656128 0004,0055,0415 LC RNF4 TRIM28 24907272,24907272,24907272,21252943 0090,0096,0004,0004 LC RNF4 PATZ1 10713105,10713105,10713105,11719514,11719514,10713105,10713105 0096,0025,0004,0018,0004,0019,0018 LC SP1 RNF4 21983342,10617653,21983342,26511642,21983342 0096,0004,0415,0004,0004 LC AR RNF4 9710597,9710597,10617653,11719514,11719514,10617653,9710597 0018,0004,0018,0018,0004,0096,0096 LC PML RNF4 24907272,23028697,21252943,22388745,24907272,15707587,23028697 0096,0004,0004,0004,0004,0004,0055 LC UBE2D1 RNF4 23504328,21857666,24714598,26950370,18408734,24969970,21857666,23560854,24882209,24656128 0096,0004,0096,0096,0096,0096,0096,0096,0096,0096 LC UBE2D3 RNF4 23560854,23530056 0096,0096 LC SUMO2 RNF4 24151981,23086935,24844634,25533185,24969970,18408734,18408734,24969970,24844634,22661230,21252943,21252943 0096,0096,0114,0004,0415,0415,0096,0096,0096,0096,0004,0096 LC UBE2D2 RNF4 25960396,23530056,23560854 0096,0096,0096 LC SUMO1 RNF4 24151981,23086935,15707587 0096,0096,0096 LC RNF4 RNF4 24656128,24656128,24656128 0004,0055,0415 LC RNF4 TRIM28 24907272,24907272,24907272,21252943 0090,0096,0004,0004 LC RNF4 PATZ1 10713105,10713105,10713105,11719514,11719514,10713105,10713105 0096,0025,0004,0018,0004,0019,0018 LC HIP2 RNF4 19549727 0397 HT NR3C4 RNF4 9710597,10617653,11719514 0018,0018,0018 LC UBE2L6 RNF4 19690564 0018 HT GSC2 RNF4 10822263 0018 LC ESR1 RNF4 9710597 0018 LC PGR RNF4 9710597 0018 LC SP1 RNF4 21983342,21983342,21983342 0096,0415,0004 LC UBC RNF4 26148049,24714598 0415,0415 LC AR RNF4 9710597,9710597,10617653,11719514,11719514,10617653,9710597 0018,0004,0018,0018,0004,0096,0096 LC SKIL RNF4 15231748 0018 HT HMGA1 RNF4 10713105,10713105 0025,0018 LC UBA1 RNF4 25260751 0997 LC PML RNF4 24637324,23028697,18408734,19380586,18708055,23028697 0090,0004,0415,0055,0415,0055 LC HNF4A RNF4 22505616 0415 LC UBE2D1 RNF4 19549727,19549727,19690564 0397,0018,0018 HT UBE2E1 RNF4 19549727,19549727 0397,0018 HT ATXN1 RNF4 24882209,24882209 0428,0415 LC UBE2D3 RNF4 19549727,19549727,19690564 0397,0018,0018 HT UBE2K RNF4 19549727 0018 HT UBE2N RNF4 25260751 0997 LC SUMO2 RNF4 23530056,26950370,23560854,24844634,24969970,18408734,18408734,24969970,24844634,20943951 0415,0415,0415,0114,0415,0415,0096,0096,0096,0055 LC UBE2H RNF4 19549727,19549727 0397,0018 HT UBE2D2 RNF4 19549727,19690564,19549727 0397,0018,0018 HT SUMO1 RNF4 24907272,24844634 0090,0114 LC UBE2I RNF4 20936779,19549727,19549727,20936779 0398,0397,0018,0018 HT RNF4 RNF4 24714598,25960396,15707587,24656128,21857666,24714598,24656128,24656128,21857666,24882209 0826,0415,0415,0004,0114,0114,0055,0415,0055,0415 LC RNF4 SRPK2 23602568,23602568 0415,0424 LC RNF4 TRIM28 24907272,24907272,24907272 0090,0096,0004 LC RNF4 UBE2V1 25260751 0997 LC RNF4 Q59FJ6 25355316 0415 LC RNF4 HIST2H3A|HIST2H3C|HIST2H3D 24714598 0415 LC RNF4 UEVLD 19549727,19549727 0397,0018 HT RNF4 UBE2E3 19549727,19549727 0397,0018 HT RNF4 UBE2W 19549727,19549727,19690564 0397,0018,0018 HT RNF4 UBE2E2 19549727,19549727 0397,0018 HT RNF4 TRAIP 22493164,22493164 0018,0397 HT RNF4 PATZ1 10713105,10713105,10713105,11719514,11719514,10713105,10713105 0096,0025,0004,0018,0004,0019,0018 LC RNF4 UBE2T 19690564 0018 HT RNF4 Q9UBT1 9710597 0018 LC RNF4 TCF20 10849425,10849425 0096,0018 LC RNF4 TRPS1 12885770,12885770,12885770,12885770,12885770 0019,0018,0007,0006,0004 LC RNF4 UBE2D4 19549727,19549727,19690564 0397,0018,0018 HT RNF4 IKBKG 20211142 0018 HT RNF4 HEL-S-71 26148049,26148049 0096,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P78317 B3KSH4 RNF4 HIP2 0.126 19549727 P78317 O14933 RNF4 UBE2L6 0.183 19690564 P78317 P61086 RNF4 UBE2K 0.183 19549727 P78317 P61088 RNF4 UBE2N 0.539 25260751,26148049 P78317 P61956 RNF4 SUMO2 0.993 21252943,24844634,24151981,26950370,23530056,23086935,22661230,18408734,20943951,25533185,23560854 Q8N5C8 P78317 TAB3 RNF4 0.21 26299341 Q8NCF5 P78317 NFATC2IP RNF4 0.21 17762865 Q8NCN4 P78317 RNF169 RNF4 0.21 21252943 Q9NPD8 P78317 UBE2T RNF4 0.183 19690564 Q9NYJ8 P78317 TAB2 RNF4 0.21 26299341 P78317 P09874 RNF4 PARP1 0.309 19779455 P78317 P03209 RNF4 P03209 0.569 23504328 Q9H7X3 P78317 ZNF696 RNF4 0.236 unassigned1304 Q9HBE1 P78317 PATZ1 RNF4 0.765 10713105,11719514 P78317 P08047 RNF4 SP1 0.74 21983342,10617653,26511642 Q8WUN7 P78317 UBTD2 RNF4 0.236 unassigned1304 Q9UGU0 P78317 TCF20 RNF4 0.523 10849425 Q96LR5 P78317 UBE2E2 RNF4 0.569 19549727,25960396 Q92734 P78317 TFG RNF4 0.236 unassigned1304 Q969T4 P78317 UBE2E3 RNF4 0.569 19549727,25960396 Q96IK5 P78317 GMCL1 RNF4 0.236 unassigned1304 Q96K80 P78317 ZC3H10 RNF4 0.236 unassigned1304 Q9BUZ4 P78317 TRAF4 RNF4 0.236 unassigned1304 P78317 A0A0G2JQ02 RNF4 A0A0G2JQ02 0.236 unassigned1304 Q15645 P78317 TRIP13 RNF4 0.236 unassigned1304 P78317 P63279 RNF4 UBE2I 0.554 19549727,20936779 Q06455 P78317 RUNX1T1 RNF4 0.236 unassigned1304 P78317 O14633 RNF4 LCE2B 0.236 unassigned1304 P78317 P0CG48 RNF4 UBC 0.523 26148049,24714598 P78317 P51965 RNF4 UBE2E1 0.569 19549727,25960396 P78317 P54253 RNF4 ATXN1 0.396 24882209 Q5TCM9 P78317 LCE5A RNF4 0.236 unassigned1304 Q5T753 P78317 LCE1E RNF4 0.236 unassigned1304 Q5TA81 P78317 LCE2C RNF4 0.236 unassigned1304 Q9P2F9 P78317 ZNF319 RNF4 0.236 unassigned1304 Q9Y2X8 P78317 UBE2D4 RNF4 0.648 19549727,19690564,23560854 P78362 P78317 SRPK2 RNF4 0.21 23602568 P78317 G2XKQ0 RNF4 G2XKQ0 0.236 unassigned1304 Q02040 P78317 AKAP17A RNF4 0.236 unassigned1304 P78317 J3KQH6 RNF4 PHC1 {ECO:0000313|ENSEMBL:ENSP00000399194} 0.236 unassigned1304 Q13158 P78317 FADD RNF4 0.236 unassigned1304 P78317 O00463 RNF4 TRAF5 0.236 unassigned1304 Q5T7P3 P78317 LCE1B RNF4 0.236 unassigned1304 P78317 B0QYN7 RNF4 UBE2I {ECO:0000313|ENSEMBL:ENSP00000384361} 0.236 unassigned1304 P78317 P35711 RNF4 SOX5 0.236 unassigned1304 P78317 P51668 RNF4 UBE2D1 0.976 19690564,23560854,23504328,19549727,26950370,18408734,21857666,24714598,24882209,24656128 P78317 O95231 RNF4 VENTX 0.236 unassigned1304 P78317 O14964 RNF4 HGS 0.236 unassigned1304 Q86UY0 P78317 TXNDC5 RNF4 0.236 unassigned1304 P78317 O60232 RNF4 SSSCA1 0.236 unassigned1304 P78317 P62837 RNF4 UBE2D2 0.832 19690564,25960396,23530056,23560854,19549727 P78317 P63165 RNF4 SUMO1 0.826 15707587,23086935,unassigned1304,24844634,24151981 P78317 P61077 RNF4 UBE2D3 0.757 19549727,19690564,23530056,23560854 P78317 P29590 RNF4 PML 0.939 15707587,21252943,18708055,24637324,22388745,23028697,18408734,19380586 P78317 P10275 RNF4 AR 0.888 9710597,10617653,11719514 P78317 P78317 RNF4 RNF4 0.98 15707587,25960396,24656128,24714598,24882209,21857666 Q9BWF2 P78317 TRAIP RNF4 0.286 22493164 P78317 O15360 RNF4 FANCA 0.376 25751062 P78317 O43290 RNF4 SART1 0.21 21252943 P78317 O43318 RNF4 MAP3K7 0.376 26299341 P78317 P03372 RNF4 ESR1 0.309 9710597 P78317 P06401 RNF4 PGR 0.309 9710597 P78317 P12757 RNF4 SKIL 0.332 15231748 P78317 P20226 RNF4 TBP 0.309 9710597 P78317 P22314 RNF4 UBA1 0.033 25260751 P78317 P27694 RNF4 RPA1 0.21 22661229 P78317 P41235 RNF4 HNF4A 0.309 22505616 P78317 P51608 RNF4 MECP2 0.309 25355316 P78317 P51784 RNF4 USP11 0.21 25969536 P78317 P62256 RNF4 UBE2H 0.376 19549727 Q13148 P78317 TARDBP RNF4 0.126 24882209 Q13263 P78317 TRIM28 RNF4 0.21 21252943 Q13404 P78317 UBE2V1 RNF4 0.033 25260751 Q14676 P78317 MDC1 RNF4 0.21 22661230 Q16236 P78317 NFE2L2 RNF4 0.21 23543742 Q5NHX5 P78317 CDSA RNF4 0.126 20711500 Q71DI3 P78317 HIST2H3D RNF4 0.309 24714598 Q8IX04 P78317 UEVLD RNF4 0.376 19549727 Q96B02 P78317 UBE2W RNF4 0.597 19549727,19690564,23560854 Q96T88 P78317 UHRF1 RNF4 0.21 21252943 Q9UHF7 P78317 TRPS1 RNF4 0.507 12885770 Q9Y6K9 P78317 IKBKG RNF4 0.183 20211142 Q15554 P78317 TERF2 RNF4 0.569 26450775

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2L6 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database FANCA RNF4 MI:0045 experimental interaction detection MI:0461 interaction database GSC2 RNF4 MI:0362 inference MI:0461 interaction database SART1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database NBN RNF4 MI:0362 inference MI:1106 pathways database RNF8 RNF4 MI:0362 inference MI:1106 pathways database HERC2 RNF4 MI:0362 inference MI:1106 pathways database WHSC1 RNF4 MI:0362 inference MI:1106 pathways database MYC RNF4 MI:0045 experimental interaction detection MI:0461 interaction database ESR1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database PGR RNF4 MI:0045 experimental interaction detection MI:0461 interaction database SP1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database PARP1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF4 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC RNF4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database AR RNF4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKIL RNF4 MI:0045 experimental interaction detection MI:0461 interaction database H2AFX RNF4 MI:0362 inference MI:1106 pathways database HMGA1 RNF4 MI:0362 inference MI:0461 interaction database TBP RNF4 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database RPA1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database APEX1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database PML RNF4 MI:0045 experimental interaction detection MI:0461 interaction database BRCA1 RNF4 MI:0362 inference MI:1106 pathways database HNF4A RNF4 MI:0045 experimental interaction detection MI:0461 interaction database BRCC3 RNF4 MI:0362 inference MI:1106 pathways database MRE11A RNF4 MI:0362 inference MI:1106 pathways database MECP2 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database USP11 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database ATXN1 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 RNF4 MI:0362 inference MI:0461 interaction database UBE2D3 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K RNF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RNF4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MAX RNF4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 RNF4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2H RNF4 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H4A RNF4 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBE2D2 RNF4 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A RNF4 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 RNF4 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SUMO1 RNF4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2I RNF4 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 SRPK2 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 E2F1 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 TP53BP1 MI:0362 inference MI:1106 pathways database RNF4 TRIM28 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 ATM MI:0362 inference MI:1106 pathways database RNF4 UBE2V1 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 TDG MI:0045 experimental interaction detection MI:0461 interaction database RNF4 MDC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF4 TERF2 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 UBE2V2 MI:0362 inference MI:1106 pathways database RNF4 NFE2L2 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 HIST3H3 MI:0362 inference MI:1106 pathways database RNF4 FAM175A MI:0362 inference MI:1106 pathways database RNF4 HIST2H3A MI:0045 experimental interaction detection MI:0461 interaction database RNF4 HIST3H2A MI:0362 inference MI:0461 interaction database RNF4 UEVLD MI:0045 experimental interaction detection MI:0461 interaction database RNF4 RNF168 MI:0362 inference MI:1106 pathways database RNF4 PIAS4 MI:0362 inference MI:1106 pathways database RNF4 TAB3 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 NFATC2IP MI:0045 experimental interaction detection MI:0461 interaction database RNF4 RNF169 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 RAD50 MI:0362 inference MI:1106 pathways database RNF4 KAT5 MI:0362 inference MI:1106 pathways database RNF4 HIST1H2AC MI:0362 inference MI:0461 interaction database RNF4 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RNF4 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 UIMC1 MI:0362 inference MI:1106 pathways database RNF4 UHRF1 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 BARD1 MI:0362 inference MI:1106 pathways database RNF4 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database RNF4 PATZ1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF4 UBE2T MI:0045 experimental interaction detection MI:0461 interaction database RNF4 BABAM1 MI:0362 inference MI:1106 pathways database RNF4 BRE MI:0362 inference MI:1106 pathways database RNF4 TAB2 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 TCF20 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 TRPS1 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database RNF4 IKBKG MI:0045 experimental interaction detection MI:0461 interaction database