PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus BTBD1 OSGIN1 26186194 biogrid exp P GP P P P G P P P G G P P P P P GP LRR1 BTBD1 25011449 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS4 BTBD1 19295130 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 C9orf78 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G CUL5 BTBD1 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G CUL3 BTBD1 19295130,19995937,17543862,25011449,21145461 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G COPS2 BTBD1 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 COPS7A 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G COPS5 BTBD1 19295130,26186194,21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G TULP3 BTBD1 23414517 intact exp G GP G G G GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP GP G BTBD1 COPS3 19295130,26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 EPN3 26186194 biogrid exp GP P P G G GP GP P P GP P G P GP GP GP P GP P PNMA1 BTBD1 26186194 biogrid exp G G G G G GP G G G G G G G G G G GP G G G G G G G G GP G GP G OTUD6B BTBD1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G FMOD BTBD1 25011449 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS6 BTBD1 26186194,19615732,21145461, 25402006 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G GP GP GP G GP GP GP GP G UBXN1 BTBD1 26186194, 25402006 biogrid exp, pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G G G GP GP G GP GP GP GP GP G TRIM5 BTBD1 12878161, 25402006 hprd exp, pred GP GP G GP P G GP GP GP GP GP GP G GP P G G G GP GP GP P GP GP GP P G TOP1 BTBD1 21092135,11818025, 25402006, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD2 BTBD1 12878161, 25402006 intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G DESI1 BTBD1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G ATP5E BTBD1 21836163 pred G G G G G G G GP GP G G G G G G GP G G G G G G G G GP G G G G HNRNPR BTBD1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SRP9 BTBD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKRIR BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G TTC19 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G DNTTIP2 BTBD1 21836163 pred GP G G G G GP G GP G G GP G G G G GP GP G G G GP G G GP GP G GP GP G BTBD1 LAMTOR3 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G GP GP GP G GP GP GP GP G BTBD1 RERE 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G G G GP GP GP G GP GP GP GP G BCAS2 BTBD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YTHDF1 BTBD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TM2D3 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP G GP GP GP GP G BTBD1 GOLPH3 21836163 pred GP GP G G GP GP G G GP G GP G G GP G GP GP G G G GP GP GP G GP G GP GP G BTBD1 NDUFB11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G EDF1 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP G GP GP GP GP G NDUFA4 BTBD1 21836163 pred G GP G G G G G G G G GP GP G G G G G G G G G G G G G G G G G BTBD1 ACTR10 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD1 FAM96B 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G NDUFC2 BTBD1 21836163 pred P P P P P P P P P P P P P P P P P BTBD1 BZW2 21836163 pred GP GP G G GP GP G GP GP G GP GP G G G GP GP G G G GP G GP GP GP GP GP GP G PTGES3 BTBD1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP G GP GP GP GP G KLHL4 BTBD1 23023127 pred P GP G P GP P G P P P G P GP G P P P P P KLHL26 BTBD1 23023127 pred GP P G P GP G P GP G GP P P GP G GP GP G G P GP GP GP GP GP GP G BTBD1 KLHDC2 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SNRPA1 BTBD1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 PFDN2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G TP53 BTBD1 25402006 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G BTBD1 UBP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KBTBD11 BTBD1 23023127 pred GP GP G G GP GP G P GP G GP GP GP GP G GP GP G P GP P GP GP GP P P G BTBD1 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP GP GP G GP GP G PIGP BTBD1 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G G G GP G G GP GP G GP GP G PITPNB BTBD1 21836163 pred G GP G G GP G G G GP G GP G G G G G G G G G GP G G G G GP G G G HMGN3 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP G GP GP G H1FX BTBD1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 MRPL18 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD1 BTBD3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP G GP GP GP GP G NIPA2 BTBD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SLIRP BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G GP GP GP GP GP G GP GP G BTBD1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 MMADHC 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 C19orf53 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G PPA1 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G TNFAIP1 BTBD1 16082366 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G ATP5L BTBD1 21836163 pred GP GP G G GP GP G GP G G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G BTBD1 ATP6V1D 21836163 pred G G G G G GP G G G G GP G GP G G GP GP G G G G GP GP GP GP G GP G G TXNDC9 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G MICU2 BTBD1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G BTBD1 GHITM 21836163 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G G G GP GP G G GP G GP GP G BTBD1 CMC2 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP G GP GP G SNRNP200 BTBD1 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP G GP GP GP GP G

PPI - HINT Gene A Gene B PMID Method Quality TOP1 BTBD1 21092135,11818025,21092135,11818025 0004,0096,0018,0018 LC UBXN1 BTBD1 26186194 0004 HT CUL3 BTBD1 25011449,21145461,19295130,17543862,19995937 0004,0004,0004,0004,0004 LC,HT Q59EL2 BTBD1 26186194 0004 HT COPS6 BTBD1 26186194,19615732,21145461,19615732 0004,0004,0004,0007 HT OTUD6B BTBD1 26186194 0004 HT PNMA1 BTBD1 26186194 0004 HT COPS5 BTBD1 21145461,26186194,19295130 0004,0004,0004 HT,LC CUL5 BTBD1 21145461 0004 HT BTBD1 EPN3 26186194 0004 HT BTBD1 C9ORF78 26186194 0004 HT BTBD1 COPS7A 26496610,26496610 0007,0004 HT BTBD1 OSGIN1 26186194 0004 HT BTBD1 COPS3 26186194,19295130 0004,0004 HT,LC UBXN1 BTBD1 26186194 0004 HT CUL3 BTBD1 21145461 0004 HT Q59EL2 BTBD1 26186194 0004 HT COPS6 BTBD1 26186194,19615732,21145461,19615732 0004,0004,0004,0007 HT OTUD6B BTBD1 26186194 0004 HT PNMA1 BTBD1 26186194 0004 HT COPS5 BTBD1 21145461,26186194 0004,0004 HT CUL5 BTBD1 21145461 0004 HT BTBD1 EPN3 26186194 0004 HT BTBD1 C9ORF78 26186194 0004 HT BTBD1 COPS7A 26496610,26496610 0007,0004 HT BTBD1 OSGIN1 26186194 0004 HT BTBD1 COPS3 26186194 0004 HT TOP1 BTBD1 21092135,11818025,21092135,11818025 0004,0096,0018,0018 LC CUL3 BTBD1 25011449,19295130,17543862,19995937 0004,0004,0004,0004 LC COPS5 BTBD1 19295130 0004 LC BTBD1 COPS3 19295130 0004 LC TULP3 BTBD1 23414517 0399 HT TOP1 BTBD1 21092135,11818025,21092135,11818025 0004,0096,0018,0018 LC MTNR1B BTBD1 26514267 0018 LC BTBD2 BTBD1 12878161 0416 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H0C5 P61201 BTBD1 COPS2 0.126 26186194 Q9H0C5 Q8N6M0 BTBD1 OTUD6B 0.126 26186194 Q9H0C5 Q8ND90 BTBD1 PNMA1 0.126 26186194 Q9H0C5 Q7CL30 BTBD1 Q7CL30 0.126 20711500 Q9H0C5 Q06828 BTBD1 FMOD 0.21 25011449 Q9H0C5 Q96L50 BTBD1 LRR1 0.21 25011449 Q9H201 Q9H0C5 EPN3 BTBD1 0.126 26186194 Q9NZ63 Q9H0C5 C9ORF78 BTBD1 0.126 26186194 Q9H0C5 O75386 BTBD1 TULP3 0.126 23414517 Q9H0C5 P03120 BTBD1 E2 0.309 18305892 Q9JLV5 Q9H0C5 CUL3 BTBD1 0.236 26496610 Q9UBW8 Q9H0C5 COPS7A BTBD1 0.236 26496610 Q9UNS2 Q9H0C5 COPS3 BTBD1 0.236 19295130,26186194 Q9H0C5 P11387 BTBD1 TOP1 0.74 21092135,11818025 Q9H0C5 Q99PL5 BTBD1 RRBP1 0.236 26496610 Q9H0C5 Q13368 BTBD1 MPP3 0.236 unassigned1304 Q9H0C5 Q13618 BTBD1 CUL3 0.636 21145461,unassigned1304,19295130,25011449,17543862 Q9H0C5 Q16401 BTBD1 PSMD5 0.236 unassigned1304 Q9H0C5 Q8TBB1 BTBD1 LNX1 0.236 unassigned1304 Q9H0C5 Q96HA8 BTBD1 WDYHV1 0.236 unassigned1304 Q9H0C5 Q9H0C5 BTBD1 BTBD1 0.286 unassigned1304 Q9H0C5 Q92905 BTBD1 COPS5 0.332 21145461,26186194,19295130 Q9H0C5 Q7L5N1 BTBD1 COPS6 0.416 21145461,26186194,19615732 Q9H0C5 Q93034 BTBD1 CUL5 0.126 21145461 Q9H0C5 Q9BT78 BTBD1 COPS4 0.236 19295130 Q9H0C5 Q9BX70 BTBD1 BTBD2 0.236 12878161 Q9UJX0 Q9H0C5 OSGIN1 BTBD1 0.126 26186194 Q9H0C5 P49286 BTBD1 MTNR1B 0.183 26514267 Q9H0C5 Q04323 BTBD1 UBXN1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TULP3 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database MYC BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database ATP5B BTBD1 MI:0362 inference MI:0461 interaction database UBC BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database TOP1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database MTNR1B BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database COPS2 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database MAX BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 BTBD1 MI:0362 inference MI:1106 pathways database SUMO1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database UBXN1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database FMOD BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 BTBD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NEDD8 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database DESI1 BTBD1 MI:0362 inference MI:0461 interaction database COPS6 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database PNMA1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database COPS5 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database COPS4 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database BTBD1 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database BTBD1 C9orf78 MI:0045 experimental interaction detection MI:0461 interaction database BTBD1 RRBP1 MI:0362 inference MI:0461 interaction database BTBD1 COPS7A MI:0045 experimental interaction detection MI:0461 interaction database BTBD1 OSGIN1 MI:0045 experimental interaction detection MI:0461 interaction database BTBD1 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database