PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB11 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G ZBTB11 NXF1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD7 ZBTB11 15231748 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G ZBTB11 RAPGEF2 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB11 RPSA 26186194 biogrid exp GP GP P P GP P P GP P P P P GP P GP P P GP P P P P G ATP6AP2 ZBTB11 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB11 LIN28A 24778252 biogrid exp P P P P P GP P P P P G P P P P G P P P GP P P P GP G ZBTB11 RPL6 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB11 SIRT7 22586326 biogrid exp GP GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G GP GP GP GP GP GP G ZBTB11 PPP1CA 22321011 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ZBTB11 NIFK 26186194 biogrid exp GP G G G GP GP G G GP G GP G G GP G GP GP GP GP G GP G G GP GP GP GP GP G ZBTB11 PRR11 26186194 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G G GP GP GP GP G GP GP G EED ZBTB11 ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O95625 Q9NRC8 affinity chromatography technology 22586326 physical association X 2 O95625 O15105-2 two hybrid 15231748 direct interaction X 2 O95625 P55854 affinity chromatography technology 25391492 physical association X 2 O95625 P62136-3 two hybrid 22321011 direct interaction X 2 Q9H9Z2 O95625 affinity chromatography technology 24778252 physical association X 2 P0CG48 O95625 affinity chromatography technology 22505724 physical association X 2 P0CG48 O95625 affinity chromatography technology 24816145 physical association X 2 P0CG48 O95625 affinity chromatography technology 18781797 physical association X 2 P0CG48 O95625 affinity chromatography technology 21987572 physical association X 2 P0CG48 O95625 affinity chromatography technology 21139048 physical association X 2 P0CG48 O95625 affinity chromatography technology 21906983 physical association X 2 O15105 O95625 two hybrid 15231748 - X 2 O15105 O95625 two hybrid 15231748 - X 2 O95625 P62136 two hybrid 22321011 physical association X 2 O15105 O95625 two hybrid 15231748 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SMAD7 ZBTB11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(intact) BIOGRID_258639|MINT_61157|MINT_32309|HPRD_106|UniProt_78831 bait|bait|bait|-|bait prey|prey|prey|-|prey ZBTB11 SIRT7 MI:0004(affinity chromatography technology) 22586326 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_189700 prey bait ZBTB11 UBC MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18781797,21139048,21906983,21987572,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_179490|BIOGRID_163223|BIOGRID_161772|BIOGRID_170247|BIOGRID_223906 prey|prey|prey|prey|prey bait|bait|bait|bait|bait ZBTB11 PPP1CA MI:0018(two hybrid)|MI:0018(two hybrid) 22321011 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_182310|UniProt_121697 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality ZBTB11 SIDT2 26496610 0007 HT ZBTB11 SIDT2 26496610 0007 HT SMAD7 ZBTB11 15231748 0018 HT ZBTB11 PPP1CA 22321011 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O95625 A2AU89 ZBTB11 A2AU89 0.126 26496610 O95625 O15105 ZBTB11 SMAD7 0.332 15231748 P62136 O95625 PPP1CA ZBTB11 0.332 22321011 Q9H9Z2 O95625 LIN28A ZBTB11 0.126 24778252 Q9HCE1 O95625 MOV10 ZBTB11 0.126 22658674 Q9NRC8 O95625 SIRT7 ZBTB11 0.126 22586326 O95625 O75787 ZBTB11 ATP6AP2 0.126 26496610 P08865 O95625 RPSA ZBTB11 0.126 26186194 Q8R050 O95625 GSPT1 ZBTB11 0.236 26496610 Q9EQU5 O95625 SET ZBTB11 0.236 26496610 P20152 O95625 VIM ZBTB11 0.236 26496610 Q96HE9 O95625 PRR11 ZBTB11 0.126 26186194 Q9BYG3 O95625 NIFK ZBTB11 0.126 26186194 Q9UBU9 O95625 NXF1 ZBTB11 0.126 22658674 P70399 O95625 TP53BP1 ZBTB11 0.126 26496610 Q02878 O95625 RPL6 ZBTB11 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SMAD7 ZBTB11 MI:0045 experimental interaction detection MI:0461 interaction database ATP6AP2 ZBTB11 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 VIM MI:0362 inference MI:0461 interaction database ZBTB11 RPSA MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 UBC MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 GSPT1 MI:0362 inference MI:0461 interaction database ZBTB11 HNF4A MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 RAD23B MI:0362 inference MI:0461 interaction database ZBTB11 PSMD4 MI:0362 inference MI:0461 interaction database ZBTB11 SUMO3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 PPP1CA MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 SET MI:0362 inference MI:0461 interaction database ZBTB11 RPL6 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 TP53BP1 MI:0362 inference MI:0461 interaction database ZBTB11 SQSTM1 MI:0362 inference MI:0461 interaction database ZBTB11 NBR1 MI:0362 inference MI:0461 interaction database ZBTB11 GSPT2 MI:0362 inference MI:0461 interaction database ZBTB11 UBQLNL MI:0362 inference MI:0461 interaction database ZBTB11 PRR11 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 NIFK MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 LIN28A MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 SIRT7 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 UBQLN4 MI:0362 inference MI:0461 interaction database ZBTB11 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB11 UBQLN2 MI:0362 inference MI:0461 interaction database ZBTB11 UBQLN1 MI:0362 inference MI:0461 interaction database ZBTB11 NUB1 MI:0362 inference MI:0461 interaction database