PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EML1 ISG20L2 19060904,16189514 hprd,biogrid,mint,intact exp G G G GP G GP GP G GP G GP G G G GP G G G GP G G GP G G G G G EML1 TUBB2A 26186194 biogrid exp G G G GP G G GP G GP G GP G G G GP G G G GP G G G G G G G G EML1 GRID2 11829466 hprd exp G GP G GP P P GP G G G P G G G EML1 TUBB3 24706829 biogrid exp G G G GP G G GP G GP G GP G G G GP G G G GP G G G G G G G G EML1 DCTN1 26638075 biogrid,intact exp G G G GP G GP GP G GP G GP G G G GP G G G GP G G GP G G G G G EML1 TUBA1B 24706829 biogrid exp G G G GP G GP GP G GP G GP G G G GP G G G GP G G GP G G G G G EML1 TUBB2B 26186194 biogrid exp G GP G GP G GP P G G GP G G G G G G G EML1 GRID1 11829466 hprd exp G G G G G G G G G G G G G G G G G G G G G G G G G EML1 DCUN1D1 21145461 biogrid exp G GP G P P G P P GP G G G GP G GP G G G EML1 NUDC 25036637 intact exp G G G GP G G GP G GP G GP G G G GP G G G GP G G G G G G G G EML1 TUBB4B 21836163 pred G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G EML1 PXN 21836163 pred G G G GP G G GP G GP G GP G G G GP G G G GP G G G G G G G G EML1 AIMP1 21836163 pred G G G GP G GP GP G GP G GP G G G GP G G G GP G G GP G G G G G EML1 TUBB6 21836163 pred G G G GP G G GP G GP G GP G G G GP G G G G G G G G G G G G EML1 NCK1 25402006 pred G G G GP G GP GP G GP G GP G G G GP G G G GP G G G G G G G G EML1 TUBB 21836163 pred G G G GP G GP GP G GP G GP G G G GP G G G GP G G GP G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9ULK0 O00423 in vitro 11829466 - X 2 Q9ULK0 O00423 in vivo 11829466 - X 2 Q9ULK0 O00423 two hybrid 11829466 - X 2 Q9ULK0 O00423 two hybrid 11829466 - X 2 Q9ULK0 O00423 in vivo 11829466 - X 2 Q9ULK0 O00423 in vitro 11829466 - X 2 O43424 O00423 in vivo 11829466 - X 2 O43424 O00423 two hybrid 11829466 - X 2 O43424 O00423 in vitro 11829466 - X 2 O43424 O00423 in vitro 11829466 - X 2 O43424 O00423 two hybrid 11829466 - X 2 O43424 O00423 in vivo 11829466 - X 2 O00423 Q9H9L3 two hybrid 16189514 - X 2 O00423 Q9H9L3 two hybrid 16189514 - X 2 Q9Y266 O00423 luminescence based mammalian interactome mapping 25036637 physical association X 2 O00423 Q9H9L3 two hybrid pooling approach 16189514 physical association X 2 O00423 Q9H9L3 two hybrid pooling approach 19060904 physical association X 2 O00423 Q9H9L3 two hybrid array 19060904 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EML1 ISG20L2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down) 16189514,19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid)|(intact)|(intact) MINT_39936|MINT_69231|BIOGRID_80870|UniProt_97089|HPRD_21892|BIOGRID_262421|UniProt_99263|UniProt_153699 bait|bait|bait|bait|-|bait|bait|unspecified role prey|prey|prey|prey|-|prey|prey|unspecified role EML1 DCUN1D1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205949 prey bait EML1 GRID1 MI:0492(in vitro) 11829466 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10211 - - EML1 GRID2 MI:0492(in vitro) 11829466 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10210 - -

PPI - HINT Gene A Gene B PMID Method Quality EML1 EML1 25740311 0004 LC EML1 TUBB2A 26186194 0004 HT EML1 DCTN1 26638075 1314 HT EML1 Q53G92 25740311,24706829 0096,0004 LC EML1 DKFZP686I0746 26638075 1313 HT EML1 DCUN1D1 21145461 0004 HT EML1 TUBB2B 26186194 0004 HT EML1 TUBB2A 26186194 0004 HT EML1 DCTN1 26638075 1314 HT EML1 DKFZP686I0746 26638075 1313 HT EML1 DCUN1D1 21145461 0004 HT EML1 TUBB2B 26186194 0004 HT EML1 EML1 25740311 0004 LC EML1 Q53G92 25740311,24706829 0096,0004 LC EML1 EML1 24706829 0114 LC EML1 GRID2 11829466 0018 LC EML1 ISG20L2 19060904,16189514,16189514,19060904,19060904 0018,0398,0018,0397,0398 HT EML1 GRID1 11829466 0018 LC EML1 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8K1R7 O00423 NEK9 EML1 0.126 26496610 Q13509 O00423 TUBB3 EML1 0.454 25740311,24706829 Q9H9L3 O00423 ISG20L2 EML1 0.554 19060904,16189514 Q96GG9 O00423 DCUN1D1 EML1 0.126 21145461 Q9BVA1 O00423 TUBB2B EML1 0.126 26186194 Q13885 O00423 TUBB2A EML1 0.126 26186194 Q14203 O00423 DCTN1 EML1 0.126 26638075 O00423 O00423 EML1 EML1 0.236 25740311 P68363 O00423 TUBA1B EML1 0.21 24706829 Q71U36 O00423 TUBA1A EML1 0.309 25740311 Q9Y266 O00423 NUDC EML1 0.126 25036637

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EML1 TUBA1B MI:0045 experimental interaction detection MI:0461 interaction database EML1 TUBB3 MI:0045 experimental interaction detection MI:0461 interaction database EML1 TUBB2A MI:0045 experimental interaction detection MI:0461 interaction database EML1 DCTN1 MI:0045 experimental interaction detection MI:0461 interaction database EML1 TUBA1A MI:0045 experimental interaction detection MI:0461 interaction database EML1 NEK9 MI:0362 inference MI:0461 interaction database EML1 DCUN1D1 MI:0045 experimental interaction detection MI:0461 interaction database EML1 TUBB2B MI:0045 experimental interaction detection MI:0461 interaction database EML1 ISG20L2 MI:0045 experimental interaction detection MI:0461 interaction database EML1 NUDC MI:0045 experimental interaction detection MI:0461 interaction database