PTM - CPLM Gene Name UniProt ID Type Position Code HDAC4; KIAA0288 P56524 Acetylation 236 K HDAC4; KIAA0288 P56524 Sumoylation 559 K HDAC4; KIAA0288 P56524 Ubiquitination 737 K HDAC4; KIAA0288 P56524 Ubiquitination 1026 K

PTM - dbPAF Gene Name UniProt ID Position Type Species HDAC4; KIAA0288 P56524 1025 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 1034 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 1057 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 1061 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 11 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 168 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 196 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 209 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 210 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 214 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 225 Y Homo sapiens(Human) HDAC4; KIAA0288 P56524 233 Y Homo sapiens(Human) HDAC4; KIAA0288 P56524 244 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 246 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 265 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 266 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 278 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 298 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 302 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 339 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 348 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 350 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 391 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 394 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 400 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 465 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 467 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 540 Y Homo sapiens(Human) HDAC4; KIAA0288 P56524 565 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 58 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 584 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 632 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 633 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 636 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 638 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 648 T Homo sapiens(Human) HDAC4; KIAA0288 P56524 741 S Homo sapiens(Human) HDAC4; KIAA0288 P56524 744 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P56524 K236-ac Acetylation VLGMyDAkDDFPLRK P56524 K548-ac Acetylation LDRLPGQkEAHAQAG P56524 T36-p Phosphorylation PSTVDVAtALPLQVA P56524 S45-p Phosphorylation LPLQVAPsAVPMDLR P56524 S58-p Phosphorylation LRLDHQFsLPVAEPA P56524 S168-p Phosphorylation GKESAVAsTEVKMKL P56524 S196-p Phosphorylation RNLNHCIsSDPRYWY P56524 S210-p Phosphorylation YGKTQHSsLDQSsPP P56524 S215-p Phosphorylation HSsLDQSsPPQSGVS P56524 Y225-p Phosphorylation QSGVSTSyNHPVLGM P56524 Y233-p Phosphorylation NHPVLGMyDAkDDFP P56524 S246-p Phosphorylation FPLRKTAsEPNLKLR P56524 S265-p Phosphorylation QKVAERRssPLLRRK P56524 S266-p Phosphorylation KVAERRssPLLRRKD P56524 T278-p Phosphorylation RKDGPVVtALKKRPL P56524 S298-p Phosphorylation ACSSAPGsGPSsPNN P56524 S302-p Phosphorylation APGsGPSsPNNSSGS P56524 S339-p Phosphorylation RLVAREGsAAPLPLY P56524 S348-p Phosphorylation APLPLYTsPsLPNIT P56524 S350-p Phosphorylation LPLYTsPsLPNITLG P56524 T391-p Phosphorylation RLSLFPGtHLtPYLS P56524 T394-p Phosphorylation LFPGtHLtPYLSTsP P56524 S400-p Phosphorylation LtPYLSTsPLERDGG P56524 T465-p Phosphorylation QHRPLGRtQsAPLPQ P56524 S467-p Phosphorylation RPLGRtQsAPLPQNA P56524 Y540-p Phosphorylation QALLDEPyLDRLPGQ P56524 S565-p Phosphorylation VkQEPIEsDEEEAEP P56524 S584-p Phosphorylation EPGQRQPsEQELLFR P56524 S611-p Phosphorylation QLRNYQAsMEAAGIP P56524 S632-p Phosphorylation RPLSRAQssPAsAtF P56524 S633-p Phosphorylation PLSRAQssPAsAtFP P56524 S636-p Phosphorylation RAQssPAsAtFPVSV P56524 T638-p Phosphorylation QssPAsAtFPVSVQE P56524 T648-p Phosphorylation VSVQEPPtKPRFTTG P56524 S741-p Phosphorylation DSKKLLGsLAsVFVR P56524 S744-p Phosphorylation KLLGsLAsVFVRLPC P56524 S1025-p Phosphorylation EKVMEIHsKYWRCLQ P56524 T1057-p Phosphorylation NEEAETVtAMAsLSV P56524 S1061-p Phosphorylation ETVtAMAsLSVGVKP P56524 K559-sm Sumoylation AQAGVQVkQEPIEsD

PTM - dbPTM UniProt ID Position Code Type Resources References P56524 246 S Phosphorylation Swiss-Prot 1010711 10958686 P56524 350 S Phosphorylation Swiss-Prot 1010711 19690332 P56524 467 S Phosphorylation Swiss-Prot 1010711 10958686 P56524 559 K Sumoylation Swiss-Prot 1010711 12032081 P56524 565 S Phosphorylation Swiss-Prot 1010711 18669648 P56524 632 S Phosphorylation Swiss-Prot 1010711 10958686;18669648 P56524 633 S Phosphorylation Swiss-Prot 1010711 18669648 P56524 246 S Phosphorylation PhosphoELM.10011 10869435;10958686 P56524 565 S Phosphorylation PhosphoELM.10011 18669648 P56524 633 S Phosphorylation PhosphoELM.10011 18669648 P56524 636 S Phosphorylation PhosphoELM.10011 18669648 P56524 467 S Phosphorylation PhosphoELM.10011 18669648;11470791 P56524 632 S Phosphorylation PhosphoELM.10011 18669648;11470791 P56524 638 T Phosphorylation PhosphoELM.10011 18669648 P56524 559 K Sumoylation Phosphositeplus.1010730 12032081 P56524 236 K Acetylation Phosphositeplus.1010730 20167786 P56524 210 S Phosphorylation Phosphositeplus.1010730 17179159;19276368 P56524 246 S Phosphorylation Phosphositeplus.1010730 10869435;10958686;16980613;18509061;20068231;20363803;21406692 P56524 265 S Phosphorylation Phosphositeplus.1010730 20068231;20363803 P56524 266 S Phosphorylation Phosphositeplus.1010730 20068231 P56524 298 S Phosphorylation Phosphositeplus.1010730 18045992;21118993 P56524 302 S Phosphorylation Phosphositeplus.1010730 21118993 P56524 339 S Phosphorylation Phosphositeplus.1010730 19690332 P56524 350 S Phosphorylation Phosphositeplus.1010730 19690332;22649097 P56524 467 S Phosphorylation Phosphositeplus.1010730 10869435;10958686;18509061 P56524 565 S Phosphorylation Phosphositeplus.1010730 18669648;19362540;20068231;21406692;22115753 P56524 632 S Phosphorylation Phosphositeplus.1010730 10869435;10958686;18509061;18669648;19276368;20068231;20736484;21406692;21659604;22115753 P56524 633 S Phosphorylation Phosphositeplus.1010730 18669648 P56524 278 T Phosphorylation Phosphositeplus.1010730 18491316 P56524 246 S Phosphorylation HPRD 9.0 10958686,10869435,20068231 P56524 265 S Phosphorylation HPRD 9.0 20068231 P56524 266 S Phosphorylation HPRD 9.0 20068231 P56524 565 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 P56524 633 S Phosphorylation HPRD 9.0 18669648 P56524 636 S Phosphorylation HPRD 9.0 18669648 P56524 278 T Phosphorylation HPRD 9.0 18491316 P56524 638 T Phosphorylation HPRD 9.0 18669648 P56524 467 S Phosphorylation (CAMK4) HPRD 9.0 11470791,18669648 P56524 632 S Phosphorylation (CAMK4) HPRD 9.0 11470791,18669648,19651622,20068231 P56524 565 S Phosphorylation SysPTM 1.1 18669648 P56524 632 S Phosphorylation SysPTM 1.1 18669648 P56524 633 S Phosphorylation SysPTM 1.1 18669648 P56524 278 T Phosphorylation SysPTM 1.1 18491316

PTM - HPRD Symbol Position Code Type References HDAC4 246 S Phosphorylation 10958686,10869435,20068231 HDAC4 265 S Phosphorylation 20068231 HDAC4 266 S Phosphorylation 20068231 HDAC4 278 T Phosphorylation 18491316 HDAC4 467 S Phosphorylation 11470791,18669648 HDAC4 565 S Phosphorylation 18669648,19651622,20068231 HDAC4 632 S Phosphorylation 11470791,18669648,19651622,20068231 HDAC4 633 S Phosphorylation 18669648 HDAC4 636 S Phosphorylation 18669648 HDAC4 638 T Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P56524 467 S 18669648 HTP Phosphorylation P56524 467 S 11470791 CaM-KIV LTP Phosphorylation P56524 565 S 18669648 HTP Phosphorylation P56524 246 S 10869435 LTP Phosphorylation P56524 246 S 10958686 LTP Phosphorylation P56524 632 S 18669648 HTP Phosphorylation P56524 632 S 11470791 CaM-KIV LTP Phosphorylation P56524 633 S 18669648 HTP Phosphorylation P56524 636 S 18669648 HTP Phosphorylation P56524 638 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P56524 246 Phosphoserine; by CaMK4 and SIK1 10958686 P56524 350 Phosphoserine 19690332;22649097 P56524 467 Phosphoserine; by CaMK4 and SIK1 10958686 P56524 632 Phosphoserine; by CaMK4 18669648;23186163;24275569;10958686 P56524 633 Phosphoserine 18669648

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type HDAC4 IPI00010088 S 11 SHPDGLpSGRDQPV phosphorylation HDAC4 IPI00010088 S 265 KVAERRpSSPLLRR phosphorylation HDAC4 IPI00010088 S 266 VAERRSpSPLLRRK phosphorylation HDAC4 IPI00010088 S 632 PLSRAQpSSPASAT phosphorylation HDAC4 IPI00010088 T 1034 WRCLQRpTTSTAGR phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9759 115106 - K Sumoylation 16955485 9759 115106 - K Sumoylation 16332688 9759 115106 - K Sumoylation 16166628 9759 115106 - K Ubiquitination 21118993 9759 115106 - K Sumoylation 11451954