PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LONRF2 OTUD5 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G PKLR OTUD5 19615732 biogrid,intact exp P G G GP GP P GP GP VARS OTUD5 19615732 biogrid,intact exp G GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G OTUD5 LANCL2 19615732 biogrid,intact exp G G G G G GP G G G G G G GP G G G GP G GP G G G G G G G GP GP G GRB2 OTUD5 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBC OTUD5 23827681,22245969,17991829 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBA52 OTUD5 22245969 dip exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G OTUD5 CTPS2 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PDCD5 OTUD5 25499082 biogrid exp G GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP G GP G GP G GP GP G GRN OTUD5 26186194 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G GPX4 OTUD5 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TP53 OTUD5 24143256,19615732,25499082 biogrid,intact exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G OTUD5 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G GYS1 OTUD5 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G OTUD5 CACYBP 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G ARPC3 OTUD5 16169070 hprd,i2d,mint,intact exp G GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G GLUL OTUD5 20936779 i2d exp GP G G G G GP G G GP G G GP GP G G GP GP GP G G GP G G G GP G GP GP G IGBP1 OTUD5 22939629 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G FLNA OTUD5 19615732 biogrid,intact exp G G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP G G G G G GP GP G OTUD5 OTUD5 19615732 intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SET OTUD5 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP11 OTUD5 19615732 biogrid,intact exp G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G TRAF3 OTUD5 24763515,17991829, 25402006 innatedb,hprd,biogrid exp, pred G GP G G G GP G G G G GP GP GP GP G GP GP GP GP G GP G GP G GP G GP GP G UBE2L6 OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G TRIM25 OTUD5 25402006 pred G GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G IRF3 OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G TAX1BP1 OTUD5 25402006 pred GP GP G G G GP G G GP G GP G G GP G G GP GP G G GP G GP GP G G GP GP G DDX58 OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP G TNFRSF9 OTUD5 25402006 pred GP G G G GP G G GP P G P G GP G GP G P GP G GP GP G RNF125 OTUD5 25402006 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G OTUD5 TBK1 25402006 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBC OTUD5 23023127 pred OTUD5 EDA2R 25402006 pred P P G P P G P P G GP G G GP P P P G PCBP2 OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CD27 OTUD5 25402006 pred G G G G G G G G G G GP G G G G G G G G G G G G G RNF135 OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2D3 OTUD5 25402006 pred GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G OTUD5 IFIH1 25402006 pred GP GP P G GP GP GP GP GP G GP P G P G GP GP GP P GP G GP P IKBKE OTUD5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TANK OTUD5 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G MAVS OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G OPTN OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TICAM1 OTUD5 25402006 pred GP GP G P G G GP GP GP GP GP G GP P GP GP GP GP GP GP GP G GP P G OTUD5 RNF216 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TRAF2 OTUD5 25402006 pred P P P P P P P P P P P P P P P P P G GP P OTUD5 TNFRSF11A 25402006 pred GP P G G P GP P P GP G GP P P G P G G P GP GP P G TNFRSF4 OTUD5 25402006 pred P GP G G RIPK1 OTUD5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B IGBP1 OTUD5 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240973 bait prey USP11 OTUD5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_119896 prey|prey bait|bait GPX4 OTUD5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119504|UniProt_100645 prey|prey bait|bait SET OTUD5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_119787 prey|prey bait|bait OTUD5 CACYBP MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120390|UniProt_100645 bait|bait prey|prey p53 OTUD5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,24143256 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_297082|BIOGRID_297083|BIOGRID_297084|BIOGRID_297085|BIOGRID_297088|BIOGRID_119827|UniProt_100645 bait|bait|prey|bait|prey|prey|prey prey|prey|bait|prey|bait|bait|bait LONRF2 OTUD5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_120831 prey|prey bait|bait OTUD5 LANCL2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_120565 bait|bait prey|prey OTUD5 CTPS2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_120580 bait|bait prey|prey TRAF3 OTUD5 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 17991829 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33492|BIOGRID_117745 -|prey -|bait UBC OTUD5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 12938929,17991829,18781797,20972266,21139048,21890473,21906983,21963094,21987572,22118674,22245969,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_174719|BIOGRID_164285|BIOGRID_163000|BIOGRID_162253|BIOGRID_160482|BIOGRID_269266|BIOGRID_224558|BIOGRID_166388|BIOGRID_117748|BIOGRID_179567|BIOGRID_196815|BIOGRID_170328|BIOGRID_167105 bait|bait|bait|bait|bait|bait|bait|bait|prey|bait|prey|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|bait|prey|bait|prey|prey GYS1 OTUD5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119509|UniProt_100645 prey|prey bait|bait FLNA OTUD5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119478|UniProt_100645 prey|prey bait|bait ARPC3 OTUD5 MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint) UniProt_156717|HPRD_29807|MINT_62196|MINT_33255 bait|-|bait|bait prey|-|prey|prey PKLR OTUD5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119651|UniProt_100645 prey|prey bait|bait NRF1 OTUD5 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295095 bait prey GRB2 OTUD5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_119505 prey|prey bait|bait VARS OTUD5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100645|BIOGRID_119853 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality TP53 OTUD5 19615732,19615732 0004,0007 HT UBC OTUD5 12938929,17991829,20972266,21963094,22118674 0096,0096,0004,0004,0004 LC GYS1 OTUD5 19615732,19615732 0004,0007 HT FLNA OTUD5 19615732,19615732 0004,0007 HT VARS OTUD5 19615732,19615732 0004,0007 HT GRN OTUD5 26186194 0004 HT PKLR OTUD5 19615732,19615732 0004,0007 HT GPX4 OTUD5 19615732,19615732 0004,0007 HT USP11 OTUD5 19615732,19615732 0004,0007 HT GRB2 OTUD5 19615732,19615732 0004,0007 HT IGBP1 OTUD5 22939629 0401 HT SET OTUD5 19615732,19615732 0004,0007 HT TRAF3 OTUD5 17991829,24763515,17991829 0007,0004,0004 LC LONRF2 OTUD5 19615732,19615732 0004,0007 HT Q53GA5 OTUD5 24143256,24143256,25499082,19615732,24143256,25499082,25499082,24143256 0004,0415,0004,0004,0096,0096,0428,0018 LC,HT OTUD5 CACYBP 19615732,19615732 0004,0007 HT OTUD5 CTPS2 19615732,19615732 0004,0007 HT OTUD5 LANCL2 19615732,19615732 0004,0007 HT TP53 OTUD5 19615732,19615732 0004,0007 HT GYS1 OTUD5 19615732,19615732 0004,0007 HT FLNA OTUD5 19615732,19615732 0004,0007 HT VARS OTUD5 19615732,19615732 0004,0007 HT GRN OTUD5 26186194 0004 HT PKLR OTUD5 19615732,19615732 0004,0007 HT GPX4 OTUD5 19615732,19615732 0004,0007 HT USP11 OTUD5 19615732,19615732 0004,0007 HT GRB2 OTUD5 19615732,19615732 0004,0007 HT IGBP1 OTUD5 22939629 0401 HT SET OTUD5 19615732,19615732 0004,0007 HT LONRF2 OTUD5 19615732,19615732 0004,0007 HT Q53GA5 OTUD5 19615732 0004 HT OTUD5 CACYBP 19615732,19615732 0004,0007 HT OTUD5 CTPS2 19615732,19615732 0004,0007 HT OTUD5 LANCL2 19615732,19615732 0004,0007 HT UBC OTUD5 12938929,17991829,20972266,21963094,22118674 0096,0096,0004,0004,0004 LC TRAF3 OTUD5 17991829,24763515,17991829 0007,0004,0004 LC Q53GA5 OTUD5 24143256,24143256,25499082,24143256,25499082,25499082,24143256 0004,0415,0004,0096,0096,0428,0018 LC PDCD5 OTUD5 25499082,25499082,25499082,25499082 0096,0004,0018,0428 LC ARPC3 OTUD5 16169070,16169070 0018,0398 HT UBC OTUD5 22245969,22245969,23827681,22245969,22245969,22245969,22245969 0998,0114,0415,0077,0990,0415,0071 LC IGBP1 OTUD5 22939629 0401 LC Q53GA5 OTUD5 24143256,24143256,24143256,24143256 0004,0415,0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE1 Q96G74 MOV10 OTUD5 0.126 22658674 Q96G74 Q81KM0 OTUD5 Q81KM0 0.126 20711500 Q96G74 Q1L5Z9 OTUD5 LONRF2 0.236 19615732 Q96G74 Q13114 OTUD5 TRAF3 0.376 17991829,24763515 Q96G74 Q01105 OTUD5 SET 0.236 19615732 Q96G74 P62993 OTUD5 GRB2 0.236 19615732 Q96G74 P51784 OTUD5 USP11 0.236 19615732 Q96G74 O14737 OTUD5 PDCD5 0.74 25499082 Q96G74 P36969 OTUD5 GPX4 0.236 19615732 Q96G74 P13807 OTUD5 GYS1 0.236 19615732 Q96G74 P30613 OTUD5 PKLR 0.236 19615732 Q96G74 P21333 OTUD5 FLNA 0.236 19615732 Q96G74 P26640 OTUD5 VARS 0.236 19615732 Q9NRF8 Q96G74 CTPS2 OTUD5 0.236 19615732 Q9HB71 Q96G74 CACYBP OTUD5 0.236 19615732 Q9NS86 Q96G74 LANCL2 OTUD5 0.236 19615732 Q96G74 P0CG48 OTUD5 UBC 0.671 22245969,17991829,23827681 Q96G74 P04637 OTUD5 TP53 0.925 24143256,19615732,25499082 Q96G74 O15145 OTUD5 ARPC3 0.126 16169070 Q96G74 Q8ZG01 OTUD5 METG 0.126 20711500 Q96G74 P28799 OTUD5 GRN 0.126 26186194 Q96G74 P78318 OTUD5 IGBP1 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PDCD5 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database ARPC3 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database UBR5 OTUD5 MI:0362 inference MI:0461 interaction database FMNL1 OTUD5 MI:0362 inference MI:0461 interaction database DDX58 OTUD5 MI:0362 inference MI:1106 pathways database TP53 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database PARP1 OTUD5 MI:0362 inference MI:0461 interaction database UBB OTUD5 MI:0362 inference MI:0461 interaction database UBC OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database GYS1 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database FLNA OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database VARS OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database GRN OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database PKLR OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database GPX4 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database USP11 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A OTUD5 MI:0362 inference MI:0461 interaction database UBA52 OTUD5 MI:0362 inference MI:0461 interaction database GRB2 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database SET OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database TRAF3 OTUD5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database GOLGA4 OTUD5 MI:0362 inference MI:0461 interaction database TRIM25 OTUD5 MI:0362 inference MI:1106 pathways database LONRF2 OTUD5 MI:0045 experimental interaction detection MI:0461 interaction database UBR4 OTUD5 MI:0362 inference MI:0461 interaction database NHS OTUD5 MI:0362 inference MI:0461 interaction database POGZ OTUD5 MI:0362 inference MI:0461 interaction database MAVS OTUD5 MI:0362 inference MI:1106 pathways database RNF135 OTUD5 MI:0362 inference MI:1106 pathways database MROH1 OTUD5 MI:0362 inference MI:0461 interaction database OTUD5 IFIH1 MI:0362 inference MI:1106 pathways database OTUD5 UACA MI:0362 inference MI:0461 interaction database OTUD5 CACYBP MI:0045 experimental interaction detection MI:0461 interaction database OTUD5 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database OTUD5 CTPS2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD5 LANCL2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD5 EPS15L1 MI:0362 inference MI:0461 interaction database