Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 2 106366232 rs997522 G A rs997522 4.10E-05 Inflammatory demyelinating disease HPOID:0002143 DOID:8869 G intron GWASdb_trait 2 106366232 rs997522 G A rs997522 7.12E-05 Calcium levels HPOID:0004363|HPOID:0002621|HPOID:0011915 DOID:10575|DOID:1936 G intron GWASdb_trait 2 106367561 rs12987484 T C rs12987484 1.17E-04 Arthritis (juvenile idiopathic) HPOID:0005681 DOID:676 T intron GWASdb_trait 2 106384133 rs11687998 C T rs11687998 7.35E-04 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 2 106386865 rs1367404 G T rs1367404 3.66E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 2 106391154 rs7589589 G C rs7589589 1.20E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 2 106391154 rs7589589 G C rs7589589 8.13E-05 Serum metabolites HPOID:0011111 NA G intron GWASdb_trait 2 106391338 rs4851864 G A rs4851864 9.24E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 106392799 rs10198057 G T rs10198057 2.08E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 2 106394809 rs17201484 G C rs17201484 3.04E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C intron GWASdb_trait 2 106394809 rs17201484 G C rs17201484 8.95E-05 Serum metabolites HPOID:0011111 NA C intron GWASdb_trait 2 106397624 rs1897169 A G rs1897169 3.97E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C intron GWASdb_trait 2 106401954 rs6732799 C T rs6732799 4.18E-05 Prion diseases HPOID:0004429 DOID:649 C intron GWASdb_trait 2 106408233 rs7588033 C T rs7588033 3.79E-05 Prion diseases HPOID:0004429 DOID:649 C intron GWASdb_trait 2 106411386 rs4851090 T C rs4851090 9.36E-05 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 106413031 rs17031793 C T rs17031793 5.22E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 2 106413077 rs2047699 C T rs2047699 5.34E-05 Prion diseases HPOID:0004429 DOID:649 A intron GWASdb_trait 2 106428404 rs6719896 C G rs6719896 3.42E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C intron GWASdb_trait 2 106429319 rs1549769 A C rs1549769 2.87E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 106433909 rs7589790 C G rs7589790 3.53E-04 Type 2 diabetes HPOID:0005978 DOID:9352 G intron GWASdb_trait 2 106433909 rs7589790 C G rs7589790 1.54E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 2 106436366 rs12995333 G T rs12995333 4.43E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 2 106436366 rs12995333 G T rs12995333 9.90E-05 Alzheimer's disease HPOID:0002511 DOID:10652 T intron GWASdb_trait 2 106445209 rs6725519 C T rs6725519 2.42E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C intron GWASdb_trait 2 106453347 rs3954042 T C rs3954042 3.97E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 106454085 rs7589561 C T rs7589561 2.02E-05 Osteoarthritis (knee and hip) HPOID:0002758 DOID:8398 T intron GWASdb_trait 2 106454085 rs7589561 C T rs7589561 5.53E-04 Osteoarthritis (knee and hip) HPOID:0002758 DOID:8398 T intron GWASdb_trait 2 106455387 rs4851877 A C rs4851877 3.26E-04 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 106455549 rs4851095 T C rs4851095 7.10E-04 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 106457291 rs2377339 A G rs2377339 2.24E-04 Fibrinogen HPOID:0011898 DOID:1287 A intron GWASdb_trait 2 106457291 rs2377339 A G rs2377339 1.00E-11 Addiction HPOID:0002720 DOID:9974 A intron GWASdb_trait 2 106457291 rs2377339 A G rs2377339 2.00E-08 Addiction HPOID:0002720 DOID:9974 A intron GWASdb_trait 2 106467506 rs6543344 C G rs6543344 8.26E-04 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 106467506 rs6543344 C G rs6543344 0.00006658 Sarcoidosis HPOID:0012220 DOID:11335 C intron GWASdb_trait 2 106469333 rs3754807 A T rs3754807 8.89E-05 Serum metabolites HPOID:0011111 NA T intron GWASdb_trait 2 106477092 rs3769504 A G rs3769504 9.03E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 2 106477285 rs3769503 T C rs3769503 9.93E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 106477781 rs6704555 G A rs6704555 1.74E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 106477946 rs9646946 A G rs9646946 4.84E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 106479806 rs3769501 C G rs3769501 5.46E-06 Kawasaki disease HPOID:0001677 DOID:13378 G intron GWASdb_trait 2 106490021 rs3769497 C A rs3769497 7.01E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 106493191 rs3754801 G A rs3754801 6.12E-05 Serum metabolites HPOID:0011111 NA C intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs1897169 2 106397624 106397624 intronic 0.985513 0.00633764252504815 GWAS of prostate cancer rs7588033 2 106408233 106408233 intronic 0.931191 0.0309612301482521 GWAS of prostate cancer rs6740343 2 106505478 106505478 intronic 0.905796 0.0429696014955912 GWAS of prostate cancer rs3769504 2 106477092 106477092 intronic 0.859481 0.0657637195427948 GWAS of prostate cancer rs10496402 2 106371313 106371313 intronic 0.848039 0.0715841747535174 GWAS of prostate cancer rs10180659 2 106465373 106465373 intronic 0.81491 0.08889035280809779 GWAS of prostate cancer rs1367406 2 106420403 106420403 intronic 0.797372 0.0983390188103142 GWAS of prostate cancer rs4851870 2 106437256 106437256 intronic 0.777888 0.109082928053318 GWAS of prostate cancer rs12464067 2 106416112 106416112 intronic 0.749567 0.125189541695222 GWAS of prostate cancer rs6543342 2 106462256 106462256 intronic 0.711251 0.14797710998994598 GWAS of prostate cancer rs2163350 2 106445281 106445281 intronic 0.693056 0.159231672302488 GWAS of prostate cancer rs7589561 2 106454085 106454085 intronic 0.650221 0.18693900832983001 GWAS of prostate cancer rs1465639 2 106439181 106439181 intronic 0.649481 0.187433549311279

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000071051.13 NCK2 604930