PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ARHGAP10 FOXQ1 25609649 intact exp GP G G G GP G G GP G GP G GP GP G G GP G G GP G G G G G G GP G ARHGAP10 PKN1 11432776 hprd exp GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 YWHAQ 15161933 biogrid exp GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G G G G G GP G ARHGAP10 C2CD2 26186194 biogrid exp GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G G G G G GP G ARHGAP10 ANKS1A 25814554 biogrid,intact exp GP GP G G G G G G GP G GP G GP GP G G G G P G GP G G G G G G GP G ARHGAP10 SH3BP2 25814554 biogrid,intact exp GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G G G G G GP G ARHGAP10 PKN3 11432776, 21836163 hprd,biogrid,intact exp, pred G GP P G G GP G G G G G P P G P G G G G G P G ARHGAP10 RHOA 11432776, 23023127 biogrid exp, pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 PAK2 15471851, 21836163 hprd exp, pred GP GP G G G GP G G GP G GP G GP GP G G GP GP G GP G G GP G G G G G ARHGAP10 CDC42 11432776, 23023127 biogrid exp, pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 PTK2B 21836163 ortho, pred GP GP G G G GP G G GP G GP G GP GP G G GP G P G P G G G G G G GP G ARHGAP10 VAV1 21836163 pred GP GP G G GP G P G P G GP GP G G GP G P G GP G G P G G GP G ARHGAP10 PLD1 25402006 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G P G G P G G G GP G ARHGAP10 WAS 23023127 pred GP GP G G G GP G G GP G G G GP GP G G GP G P G GP G G GP G G G GP G ARHGAP10 NRAS 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 ECT2 21836163 pred G G G G G G G G G G ARHGAP10 ARHGAP6 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP G P G GP G G GP G G G GP G ARHGAP10 ARHGEF7 21836163 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 ARHGEF11 21836163 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 ARHGAP15 23023127 pred GP GP G G P G G GP P G GP GP G G GP P P P G G P G G G GP ARHGAP10 PLEK 23023127 pred G G G G G GP G G G G G G GP GP G G GP G G G G G G G G G G G ARHGAP10 FRMD4A 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G G G G GP G G G GP G ARHGAP10 RAC1 23023127 pred GP GP G G G G G G GP G G G GP G G G G G P G GP G G GP G G G GP G ARHGAP10 RAC2 23023127 pred G GP G G G GP G G G G G G GP GP G G GP G G G G G GP G G G GP G ARHGAP10 SOS1 21836163 pred GP G G G G G G G GP G GP G GP GP G G G G P G GP G G GP G G G G G ARHGAP10 RACGAP1 23023127 pred GP G G G G G G GP G GP G G GP G G G G GP G G G G G G GP G ARHGAP10 RHOG 23023127 pred GP GP G G G GP G G G G GP G GP GP G G GP G G G G G G G G G G G ARHGAP10 PKN2 21836163 pred GP GP G G G GP G G GP G GP G GP G G G GP G P G GP G G GP G G G GP G ARHGAP10 ARF1 23023127 pred GP GP G G G GP G GP G GP G GP GP G G GP G P G GP G G P G G GP G ARHGAP10 MCF2 21836163 pred P GP G GP G P G P P P GP GP P G P P GP ARHGAP10 ARAP1 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G G G G G GP G ARHGAP10 RHOF 23023127 pred G G G G G GP G G GP G G G G GP G G GP G G GP G G G G G G G G ARHGAP10 ARHGAP26 25402006 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G G G G G GP G ARHGAP10 ARHGEF12 21836163 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 RHOQ 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARHGAP10 ARHGDIA 21836163 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 OPHN1 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 ARHGAP4 23023127 pred G G G G G GP GP G G G G G ARHGAP10 RHOJ 23023127 pred GP GP G GP G G GP G GP GP GP G G GP GP P G GP G G GP G G G P G ARHGAP10 ABR 21836163 pred GP GP G G G GP G G GP G GP G GP G G G GP GP P G GP G G GP G G G GP G ARHGAP10 KALRN 21836163 pred P P G GP G P G P P P GP P P P G P ARHGAP10 RND3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARHGAP10 RHOB 21836163 pred G GP G G G GP G G G G G G GP G G G GP G P G GP G G G G G G GP G ARHGAP10 ARHGAP17 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G ARHGAP10 RASGRF1 21836163 pred P GP G G G GP G P G P P P GP P P P G P P G ARHGAP10 RHOU 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP GP P G GP G G GP G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R8D6 A1A4S6 two hybrid 11432776 direct interaction X 2 A0A024R8D6 A1A4S6 affinity chromatography technology 11432776 physical association X 2 A0A024R8D6 A1A4S6 pull down 11432776 direct interaction X 2 P0CG48 A1A4S6 affinity chromatography technology 21906983 physical association X 2 A1A4S6 A0A024RAE4 enzymatic study 11432776 direct interaction X 2 P27348 A1A4S6 pull down 15161933 direct interaction X 2 A0A024R324 A1A4S6 enzymatic study 11432776 direct interaction X 2 P35221 A1A4S6 two hybrid 16184169 association X 2 A0A024R8D6 A1A4S6 in vitro 11432776 - X 2 A0A024R8D6 A1A4S6 in vitro 11432776 - X 2 Q16512 A1A4S6 in vivo 11432776 - X 2 Q16512 A1A4S6 in vitro 11432776 - X 2 Q16512 A1A4S6 in vitro 11432776 - X 2 Q16512 A1A4S6 in vivo 11432776 - X 2 Q13177 A1A4S6 two hybrid 15471851 - X 2 Q13177 A1A4S6 in vitro 15471851 - X 2 Q13177 A1A4S6 in vivo 15471851 - X 2 Q13177 A1A4S6 two hybrid 15471851 - X 2 Q13177 A1A4S6 in vivo 15471851 - X 2 Q13177 A1A4S6 in vitro 15471851 - X 2 A0A024R8D6 A1A4S6 two hybrid 11432776 physical association X 2 A0A024R8D6 A1A4S6 anti tag coimmunoprecipitation 11432776 physical association X 2 A0A024R8D6 A1A4S6 pull down 11432776 physical association X 2 A0A024R8D6 A1A4S6 pull down 11432776 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality ARHGAP10 FOXQ1 25609649,25609649 0676,0004 HT ARHGAP10 C2CD2 26186194 0004 HT ARHGAP10 FOXQ1 25609649,25609649 0676,0004 HT ARHGAP10 C2CD2 26186194 0004 HT ARHGAP10 CTNNA1 16184169 0018 LC ARHGAP10 CDC42 11432776 0415 LC ARHGAP10 RHOA 11432776 0415 LC ARHGAP10 SH3BP2 25814554,25814554,25814554 0397,0018,1356 HT ARHGAP10 PAK2 15471851 0018 LC ARHGAP10 PKN3 11432776,11432776,11432776,11432776 0096,0007,0018,0004 LC ARHGAP10 ANKS1A 25814554,25814554 0397,0018 HT ARHGAP10 ARHA 11432776 0415 LC

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ARHGAP10 RHOD MI:0362 inference MI:1106 pathways database ARHGAP10 RHOBTB1 MI:0362 inference MI:1106 pathways database ARHGAP10 RHOC MI:0362 inference MI:1106 pathways database ARHGAP10 UBC MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP10 RAC2 MI:0362 inference MI:1106 pathways database ARHGAP10 RHOQ MI:0362 inference MI:1106 pathways database ARHGAP10 YWHAQ MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP10 RAC3 MI:0362 inference MI:1106 pathways database ARHGAP10 CDC42 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ARHGAP10 RHOA MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ARHGAP10 RHOB MI:0362 inference MI:1106 pathways database ARHGAP10 RAC1 MI:0362 inference MI:1106 pathways database ARHGAP10 SH3BP2 MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP10 RHOG MI:0362 inference MI:1106 pathways database ARHGAP10 PAK2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database ARHGAP10 PTK2B MI:0362 inference MI:0461 interaction database ARHGAP10 RHOH MI:0362 inference MI:1106 pathways database ARHGAP10 PKN3 MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP10 RHOU MI:0362 inference MI:1106 pathways database ARHGAP10 RHOT2 MI:0362 inference MI:1106 pathways database ARHGAP10 RHOT1 MI:0362 inference MI:1106 pathways database ARHGAP10 ANKS1A MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP10 RHOV MI:0362 inference MI:1106 pathways database ARHGAP10 RHOBTB2 MI:0362 inference MI:1106 pathways database ARHGAP10 FOXQ1 MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP10 RHOJ MI:0362 inference MI:1106 pathways database ARHGAP10 RHOF MI:0362 inference MI:1106 pathways database ARHGAP10 C2CD2 MI:0045 experimental interaction detection MI:0461 interaction database