PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RHOBTB1 COPS5 21145461 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G RHOBTB1 HSP90AB1 22939624 intact exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G DVL2 RHOBTB1 19888210 i2d exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G RHOBTB1 SMAD1 15761153 i2d exp G G G G G G GP G G G G G G G G G G G G G G G G G GP G RHOBTB1 COPS6 26186194,21145461 biogrid exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP P G GP GP GP GP G RHOBTB1 HSP90AA1 22939624 biogrid exp GP GP G GP G G GP G G G G G G G GP G G G GP G G G G G GP G RHOBTB1 CUL5 18835386 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G RHOBTB1 ACVR1 15761153 i2d exp GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP G RHOBTB1 AXIN2 19888210 i2d exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G RHOBTB1 CSNK1A1 19888210 i2d exp G G G G G G G G G G G G G G G G GP G G G G G G G G G BMPR1B RHOBTB1 15761153 i2d exp P GP G P GP G GP GP G GP P GP G GP GP GP GP G P GP P GP GP GP GP GP G RHOBTB1 CUL3 18835386,23040068,21145461 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G RHOBTB1 CSNK1E 19888210 i2d exp GP GP G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP P GP GP GP GP GP G RHOBTB1 TGFBR1 15761153 i2d exp GP G G P GP G GP GP G GP GP GP G G GP GP G G G G G G GP G GP G G RHOBTB1 SMAD2 15761153 i2d exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G RHOBTB1 CLIC4 25402006 pred G GP G P GP G GP GP G GP GP GP GP G G GP G GP G GP GP G G GP GP GP G RHOBTB1 RIN2 16082366 pred GP GP G P GP G GP GP G GP GP GP G G GP GP G GP G GP GP P GP GP GP GP P G RHOBTB1 RIN1 16082366 pred GP GP G P GP G GP GP G GP GP GP G G GP GP GP GP G GP GP P GP GP G GP GP G RHOBTB1 UBXN2B 25402006 pred G GP G G G G GP G GP G GP G G GP G GP G G G GP G GP G GP GP G RHOBTB1 EGR2 21836163 pred G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RHOBTB1 UBC MI:0004(affinity chromatography technology) 21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_178034 prey bait RHOBTB1 HSP90AB1 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125081 bait prey RHOBTB1 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205459 prey bait RHOBTB1 COPS6 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205731 prey bait RHOBTB1 CUL3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18835386,21145461,23040068 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_227299|BIOGRID_201946|BIOGRID_209134|BIOGRID_227300|BIOGRID_209215|BIOGRID_209129 prey|prey|bait|bait|prey|bait bait|bait|prey|prey|bait|prey RHOBTB1 HSP90AA1 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255446 prey bait RHOBTB1 CUL5 MI:0004(affinity chromatography technology) 18835386 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_209135 bait prey

PPI - HINT Gene A Gene B PMID Method Quality RHOBTB1 CUL3 23040068,21145461,26100637,18835386,18835386 0004,0004,0004,0004,0018 LC,HT RHOBTB1 COPS6 21145461,26186194 0004,0004 HT RHOBTB1 COPS5 21145461 0004 HT RHOBTB1 CUL3 21145461 0004 HT RHOBTB1 COPS6 21145461,26186194 0004,0004 HT RHOBTB1 COPS5 21145461 0004 HT RHOBTB1 CUL3 23040068,26100637,18835386,18835386 0004,0004,0004,0018 LC BMPR1B RHOBTB1 15761153 0019 HT RHOBTB1 HSP90AB1 22939624 0729 HT RHOBTB1 TGFBR1 15761153 0019 HT RHOBTB1 ACVR1 15761153 0019 HT RHOBTB1 CUL3 18835386,18835386 0004,0018 LC RHOBTB1 SMAD2 15761153 0019 HT RHOBTB1 SMAD1 15761153 0019 HT RHOBTB1 CUL5 18835386 0018 LC RHOBTB1 SMURF1 15761153 0019 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8K1C9 O94844 LRRC41 RHOBTB1 0.376 22709582 P08238 O94844 HSP90AB1 RHOBTB1 0.126 22939624 Q93034 O94844 CUL5 RHOBTB1 0.309 18835386 P07900 O94844 HSP90AA1 RHOBTB1 0.126 22939624 Q7L5N1 O94844 COPS6 RHOBTB1 0.236 21145461,26186194 O94844 A2AUM9 RHOBTB1 CEP152 0.236 26496610 Q13618 O94844 CUL3 RHOBTB1 0.814 18835386,21145461,26100637,23040068 Q92905 O94844 COPS5 RHOBTB1 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ARHGAP10 RHOBTB1 MI:0362 inference MI:1106 pathways database ARHGAP32 RHOBTB1 MI:0362 inference MI:1106 pathways database MYO9A RHOBTB1 MI:0362 inference MI:1106 pathways database BMPR1B RHOBTB1 MI:0045 experimental interaction detection MI:0461 interaction database PIK3R2 RHOBTB1 MI:0362 inference MI:1106 pathways database ARHGAP33 RHOBTB1 MI:0362 inference MI:1106 pathways database RASGRF2 RHOBTB1 MI:0362 inference MI:1106 pathways database MCF2L RHOBTB1 MI:0362 inference MI:1106 pathways database ARHGEF11 RHOBTB1 MI:0362 inference MI:1106 pathways database ARHGAP6 RHOBTB1 MI:0362 inference MI:1106 pathways database SRGAP3 RHOBTB1 MI:0362 inference MI:1106 pathways database ARHGEF9 RHOBTB1 MI:0362 inference MI:1106 pathways database KALRN RHOBTB1 MI:0362 inference MI:1106 pathways database OPHN1 RHOBTB1 MI:0362 inference MI:1106 pathways database SRGAP2 RHOBTB1 MI:0362 inference MI:1106 pathways database TRIO RHOBTB1 MI:0362 inference MI:1106 pathways database PLEKHG5 RHOBTB1 MI:0362 inference MI:1106 pathways database RHOBTB1 CEP152 MI:0362 inference MI:0461 interaction database RHOBTB1 FAM13A MI:0362 inference MI:1106 pathways database RHOBTB1 A2M MI:0362 inference MI:1106 pathways database RHOBTB1 HSP90AA1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 HSP90AB1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 UBC MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 MCF2 MI:0362 inference MI:1106 pathways database RHOBTB1 BCR MI:0362 inference MI:1106 pathways database RHOBTB1 VAV1 MI:0362 inference MI:1106 pathways database RHOBTB1 CHN1 MI:0362 inference MI:1106 pathways database RHOBTB1 TAF1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 GDI1 MI:0362 inference MI:1106 pathways database RHOBTB1 INPP5B MI:0362 inference MI:1106 pathways database RHOBTB1 TGFBR1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 ARHGAP25 MI:0362 inference MI:1106 pathways database RHOBTB1 GDI2 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGDIA MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGDIB MI:0362 inference MI:1106 pathways database RHOBTB1 VAV2 MI:0362 inference MI:1106 pathways database RHOBTB1 CHN2 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP8 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP4 MI:0362 inference MI:1106 pathways database RHOBTB1 FGD1 MI:0362 inference MI:1106 pathways database RHOBTB1 OCRL MI:0362 inference MI:1106 pathways database RHOBTB1 ACVR1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 SOS1 MI:0362 inference MI:1106 pathways database RHOBTB1 SOS2 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP1 MI:0362 inference MI:1106 pathways database RHOBTB1 AKAP13 MI:0362 inference MI:1106 pathways database RHOBTB1 ABR MI:0362 inference MI:1106 pathways database RHOBTB1 TIAM1 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP5 MI:0362 inference MI:1106 pathways database RHOBTB1 MYO9B MI:0362 inference MI:1106 pathways database RHOBTB1 CUL3 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 ARHGEF7 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP19 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF6 MI:0362 inference MI:1106 pathways database RHOBTB1 RALBP1 MI:0362 inference MI:1106 pathways database RHOBTB1 LRRC41 MI:0362 inference MI:0461 interaction database RHOBTB1 TRIP10 MI:0362 inference MI:1106 pathways database RHOBTB1 SMAD2 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 SMAD1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 ITSN1 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP44 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP31 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP11B MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP29 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP15 MI:0362 inference MI:1106 pathways database RHOBTB1 FGD3 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP40 MI:0362 inference MI:1106 pathways database RHOBTB1 OBSCN MI:0362 inference MI:1106 pathways database RHOBTB1 SYDE2 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF16 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP17 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP11A MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP36 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF18 MI:0362 inference MI:1106 pathways database RHOBTB1 SYDE1 MI:0362 inference MI:1106 pathways database RHOBTB1 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 ARHGAP22 MI:0362 inference MI:1106 pathways database RHOBTB1 NET1 MI:0362 inference MI:1106 pathways database RHOBTB1 SRGAP1 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP30 MI:0362 inference MI:1106 pathways database RHOBTB1 FGD2 MI:0362 inference MI:1106 pathways database RHOBTB1 TIAM2 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF19 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP12 MI:0362 inference MI:1106 pathways database RHOBTB1 TAGAP MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP24 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP18 MI:0362 inference MI:1106 pathways database RHOBTB1 NGEF MI:0362 inference MI:1106 pathways database RHOBTB1 PREX1 MI:0362 inference MI:1106 pathways database RHOBTB1 DEPDC1B MI:0362 inference MI:1106 pathways database RHOBTB1 ARAP3 MI:0362 inference MI:1106 pathways database RHOBTB1 ARAP2 MI:0362 inference MI:1106 pathways database RHOBTB1 STARD8 MI:0362 inference MI:1106 pathways database RHOBTB1 HMHA1 MI:0362 inference MI:1106 pathways database RHOBTB1 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 ARHGEF2 MI:0362 inference MI:1106 pathways database RHOBTB1 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 FGD4 MI:0362 inference MI:1106 pathways database RHOBTB1 ARAP1 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF17 MI:0362 inference MI:1106 pathways database RHOBTB1 DLC1 MI:0362 inference MI:1106 pathways database RHOBTB1 DEPDC7 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGDIG MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP9 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP39 MI:0362 inference MI:1106 pathways database RHOBTB1 RACGAP1 MI:0362 inference MI:1106 pathways database RHOBTB1 PLEKHG2 MI:0362 inference MI:1106 pathways database RHOBTB1 ECT2 MI:0362 inference MI:1106 pathways database RHOBTB1 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB1 ARHGEF4 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF3 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP35 MI:0362 inference MI:1106 pathways database RHOBTB1 FAM13B MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGEF12 MI:0362 inference MI:1106 pathways database RHOBTB1 GMIP MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP23 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP20 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP28 MI:0362 inference MI:1106 pathways database RHOBTB1 VAV3 MI:0362 inference MI:1106 pathways database RHOBTB1 ARHGAP26 MI:0362 inference MI:1106 pathways database RHOBTB1 STARD13 MI:0362 inference MI:1106 pathways database