PTM - CPLM Gene Name UniProt ID Type Position Code MARK2; EMK1 Q7KZI7 Ubiquitination 637 K

PTM - dbPAF Gene Name UniProt ID Position Type Species MARK2; EMK1 Q7KZI7 10 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 197 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 2 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 20 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 201 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 208 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 212 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 26 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 29 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 290 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 3 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 30 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 323 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 329 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 337 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 338 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 351 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 357 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 358 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 363 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 365 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 366 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 380 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 384 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 386 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 387 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 390 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 392 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 40 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 400 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 409 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 419 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 42 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 420 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 422 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 423 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 43 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 449 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 450 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 456 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 466 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 467 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 469 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 471 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 472 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 474 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 477 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 478 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 479 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 483 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 486 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 493 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 498 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 514 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 515 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 533 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 535 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 559 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 560 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 569 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 571 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 576 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 577 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 578 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 58 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 592 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 593 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 595 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 596 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 6 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 613 Y Homo sapiens(Human) MARK2; EMK1 Q7KZI7 616 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 619 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 621 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 624 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 631 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 633 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 648 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 667 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 675 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 692 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 698 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 701 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 702 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 722 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 769 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 87 T Homo sapiens(Human) MARK2; EMK1 Q7KZI7 91 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 92 S Homo sapiens(Human) MARK2; EMK1 Q7KZI7 93 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type MARK2; EMK1 rs1135236 GCC->CCC A->P 422 Y AIPTSNSYSKKTQSN 423 Phosphorylation TypeIII- MARK2; EMK1 rs1135236 GCC->CCC A->P 389 Y AIPTSNSYSKKTQSN 423 Phosphorylation TypeIII- MARK2; EMK1 rs1135236 GCC->CCC A->P 389 Y AIPTSNSYSKKTQSN 423 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q7KZI7 R589-m1 Methylation PDRTNFPrGVssRst Q7KZI7 R628-m1 Methylation sGHsQGRrGAsGsIF Q7KZI7 T6-p Phosphorylation __MSSARtPLPTLNE Q7KZI7 T20-p Phosphorylation ERDTEQPtLGHLDsK Q7KZI7 S26-p Phosphorylation PtLGHLDsKPssKSN Q7KZI7 S29-p Phosphorylation GHLDsKPssKSNMIR Q7KZI7 S30-p Phosphorylation HLDsKPssKSNMIRG Q7KZI7 S40-p Phosphorylation NMIRGRNsAtsADEQ Q7KZI7 T42-p Phosphorylation IRGRNsAtsADEQPH Q7KZI7 S43-p Phosphorylation RGRNsAtsADEQPHI Q7KZI7 T58-p Phosphorylation GNYRLLKtIGKGNFA Q7KZI7 T87-p Phosphorylation AVKIIDKtQLNSSSL Q7KZI7 S197-p Phosphorylation KIADFGFsNEFtFGN Q7KZI7 T201-p Phosphorylation FGFsNEFtFGNKLDt Q7KZI7 T208-p Phosphorylation tFGNKLDtFCGsPPY Q7KZI7 S212-p Phosphorylation KLDtFCGsPPYAAPE Q7KZI7 S290-p Phosphorylation KFLILNPsKRGTLEQ Q7KZI7 Y323-p Phosphorylation YVEPLPDyKDPRRtE Q7KZI7 T329-p Phosphorylation DyKDPRRtELMVSMG Q7KZI7 Y337-p Phosphorylation ELMVSMGytREEIQD Q7KZI7 T338-p Phosphorylation LMVSMGytREEIQDS Q7KZI7 Y351-p Phosphorylation DSLVGQRyNEVMATy Q7KZI7 Y358-p Phosphorylation yNEVMATyLLLGyKs Q7KZI7 Y363-p Phosphorylation ATyLLLGyKsSELEG Q7KZI7 S365-p Phosphorylation yLLLGyKsSELEGDT Q7KZI7 S380-p Phosphorylation ITLKPRPsADLTNsS Q7KZI7 S386-p Phosphorylation PsADLTNsSAPsPSH Q7KZI7 S390-p Phosphorylation LTNsSAPsPSHKVQR Q7KZI7 S398-p Phosphorylation PSHKVQRsVsANPKQ Q7KZI7 S400-p Phosphorylation HKVQRsVsANPKQRR Q7KZI7 S409-p Phosphorylation NPKQRRFsDQAAGPA Q7KZI7 S422-p Phosphorylation PAIPTSNsYSKKTQS Q7KZI7 S449-p Phosphorylation ESGRKASsTAKVPAs Q7KZI7 S456-p Phosphorylation sTAKVPAsPLPGLER Q7KZI7 T466-p Phosphorylation PGLERKKttPtPstN Q7KZI7 T467-p Phosphorylation GLERKKttPtPstNS Q7KZI7 T469-p Phosphorylation ERKKttPtPstNSVL Q7KZI7 S471-p Phosphorylation KKttPtPstNSVLsT Q7KZI7 T472-p Phosphorylation KttPtPstNSVLsTs Q7KZI7 S477-p Phosphorylation PstNSVLsTsTNRsR Q7KZI7 S479-p Phosphorylation tNSVLsTsTNRsRNs Q7KZI7 S483-p Phosphorylation LsTsTNRsRNsPLLE Q7KZI7 S486-p Phosphorylation sTNRsRNsPLLERAs Q7KZI7 S493-p Phosphorylation sPLLERAsLGQAsIQ Q7KZI7 S498-p Phosphorylation RAsLGQAsIQNGKDs Q7KZI7 S505-p Phosphorylation sIQNGKDsLTMPGSR Q7KZI7 S514-p Phosphorylation TMPGSRAsTASASAA Q7KZI7 S533-p Phosphorylation RPRQHQKsMsASVHP Q7KZI7 S535-p Phosphorylation RQHQKsMsASVHPNK Q7KZI7 S569-p Phosphorylation PQRVPVAsPsAHNIs Q7KZI7 S571-p Phosphorylation RVPVAsPsAHNIsSs Q7KZI7 S576-p Phosphorylation sPsAHNIsSsGGAPD Q7KZI7 S578-p Phosphorylation sAHNIsSsGGAPDRT Q7KZI7 S592-p Phosphorylation TNFPrGVssRstFHA Q7KZI7 S593-p Phosphorylation NFPrGVssRstFHAG Q7KZI7 S595-p Phosphorylation PrGVssRstFHAGQL Q7KZI7 T596-p Phosphorylation rGVssRstFHAGQLR Q7KZI7 Y613-p Phosphorylation RDQQNLPyGVtPAsP Q7KZI7 T616-p Phosphorylation QNLPyGVtPAsPsGH Q7KZI7 S619-p Phosphorylation PyGVtPAsPsGHsQG Q7KZI7 S621-p Phosphorylation GVtPAsPsGHsQGRr Q7KZI7 S624-p Phosphorylation PAsPsGHsQGRrGAs Q7KZI7 S631-p Phosphorylation sQGRrGAsGsIFSkF Q7KZI7 S633-p Phosphorylation GRrGAsGsIFSkFTS Q7KZI7 S648-p Phosphorylation KFVRRNLsFRFARRN Q7KZI7 T667-p Phosphorylation ESKDRVEtLRPHVVG Q7KZI7 S675-p Phosphorylation LRPHVVGsGGNDKEK Q7KZI7 S692-p Phosphorylation FREAKPRsLRFTWsM Q7KZI7 S698-p Phosphorylation RsLRFTWsMKTTSSM Q7KZI7 S722-p Phosphorylation RKVLDANsCQSELHE Q7KZI7 S759-p Phosphorylation VCKLPRLsLNGVRFK Q7KZI7 K637-ub Ubiquitination AsGsIFSkFTSKFVR

PTM - dbPTM UniProt ID Position Code Type Resources References Q7KZI7 29 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 40 S Phosphorylation Swiss-Prot 1010711 17192257;18220336;18691976;19369195 Q7KZI7 42 T Phosphorylation Swiss-Prot 1010711 18220336;19369195 Q7KZI7 43 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q7KZI7 197 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 208 T Phosphorylation Swiss-Prot 1010711 14976552;17192257;19369195 Q7KZI7 365 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 390 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q7KZI7 409 S Phosphorylation Swiss-Prot 1010711 18669648;18691976;19369195 Q7KZI7 419 T Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 420 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 422 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 423 Y Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 456 S Phosphorylation Swiss-Prot 1010711 15302935;16964243;17192257;18088087;18220336;18669648;18691976;19369195;19413330;19690332 Q7KZI7 469 T Phosphorylation Swiss-Prot 1010711 17192257 Q7KZI7 471 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 479 S Phosphorylation Swiss-Prot 1010711 17192257;19369195 Q7KZI7 483 S Phosphorylation Swiss-Prot 1010711 18691976 Q7KZI7 486 S Phosphorylation Swiss-Prot 1010711 17081983;17192257;18220336;18691976;19369195 Q7KZI7 493 S Phosphorylation Swiss-Prot 1010711 18691976 Q7KZI7 533 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 569 S Phosphorylation Swiss-Prot 1010711 17192257;18220336;18669648;18691976;19369195 Q7KZI7 571 S Phosphorylation Swiss-Prot 1010711 17192257;18220336;19369195;19690332 Q7KZI7 576 S Phosphorylation Swiss-Prot 1010711 18220336 Q7KZI7 596 T Phosphorylation Swiss-Prot 1010711 15084291;15324659 Q7KZI7 619 S Phosphorylation Swiss-Prot 1010711 17192257;18220336;18691976;19369195 Q7KZI7 621 S Phosphorylation Swiss-Prot 1010711 18220336;19369195 Q7KZI7 631 S Phosphorylation Swiss-Prot 1010711 17192257;18691976;19369195 Q7KZI7 667 T Phosphorylation Swiss-Prot 1010711 18691976 Q7KZI7 722 S Phosphorylation Swiss-Prot 1010711 19369195 Q7KZI7 40 S Phosphorylation PhosphoELM.10011 18220336;17192257 Q7KZI7 43 S Phosphorylation PhosphoELM.10011 18220336 Q7KZI7 409 S Phosphorylation PhosphoELM.10011 18669648 Q7KZI7 456 S Phosphorylation PhosphoELM.10011 18669648;18220336;18088087;16964243;17192257;15302935 Q7KZI7 479 S Phosphorylation PhosphoELM.10011 17192257 Q7KZI7 486 S Phosphorylation PhosphoELM.10011 18220336;17192257;17081983 Q7KZI7 569 S Phosphorylation PhosphoELM.10011 18669648;18220336;17192257 Q7KZI7 571 S Phosphorylation PhosphoELM.10011 18220336;17192257 Q7KZI7 576 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q7KZI7 595 S Phosphorylation PhosphoELM.10011 18220336 Q7KZI7 619 S Phosphorylation PhosphoELM.10011 18669648;18220336;17192257 Q7KZI7 621 S Phosphorylation PhosphoELM.10011 18220336 Q7KZI7 624 S Phosphorylation PhosphoELM.10011 18669648 Q7KZI7 631 S Phosphorylation PhosphoELM.10011 17192257 Q7KZI7 42 T Phosphorylation PhosphoELM.10011 18220336 Q7KZI7 469 T Phosphorylation PhosphoELM.10011 17192257 Q7KZI7 208 T Phosphorylation PhosphoELM.10011 17192257;14976552 Q7KZI7 596 T Phosphorylation PhosphoELM.10011 15324659 Q7KZI7 637 K Ubiquitylation Phosphositeplus.1010730 21890473 Q7KZI7 197 S Phosphorylation Phosphositeplus.1010730 19369195 Q7KZI7 212 S Phosphorylation Phosphositeplus.1010730 18424437;18669648;18691976;19664994;22238344 Q7KZI7 290 S Phosphorylation Phosphositeplus.1010730 21406692 Q7KZI7 365 S Phosphorylation Phosphositeplus.1010730 19369195 Q7KZI7 390 S Phosphorylation Phosphositeplus.1010730 18691976;19276368;19369195 Q7KZI7 40 S Phosphorylation Phosphositeplus.1010730 17192257;18220336;18691976;19276368;19369195;20363803;21406692;22067460 Q7KZI7 400 S Phosphorylation Phosphositeplus.1010730 19011111 Q7KZI7 409 S Phosphorylation Phosphositeplus.1010730 18691976;19276368;19369195;22067460 Q7KZI7 422 S Phosphorylation Phosphositeplus.1010730 19369195 Q7KZI7 43 S Phosphorylation Phosphositeplus.1010730 18220336;18691976;19276368;19369195 Q7KZI7 456 S Phosphorylation Phosphositeplus.1010730 15302935;16964243;17192257;18088087;18220336;18669648;18691976;19276368;19369195;19664994;19664995;19690332;20058876;20068231;21659604;22067460;22115753 Q7KZI7 471 S Phosphorylation Phosphositeplus.1010730 19369195 Q7KZI7 479 S Phosphorylation Phosphositeplus.1010730 17192257;19369195;22067460 Q7KZI7 483 S Phosphorylation Phosphositeplus.1010730 18691976;20363803 Q7KZI7 486 S Phosphorylation Phosphositeplus.1010730 17192257;18220336;18691976;19276368;19369195;19664995;19691289;20166139;20363803;20815410;21406692;22067460;22115753 Q7KZI7 493 S Phosphorylation Phosphositeplus.1010730 18691976;22067460 Q7KZI7 533 S Phosphorylation Phosphositeplus.1010730 19369195 Q7KZI7 569 S Phosphorylation Phosphositeplus.1010730 17192257;18220336;18669648;18691976;19276368;19369195;22067460 Q7KZI7 571 S Phosphorylation Phosphositeplus.1010730 17192257;18220336;19276368;19362540;19369195;19690332;22067460 Q7KZI7 576 S Phosphorylation Phosphositeplus.1010730 18220336 Q7KZI7 578 S Phosphorylation Phosphositeplus.1010730 19276368 Q7KZI7 592 S Phosphorylation Phosphositeplus.1010730 22322096 Q7KZI7 593 S Phosphorylation Phosphositeplus.1010730 22322096 Q7KZI7 595 S Phosphorylation Phosphositeplus.1010730 18220336;19276368;22322096 Q7KZI7 619 S Phosphorylation Phosphositeplus.1010730 17192257;18220336;18669648;18691976;19276368;19369195;20068231;21406692;22067460 Q7KZI7 621 S Phosphorylation Phosphositeplus.1010730 18220336 Q7KZI7 624 S Phosphorylation Phosphositeplus.1010730 18669648;19276368 Q7KZI7 631 S Phosphorylation Phosphositeplus.1010730 17192257;18691976;19369195;21406692;22115753 Q7KZI7 675 S Phosphorylation Phosphositeplus.1010730 22067460 Q7KZI7 722 S Phosphorylation Phosphositeplus.1010730 19369195 Q7KZI7 208 T Phosphorylation Phosphositeplus.1010730 14976552;17192257;18424437;18691976;19276368;19362540;19369195;19664994;21406692;21659604;22238344 Q7KZI7 42 T Phosphorylation Phosphositeplus.1010730 18220336;19369195 Q7KZI7 469 T Phosphorylation Phosphositeplus.1010730 17192257 Q7KZI7 472 T Phosphorylation Phosphositeplus.1010730 17192257;18691976 Q7KZI7 58 T Phosphorylation Phosphositeplus.1010730 17192257;18691976;19276368;19369195;22067460 Q7KZI7 596 T Phosphorylation Phosphositeplus.1010730 15084291;15324659;19011111;22322096 Q7KZI7 667 T Phosphorylation Phosphositeplus.1010730 18691976 Q7KZI7 613 Y Phosphorylation Phosphositeplus.1010730 18180459;20007894 Q7KZI7 2 S Acetylation HPRD 9.0 19413330 Q7KZI7 40 S Phosphorylation HPRD 9.0 18691976,20068231 Q7KZI7 43 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 212 S Phosphorylation HPRD 9.0 19664994 Q7KZI7 390 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 409 S Phosphorylation HPRD 9.0 18669648,19651622 Q7KZI7 409 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 422 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,18088087,19664995,19664994,18691976,20068231,20058876 Q7KZI7 449 S Phosphorylation HPRD 9.0 19651622,18691976 Q7KZI7 456 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,18088087,19664995,19664994,18691976,20068231,20058876 Q7KZI7 471 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 479 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 483 S Phosphorylation HPRD 9.0 19651622,18691976 Q7KZI7 486 S Phosphorylation HPRD 9.0 17322306,19664995,19651622,19691289,18767875,18691976,18212344,20166139 Q7KZI7 493 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 514 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 Q7KZI7 535 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 Q7KZI7 569 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 Q7KZI7 569 S Phosphorylation HPRD 9.0 18669648 Q7KZI7 576 S Phosphorylation HPRD 9.0 18669648,18691976 Q7KZI7 576 S Phosphorylation HPRD 9.0 18691976,20068231 Q7KZI7 619 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 Q7KZI7 621 S Phosphorylation HPRD 9.0 18691976,20068231 Q7KZI7 624 S Phosphorylation HPRD 9.0 18669648 Q7KZI7 631 S Phosphorylation HPRD 9.0 18691976,20068231 Q7KZI7 769 S Phosphorylation HPRD 9.0 18691976 Q7KZI7 6 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 42 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 208 T Phosphorylation HPRD 9.0 19664994 Q7KZI7 384 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 419 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 466 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 472 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 596 T Phosphorylation HPRD 9.0 20068231 Q7KZI7 667 T Phosphorylation HPRD 9.0 18691976 Q7KZI7 613 Y Phosphorylation HPRD 9.0 18691976 Q7KZI7 40 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 43 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 390 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 409 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 456 S Phosphorylation SysPTM 1.1 18691976;15302935;18088087 Q7KZI7 483 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 486 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 493 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 577 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 456 S Phosphorylation SysPTM 1.1 16964243;18669648 Q7KZI7 486 S Phosphorylation SysPTM 1.1 17081983;18212344 Q7KZI7 569 S Phosphorylation SysPTM 1.1 18669648 Q7KZI7 619 S Phosphorylation SysPTM 1.1 18691976 Q7KZI7 667 T Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References MARK2 10 S Phosphorylation 18691976 MARK2 175 T Phosphorylation 19664994 MARK2 179 S Phosphorylation 19664994 MARK2 2 S Acetylation 19413330 MARK2 208 T Phosphorylation 19664994 MARK2 212 S Phosphorylation 19664994 MARK2 351 T Phosphorylation 18691976 MARK2 357 S Phosphorylation 18691976 MARK2 376 S Phosphorylation 18669648,19651622 MARK2 384 T Phosphorylation 18691976 MARK2 390 S Phosphorylation 18691976 MARK2 40 S Phosphorylation 18691976,20068231 MARK2 409 S Phosphorylation 18669648,19651622 MARK2 409 S Phosphorylation 18691976 MARK2 419 T Phosphorylation 18691976 MARK2 42 T Phosphorylation 18691976 MARK2 422 S Phosphorylation 17322306,18669648,19413330,18088087,19664995,19664994,18691976,20068231,20058876 MARK2 43 S Phosphorylation 18691976 MARK2 432 T Phosphorylation 18691976 MARK2 437 S Phosphorylation 18691976 MARK2 438 T Phosphorylation 18691976 MARK2 445 S Phosphorylation 18691976 MARK2 449 S Phosphorylation 19651622,18691976 MARK2 452 S Phosphorylation 17322306,19664995,19651622,19691289,18767875,18691976,18212344,20166139 MARK2 455 S Phosphorylation 17322306,18669648,19413330,18088087,19664995,19664994,18691976,20068231,20058876 MARK2 456 S Phosphorylation 17322306,18669648,19413330,18088087,19664995,19664994,18691976,20068231,20058876 MARK2 459 S Phosphorylation 18691976 MARK2 465 T Phosphorylation 18691976 MARK2 466 T Phosphorylation 18691976 MARK2 470 S Phosphorylation 18691976 MARK2 471 S Phosphorylation 18691976 MARK2 471 T Phosphorylation 18691976 MARK2 472 T Phosphorylation 18691976 MARK2 478 S Phosphorylation 18691976 MARK2 479 S Phosphorylation 18691976 MARK2 482 S Phosphorylation 19651622,18691976 MARK2 483 S Phosphorylation 19651622,18691976 MARK2 485 S Phosphorylation 17322306,19664995,19651622,19691289,18767875,18691976,18212344,20166139 MARK2 486 S Phosphorylation 17322306,19664995,19651622,19691289,18767875,18691976,18212344,20166139 MARK2 492 S Phosphorylation 18691976 MARK2 493 S Phosphorylation 18691976 MARK2 514 S Phosphorylation 18669648,18691976,20068231 MARK2 516 S Phosphorylation 18691976 MARK2 521 S Phosphorylation 18669648,18691976 MARK2 535 S Phosphorylation 18669648,18691976,20068231 MARK2 541 T Phosphorylation 15324659,20068231 MARK2 541 T Phosphorylation 20068231 MARK2 542 S Phosphorylation 18669648,18691976 MARK2 558 Y Phosphorylation 18691976 MARK2 562 T Phosphorylation 15324659,20068231 MARK2 564 S Phosphorylation 18669648,18691976,20068231 MARK2 566 S Phosphorylation 18691976,20068231 MARK2 569 S Phosphorylation 18669648 MARK2 569 S Phosphorylation 18669648,18691976,20068231 MARK2 576 S Phosphorylation 18669648,18691976 MARK2 576 S Phosphorylation 18691976,20068231 MARK2 579 Y Phosphorylation 18691976 MARK2 585 S Phosphorylation 18669648,18691976,20068231 MARK2 587 S Phosphorylation 18691976,20068231 MARK2 590 S Phosphorylation 18669648 MARK2 596 T Phosphorylation 20068231 MARK2 597 S Phosphorylation 18691976,20068231 MARK2 6 T Phosphorylation 18691976 MARK2 603 T Phosphorylation 18691976 MARK2 613 Y Phosphorylation 18691976 MARK2 619 S Phosphorylation 18669648,18691976,20068231 MARK2 621 S Phosphorylation 18691976,20068231 MARK2 624 S Phosphorylation 18669648 MARK2 624 T Phosphorylation 18691976 MARK2 631 S Phosphorylation 18691976,20068231 MARK2 667 T Phosphorylation 18691976 MARK2 7 S Phosphorylation 18691976,20068231 MARK2 705 S Phosphorylation 18691976 MARK2 726 S Phosphorylation 18691976 MARK2 769 S Phosphorylation 18691976 MARK2 9 T Phosphorylation 18691976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q7KZI7 208 T 17192257 HTP Phosphorylation Q7KZI7 208 T 14976552 LKB1 LTP Phosphorylation Q7KZI7 576 S 18669648 HTP Phosphorylation Q7KZI7 576 S 18220336 HTP Phosphorylation Q7KZI7 619 S 18669648 HTP Phosphorylation Q7KZI7 619 S 18220336 HTP Phosphorylation Q7KZI7 619 S 17192257 HTP Phosphorylation Q7KZI7 569 S 18669648 HTP Phosphorylation Q7KZI7 569 S 18220336 HTP Phosphorylation Q7KZI7 569 S 17192257 HTP Phosphorylation Q7KZI7 486 S 18220336 HTP Phosphorylation Q7KZI7 486 S 17192257 HTP Phosphorylation Q7KZI7 486 S 17081983 HTP Phosphorylation Q7KZI7 456 S 18669648 HTP Phosphorylation Q7KZI7 456 S 18220336 HTP Phosphorylation Q7KZI7 456 S 18088087 HTP Phosphorylation Q7KZI7 456 S 16964243 HTP Phosphorylation Q7KZI7 456 S 17192257 HTP Phosphorylation Q7KZI7 456 S 15302935 HTP Phosphorylation Q7KZI7 42 T 18220336 HTP Phosphorylation Q7KZI7 43 S 18220336 HTP Phosphorylation Q7KZI7 621 S 18220336 HTP Phosphorylation Q7KZI7 624 S 18669648 HTP Phosphorylation Q7KZI7 40 S 18220336 HTP Phosphorylation Q7KZI7 40 S 17192257 HTP Phosphorylation Q7KZI7 595 S 18220336 HTP Phosphorylation Q7KZI7 596 T 15324659 PKC_alpha LTP Phosphorylation Q7KZI7 469 T 17192257 HTP Phosphorylation Q7KZI7 631 S 17192257 HTP Phosphorylation Q7KZI7 409 S 18669648 HTP Phosphorylation Q7KZI7 571 S 18220336 HTP Phosphorylation Q7KZI7 571 S 17192257 HTP Phosphorylation Q7KZI7 479 S 17192257 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q7KZI7 40 Phosphoserine 21406692;23186163 Q7KZI7 208 Phosphothreonine; by LKB1 and TAOK1 19369195;14976552 Q7KZI7 409 Phosphoserine 18691976;19369195 Q7KZI7 456 Phosphoserine 16964243;18088087;18220336;18691976;19369195;23186163 Q7KZI7 467 Phosphothreonine 23186163 Q7KZI7 486 Phosphoserine 17081983;18220336;18691976;19369195;21406692;23186163 Q7KZI7 493 Phosphoserine 18691976 Q7KZI7 569 Phosphoserine 18669648;23186163 Q7KZI7 571 Phosphoserine 23186163 Q7KZI7 592 Phosphoserine 23186163 Q7KZI7 596 Phosphothreonine; by PKC/PRKCZ 23186163;15084291;15324659 Q7KZI7 619 Phosphoserine 21406692;23186163 Q7KZI7 722 Phosphoserine 19369195

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type MARK2 IPI00290158 S 453 TNRSRNpSPLLERA phosphorylation MARK2 IPI00555838 S 2 _____MpSSARTPL phosphorylation MARK2 IPI00555838 S 3 ____MSpSARTPLP phosphorylation MARK2 IPI00555838 S 409 PKQRRFpSDQAAGP phosphorylation MARK2 IPI00555838 S 422 AIPTSNpSYSKKTQ phosphorylation MARK2 IPI00555838 S 569 QRVPVApSPSAHNI phosphorylation MARK2 IPI00555838 S 619 YGVTPApSPSGHSQ phosphorylation MARK2 IPI00555838 T 10 ARTPLPpTLNERDT phosphorylation MARK2 IPI00555838 T 596 GVSSRSpTFHAGQL phosphorylation MARK2 IPI00555838 T 6 _MSSARpTPLPTLN phosphorylation MARK2 IPI00556171 S 212 LDTFCGpSPPYAAP phosphorylation MARK2 IPI00556171 S 390 TNSSAPpSPSHKVQ phosphorylation MARK2 IPI00556171 S 40 MIRGRNpSATSADE phosphorylation MARK2 IPI00556171 S 409 PKQRRFpSDQAAGP phosphorylation MARK2 IPI00556171 S 43 GRNSATpSADEQPH phosphorylation MARK2 IPI00556171 S 456 TAKVPApSPLPGLE phosphorylation MARK2 IPI00556171 S 483 STSTNRpSRNSPLL phosphorylation MARK2 IPI00556171 S 486 TNRSRNpSPLLERA phosphorylation MARK2 IPI00556171 S 493 PLLERApSLGQASI phosphorylation MARK2 IPI00556171 S 515 QRVPVApSPSAHNI phosphorylation MARK2 IPI00556171 S 565 YGVTPApSPSGHSQ phosphorylation MARK2 IPI00556171 S 577 QGRRGApSGSIFSK phosphorylation MARK2 IPI00556171 T 208 FGNKLDpTFCGSPP phosphorylation MARK2 IPI00556171 T 472 TTPTPSpTNSVLST phosphorylation MARK2 IPI00556171 T 58 NYRLLKpTIGKGNF phosphorylation MARK2 IPI00556171 T 604 SKDRVEpTLRPHVV phosphorylation MARK2 IPI00719075 S 10 GRNSATpSADEQPH phosphorylation MARK2 IPI00719075 S 164 IADFGFpSNEFTFG phosphorylation MARK2 IPI00719075 S 332 LLLGYKpSSELEGD phosphorylation MARK2 IPI00719075 S 357 TNSSAPpSPSHKVQ phosphorylation MARK2 IPI00719075 S 376 PKQRRFpSDQAGPA phosphorylation MARK2 IPI00719075 S 388 AIPTSNpSYSKKTQ phosphorylation MARK2 IPI00719075 S 422 TAKVPApSPLPGLE phosphorylation MARK2 IPI00719075 S 437 KTTPTPpSTNSVLS phosphorylation MARK2 IPI00719075 S 445 NSVLSTpSTNRSRN phosphorylation MARK2 IPI00719075 S 452 TNRSRNpSPLLERA phosphorylation MARK2 IPI00719075 S 481 QRVPVApSPSAHNI phosphorylation MARK2 IPI00719075 S 483 VPVASPpSAHNISS phosphorylation MARK2 IPI00719075 S 531 YGVTPApSPSGHSQ phosphorylation MARK2 IPI00719075 S 543 QGRRGApSGSIFSK phosphorylation MARK2 IPI00719075 S 625 KVLDANpSCQSELH phosphorylation MARK2 IPI00719075 S 7 MIRGRNpSATSADE phosphorylation MARK2 IPI00719075 T 175 FGNKLDpTFCGSPP phosphorylation MARK2 IPI00719075 T 9 RGRNSApTSADEQP phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 2011 108326 - K Ubiquitination 21139048 2011 108326 - K Ubiquitination 21890473 2011 108326 - K Ubiquitination 23000965 2011 108326 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID MARK2 Homo sapiens (Human) 604 "604,SGSIFSKFTSKFV" 604:21890473 MARK2 Homo sapiens (Human) 583 "583,SGSIFSKFTSKFV" 583:21890473 MARK2 Homo sapiens (Human) 603 "603,SGSIFSKFTSKFV" 603:21890473 MARK2 Homo sapiens (Human) 557 "557,SGSIFSKFTSKFV" 557:21890473 MARK2 Homo sapiens (Human) 637 "637,SGSIFSKFTSKFV" 637:21890473 MARK2 Homo sapiens (Human) 583 "583,SGSIFSKFTSKFV" 583:21890473 MARK2 Homo sapiens (Human) 604 "604,SGSIFSKFTSKFV" 604:21890473 MARK2 Homo sapiens (Human) 550 "550,SGSIFSKFTSKFV" 550:21890473 MARK2 Homo sapiens (Human) 583 "583,SGSIFSKFTSKFV" 583:21890473 MARK2 Homo sapiens (Human) 583 "583,SGSIFSKFTSKFV" 583:21890473 MARK2 Homo sapiens (Human) 550 "550,SGSIFSKFTSKFV" 550:21890473 MARK2 Homo sapiens (Human) 604 "604,SGSIFSKFTSKFV" 604:21890473 MARK2 Homo sapiens (Human) 637 "637,SGSIFSKFTSKFV" 637:21890473 MARK2 Homo sapiens (Human) 582 "582,SGSIFSKFTSKFV" 582:21890473 MARK2 Homo sapiens (Human) 604 "604,SGSIFSKFTSKFV" 604:21890473 MARK2 Homo sapiens (Human) 550 "550,SGSIFSKFTSKFV" 550:21890473 MARK2 Homo sapiens (Human) 604 "604,SGSIFSKFTSKFV" 604:21890473 MARK2 Homo sapiens (Human) 637 "637,SGSIFSKFTSKFV" 637:21890473