PTM - CPLM Gene Name UniProt ID Type Position Code TSG101 Q99816 Acetylation 90 K TSG101 Q99816 Ubiquitination 237 K TSG101 Q99816 Ubiquitination 257 K TSG101 Q99816 Ubiquitination 361 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TSG101 Q99816 110 Y Homo sapiens(Human) TSG101 Q99816 15 Y Homo sapiens(Human) TSG101 Q99816 220 T Homo sapiens(Human) TSG101 Q99816 222 S Homo sapiens(Human) TSG101 Q99816 225 T Homo sapiens(Human) TSG101 Q99816 229 S Homo sapiens(Human) TSG101 Q99816 232 S Homo sapiens(Human) TSG101 Q99816 299 S Homo sapiens(Human) TSG101 Q99816 300 S Homo sapiens(Human) TSG101 Q99816 309 S Homo sapiens(Human) TSG101 Q99816 32 Y Homo sapiens(Human) TSG101 Q99816 390 Y Homo sapiens(Human) TSG101 Q99816 48 S Homo sapiens(Human) TSG101 Q99816 49 S Homo sapiens(Human) TSG101 Q99816 6 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type TSG101 rs11542667 CTC->TTC L->F 390 Y TAGLSDLY******* 390 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q99816 K14-ac Acetylation QLKKMVSkykYRDLT Q99816 K16-ac Acetylation KKMVSkykYRDLTVR Q99816 K90-ac Acetylation NPPICFVkPTSSMTI Q99816 K237-ac Acetylation LISAVSDkLRWRMKE Q99816 S6-p Phosphorylation __MAVSEsQLKKMVS Q99816 Y15-p Phosphorylation LKKMVSkykYRDLTV Q99816 Y32-p Phosphorylation TVNVITLyKDLKPVL Q99816 S48-p Phosphorylation SYVFNDGsSRELMNL Q99816 T56-p Phosphorylation SRELMNLtGTIPVPy Q99816 Y63-p Phosphorylation tGTIPVPyRGNTYNI Q99816 T220-p Phosphorylation VGPSRDGtIsEDtIR Q99816 S222-p Phosphorylation PSRDGtIsEDtIRAS Q99816 T225-p Phosphorylation DGtIsEDtIRASLIS Q99816 S299-p Phosphorylation KKKDEELssALEKME Q99816 S300-p Phosphorylation KKDEELssALEKMEN Q99816 S309-p Phosphorylation LEKMENQsENNDIDE Q99816 Y390-p Phosphorylation TAGLSDLy_______ Q99816 K237-ub Ubiquitination LISAVSDkLRWRMKE Q99816 K257-ub Ubiquitination QAELNALkRTEEDLK Q99816 K361-ub Ubiquitination IDLDVFLkHVRLLSR

PTM - dbPTM UniProt ID Position Code Type Resources References Q99816 2 A Acetylation Swiss-Prot 1010711 19413330 Q99816 220 T Phosphorylation Swiss-Prot 1010711 19007248 Q99816 390 Y Phosphorylation Swiss-Prot 1010711 18083107 Q99816 390 Y Phosphorylation PhosphoELM.10011 18083107 Q99816 237 K Ubiquitylation Phosphositeplus.1010730 21890473 Q99816 257 K Ubiquitylation Phosphositeplus.1010730 21890473 Q99816 361 K Ubiquitylation Phosphositeplus.1010730 21890473 Q99816 90 K Acetylation Phosphositeplus.1010730 20167786 Q99816 299 S Phosphorylation Phosphositeplus.1010730 20068231 Q99816 300 S Phosphorylation Phosphositeplus.1010730 20068231 Q99816 220 T Phosphorylation Phosphositeplus.1010730 19362540 Q99816 390 Y Phosphorylation Phosphositeplus.1010730 18083107;19605366;20736484;21253578;21403953;21447384 Q99816 299 S Phosphorylation HPRD 9.0 20068231 Q99816 300 S Phosphorylation HPRD 9.0 20068231 Q99816 220 T Phosphorylation HPRD 9.0 19007248 Q99816 390 Y Phosphorylation HPRD 9.0 18083107

PTM - HPRD Symbol Position Code Type References TSG101 220 T Phosphorylation 19007248 TSG101 299 S Phosphorylation 20068231 TSG101 300 S Phosphorylation 20068231 TSG101 390 Y Phosphorylation 18083107

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q99816 390 Y 18083107 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q99816 2 N-acetylalanine 19413330;22814378 Q99816 220 Phosphothreonine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TSG101 IPI00018434 S 299 KKDEELpSSALEKM phosphorylation TSG101 IPI00018434 S 300 KDEELSpSALEKME phosphorylation TSG101 IPI00018434 Y 15 KKMVSKpYKYRDLT phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7251 113102 - K Ubiquitination 18321968 7251 113102 - K Ubiquitination 16434471 7251 113102 - K Ubiquitination 18077552 7251 113102 - K Ubiquitination 17229889 7251 113102 - K Ubiquitination 20654576 7251 113102 - K Ubiquitination 19703557 7251 113102 - K Ubiquitination 21139048 7251 113102 - K Ubiquitination 21890473 7251 113102 - K FAT10ylation 22797925 7251 113102 - K Ubiquitination 23077308 7251 113102 - K Ubiquitination 23000965 7251 113102 - K Ubiquitination 24816145 7251 113102 - K Ubiquitination 15256501

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TSG101 Homo sapiens (Human) 152; 256; 132 "152,AELNALKRTEEDL; 256,DLDVFLKHVRLLS; 132,ISAVSDKLRWRMK" 152:21890473; 256:21890473; 132:21890473 TSG101 Homo sapiens (Human) 237; 257; 361 "237,ISAVSDKLRWRMK; 257,AELNALKRTEEDL; 361,DLDVFLKHVRLLS" 237:21890473; 257:21890473; 361:21890473