PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PIAS2 ACY3 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G PIAS2 HIC1 23704280,17283066 biogrid exp G G G G G G G G G G G G G G G G G G PIAS2 DDX39B 14667819 hprd,intact exp PIAS2 TRIM23 25416956 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 FLI1 16148010 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EPAS1 20661221 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TRIM27 15907835 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 AKT1 25241761,17533377 biogrid,intact,bci exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GFAP 25416956 biogrid,intact exp G G G G G G G G PIAS2 CTBP1 24722188 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CCNDBP1 25416956,21516116 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SREBF2 20936779 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TICAM2 21988832 biogrid,intact exp PIAS2 MX2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GOLGA2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GLUL 20936779 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 LMNB1 21516116 biogrid,mint,intact exp G G G G G G G G G G G G G G PIAS2 PAXIP1 22990118 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TRAF2 22184250 biogrid exp G G PIAS2 PML 22406621,21779164 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRM8 PIAS2 16144832 hprd exp G G G G G G G G G G G G G PIAS2 YWHAH bci exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 IFIH1 21156324 biogrid exp G G G G G G G G G G G G G G G G G G PIAS2 TSR2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PLAG1 15208321 biogrid exp G G G G G G G G G G G G G G PIAS2 NAV2 25416956,16189514 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MAPKAPK2 23202365 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RUFY1 21988832 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 C1QA 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ARNT 24618291 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CCHCR1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZNF451 18656483 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CLDN2 22731716 biogrid exp G G G G G G G G G G G G G G G PIAS2 ZBTB8A 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CHMP4B 16730941 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PHC1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TRIM63 18157088 biogrid exp G G G G PIAS2 PLAGL1 15208321 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CDKN2B 25241761 intact exp G G G G G G G G PIAS2 PIAS2 25416956,11867732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ADA 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKAB2 PIAS2 25416956,24722188 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CDCA8 18946085 biogrid exp G G G G G G G PIAS2 STAT4 12716907 hprd,biogrid,bci exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZBED1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 YWHAE 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CDKN2A 20308430 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SIAH1 17533377 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SNIP1 15231748 hprd exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TRIM55 18157088 biogrid exp G G G G G PIAS2 GTF2IRD1 12193603 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GNB2L1 22210188 mint,intact exp, ortho PIAS2 STAT1 12764129, 25402006 innatedb exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SUMO3 16524884, 25402006, 23023127 biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TP53 19339993,25241761,11867732,18624398, 25402006 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HDAC3 PIAS2 12239342, 25402006, 21836163 hprd,bci exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GTF2I 12193603,24722188, 25402006, 21836163 hprd,biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G PIAS2 JUN 11867732, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMAD3 16777850, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MITF PIAS2 16029420, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SIAH2 PIAS2 17533377, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G PIAS2 UBE2I 21988832,19549727,20936779,16189514,16148010,11867732,12177000,25416956,12764129,14609633,25409927, 25402006, 21836163 innatedb,hprd,biogrid,i2d,mint,intact,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MYC 17418410,17471507, 25402006, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PARK7 11477070,12526767, 25402006, 21836163 hprd,biogrid,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NR3C1 11117529, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SUMO2 25416956,19217413,19394292,22578841,16524884, 25402006, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MSX2 9256341, 21836163 hprd,biogrid exp, pred G G G G PIAS2 DNMT3A 14752048, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SAE1 12764129, 25402006 innatedb exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ESR2 11117529, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SUMO1 25416956,12764129,19217413,21988832,14609633,16524884, 25402006, 23023127, 21836163 innatedb,hprd,biogrid,intact,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PIAS4 21988832, 25402006 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G PIAS2 AR 12764129,9920921,11117529,12177000, 25402006, 21836163 innatedb,hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MAPK8 19815509, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ELK1 15920481, 21836163 hprd,i2d,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ESR1 11117529, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PARP1 19779455, 25402006 mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS1 PIAS2 11877418,25241761, 25402006 hprd,intact,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HUWE1 20624960, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TOPBP1 17006541, 21836163 mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 UBA2 12764129, 25402006, 23023127 innatedb exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MBD1 17066076, 25402006 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NEDD8 18274552, 25402006 intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMAD4 16777850,14514699, 25402006 hprd,biogrid,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PGR 11117529, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G PIAS2 NFKB1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PLAGL2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AXIN1 PIAS2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TRIM32 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PPARG ortho G G G G G G G G PIAS2 DAB2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TOLLIP ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 UXT ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EGR2 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G PIAS2 SMAD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 APEX1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 IFI16 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ELL 25402006 pred G G G G G G G G G G G G PIAS2 TRIM68 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 THRB 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZMIZ1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMARCC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NKX3-1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NR4A1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MAPK9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GTF2F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 WRNIP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NCL 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CDK1 25402006 pred G G G G G G G G G G G G G G PIAS2 RANBP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NCOA1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TP63 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PRDX1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CCNH 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CBX5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PIAS3 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 BRD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RFWD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RAN 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EFCAB6 25402006 pred G PIAS2 SMARCB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RNF14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM24 PIAS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HDAC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TAF9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HIF1A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GSK3B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 BCL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MED14 PIAS2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 UHRF1 25402006 pred G G G G G G G G G G G G G G G PIAS2 FBXO11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SKP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RELA 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 THRAP3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CSNK1A1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PRKDC 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PKN1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 WT1 25402006 pred G G G G G G G G PIAS2 SALL1 25402006 pred G G G G G G G G G G G G PIAS2 HSP90AA1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MED16 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TFAP2B 25402006 pred G G G PIAS2 RNF6 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 DNMT3L 25402006 pred G G PIAS2 CDK9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 LEF1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 BARD1 25402006 pred G G G G G G G G G G G G G PIAS2 NR0B1 25402006 pred G G G G G G G PIAS2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CDKN1A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HIPK2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GTF2H1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ETV6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SIN3A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MAPK1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 KAT7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ATF2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 H3F3A, H3F3B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EZH2 25402006 pred G G G G G G G G G G G G PIAS2 UBE2A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EP400 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ATF7IP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CREB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CBX4 PIAS2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SEPT7 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 DNAJA1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 FHL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PFDN5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MYCBP 25402006 pred PIAS2 SMC4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PRMT2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 BLMH 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RNF4 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SETDB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMAD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MED1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NR2C1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 REL 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RNF111 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MYBBP1A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CSNK2A1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RAD51 25402006 pred G G G G G G G G G G G G G PIAS2 NCOA4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CHAF1A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SP3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GMEB1 25402006 pred G G G G G G G G G G G G PIAS2 RHOA 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PYHIN1 25402006 pred G G G G G G G G G G G PIAS2 RAD54L2 25402006 pred G G G G G G G G PIAS2 IPO13 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SIRT1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZBTB4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZNF512B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NCOA2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PPARGC1A 25402006 pred G G G G G G G G G G G G G PIAS2 ERG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G TP73 PIAS2 25402006 pred G G G G G PIAS2 NUDCD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMARCA4 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SOX2 23023127 pred G G G G G G G G G G G G G G PIAS2 VDR 25402006 pred G G G G G G G G G G G G G G G G G G G G PIAS2 UBE2N 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 DNMT1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD7 PIAS2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EFTUD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RPL11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RCOR1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TGFB1I1 PIAS2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 DNMT3B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CREBBP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ETV5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NFYC 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TFAP2A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 POLE 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TBP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 FOXO1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MED17 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NCOA3 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 DAXX 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TOP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMYD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EGR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MED13 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ETS1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CTNNB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 STAT3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 BRCA1 25402006 pred G G G G PIAS2 TP53BP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 JMJD1C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BHLHE40 PIAS2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SMARCAD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RUVBL1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HMGA2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MED4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MED12 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NFATC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PDLIM7 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SP100 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G PIAS2 LRPPRC 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HDAC4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RWDD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 APLF 21836163 pred G G G G G G G G G G G PIAS2 TMF1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RYBP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MAPK11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HDAC2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 HMGB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 METTL13 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 BAG1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 KAT5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ACTL6A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MDM2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 FBXW7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZBTB16 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 FZD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 EP300 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 KAT2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 POLR2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TADA3 PIAS2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 DACH1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G PIAS2 GCN1L1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MAX 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RCHY1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 MSH6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 SOX10 25402006 pred G G G G G G G G G G G G G G G G G G PIAS2 YY1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TOPORS 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 XRCC6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TOP3A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PATZ1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CCND1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 RFC3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 NFYB 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 AES 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PRPF6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 PHB 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 XRCC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 CD276 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 TCF3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O75928 A0A024RCM3 two hybrid 14667819 physical association X 2 O75928 P04014 pull down 15582666 physical association X 2 O75928 P63279 two hybrid pooling approach 16189514 physical association X 2 O75928 Q92547 anti bait coimmunoprecipitation 17006541 physical association X 2 O75928 K7PPA8 two hybrid 18624398 physical association X 2 O75928 P63279 two hybrid 19549727 physical association X 2 O75928 P63279 two hybrid pooling approach 20936779 physical association X 2 O75928 A0A024R1Q0 two hybrid pooling approach 20936779 physical association X 2 O75928 O95273 two hybrid 21516116 physical association X 2 O75928 P63279 confocal microscopy 21988832 colocalization X 2 O75928 P00813 two hybrid array 21988832 physical association X 2 O75928 K7PPA8 proximity ligation assay 25241761 physical association X 2 O75928 B0LPE5 proximity ligation assay 25241761 physical association X 2 O75928 O43741 two hybrid prey pooling approach 25416956 physical association X 2 O75928 O95273 two hybrid prey pooling approach 25416956 physical association X 2 O75928 P20592 two hybrid prey pooling approach 25416956 physical association X 2 O75928 P63279 two hybrid prey pooling approach 25416956 physical association X 2 O75928 A0A024R9U9 two hybrid prey pooling approach 25416956 physical association X 2 O75928 O43741 two hybrid array 25416956 physical association X 2 O75928 O95273 two hybrid array 25416956 physical association X 2 O75928 P20592 two hybrid array 25416956 physical association X 2 O75928 P63279 two hybrid array 25416956 physical association X 2 O75928 A0A024R9U9 two hybrid array 25416956 physical association X 2 O75928 O43741 validated two hybrid 25416956 physical association X 2 O75928 O95273 validated two hybrid 25416956 physical association X 2 O75928 P63279 validated two hybrid 25416956 physical association X 2 O75928 P20592 validated two hybrid 25416956 physical association X 2 O75928 A0A024R9U9 validated two hybrid 25416956 physical association X 2 Q86XR7 O75928 two hybrid array 21988832 physical association X 2 O75928 anti bait coimmunoprecipitation 17418410 association C 4 O75928 anti bait coimmunoprecipitation 17418410 association C 4 O75928 tandem affinity purification 18274552 association C 75 O75928 P03116 pull down 15582666 physical association X 2 O75928 Q8IVL1 two hybrid pooling approach 16189514 physical association X 2 O75928 P01106 anti bait coimmunoprecipitation 17418410 physical association X 2 O75928 P01106 anti bait coimmunoprecipitation 17418410 physical association X 2 O75928 A8YXX4 two hybrid pooling approach 20936779 physical association X 2 O75928 P20700 two hybrid 21516116 physical association X 2 O75928 A0A024RAG6 two hybrid array 21988832 physical association X 2 O75928 Q96T51 anti tag coimmunoprecipitation 21988832 physical association X 2 O75928 Q96T51 pull down 21988832 physical association X 2 O75928 E9KL35 anti bait coimmunoprecipitation 22210188 physical association X 2 O75928 E9KL35 anti bait coimmunoprecipitation 22210188 physical association X 2 O75928 P0C206 two hybrid pooling approach 22458338 physical association X 2 O75928 P0C206 two hybrid array 22458338 physical association X 2 O75928 K7PPU3 proximity ligation assay 25241761 physical association X 2 O75928 O75925 proximity ligation assay 25241761 physical association X 2 O75928 O75928 two hybrid array 25416956 physical association X 2 O75928 G2XKQ0 two hybrid prey pooling approach 25416956 physical association X 2 O75928 A0A024R3Z2 two hybrid prey pooling approach 25416956 physical association X 2 O75928 Q08379 two hybrid prey pooling approach 25416956 physical association X 2 O75928 Q8IVL1 two hybrid prey pooling approach 25416956 physical association X 2 O75928 A0A024RBU4 two hybrid prey pooling approach 25416956 physical association X 2 O75928 P36406 two hybrid prey pooling approach 25416956 physical association X 2 O75928 P14136 two hybrid prey pooling approach 25416956 physical association X 2 O75928 A0A024R3Z2 two hybrid prey pooling approach 25416956 physical association X 2 O75928 Q7KZS0 two hybrid prey pooling approach 25416956 physical association X 2 O75928 Q59GP6 two hybrid prey pooling approach 25416956 physical association X 2 O75928 Q8TD31-3 two hybrid prey pooling approach 25416956 physical association X 2 O75928 Q96BR9 two hybrid prey pooling approach 25416956 physical association X 2 O75928 A0A024R5L2 two hybrid prey pooling approach 25416956 physical association X 2 O75928 G2XKQ0 two hybrid array 25416956 physical association X 2 O75928 A0A024R3Z2 two hybrid array 25416956 physical association X 2 O75928 Q08379 two hybrid array 25416956 physical association X 2 O75928 Q8IVL1 two hybrid array 25416956 physical association X 2 O75928 A0A024RBU4 two hybrid array 25416956 physical association X 2 O75928 P36406 two hybrid array 25416956 physical association X 2 O75928 P14136 two hybrid array 25416956 physical association X 2 O75928 A0A024R3Z2 two hybrid array 25416956 physical association X 2 O75928 Q7KZS0 two hybrid array 25416956 physical association X 2 O75928 Q59GP6 two hybrid array 25416956 physical association X 2 O75928 Q8TD31-3 two hybrid array 25416956 physical association X 2 O75928 Q96BR9 two hybrid array 25416956 physical association X 2 O75928 A0A024R5L2 two hybrid array 25416956 physical association X 2 O75928 G2XKQ0 validated two hybrid 25416956 physical association X 2 O75928 A0A024RBU4 validated two hybrid 25416956 physical association X 2 O75928 P14136 validated two hybrid 25416956 physical association X 2 O75928 P36406 validated two hybrid 25416956 physical association X 2 O75928 A0A024R3Z2 validated two hybrid 25416956 physical association X 2 O75928 Q7KZS0 validated two hybrid 25416956 physical association X 2 O75928 Q96BR9 validated two hybrid 25416956 physical association X 2 O75928 A0A024R5L2 validated two hybrid 25416956 physical association X 2 O75928 Q08379 validated two hybrid 25416956 physical association X 2 O75928 Q59GP6 validated two hybrid 25416956 physical association X 2 O75928 Q8IVL1 validated two hybrid 25416956 physical association X 2 O75928 Q8TD31-3 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PIAS2 ESR1 MI:0018(two hybrid) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_107755 bait prey PIAS2 GTF2I MI:0493(in vivo) 12193603 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_9566 - - PIAS2 CDKN2A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19901969,20308430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_127347|BIOGRID_127346|BIOGRID_127348|BIOGRID_210332|BIOGRID_210331 bait|prey|prey|bait|prey prey|bait|bait|prey|bait PIAS2 PLAG1 MI:0096(pull down) 15208321 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226823 bait prey PIAS2 PLAGL1 MI:0096(pull down) 15208321 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226826 bait prey PIAS2 MBD1 MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid) 17066076 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_128107|HPRD_31907|BIOGRID_128109 prey|-|prey bait|-|bait PIAS2 GTF2IRD1 MI:0018(two hybrid)|MI:0493(in vivo) 12193603 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_112309|HPRD_14531 bait|- prey|- PIAS2 EPAS1 MI:0007(anti tag coimmunoprecipitation) 20661221 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_108830 null bait PIAS2 SREBF2 MI:0018(two hybrid)|MI:0096(pull down) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_126923|UniProt_110749 prey|prey bait|bait PIAS2 GFI1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19164764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_210284|BIOGRID_210282|BIOGRID_210283 prey|bait|bait bait|prey|prey PIAS2 TRAF2 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 22184250 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_160010|BIOGRID_160011|BIOGRID_160019 bait|prey|bait prey|bait|prey PIAS2 PARK7 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid) 11477070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_115243|BIOGRID_115242|HPRD_10999|BIOGRID_115241 prey|prey|-|prey bait|bait|-|bait PIAS2 HUWE1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 16269333,20624960 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_126275|BIOGRID_153708|BIOGRID_126273|BIOGRID_153707 prey|bait|prey|prey bait|prey|bait|bait PIAS2 AKT1 MI:0018(two hybrid) 17533377 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_119234 prey bait PIAS2 ELK1 MI:0493(in vivo) 15920481 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17682 - - PIAS2 UBC MI:0415(enzymatic study)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 20624960,21139048,21906983,22184250,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_160024|BIOGRID_153709|BIOGRID_172184|BIOGRID_225455|BIOGRID_160022|BIOGRID_181283|BIOGRID_153705 bait|bait|prey|prey|bait|prey|bait prey|prey|bait|bait|prey|bait|prey PIAS2 CCNDBP1 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114620 bait prey PIAS2 FLI1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16148010 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_208058|BIOGRID_208057|BIOGRID_208030|BIOGRID_208043|BIOGRID_208065 prey|bait|prey|prey|bait bait|prey|bait|bait|prey PIAS2 BCL6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16142238 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_225745|BIOGRID_225746 bait|bait prey|prey PIAS2 SMAD4 MI:0493(in vivo)|MI:0096(pull down) 14514699,16777850 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_25429|BIOGRID_217717 -|bait -|prey PIAS2 DDX39B MI:0018(two hybrid)|MI:0018(two hybrid) 14667819 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (intact)|MI:0468(hprd) UniProt_73655|HPRD_35588 prey|- bait|- PIAS2 AR MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11117529,9920921 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) HPRD_5971|BIOGRID_77644|BIOGRID_107754|BIOGRID_103537|BIOGRID_77643 -|prey|bait|bait|prey -|bait|prey|prey|bait PIAS2 ESR2 MI:0018(two hybrid) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_107756 bait prey PIAS2 TOPBP1 MI:0424(protein kinase assay)|MI:0415(enzymatic study)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 17006541 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact) MINT_51726|BIOGRID_210668|MINT_84137|UniProt_88301 bait|bait|bait|bait prey|prey|prey|prey PIAS2 ITGB5 MI:0018(two hybrid) 12356872 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_115760 prey bait PIAS2 C1QA MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_116862|BIOGRID_287132 unspecified role|prey unspecified role|bait PIAS1 PIAS2 MI:0492(in vitro) 11877418 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_14534 - - PIAS2 SIAH1 MI:0018(two hybrid) 17533377 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_119230 prey bait PIAS2 NAV2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd) MINT_65930|BIOGRID_78717|MINT_36776|UniProt_151574|HPRD_22909 bait|bait|bait|unspecified role|- prey|prey|prey|unspecified role|- PIAS2 STAT4 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12716907 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_7264|BIOGRID_89534 -|bait -|prey PIAS2 HIC1 MI:0415(enzymatic study) 17283066 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_138131 bait prey GRM8 PIAS2 MI:0018(two hybrid) 16144832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_19897 - - PIAS2 IFIH1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21156324 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_164801|BIOGRID_164802 prey|bait bait|prey PIAS2 MYC MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 11283613,17418410,17471507 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_89767|UniProt_89774|UniProt_89770|BIOGRID_100552|BIOGRID_136706|UniProt_89776 prey|prey|bait|bait|prey|bait bait|bait|prey|prey|bait|prey PIAS2 UBE2I MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0397(two hybrid array) 11867732,12177000,14609633,16189514,19549727,20936779,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(biogrid)|MI:0468(hprd)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact) BIOGRID_287849|UniProt_120408|UniProt_110788|BIOGRID_87561|HPRD_15028|BIOGRID_126921|UniProt_100857|UniProt_154077|BIOGRID_81254|BIOGRID_136412|UniProt_119318 bait|neutral component|prey|prey|-|prey|prey|unspecified role|prey|prey|unspecified role prey|neutral component|bait|bait|-|bait|bait|unspecified role|bait|bait|unspecified role PIAS2 GNB2L1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 22210188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_122020|UniProt_122021 prey|bait bait|prey PIAS2 SUMO1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 11867732,14609633,16524884,17036045,19217413,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_286799|BIOGRID_245390|HPRD_18469|UniProt_119320|BIOGRID_289478|BIOGRID_208435|BIOGRID_136414|BIOGRID_289484|BIOGRID_87565 bait|bait|-|unspecified role|prey|prey|bait|prey|prey prey|prey|-|unspecified role|bait|bait|prey|bait|bait PIAS2 SUMO3 MI:0018(two hybrid) 16524884 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_289490 prey bait SIAH2 PIAS2 MI:0018(two hybrid) 17533377 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_119231 bait prey PIAS2 MSX2 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 9256341 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_221087|HPRD_24958|BIOGRID_221088 prey|-|bait bait|-|prey PIAS2 NEDD8 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18274552 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|MI:0471(mint)|MI:0471(mint) BIOGRID_148898|UniProt_96281|MINT_65006|MINT_35952 prey|prey|prey|prey bait|bait|bait|bait PIAS2 ADA MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286989|UniProt_116710 prey|unspecified role bait|unspecified role PIAS2 PARP1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10,19779455 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint) MINT_46853|UniProt_103892|MINT_78618 null|null|null prey|prey|prey PIAS2 NGFR MI:0004(affinity chromatography technology) 21123453 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_146192 bait prey PIAS2 GLUL MI:0018(two hybrid)|MI:0096(pull down) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_126922|UniProt_110438 prey|prey bait|bait PIAS2 UBE2I MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_69699|MINT_40326 prey|prey bait|bait PIAS2 SNIP1 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_915 - - PIAS2 TRIM27 MI:0018(two hybrid)|MI:0018(two hybrid) 15907835 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_133119|BIOGRID_133122 prey|prey bait|bait PIAS2 PGR MI:0018(two hybrid) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_107758 bait prey PIAS2 CLDN2 MI:0018(two hybrid) 22731716 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_196858 prey bait PIAS2 MAPK8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19815509 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_154895|BIOGRID_154896|BIOGRID_154891|BIOGRID_154892 bait|bait|prey|prey prey|prey|bait|bait PIAS2 SUMO2 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16524884,19217413,19394292,21252943,21693764,22578841 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_248337|BIOGRID_289487|BIOGRID_208436|BIOGRID_130982|BIOGRID_289471|BIOGRID_183878|BIOGRID_165391 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait PIAS2 PAXIP1 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_246218 prey bait PIAS2 SIRT1 MI:0428(imaging technique) 23704280 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_289626 bait prey PIAS2 c-Jun MI:0096(pull down) 11867732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_136415 bait prey PIAS2 RUFY1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact)|(biogrid) UniProt_120339|BIOGRID_288549|UniProt_120298|UniProt_119955|BIOGRID_285305 unspecified role|bait|unspecified role|unspecified role|bait unspecified role|prey|unspecified role|unspecified role|prey PIAS2 LMNB1 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114278 prey bait PIAS2 PML MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21779164,22406621 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_197539|BIOGRID_161198|BIOGRID_197531|BIOGRID_197517 bait|bait|prey|bait prey|prey|bait|prey PIAS2 CHMP4B MI:0018(two hybrid)|MI:0492(in vitro) 16730941 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_210921|HPRD_36200 prey|- bait|- PIAS2 PIAS4 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119862|BIOGRID_288421 unspecified role|bait unspecified role|prey HDAC3 PIAS2 MI:0492(in vitro) 12239342 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_14533 - - PIAS2 SMAD3 MI:0096(pull down) 16777850 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217716 bait prey PIAS2 ZBTB4 MI:0004(affinity chromatography technology) 18451802 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_134127 prey bait PIAS2 DNMT3A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14752048,22162396 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_87061|BIOGRID_87065|BIOGRID_193928|BIOGRID_193923|BIOGRID_87067|BIOGRID_87069 prey|prey|bait|prey|bait|bait bait|bait|prey|bait|prey|prey PIAS2 MAGEA4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14739298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_210324|BIOGRID_210323 bait|prey prey|bait PIAS2 TICAM2 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288752|UniProt_118390 bait|unspecified role prey|unspecified role PIAS2 MYCN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21123453 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_146203|BIOGRID_146196 prey|bait bait|prey PIAS2 NR3C1 MI:0018(two hybrid) 11117529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_107757 bait prey PIAS2 NTRK1 MI:0004(affinity chromatography technology) 21123453 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_146191 bait prey PIAS2 p53 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 11867732,18624398,19901969 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_96584|BIOGRID_127349|BIOGRID_136417|BIOGRID_155268|BIOGRID_127350|BIOGRID_136413 prey|prey|bait|prey|bait|prey bait|bait|prey|bait|prey|bait MITF PIAS2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16029420 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_127313|BIOGRID_127314 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality PIAS2 MYC 20426839,11283613,17471507,17418410,18923429,19786833,17418410 0004,0004,0004,0004,0004,0004,0006 LC PIAS2 TP53 11867732,25241761,19901969 0096,0813,0004 LC PIAS2 UBC 20624960,22184250,20624960 0004,0004,0096 LC PIAS2 AR 11117529,9920921,11117529,9920921 0096,0096,0018,0018 LC PIAS2 PML 22406621,21779164,22406621 0415,0428,0004 LC PIAS2 CDKN2A 19901969,19901969,20308430 0018,0004,0004 LC PIAS2 SUMO2 19394292,16524884,21252943,16524884,22578841,19394292 0096,0096,0004,0018,0096,0004 LC PIAS2 SUMO1 16524884,11867732,16524884 0096,0096,0018 LC PIAS2 UBE2I 21988832,16148010,25409927,21988832,11867732 0663,0096,0004,0018,0096 LC PIAS2 Q53GA5 11867732,25241761,11867732 0096,0428,0415 LC PIAS2 HUWE1 16269333,20624960,20624960,16269333 0004,0004,0415,0096 LC PIAS2 DNMT3A 14752048,14752048,22162396,14752048,19786833,22162396 0004,0018,0004,0096,0004,0018 LC PIAS2 MYC 20426839,11283613,17471507,17418410,18923429,19786833,17418410 0004,0004,0004,0004,0004,0004,0006 LC PIAS2 TP53 11867732,25241761,19901969 0096,0813,0004 LC PIAS2 UBC 20624960,22184250,20624960 0004,0004,0096 LC PIAS2 AR 11117529,9920921,11117529,9920921 0096,0096,0018,0018 LC PIAS2 PML 22406621,21779164,22406621 0415,0428,0004 LC PIAS2 CDKN2A 19901969,19901969,20308430 0018,0004,0004 LC PIAS2 SUMO2 19394292,16524884,21252943,16524884,22578841,19394292 0096,0096,0004,0018,0096,0004 LC PIAS2 SUMO1 16524884,11867732,16524884 0096,0096,0018 LC PIAS2 UBE2I 21988832,16148010,25409927,21988832,11867732 0663,0096,0004,0018,0096 LC PIAS2 Q53GA5 11867732,25241761,11867732 0096,0428,0415 LC PIAS2 HUWE1 16269333,20624960,20624960,16269333 0004,0004,0415,0096 LC PIAS2 DNMT3A 14752048,14752048,22162396,14752048,19786833,22162396 0004,0018,0004,0096,0004,0018 LC PIG59 PIAS2 20936779,20936779 0398,0018 HT B4DUR3 PIAS2 17066076,17066076 0096,0018 LC B4DZT3 PIAS2 21516116 0018 HT NR3C4 PIAS2 12177000,11117529,9920921 0018,0018,0018 LC G2XKQ0 PIAS2 25416956,25416956,25416956 1112,0397,1356 HT GRM8 PIAS2 16144832 0018 LC SIAH2 PIAS2 17533377 0018 LC PRKAB2 PIAS2 25416956,25416956,25416956,25416956,24722188 1356,1112,0397,0018,0018 HT PIAS1 PIAS2 11877418 0018 LC PIAS2 PIAS2 25416956,25416956,11867732 0397,0018,0415 HT,LC PIAS2 CCNDBP1 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT PIAS2 ZBED1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 ADA 21988832,21988832 0397,0018 HT PIAS2 C1QA 21988832,21988832 0397,0018 HT PIAS2 TP53 18624398 0018 HT PIAS2 JUN 11867732,11867732 0096,0415 LC PIAS2 AR 11117529,9920921,12177000,11117529,9920921 0096,0096,0018,0018,0018 LC PIAS2 GFAP 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 TRIM27 15907835,15907835 0018,0004 LC PIAS2 GLUL 20936779,20936779 0398,0018 HT PIAS2 ITGB5 12356872 0018 LC PIAS2 ELK1 15920481 0019 LC PIAS2 MX2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 LMNB1 21516116 0018 HT PIAS2 PML 22406621,22406621 0415,0004 LC PIAS2 AKT1 17533377,15580267 0018,0045 LC PIAS2 MSX2 9256341,9256341 0018,0096 LC PIAS2 TRIM23 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 CDKN2A 19901969,19901969 0018,0004 LC PIAS2 MAPK8 19815509,19815509,19815509 0096,0018,0004 LC PIAS2 MAPKAPK2 23202365 0415 LC PIAS2 CLDN2 22731716 0018 LC PIAS2 SUMO2 16524884,19217413,16524884 0096,0018,0018 LC PIAS2 SUMO1 16524884,14609633,19217413,25416956,25416956,25416956,25416956,16524884,21988832,16204249 0096,0018,0018,1112,0397,0018,1356,0018,0018,0114 LC,HT PIAS2 UBE2I 16189514,21988832,14609633,12177000,25416956,25416956,20936779,16189514,25416956,25416956,19549727,21988832,20936779 0398,0663,0018,0018,1112,0397,0398,0018,1356,0018,0018,0018,0018 HT,LC PIAS2 GTF2I 12193603,24722188 0018,0018 LC,HT PIAS2 FLI1 16148010,16148010,16148010,16148010 0018,0096,0004,0415 LC PIAS2 YWHAH 15580267,15580267 0019,0004 LC PIAS2 GOLGA2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 SREBF2 20936779,20936779 0398,0018 HT PIAS2 CTBP1 24722188 0018 HT PIAS2 DDX39B 14667819 0018 HT PIAS2 HIC1 17283066 0415 LC PIAS2 Q53GA5 19339993,18624398,11867732,11867732 0415,0018,0096,0415 LC,HT PIAS2 CDCA8 18946085 0018 LC PIAS2 Q59GP6 25416956,25416956,25416956 1112,0397,1356 HT PIAS2 DKFZP686A1782 25416956 0018 HT PIAS2 PAXIP1 22990118 0018 LC PIAS2 HUWE1 20624960,20624960 0004,0415 LC PIAS2 TICAM2 21988832,21988832 0397,0018 HT PIAS2 SIAH1 17533377 0018 LC PIAS2 NAV2 16189514,25416956,25416956,25416956,16189514,25416956 0398,1112,0397,0018,0018,1356 HT PIAS2 PIAS4 21988832 0018 HT PIAS2 SNIP1 15231748 0018 HT PIAS2 CCHCR1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 TSR2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 TRIM63 18157088 0018 LC PIAS2 ZBTB8A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 ACY3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PIAS2 RUFY1 21988832,21988832,21988832,21988832 0004,0096,0007,0018 HT PIAS2 PARK7 11477070,11477070,12526767,11477070 0004,0018,0018,0096 LC PIAS2 TRIM55 18157088 0018 LC PIAS2 CHMP4B 16730941 0018 LC PIAS2 CHMP1A 16730941 0018 LC PIAS2 CHMP5 16730941 0018 LC PIAS2 GTF2IRD1 12193603,12193603,12193603 0004,0096,0018 LC PIAS2 MBD1 17066076,17066076 0096,0018 LC PIAS2 ZNF451 18656483 0018 LC PIAS2 DNMT3A 14752048,14752048,22162396,14752048,22162396 0004,0018,0004,0096,0018 LC PIAS2 HEL-S-67P 11477070,11477070,12526767,11477070 0004,0018,0018,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P57739 O75928 CLDN2 PIAS2 0.309 22731716 Q59GP6 O75928 Q59GP6 PIAS2 0.332 25416956 O75928 O43255 PIAS2 SIAH2 0.309 17533377 Q8N2W9 O75928 PIAS4 PIAS2 0.332 21988832 Q12439 O75928 TY2A-OR1 PIAS2 0.332 27107014 Q8N726 O75928 CDKN2A PIAS2 0.376 20308430 Q8IUQ4 O75928 SIAH1 PIAS2 0.309 17533377 Q9NZZ3 O75928 CHMP5 PIAS2 0.183 16730941 O75928 O75030 PIAS2 MITF 0.523 16029420 Q9Y4E5 O75928 ZNF451 PIAS2 0.309 18656483 O75928 O75925 PIAS2 PIAS1 0.196 25241761 O75928 O43741 PIAS2 PRKAB2 0.554 25416956,24722188 P00813 O75928 ADA PIAS2 0.286 21988832 P01106 O75928 MYC PIAS2 0.61 17418410,17471507 P02745 O75928 C1QA PIAS2 0.286 21988832 P03372 O75928 ESR1 PIAS2 0.309 11117529 P04150 O75928 NR3C1 PIAS2 0.309 11117529 P06401 O75928 PGR PIAS2 0.309 11117529 P09874 O75928 PARP1 PIAS2 0.21 19779455 P27540 O75928 ARNT PIAS2 0.21 24618291 P31749 O75928 AKT1 PIAS2 0.445 25241761,17533377 P36406 O75928 TRIM23 PIAS2 0.454 25416956 P84022 O75928 SMAD3 PIAS2 0.309 16777850 Q08379 O75928 GOLGA2 PIAS2 0.454 25416956 Q13485 O75928 SMAD4 PIAS2 0.309 16777850 Q13838 O75928 DDX39B PIAS2 0.183 14667819 Q14765 O75928 STAT4 PIAS2 0.21 12716907 Q6DJT9 O75928 PLAG1 PIAS2 0.309 15208321 Q7Z6Z7 O75928 HUWE1 PIAS2 0.454 20624960 Q8TD31 O75928 CCHCR1 PIAS2 0.454 25416956 Q92731 O75928 ESR2 PIAS2 0.309 11117529 Q9HD42 O75928 CHMP1A PIAS2 0.183 16730941 Q9UHL9 O75928 GTF2IRD1 PIAS2 0.309 12193603 Q9UM63 O75928 PLAGL1 PIAS2 0.309 15208321 Q6ZW49 O75928 PAXIP1 PIAS2 0.183 22990118 P03116 O75928 E1 PIAS2 0.21 15582666 P04014 O75928 E1 PIAS2 0.21 15582666 P14136 O75928 GFAP PIAS2 0.722 25416956,unassigned1304,25910212 Q9Y6K1 O75928 DNMT3A PIAS2 0.702 14752048 Q9UGU5 O75928 HMGXB4 PIAS2 0.236 unassigned1304 Q9UIS9 O75928 MBD1 PIAS2 0.523 17066076 P0C206 O75928 P0C206 PIAS2 0.236 22458338 P10275 O75928 AR PIAS2 0.772 11117529,9920921 P05214 O75928 TUBA3B PIAS2 0.236 26496610 Q96BR9 O75928 ZBTB8A PIAS2 0.454 25416956 Q96T51 O75928 RUFY1 PIAS2 0.554 21988832 Q96K80 O75928 ZC3H10 PIAS2 0.236 unassigned1304 P07101 O75928 TH PIAS2 0.236 unassigned1304 Q9BUJ2 O75928 HNRNPUL1 PIAS2 0.236 unassigned1304 Q9H0A9 O75928 SPATC1L PIAS2 0.236 unassigned1304 P14373 O75928 TRIM27 PIAS2 0.454 15907835 Q9H444 O75928 CHMP4B PIAS2 0.332 16730941 P80315 O75928 CCT4 PIAS2 0.236 26496610 Q12772 O75928 SREBF2 PIAS2 0.286 20936779 P20591 O75928 MX1 PIAS2 0.236 unassigned1304 P20592 O75928 MX2 PIAS2 0.454 25416956 P20839 O75928 IMPDH1 PIAS2 0.236 unassigned1304 Q13114 O75928 TRAF3 PIAS2 0.236 unassigned1304 Q05516 O75928 ZBTB16 PIAS2 0.236 unassigned1304 Q86XT4 O75928 TRIM50 PIAS2 0.236 unassigned1304 O75928 O60812 PIAS2 HNRNPCL1 0.236 unassigned1304 Q86YM7 O75928 HOMER1 PIAS2 0.236 unassigned1304 P41219 O75928 PRPH PIAS2 0.236 unassigned1304 O75928 O75569 PIAS2 PRKRA 0.236 unassigned1304 O75928 O75344 PIAS2 FKBP6 0.236 unassigned1304 O75928 O60232 PIAS2 SSSCA1 0.236 unassigned1304 O75928 B0QYN7 PIAS2 UBE2I {ECO:0000313|ENSEMBL:ENSP00000384361} 0.236 unassigned1304 O75928 O00463 PIAS2 TRAF5 0.236 unassigned1304 O75928 F5H3M2 PIAS2 KIFC3 {ECO:0000313|ENSEMBL:ENSP00000438805} 0.236 unassigned1304 Q15436 O75928 SEC23A PIAS2 0.236 unassigned1304 P35520 O75928 CBS PIAS2 0.236 unassigned1304 P15336 O75928 ATF2 PIAS2 0.236 unassigned1304 P05412 O75928 JUN PIAS2 0.523 11867732 P17661 O75928 DES PIAS2 0.236 unassigned1304 P16220 O75928 CREB1 PIAS2 0.236 unassigned1304 P22234 O75928 PAICS PIAS2 0.236 unassigned1304 Q14565 O75928 DMC1 PIAS2 0.236 unassigned1304 P40222 O75928 TXLNA PIAS2 0.236 unassigned1304 P35711 O75928 SOX5 PIAS2 0.236 unassigned1304 P48378 O75928 RFX2 PIAS2 0.236 unassigned1304 P42772 O75928 CDKN2B PIAS2 0.196 25241761 Q14526 O75928 HIC1 PIAS2 0.396 17283066,23704280 Q06455 O75928 RUNX1T1 PIAS2 0.236 unassigned1304 Q01543 O75928 FLI1 PIAS2 0.794 16148010 Q13422 O75928 IKZF1 PIAS2 0.236 unassigned1304 Q12933 O75928 TRAF2 PIAS2 0.671 22184250,unassigned1304 Q96B26 O75928 EXOSC8 PIAS2 0.236 unassigned1304 Q6ISB3 O75928 GRHL2 PIAS2 0.236 unassigned1304 Q17R54 O75928 SYN3 {ECO:0000313|EMBL:AAI17461.1} PIAS2 0.236 unassigned1304 Q5TA81 O75928 LCE2C PIAS2 0.236 unassigned1304 Q5T753 O75928 LCE1E PIAS2 0.236 unassigned1304 Q969E8 O75928 TSR2 PIAS2 0.583 25416956,unassigned1304 Q86UR1 O75928 NOXA1 PIAS2 0.236 unassigned1304 Q6NT76 O75928 HMBOX1 PIAS2 0.236 unassigned1304 Q7Z6I8 O75928 C5ORF24 PIAS2 0.236 unassigned1304 Q8TF42 O75928 UBASH3B PIAS2 0.236 unassigned1304 Q86XR7 O75928 TICAM2 PIAS2 0.286 21988832 Q9BUA3 O75928 C11ORF84 PIAS2 0.236 unassigned1304 Q96F86 O75928 EDC3 PIAS2 0.236 unassigned1304 Q9BPY3 O75928 FAM118B PIAS2 0.236 unassigned1304 Q96MM3 O75928 ZFP42 PIAS2 0.236 unassigned1304 Q9Y5B8 O75928 NME7 PIAS2 0.236 unassigned1304 Q9P2F9 O75928 ZNF319 PIAS2 0.236 unassigned1304 Q9NP66 O75928 HMG20A PIAS2 0.236 unassigned1304 Q9P0W2 O75928 HMG20B PIAS2 0.236 unassigned1304 Q9UMX0 O75928 UBQLN1 PIAS2 0.236 unassigned1304 Q9UH92 O75928 MLX PIAS2 0.236 unassigned1304 Q9UJC3 O75928 HOOK1 PIAS2 0.236 unassigned1304 Q7KZS0 O75928 UBE2I {ECO:0000313|EMBL:EAW85674.1} PIAS2 0.332 25416956 O95273 O75928 CCNDBP1 PIAS2 0.636 21516116,25416956 Q8IVL1 O75928 NAV2 PIAS2 0.61 25416956,16189514 P61956 O75928 SUMO2 PIAS2 0.539 16524884,19217413 O75928 O75928 PIAS2 PIAS2 0.554 25416956,11867732 Q99497 O75928 PARK7 PIAS2 0.623 11477070 P04637 O75928 TP53 PIAS2 0.878 11867732,19339993,25241761,18624398 O75928 G2XKQ0 PIAS2 G2XKQ0 0.49 25416956,unassigned1304 O96006 O75928 ZBED1 PIAS2 0.583 25416956,unassigned1304 P63165 O75928 SUMO1 PIAS2 0.932 25416956,unassigned1304,19217413,21988832,16524884,14609633 P63279 O75928 UBE2I PIAS2 0.979 25416956,16189514,21988832,19549727,14609633,20936779,11867732,25409927,16148010 P29590 O75928 PML PIAS2 0.623 22406621,21779164 Q96HD9 O75928 ACY3 PIAS2 0.454 25416956 Q92547 O75928 TOPBP1 PIAS2 0.21 17006541 P35548 O75928 MSX2 PIAS2 0.523 9256341 Q9BYX4 O75928 IFIH1 PIAS2 0.376 21156324 P45983 O75928 MAPK8 PIAS2 0.623 19815509 P42771 O75928 CDKN2A PIAS2 0.376 20308430 P78347 O75928 GTF2I PIAS2 0.183 24722188 P78364 O75928 PHC1 PIAS2 0.183 25416956 P49137 O75928 MAPKAPK2 PIAS2 0.309 23202365 Q13363 O75928 CTBP1 PIAS2 0.183 24722188 P63244 O75928 GNB2L1 PIAS2 0.376 22210188 P20049 O75928 TYR1 PIAS2 0.332 27107014 P15104 O75928 GLUL PIAS2 0.286 20936779 Q15843 O75928 NEDD8 PIAS2 0.126 18274552 Q03267 O75928 IKZF1 PIAS2 0.21 15767674 P20700 O75928 LMNB1 PIAS2 0.332 21516116 P55854 O75928 SUMO3 PIAS2 0.183 16524884

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 GRM8 PIAS2 MI:0362 inference MI:0461 interaction database AXIN1 PIAS2 MI:0362 inference MI:0461 interaction database GRM6 PIAS2 MI:0362 inference MI:0461 interaction database HDAC3 PIAS2 MI:0362 inference MI:0461 interaction database SIAH2 PIAS2 MI:0045 experimental interaction detection MI:0461 interaction database PRKAB2 PIAS2 MI:0045 experimental interaction detection MI:0461 interaction database MITF PIAS2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS1 PIAS2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CCNDBP1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ZBED1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ADA MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MYC MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 C1QA MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ESR1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 NR3C1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MYCN MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 NTRK1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TP53 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 JUN MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PGR MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SP1 MI:0362 inference MI:0461 interaction database PIAS2 NGFR MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PARP1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 UBC MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 AR MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 EGR2 MI:0362 inference MI:0461 interaction database PIAS2 GFAP MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRIM27 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 GLUL MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ITGB5 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ELK1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 NFKB1 MI:0362 inference MI:0461 interaction database PIAS2 MX2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 LMNB1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ARNT MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PML MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 AKT1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MSX2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRIM23 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PPARG MI:0362 inference MI:0461 interaction database PIAS2 CDKN1A MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 BCL6 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CDKN2A MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CDKN2B MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MAGEA4 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MAPK8 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MAPKAPK2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CDKN1C MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CCT4 MI:0362 inference MI:0461 interaction database PIAS2 SUMO3 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CLDN2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MAX MI:0362 inference MI:0461 interaction database PIAS2 SUMO2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SUMO1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PIAS2 RACK1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 UBE2I MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PIAS2 TUBA1B MI:0362 inference MI:0461 interaction database PIAS2 TUBA4A MI:0362 inference MI:0461 interaction database PIAS2 GTF2I MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PHC1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SMAD3 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 DAB2 MI:0362 inference MI:0461 interaction database PIAS2 FLI1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 YWHAH MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 RAD51 MI:0362 inference MI:0461 interaction database PIAS2 DHX9 MI:0362 inference MI:0461 interaction database PIAS2 GOLGA2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SREBF2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRAF2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRIM32 MI:0362 inference MI:0461 interaction database PIAS2 CTBP1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 XRCC4 MI:0362 inference MI:1106 pathways database PIAS2 SMAD4 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TUBA3C MI:0362 inference MI:0461 interaction database PIAS2 DDX39B MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 STAT4 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 GRM7 MI:0362 inference MI:0461 interaction database PIAS2 NEDD8 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 IFI16 MI:0362 inference MI:0461 interaction database PIAS2 CDCA8 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PLAG1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SUMO4 MI:0362 inference MI:0461 interaction database PIAS2 TUBA3E MI:0362 inference MI:0461 interaction database PIAS2 PAXIP1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TUBA1A MI:0362 inference MI:0461 interaction database PIAS2 HUWE1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TICAM2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SIAH1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 NAV2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PIAS4 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CDKN2A MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 SNIP1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CCHCR1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TOPBP1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ESR2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TSR2 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRIM63 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ZBTB8A MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ACY3 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 RUFY1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PARK7 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 GFI1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 EPAS1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 IFIH1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TOLLIP MI:0362 inference MI:0461 interaction database PIAS2 CHMP4B MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CHMP1A MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CHMP5 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 ZBTB4 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 UXT MI:0362 inference MI:0461 interaction database PIAS2 GTF2IRD1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 MBD1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 CDV3 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PLAGL1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 PLAGL2 MI:0362 inference MI:0461 interaction database PIAS2 ZNF451 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 DNMT3A MI:0045 experimental interaction detection MI:0461 interaction database