PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus N4BP2 CREBBP 12730195 hprd,biogrid exp P GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP P G N4BP2 TOLLIP 20936779 biogrid,i2d,intact exp P GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP P G KDM6A N4BP2 17761849 biogrid exp P G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP P G N4BP2 TP63 20308539 biogrid exp P G G G G G G G G G G G G G G G G G G GP GP G G G G N4BP2 N4BP2 22072629 biogrid exp P GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP P G N4BP2 CEP250 23443559 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G RPGRIP1L N4BP2 26638075 biogrid,intact exp P P P P P P P P P P P P G P G P P P P P P P G EP300 N4BP2 12730195 hprd,biogrid exp P GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP P G TP73 N4BP2 20308539 biogrid exp G G G G BCL3 N4BP2 12730195, 21836163 hprd,biogrid exp, pred G G GP G GP GP G G G GP G GP G G GP G G G GP G GP G NEDD4 N4BP2 11717310, 21836163 hprd exp, pred P GP G GP P G GP GP GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP P G PIR N4BP2 25402006 pred P GP G GP G G GP G GP GP GP G G GP GP G P G GP GP P G GP G GP P G RAB9A N4BP2 25402006 pred P GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP P G RELB N4BP2 25402006 pred P GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G G GP GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86UW6 P20749 two hybrid 12730195 direct interaction X 2 Q86UW6 P20749 pull down 12730195 direct interaction X 2 Q86UW6 O15550 affinity chromatography technology 17761849 physical association X 2 Q86UW6 Q9H3D4-7 affinity chromatography technology 20308539 physical association X 2 Q6FIE9 Q86UW6 two hybrid 20936779 direct interaction X 2 P0CG48 Q86UW6 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q86UW6 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q86UW6 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q86UW6 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q86UW6 affinity chromatography technology 21906983 physical association X 2 Q86UW6 Q86UW6 x-ray crystallography 22072629 association X 2 Q86UW6 Q9BV73 affinity chromatography technology 23443559 physical association X 2 Q86UW6 affinity chromatography technology 12730195 physical association X 2 Q86UW6 O15350-4 affinity chromatography technology 20308539 physical association X 2 Q09472 Q86UW6 affinity chromatography technology 12730195 physical association X 2 Q86UW6 anti tag coimmunoprecipitation 17761849 association C 12 Q86UW6 P20749 in vitro 12730195 - X 2 Q86UW6 P20749 in vivo 12730195 - X 2 Q86UW6 P20749 in vitro 12730195 - X 2 Q86UW6 P20749 in vivo 12730195 - X 2 Q86UW6 in vivo 12730195 - X 2 Q86UW6 in vivo 12730195 - X 2 Q09472 Q86UW6 in vivo 12730195 - X 2 Q09472 Q86UW6 in vivo 12730195 - X 2 P46934-3 Q86UW6 in vitro 11717310 - X 2 P46934-3 Q86UW6 two hybrid 11717310 - X 2 P46934-3 Q86UW6 in vivo 11717310 - X 2 P46934-3 Q86UW6 in vivo 11717310 - X 2 P46934-3 Q86UW6 two hybrid 11717310 - X 2 P46934-3 Q86UW6 in vitro 11717310 - X 2 Q86UW6 Q5NET8 two hybrid pooling approach 20711500 physical association X 2 Q6FIE9 Q86UW6 two hybrid pooling approach 20936779 physical association X 2 Q7ARD3 Q86UW6 two hybrid pooling approach 20711500 physical association X 2 Q86UW6 Q81WN6 two hybrid pooling approach 20711500 physical association X 2 Q86UW6 Q7CJF7 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B N4BP2 CREBBP MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12730195 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_85053|HPRD_6412 bait|- prey|- TP73 N4BP2 MI:0004(affinity chromatography technology) 20308539 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_123811 bait prey N4BP2 TP63 MI:0004(affinity chromatography technology) 20308539 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_123781 prey bait N4BP2 TOLLIP MI:0096(pull down)|MI:0018(two hybrid) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_110774|BIOGRID_127137 prey|prey bait|bait KDM6A N4BP2 MI:0004(affinity chromatography technology) 17761849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118773 bait prey NEDD4 N4BP2 MI:0493(in vivo) 11717310 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10580 - - BCL3 N4BP2 MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12730195 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_85054|HPRD_6281|BIOGRID_89448 bait|-|prey prey|-|bait EP300 N4BP2 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12730195 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_11385|BIOGRID_89447 -|bait -|prey

PPI - HINT Gene A Gene B PMID Method Quality RPGRIP1L N4BP2 26638075,26638075 1314,1313 HT N4BP2 CEP250 23443559 0004 HT RPGRIP1L N4BP2 26638075,26638075 1314,1313 HT N4BP2 CEP250 23443559 0004 HT BCL3 N4BP2 12730195,12730195 0018,0096 LC HLA-A N4BP2 18836451 0114 LC NEDD4 N4BP2 11717310 0018 LC N4BP2 N4BP2 22072629,PDB_3FAU 0114,0114 LC N4BP2 TOLLIP 20936779,20936779 0398,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86UW6 Q09472 N4BP2 EP300 0.21 12730195 Q86UW6 Q5NET8 N4BP2 HRPA 0.126 20711500 Q86UW6 O15350 N4BP2 TP73 0.126 20308539 Q86UW6 O15550 N4BP2 KDM6A 0.21 17761849 Q9H3D4 Q86UW6 TP63 N4BP2 0.126 20308539 Q86UW6 Q7ARD3 N4BP2 Q7ARD3 0.126 20711500 Q86UW6 Q7CJF7 N4BP2 PTSI 0.126 20711500 Q86UW6 Q81WN6 N4BP2 DAPG2 0.126 20711500 Q86UW6 Q86UW6 N4BP2 N4BP2 0.332 22072629 Q92793 Q86UW6 CREBBP N4BP2 0.21 12730195 Q9H0E2 Q86UW6 TOLLIP N4BP2 0.286 20936779 Q86UW6 Q68CZ1 N4BP2 RPGRIP1L 0.236 26638075 Q9BV73 Q86UW6 CEP250 N4BP2 0.126 23443559 Q86UW6 P20749 N4BP2 BCL3 0.523 12730195

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TP73 N4BP2 MI:0045 experimental interaction detection MI:0461 interaction database KDM6A N4BP2 MI:0045 experimental interaction detection MI:0461 interaction database UBC N4BP2 MI:0045 experimental interaction detection MI:0461 interaction database BCL3 N4BP2 MI:0045 experimental interaction detection MI:0461 interaction database EP300 N4BP2 MI:0045 experimental interaction detection MI:0461 interaction database RPGRIP1L N4BP2 MI:0045 experimental interaction detection MI:0461 interaction database N4BP2 CREBBP MI:0045 experimental interaction detection MI:0461 interaction database N4BP2 CEP250 MI:0045 experimental interaction detection MI:0461 interaction database N4BP2 TOLLIP MI:0045 experimental interaction detection MI:0461 interaction database N4BP2 TP63 MI:0045 experimental interaction detection MI:0461 interaction database