PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SP100 SENP1 22878415 biogrid exp GP GP G GP P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P G NUP153 SENP1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZNF420 SENP1 25691462 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HDAC2 SENP1 22493095 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KPNB1 SENP1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PML SENP1 21098080 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G HERC2 SENP1 25476789 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KCNK1 SENP1 15820677 hprd,i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRDM1 SENP1 21722636 biogrid exp GP GP G G G G GP GP G G G G G G GP G G GP G GP G G GP GP G GP G G PARP1 SENP1 19622798 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HDAC1 SENP1 15199155 hprd,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBE2K SENP1 21098080 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LMNA SENP1 24927568,22412018 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCARA3 SENP1 26186194 biogrid exp GP P G GP G P GP G P P P G GP GP P GP GP GP P P P GP P G SENP1 USP25 18538659 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CAV3 SENP1 21362625 biogrid exp G G G G GP GP P G G GP GP G G G G GP GP P G G APC SENP1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP GP GP GP NUP107 SENP1 24927568 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARRB2 SENP1 25425640 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G GCM1 SENP1 21791615 biogrid exp P P GP P P APP SENP1 21244100,21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G HIPK2 SENP1 16253240 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RANBP2 SENP1 22194619 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP1 SENP1 17704192 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP1 RUVBL2 20603076,16699503 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NUP43 SENP1 24927568 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BAG3 SENP1 23824909 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SP3 SENP1 i2d exp GP G G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP GP GP GP GP GP G SENP1 RABGAP1 16608850 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 SENP1 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SUMO2 SENP1 22878415,17000875,17099698,16553580, 25402006 biogrid,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO3 SENP1 16608850,22878415,doi:10.1038/embor.2012.125,16553580, 25402006, 23023127 biogrid,i2d,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HDAC4 SENP1 20079608, 25402006 biogrid exp, pred GP G G G GP GP G G GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G TP53 SENP1 19339993, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G ISG15 SENP1 16009940, 23023127 innatedb,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO1 SENP1 16608850,22878415,15896780,17000875,17099698,doi:10.1038/embor.2012.125,16553580, 25402006, 21836163 biogrid,mint,intact,dip exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RANGAP1 SENP1 25027693,17099698,16553580, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAE SENP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIF1A SENP1 ortho GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP G IRAK1 SENP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CIDEA SENP1 23023127 pred G G G G G G G G USP11 SENP1 23023127 pred G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G UBC SENP1 23023127 pred PLEKHG2 SENP1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NEDD8 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP33 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G CIDEC SENP1 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ELF4 SENP1 21836163 pred GP GP G G G G GP GP GP GP G G GP GP P G GP GP P GP GP GP GP G SENP1 DAXX 21836163, 21836163, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP2 SENP1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G EPB41 SENP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DFFA SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO4 SENP1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP GP G GP GP GP GP G GP GP GP G PIAS4 SENP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G SMC6 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP UBL4B SENP1 23023127 pred P P P P P P P P P P P P P P P P P P P P RBBP6 SENP1 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP G GP GP GP GP G USP28 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CYLD SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP UBXN7 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SART1 SENP1 25402006 pred GP GP G G G GP G G GP G GP G G G G P GP G GP G GP G G G P G P GP G MIDN SENP1 23023127 pred GP GP G G GP GP G GP GP G GP G G G G GP GP G G G GP GP GP GP GP G GP GP G SENP1 ZMYM2 25402006 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FGD4 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G EIF4E SENP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SQSTM1 SENP1 23023127 pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP GP GP GP GP GP G BAP1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TMUB2 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAF1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP1 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G UBL4A SENP1 23023127 pred GP GP G G G GP G G GP G GP G G G G G GP G GP G GP G G G G G GP P G CBX8 SENP1 21836163 pred P P P P P P P P P P P P P P P P P P P P DLC1 SENP1 23023127 pred G G G G G GP G G GP G GP G G G G GP GP G G G G G G G GP G G GP G PIK3CA SENP1 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G P GP GP GP G P GP GP GP GP GP GP GP SENP1 UBA2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP GP GP GP G TMUB1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CALCOCO2 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G DEAF1 SENP1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2I SENP1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBTD1 SENP1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G G GP GP GP G P G GP G G G GP G HERPUD1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP1 PLCE1 23023127 pred GP P G P GP G GP GP G GP P GP P G GP GP GP GP G P GP GP GP GP GP GP P G BAG6 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMC5 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SENP2 SENP1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TDG SENP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BIRC5 SENP1 23023127 pred P G GP P GP GP P G GP P P GP GP GP TNIP3 SENP1 21836163 pred P P P P P P P P P P P P P P P P P P P SENP1 USP16 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP GP GP GP G PIAS1 SENP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TAF5 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RASSF1 SENP1 23023127 pred GP GP G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SENP1 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAD23B SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS SENP1 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DDI1 SENP1 23023127 pred P P P P G GP GP P G P P GP CHD3 SENP1 25402006 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBXN2B SENP1 23023127 pred G GP G G G G G G GP G GP G GP G G GP G GP G G G GP G G GP G GP GP G SENP1 WBP11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AXIN1 SENP1 23023127 pred GP GP G GP GP G P GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIO SENP1 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G EPB41L5 SENP1 23023127 pred G GP G G GP GP G G G G GP GP G G G GP GP G GP G GP G G G GP P GP GP G OBSCN SENP1 23023127 pred GP P P P GP GP GP P P GP G P P P P G P GP GP GP GP GP GP P HSF2 SENP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP G SENP1 NSFL1C 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBQLN3 SENP1 23023127 pred G G G G G G GP G MYLIP SENP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCSTAMP SENP1 21836163 pred P G GP G G P P G G P G G G G P P P G HUWE1 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBXN2A SENP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBXN1 SENP1 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G USP5 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G BAG1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIPK3 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MEF2A SENP1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP G GP G ZBTB14 SENP1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP G GP G GP P DVL1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PELP1 SENP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UFM1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G FGD1 SENP1 23023127 pred G GP G G G GP G G G G G G GP G G G GP G G G GP GP G G G G GP GP G SAP30L SENP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SENP1 SAE1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FAU SENP1 23023127 pred GP G G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UHRF2 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DDI2 SENP1 23023127 pred P P P P P P P P P P P P P P P GABARAPL2 SENP1 23023127 pred G GP G G GP GP G GP GP G GP G G G G GP GP G GP G G GP GP G GP G GP GP G SENP1 USP20 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBTD2 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SENP3 SENP1 25402006, 23023127 pred GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP G GP GP GP G GP GP G USP44 SENP1 23023127 pred P P P P P P P P P P P P P GP G P P P P P P GP SENP1 UBQLN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZNF385D SENP1 21836163 pred GP P G G GP GP G G GP G G P G P GP P G P G GP G P SENP1 USP3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SF3A1 SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PARK2 SENP1 23023127 pred P GP G P GP G GP GP G GP P P G P GP GP P G P GP GP GP P GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9P0U3 Q81SR0 two hybrid pooling approach 20711500 physical association X 2 Q9P0U3 Q8CLR7 two hybrid pooling approach 20711500 physical association X 2 Q9P0U3 P55854 enzymatic study 22878415 cleavage reaction X 2 Q9P0U3 A0A024R3Z2 coimmunoprecipitation 15896780 physical association X 2 Q9P0U3 A0A024R3Z2 cross-linking study 22878415 direct interaction X 2 Q9P0U3 A0A024R3Z2 enzymatic study 22878415 cleavage reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SUMO1 SENP1 MI:0065(isothermal titration calorimetry)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0065(isothermal titration calorimetry)|MI:0030(cross-linking study)|MI:0045(experimental interaction detection)|MI:0114(x-ray crystallography)|MI:0428(imaging technique)|MI:0114(x-ray crystallography)|MI:0030(cross-linking study)|MI:0114(x-ray crystallography) 15896780,17000875,17099698,22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0465(dip)|MI:0471(mint)|MI:0471(mint)|MI:0465(dip)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid) DIP_53649|MINT_31311|MINT_60034|DIP_53650|UniProt_126155|UniProt_81168|BIOGRID_289507|BIOGRID_201398|BIOGRID_289502|UniProt_126141|BIOGRID_289504 -|prey|prey|-|neutral component|prey|prey|prey|prey|neutral component|prey -|bait|bait|-|neutral component|bait|bait|bait|bait|neutral component|bait KCNK1 SENP1 MI:0018(two hybrid) 15820677 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_18201 - - HIPK2 SENP1 MI:0415(enzymatic study) 16253240 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_200056 prey bait UBD SENP1 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226577 bait prey GCM1 SENP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21791615 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_164662|BIOGRID_164664|BIOGRID_164665 bait|prey|prey prey|bait|bait ELAVL1 SENP1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187828 bait prey HDAC4 SENP1 MI:0428(imaging technique) 20079608 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_122746 bait prey LMNA SENP1 - 22412018 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_280448 bait prey RANBP2 SENP1 MI:0415(enzymatic study) 22194619 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_194126 prey bait ISG15 SENP1 MI:0004(affinity chromatography technology) 16009940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196228 bait prey SUMO3 SENP1 MI:0096(pull down)|MI:0030(cross-linking study) 22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0194(cleavage reaction) (biogrid)|(intact) BIOGRID_208442|UniProt_126156 prey|neutral component bait|neutral component BAG3 SENP1 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283104 bait prey RANGAP1 SENP1 MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 17099698 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction) MI:0465(dip)|MI:0465(dip)|(biogrid)|(biogrid)|(biogrid) DIP_53652|DIP_53649|BIOGRID_289506|BIOGRID_289501|BIOGRID_289503 -|-|prey|prey|prey -|-|bait|bait|bait APP SENP1 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228830 prey bait SUMO2 SENP1 MI:0065(isothermal titration calorimetry)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0428(imaging technique)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0065(isothermal titration calorimetry) 16553580,17000875,17099698,20212317,21252943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip) DIP_53652|BIOGRID_196360|BIOGRID_183928|BIOGRID_289505|BIOGRID_201399|BIOGRID_289508|BIOGRID_289742|BIOGRID_289741|DIP_53651 -|prey|bait|prey|prey|prey|prey|prey|- -|bait|prey|bait|bait|bait|bait|bait|- PARP1 SENP1 MI:0415(enzymatic study) 19622798 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128038 prey bait SENP1 RUVBL2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16699503,20603076 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_138698|BIOGRID_129988 prey|bait bait|prey HDAC1 SENP1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 15199155 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_135314|HPRD_25458 bait|- prey|- UBC SENP1 MI:0004(affinity chromatography technology) 21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_175386 bait prey HDAC2 SENP1 MI:0004(affinity chromatography technology) 22493095 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_190384 bait prey

PPI - HINT Gene A Gene B PMID Method Quality LMNA SENP1 22412018,24927568 1313,1313 LC APP SENP1 21832049,21244100 0096,0096 LC APC SENP1 26496610,26496610 0007,0004 HT NUP153 SENP1 26496610,26496610 0007,0004 HT SUMO2 SENP1 16553580,17099698,17099698,16553580,17099698,16553580,17099698 0096,0096,0065,0114,0415,0415,0055 LC SUMO1 SENP1 22878415,17099698,22878415,17099698,22878415,17099698,17099698,17099698 0030,0065,0415,0114,0096,0415,0096,0055 LC KPNB1 SENP1 26496610,26496610 0007,0004 HT SCARA3 SENP1 26186194 0004 HT SENP1 SENP1 17704192,17704192 0096,0004 LC SENP1 RUVBL2 20603076,16699503 0004,0004 LC APC SENP1 26496610,26496610 0007,0004 HT NUP153 SENP1 26496610,26496610 0007,0004 HT KPNB1 SENP1 26496610,26496610 0007,0004 HT SCARA3 SENP1 26186194 0004 HT LMNA SENP1 22412018,24927568 1313,1313 LC APP SENP1 21832049,21244100 0096,0096 LC SUMO2 SENP1 16553580,17099698,17099698,16553580,17099698,16553580,17099698 0096,0096,0065,0114,0415,0415,0055 LC SUMO1 SENP1 22878415,17099698,22878415,17099698,22878415,17099698,17099698,17099698 0030,0065,0415,0114,0096,0415,0096,0055 LC SENP1 SENP1 17704192,17704192 0096,0004 LC SENP1 RUVBL2 20603076,16699503 0004,0004 LC PARP1 SENP1 19622798 0415 LC PML SENP1 21098080 0415 LC RANGAP1 SENP1 17099698 0114 LC RANBP2 SENP1 22194619 0415 LC SUMO3 SENP1 16553580,16608850,22878415,22878415 0415,0415,0096,0415 LC CAV3 SENP1 21362625 0415 LC UBE2K SENP1 21098080 0415 LC SUMO2 SENP1 16553580,17099698,17099698,16553580,22878415,PDB_2IYD,17099698,16553580,17000875,17099698 0096,0096,0065,0114,0415,0114,0415,0415,0415,0055 LC SUMO1 SENP1 16712526,22878415,17099698,22878415,16608850,17099698,22878415,17099698,16553580,15896780,17099698,17000875,17099698 0114,0030,0065,0415,0415,0114,0096,0415,0415,0019,0096,0415,0055 LC FLJ00340 SENP1 22878415 0415 LC NACC1 SENP1 25891951 0415 LC Q9BSK3 SENP1 16553580,17099698,25027693,17099698,17099698 0415,0096,0415,0055,0114 LC HIPK2 SENP1 16253240 0415 LC SENP1 SENP1 16712526,PDB_2IYC,16553580,21505236 0114,0114,0114,0114 LC SENP1 USP25 18538659 0415 LC SENP1 RABGAP1 16608850 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9P0U3 P57078 SENP1 RIPK4 0.126 26972000 Q9P0U3 P57740 SENP1 NUP107 0.126 24927568 Q9P0U3 Q8CLR7 SENP1 Q8CLR7 0.126 20711500 Q9P0U3 Q8NFH3 SENP1 NUP43 0.126 24927568 Q9P0U3 Q9NP62 SENP1 GCM1 0.569 21791615 Q9P0U3 Q8TAQ5 SENP1 ZNF420 0.569 25691462 Q9P0U3 Q6RT24 SENP1 CENPE 0.126 26496610 Q9P0U3 Q6AZY7 SENP1 SCARA3 0.126 26186194 Q9P0U3 O95714 SENP1 HERC2 0.126 25476789 Q9P0U3 P04637 SENP1 TP53 0.21 19339993 Q9P0U3 P05161 SENP1 ISG15 0.126 16009940 Q9P0U3 O95817 SENP1 BAG3 0.126 23824909 Q9P0U3 G2XKQ0 SENP1 G2XKQ0 0.236 unassigned1304 Q9P0U3 Q9P0U3 SENP1 SENP1 0.49 17704192 Q9P0U3 P02545 SENP1 LMNA 0.236 24927568,22412018 Q9P0U3 Q8VC57 SENP1 KCTD5 0.236 26496610 Q9P0U3 Q14974 SENP1 KPNB1 0.236 26496610 Q9P0U3 Q9ERU9 SENP1 RANBP2 0.236 26496610 Q9P0U3 P25054 SENP1 APC 0.236 26496610 Q9P0U3 P49790 SENP1 NUP153 0.236 26496610 Q9P0U3 Q8BH74 SENP1 NUP107 0.236 26496610 Q9P0U3 Q8BHX1 SENP1 HAUS1 0.236 26496610 Q9P0U3 P63280 SENP1 UBE2I 0.236 26496610 Q9P0U3 P61956 SENP1 SUMO2 0.981 17000875,22878415,unassigned1304,17099698,16553580 Q9P0U3 P46060 SENP1 RANGAP1 0.843 17099698,16553580,25027693 Q9P0U3 Q92769 SENP1 HDAC2 0.21 22493095 Q9P0U3 P09874 SENP1 PARP1 0.309 19622798 Q9P0U3 P56539 SENP1 CAV3 0.309 21362625 Q9P0U3 P05067 SENP1 APP 0.332 21244100,21832049 Q9P0U3 O75626 SENP1 PRDM1 0.21 21722636 Q9P0U3 P29590 SENP1 PML 0.309 21098080 Q9P0U3 P23497 SENP1 SP100 0.309 22878415 Q9P0U3 P49792 SENP1 RANBP2 0.309 22194619 Q9P0U3 P32121 SENP1 ARRB2 0.21 25425640 Q9P0U3 P61086 SENP1 UBE2K 0.309 21098080 Q9P0U3 Q81SR0 SENP1 Q81SR0 0.126 20711500 Q9Y230 Q9P0U3 RUVBL2 SENP1 0.376 20603076,16699503 Q9P0U3 Q96RE7 SENP1 NACC1 0.309 25891951 Q9UHP3 Q9P0U3 USP25 SENP1 0.309 18538659 Q9Y3P9 Q9P0U3 RABGAP1 SENP1 0.309 16608850 Q9P0U3 Q13547 SENP1 HDAC1 0.21 15199155 Q9P0U3 E9QKK1 SENP1 E9QKK1 0.126 26496610 Q9P0U3 P63165 SENP1 SUMO1 0.993 17000875,16608850,22878415,unassigned1304,15896780,17099698,16553580 Q9P0U3 Q15717 SENP1 ELAVL1 0.126 19322201 Q9P0U3 P55854 SENP1 SUMO3 0.78 22878415,16608850,16553580 Q9P0U3 P56524 SENP1 HDAC4 0.126 20079608

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RGPD3 SENP1 MI:0362 inference MI:0461 interaction database KCNK1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database RGPD8 SENP1 MI:0362 inference MI:0461 interaction database UBD SENP1 MI:0045 experimental interaction detection MI:0461 interaction database PRDM1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database HERC2 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database BAG3 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database LMNA SENP1 MI:0045 experimental interaction detection MI:0461 interaction database TP53 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database APP SENP1 MI:0045 experimental interaction detection MI:0461 interaction database ISG15 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database PARP1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database UBC SENP1 MI:0045 experimental interaction detection MI:0461 interaction database RGPD1 SENP1 MI:0362 inference MI:0461 interaction database RGPD2 SENP1 MI:0362 inference MI:0461 interaction database SP100 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database APC SENP1 MI:0045 experimental interaction detection MI:0461 interaction database PML SENP1 MI:0045 experimental interaction detection MI:0461 interaction database ARRB2 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A SENP1 MI:0045 experimental interaction detection MI:0461 interaction database RANGAP1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database NUP153 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database RANBP2 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 SENP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CAV3 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database NUP107 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K SENP1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 SENP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SUMO1 SENP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2I SENP1 MI:0362 inference MI:0461 interaction database CENPE SENP1 MI:0362 inference MI:0461 interaction database HDAC1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database KPNB1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database HIF1A SENP1 MI:0362 inference MI:0461 interaction database SCARA3 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database RGPD4 SENP1 MI:0362 inference MI:0461 interaction database NUP43 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF420 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database HDAC2 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database HAUS1 SENP1 MI:0362 inference MI:0461 interaction database NACC1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database RGPD5 SENP1 MI:0362 inference MI:0461 interaction database HIPK2 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database GCM1 SENP1 MI:0045 experimental interaction detection MI:0461 interaction database KCTD5 SENP1 MI:0362 inference MI:0461 interaction database SENP1 USP25 MI:0045 experimental interaction detection MI:0461 interaction database SENP1 RUVBL2 MI:0045 experimental interaction detection MI:0461 interaction database SENP1 RABGAP1 MI:0045 experimental interaction detection MI:0461 interaction database