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AMFR 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA2 CNOT4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 BRAP 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP CNOT4 PABPC1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CNOT4 G3BP1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 LNX1 21836163 pred GP G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP P GP GP HNRNPDL CNOT4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 PMF1 21836163 pred G GP G G G GP G GP GP G GP G GP G G G GP G G G G GP G G G G GP GP G CNOT4 SIAH1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 DZIP3 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP GP G 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GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 GATAD2A 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 NCOR2 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP GP GP GP G CNOT4 UFC1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2C CNOT4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 RNF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2L6 CNOT4 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CNOT4 SNAPC3 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CNOT4 CPEB4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G CNOT4 HIPK4 23023127 pred G G G G G GP G GP GP G GP G G G G GP GP G GP G GP G GP GP GP G GP GP G CNOT4 RBM12B 23023127 pred GP GP G G GP GP G G GP G GP GP G G G GP GP GP GP G GP G GP G GP G GP G G CNOT4 HDAC5 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 RNF144B 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G G G GP G G GP G CNOT4 OTUB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 TRIM5 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G CNOT4 NFKBIA 25402006 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CNOT4 CDC34 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNOT4 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G CNOT4 TRIM17 23023127 pred P P P P P P P P P P P P P P P P P P GP CNOT4 RNF25 25402006, 21836163 pred P G P P P P P P P P P P P P P GP P P CNOT4 RNF115 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EDF1 CNOT4 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CNOT4 BIRC3 25402006 pred GP G GP G G GP P GP G GP G GP G GP P G GP GP GP GP GP CNOT4 RNF14 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP2 CNOT4 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G CNOT4 SUDS3 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CNOT4 UBE2B MI:0018(two hybrid) 15001359 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_30768 - - CNOT4 CNOT1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 10637334,11823428 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(intact)|(intact)|(biogrid)|(intact)|MI:0468(hprd) BIOGRID_110169|UniProt_187203|UniProt_65667|BIOGRID_207691|UniProt_159983|HPRD_13316 prey|null|null|prey|null|- bait|bait|bait|bait|bait|- CNOT4 CNOT8 MI:0493(in vivo) 10637334 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_13314 - - CNOT4 EP300 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286702|UniProt_118819 bait|unspecified role prey|unspecified role CNOT4 UBE2D2 MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11823428,15001359,15062086,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_123443|BIOGRID_197872|BIOGRID_225941|BIOGRID_207660|UniProt_102432|BIOGRID_207694|HPRD_30766|BIOGRID_207702|BIOGRID_225944|BIOGRID_207663|BIOGRID_207705 prey|prey|bait|bait|prey|bait|-|prey|bait|prey|prey bait|bait|prey|prey|bait|prey|-|bait|prey|bait|bait CNOT4 UBE2D4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123509|UniProt_102499 prey|prey bait|bait CNOT4 UBE2D3 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102465|BIOGRID_123477 prey|prey bait|bait CNOT4 UBE2N MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102598|BIOGRID_123609 prey|prey bait|bait CNOT4 UBE2E3 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11823428,15001359,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) UniProt_102547|BIOGRID_207696|BIOGRID_123560|HPRD_30770|BIOGRID_207662 prey|bait|prey|-|bait bait|prey|bait|-|prey CNOT4 UBE2W MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123695|UniProt_102685 prey|prey bait|bait CNOT4 NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296412 prey bait CNOT4 UBE2E1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11823428,15001359 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_207695|BIOGRID_207661|HPRD_30769 bait|bait|- prey|prey|- CNOT4 UBE2D1 MI:0415(enzymatic study) 19346402 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_221611 bait prey CNOT4 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187257 prey bait CNOT4 UBC MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 15001359,21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_169370|BIOGRID_207675 prey|bait bait|prey CNOT4 KDM5C MI:0415(enzymatic study) 19346402 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_164595 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CNOT4 MCM2 25963833 0004 HT CNOT4 UBE2D2 26575292,15001359,15001359,11823428,11823428 0096,0018,0096,0096,0018 LC CNOT4 MCM2 25963833 0004 HT CNOT4 UBE2D2 26575292,15001359,15001359,11823428,11823428 0096,0018,0096,0096,0018 LC CNOT1 CNOT4 10637334,11823428 0018,0018 LC CNOT4 CNOT4 11823428,15001359 0415,0415 LC CNOT4 KDM5C 19346402 0415 LC CNOT4 UBE2E1 15001359,11823428 0018,0018 LC CNOT4 UBE2D3 19690564,19690564 0397,0018 HT CNOT4 UBE2N 19690564 0397 HT CNOT4 UBE2D2 19690564,15001359,15001359,11823428,19690564,15062086,11823428 0397,0018,0096,0096,0018,0114,0018 HT,LC CNOT4 UBE2B 15001359 0018 LC CNOT4 EP300 21988832 0018 HT CNOT4 UBE2E3 19690564,15001359,11823428,19690564 0397,0018,0018,0018 HT,LC CNOT4 UBE2W 19690564,19690564 0397,0018 HT CNOT4 RBM15 26575292,26575292 0415,0004 LC CNOT4 CNOT8 10637334 0018 LC CNOT4 UBE2D4 19690564,19690564 0397,0018 HT CNOT4 HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q09472 O95628 EP300 CNOT4 0.332 21988832 P15732 O95628 UBC5 CNOT4 0.523 11823428 P61077 O95628 UBE2D3 CNOT4 0.286 19690564 P25655 O95628 CDC39 CNOT4 0.309 10637334 Q6P5F9 O95628 XPO1 CNOT4 0.126 26673895 P01106 O95628 MYC CNOT4 0.126 21150319 P41229 O95628 KDM5C CNOT4 0.309 19346402 Q9Y2X8 O95628 UBE2D4 CNOT4 0.376 19690564 P51668 O95628 UBE2D1 CNOT4 0.309 19346402 Q96T37 O95628 RBM15 CNOT4 0.623 26575292 Q96B02 O95628 UBE2W CNOT4 0.376 19690564 Q9UBH0 O95628 IL36RN CNOT4 0.236 unassigned1304 Q969T4 O95628 UBE2E3 CNOT4 0.702 19690564,15001359,11823428 O95628 A5YKK6 CNOT4 CNOT1 0.523 11823428,10637334 O95628 O95628 CNOT4 CNOT4 0.554 11823428,15001359 P51965 O95628 UBE2E1 CNOT4 0.523 15001359,11823428 P61088 O95628 UBE2N CNOT4 0.286 19690564 P62837 O95628 UBE2D2 CNOT4 0.946 19690564,15001359,11823428,15062086,26575292 P49736 O95628 MCM2 CNOT4 0.126 25963833 Q15717 O95628 ELAVL1 CNOT4 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CNOT1 CNOT4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMD14 CNOT4 MI:0362 inference MI:0461 interaction database PSMA7 CNOT4 MI:0362 inference MI:0461 interaction database XPO1 CNOT4 MI:0045 experimental interaction detection MI:0461 interaction database CNOT3 CNOT4 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 MYC MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 EIF4E MI:0362 inference MI:1106 pathways database CNOT4 HSP90AB1 MI:0362 inference MI:0461 interaction database CNOT4 POLA1 MI:0362 inference MI:0461 interaction database CNOT4 UBC MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 HSPA1A MI:0362 inference MI:0461 interaction database CNOT4 HSPA1B MI:0362 inference MI:0461 interaction database CNOT4 HSPA8 MI:0362 inference MI:0461 interaction database CNOT4 PABPC1 MI:0362 inference MI:1106 pathways database CNOT4 TPR MI:0362 inference MI:0461 interaction database CNOT4 HSPA6 MI:0362 inference MI:0461 interaction database CNOT4 RCC1 MI:0362 inference MI:0461 interaction database CNOT4 BTF3 MI:0362 inference MI:0461 interaction database CNOT4 RAB3A MI:0362 inference MI:0461 interaction database CNOT4 TAF1 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 EIF4B MI:0362 inference MI:1106 pathways database CNOT4 CCNC MI:0362 inference MI:0461 interaction database CNOT4 PSMA1 MI:0362 inference MI:0461 interaction database CNOT4 PSMA2 MI:0362 inference MI:0461 interaction database CNOT4 PSMA3 MI:0362 inference MI:0461 interaction database CNOT4 PSMA4 MI:0362 inference MI:0461 interaction database CNOT4 DDX6 MI:0362 inference MI:0461 interaction database CNOT4 PSMA5 MI:0362 inference MI:0461 interaction database CNOT4 MAT2A MI:0362 inference MI:0461 interaction database CNOT4 HSPA1L MI:0362 inference MI:0461 interaction database CNOT4 COPB2 MI:0362 inference MI:0461 interaction database CNOT4 ATP6V1A MI:0362 inference MI:0461 interaction database CNOT4 EIF4A3 MI:0362 inference MI:1106 pathways database CNOT4 CCT6A MI:0362 inference MI:0461 interaction database CNOT4 KDM5C MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 HNF4A MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 SKIV2L2 MI:0362 inference MI:0461 interaction database CNOT4 PRIM1 MI:0362 inference MI:0461 interaction database CNOT4 PRIM2 MI:0362 inference MI:0461 interaction database CNOT4 MCM2 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 PSMD7 MI:0362 inference MI:0461 interaction database CNOT4 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 UBE2E1 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 COPA MI:0362 inference MI:0461 interaction database CNOT4 HSPA2 MI:0362 inference MI:0461 interaction database CNOT4 EIF4A1 MI:0362 inference MI:1106 pathways database CNOT4 PSMA6 MI:0362 inference MI:0461 interaction database CNOT4 UBE2D3 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 UBE2N MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 MAX MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 RPS7 MI:0362 inference MI:0461 interaction database CNOT4 PSMC5 MI:0362 inference MI:0461 interaction database CNOT4 LSM3 MI:0362 inference MI:0461 interaction database CNOT4 RAB1A MI:0362 inference MI:0461 interaction database CNOT4 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 HIST1H3A MI:0362 inference MI:0461 interaction database CNOT4 BTG2 MI:0362 inference MI:1106 pathways database CNOT4 H3F3A MI:0362 inference MI:0461 interaction database CNOT4 MAT1A MI:0362 inference MI:0461 interaction database CNOT4 EIF4G1 MI:0362 inference MI:1106 pathways database CNOT4 RBL2 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 EP300 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 POLA2 MI:0362 inference MI:0461 interaction database CNOT4 EIF4A2 MI:0362 inference MI:1106 pathways database CNOT4 TRIP12 MI:0362 inference MI:0461 interaction database CNOT4 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 E2F4 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 HIST3H3 MI:0362 inference MI:0461 interaction database CNOT4 H3F3C MI:0362 inference MI:0461 interaction database CNOT4 HIST2H3A MI:0362 inference MI:0461 interaction database CNOT4 NUP93 MI:0362 inference MI:0461 interaction database CNOT4 PSMA8 MI:0362 inference MI:0461 interaction database CNOT4 CCT6B MI:0362 inference MI:0461 interaction database CNOT4 RQCD1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 GCN1 MI:0362 inference MI:0461 interaction database CNOT4 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 BTF3L4 MI:0362 inference MI:0461 interaction database CNOT4 CNOT6L MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 UBE2E2 MI:0362 inference MI:0461 interaction database CNOT4 RBM15 MI:0045 experimental interaction detection MI:0461 interaction database CNOT4 MMS19 MI:0362 inference MI:0461 interaction database CNOT4 TNKS1BP1 MI:0362 inference MI:1106 pathways database CNOT4 NACA2 MI:0362 inference MI:0461 interaction database CNOT4 PAIP1 MI:0362 inference MI:1106 pathways database CNOT4 CNOT10 MI:0362 inference MI:1106 pathways database CNOT4 EXOSC4 MI:0362 inference MI:0461 interaction database CNOT4 CNOT2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 CNOT8 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 CNOT7 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 CNOT11 MI:0362 inference MI:1106 pathways database CNOT4 CNOT6 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CNOT4 RUVBL2 MI:0362 inference MI:0461 interaction database CNOT4 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database