PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PSEN1 FGF13 21163940 biogrid exp G G G GP GP G G GP G GP G GP G G GP G G GP G GP G G GP GP GP G PSEN1 DHX9 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 STX1A i2d,bci exp G G G GP G G P G G G G GP GP GP G G G G G GP GP G G PSEN1 PDCD4 21163940 biogrid exp P P P P P P P P P P P P GP GP P P P P P P P PSEN1 DTNA 22939629 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G G GP G GP G P G GP GP G G GP GP G GDI1 PSEN1 15480879 hprd,bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 PRAM1 21163940 biogrid,intact exp P G GP P P P P P GP P P P P P P P GP P P PSEN1 TUBA1B 21163940 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 RAD23A 21163940 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 ITSN2 21163940 biogrid exp G G G G G GP G G GP G GP GP G G G GP GP G GP G GP GP G G GP G GP GP G PSEN1 RAB11A 10369872 hprd,dip,bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G GAPDH PSEN1 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CASP4 PSEN1 10069390 hprd,i2d,bci exp GP GP G GP P G G GP GP GP GP GP G GP P G GP G GP GP GP G GP G GP P G PSEN1 OXCT1 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ACTN1 PSEN1 21163940 biogrid,intact exp G G G G GP GP G G G G G GP GP GP G G GP G G G GP G GP GP G GP G G G TCF4 PSEN1 16306047 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NPR1 PSEN1 18942891 dip exp GP GP P P GP GP GP GP GP GP G GP P G P G GP P P GP GP P GP GP G PSEN1 NDUFA9 20515039 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SCN1A PSEN1 21163940 biogrid exp P P G P GP G P P G P P P P P GP P P P P P P P P P RAB3A PSEN1 21163940 biogrid,intact exp GP G G G GP G G G G G G G GP G GP G G G G G G G PSEN1 DNER 18942891 dip exp G G GP G G GP G G G GP G G G G G GP CD44 PSEN1 bci exp GP G G G GP GP G G GP G G G GP GP G G GP G GP G G GP GP G G GP G G G PSMB1 PSEN1 10527805 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CYP2C18 PSEN1 21163940 biogrid exp G G G G G G G G G G G G G G G PSEN1 FBXL12 21163940 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SH2B2 PSEN1 bci exp GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP GP GP GP G UBC PSEN1 24399296 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 AP1M2 21163940 biogrid exp G G G G G G G G G G G G G G G G G PSEN1 STAMBPL1 21163940 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP PSEN1 EFHD1 21163940 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP GP G PSEN1 DAG1 18942891 dip exp G G G G G GP G GP GP G GP G GP G G G GP G GP G GP GP G GP G G GP GP G TDP2 PSEN1 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CFL1 PSEN1 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 KANK2 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP G GP G PSEN1 BCAP31 bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RIOK3 PSEN1 bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CXCR1 PSEN1 24914212 innatedb exp P P G GP P P P P P P P GP P P P P G P P NOS3 PSEN1 21163940 biogrid exp G P P G GP G APOE PSEN1 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP G G G GP GP G G G GP GP GP G PSEN1 RNF32 21163940 biogrid exp P P P P P P P P P P P P P P P P GP PRDX2 PSEN1 21163940 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 VASN 18942891 dip exp G GP G GP G GP GP G GP GP GP G G G GP G GP G GP G GP G G G GP GP G ETFA PSEN1 10527805 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 TP63 bci exp GP G G G G G G G G G G G G G G G G G G GP GP G G G G G PSEN1 YME1L1 12214059 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 ECSIT 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP G IRAK2 PSEN1 18996842 innatedb,biogrid exp GP GP G G GP GP G P P G GP GP GP GP GP GP G G G GP GP GP G GP P PSEN1 SCAF11 10069390 hprd,bci exp GP G G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G PSEN1 RHEB 21163940 biogrid exp GP G G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 BARD1 bci exp P G GP P P GP P P P GP G GP P G P P GP P GP P GP GP GP G PSEN1 EPB41L3 21163940 biogrid,intact exp G GP G GP G G GP G GP G GP G GP GP G GP G GP G GP G GP HSPA5 PSEN1 bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSMA5 PSEN1 10527805 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 CDC37 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UMPS PSEN1 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 SRPK1 bci exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 NCLN bci exp P GP P P GP P P P P GP P P P P P P P P P P PSEN1 RMDN3 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 PLXDC2 18942891 dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G HMGB1 PSEN1 21163940 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ENSA PSEN1 21163940 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 METTL2B 11738826 hprd exp G G G G G G G G G TGFBR1 PSEN1 24399296 biogrid exp GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G PSEN1 GCDH 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ELK1 PSEN1 12750007 intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP G G G GP GP GP G GP GP GP GP G HTRA2 PSEN1 10971580 intact exp GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G CYP2C8 PSEN1 21163940 biogrid exp G P GP P G P G G PSEN1 ST13 21163940 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NDUFS8 PSEN1 22939629 biogrid exp P P P P P P P P P P P P P P P CLSTN1 PSEN1 15037614 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP GP GP GP G PSEN1 UNK 25737280 biogrid exp, ortho G GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G PSEN1 EFNB2 16511561 hprd exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ERLIN2 PSEN1 22771797 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G GSAP PSEN1 20811458 biogrid exp, ortho G GP G G GP GP G GP GP G G GP GP G G G GP G GP G GP G GP GP G G GP P G PIK3R1 PSEN1 15192701 hprd,bci exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 NOTCH4 11518718 hprd exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 PSEN1 12535650,15474363,22771797,22036569,12297508 hprd,biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 PSENEN 14572442,22074918,12639958,12198112,15474363, 25402006, 21836163 hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CTNNB1 PSEN1 10341227,11226248,11168528,9738936,16126725,17360711,9852041,16306047,12070348,10092585, 25402006, 21836163 innatedb,hprd,biogrid,i2d,intact,bci exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G PSEN1 NCSTN 12603837,16641999,10993067,12297508,14572442,18201567,17911105,15474363,15257293,12471034, 25402006, 21836163 hprd,biogrid,i2d,mint,intact exp, ortho, pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G PSEN1 APH1B 15474363,12471034, 25402006, 21836163 hprd,biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 NOTCH3 11518718, 25402006, 21836163 hprd,bci exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 DOCK3 10854253, 25402006 hprd exp, ortho, pred P P G P GP G P P G P P P P P GP P P P P P P P PSEN1 NOTCH2 11518718, 25402006, 21836163 hprd exp, ortho, pred G GP G G G G G G GP G G G G G G G G G G G G G G G G G GP G G DLL1 PSEN1 12794186, 25402006 hprd exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G APP PSEN1 10593990,21163940,9223340,21115843,11083918, 25402006, 21836163 hprd,biogrid,i2d,intact,dip,bci exp, ortho, pred G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G PSEN1 PSEN2 21163940,15474363,12471034, 25402006 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G CDH1 PSEN1 16126725,11226248,11953314,10635315, 25402006, 21836163 innatedb,hprd,biogrid,mint,intact,bci exp, ortho, pred GP G G G GP GP GP GP G G GP G GP G GP GP GP GP G GP G PSEN1 APH1A 14572442,17911105,15474363,12471034,12297508, 25402006, 21836163 hprd,biogrid,i2d,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NOTCH1 PSEN1 10206645,10077672,12374741, 25402006, 21836163 hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 GSK3B 16814287,17360711,11104755, 25402006, 21836163 hprd,biogrid,mint,intact,bci exp, ortho, pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G PSEN1 ICAM5 11719200, 25402006, 21836163 hprd,biogrid exp, ortho, pred G G G GP G GP G CASP1 PSEN1 10069390, 25402006 hprd,i2d,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PSEN1 CDK5 12056836,21163940, 25402006, 21836163 hprd,biogrid,intact,bci exp, pred P GP G P GP G P P G GP GP P GP GP GP P G P G P P P P P PSEN1 KCNIP3 10854253,12207970,9771752, 25402006, 21836163 hprd,biogrid exp, pred P G GP G P G G P P G GP G P G P G P P GP GP G PSEN1 CASP8 10069390, 25402006 hprd,bci exp, pred GP GP G GP P GP GP GP GP GP GP G GP P G P G GP GP GP P GP GP GP GP G PSEN1 ETV1 12750007, 21836163 intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FLNB PSEN1 9437013, 25402006 hprd,biogrid,mint,intact,bci exp, pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G PSEN1 FBXW7 12354302, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP DSP PSEN1 16306047,22939629, 25402006 biogrid exp, pred G G G G G G G GP G G G G G G G G G G GP G GP G GP G G G GP G G PSEN1 UBQLN1 16813565,16815845,11076969, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 GRB2 17314098, 25402006 innatedb exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G JUP PSEN1 11226248,16306047, 25402006 hprd,intact,bci exp, pred GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G PRKACA PSEN1 14576165, 25402006, 21836163 hprd,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ERN1 PSEN1 10587643, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CTNND1 PSEN1 11226248,10208590, 25402006 hprd,biogrid exp, pred P P P P P P P P P P P P P P P P P P P P PSEN1 CASP7 10069390, 25402006 hprd,i2d,bci exp, pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G PSEN1 CIB1 10366599, 25402006 hprd,biogrid,i2d exp, pred GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP GP GP GP GP G GP GP G BCL2 PSEN1 10521466, 25402006 hprd,biogrid,bci exp, pred G G G G GP GP G G GP G GP G G GP G G GP G G G GP GP G G G GP G G G CASP3 PSEN1 10069390, 25402006 hprd,i2d,bci exp, pred GP G G G GP G G GP G G G GP GP G GP G G GP G GP G G G GP GP GP GP G PSEN1 MTCH1 10551805,12377771, 25402006 hprd,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TMED10 PSEN1 16641999, 25402006, 21836163 intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ETS2 PSEN1 12750007, 21836163 intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 PRKCZ 14576165, 21836163 hprd,bci exp, pred G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP P GP GP GP GP GFAP PSEN1 12058025, 25402006, 21836163 hprd,biogrid exp, pred G GP G G G GP G G PSEN1 HERPUD1 14550564,11799129, 21836163 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 CDH15 25402006 bci exp, pred G G G G G GP G GP G G G G G G GP G G G GP G GP GP G P G G PSEN1 KCNIP4 11847232, 25402006, 21836163 biogrid exp, pred P GP G G GP GP G G GP G GP P GP G GP GP G P G P GP P P GP GP P G MAPT PSEN1 9689133, 25402006, 21836163 hprd,biogrid,bci exp, pred G GP G G G GP G GP GP G GP GP G GP G G GP G GP G G GP GP GP G G GP GP G PSEN1 CASP6 10069390, 25402006 hprd exp, pred GP G G GP G G GP GP G G GP G GP G GP P GP GP GP G GP G PSEN1 BCL2L1 10446169, 25402006 hprd,biogrid,mint,intact,bci exp, pred G GP G G GP GP G G G G GP GP G GP G GP GP G G G G G GP G GP G GP GP G PSEN1 TRAF6 19012753,18996842,24399296,23707529, 25402006 innatedb,biogrid exp, pred GP GP G G GP G G GP GP G GP GP GP G G GP G G G G GP GP GP G GP GP GP GP G CTNNA1 PSEN1 10635315, 25402006 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 DSG2 18942891, 21836163 dip exp, pred GP P P GP GP GP GP GP G GP G GP G GP GP GP G GP GP P PSEN1 TCF7L2 16306047,11504726, 25402006 hprd,biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 APBA1 11083918,16007100,12196555, 25402006, 21836163 hprd,mint,intact exp, pred P GP G P GP G GP P G GP GP P GP G GP GP G P G P P GP GP GP GP GP GP G TP53 PSEN1 25402006 bci exp, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G FLNA PSEN1 9437013, 25402006 hprd,mint,intact,bci exp, pred G G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP G G G G G GP GP G PSEN1 CTNND2 10208590,10037471,9223106, 25402006 hprd,i2d,dip exp, pred P G GP G G G G P G GP G G G G GP G G G GP G RPL10 PSEN1 10508860, 25402006 dip exp, pred P P P P P P P P P P P P P P P P P P P P P PSEN1 PKP4 10037471,10092585, 25402006, 21836163 hprd,biogrid,i2d,mint,intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G G GP GP G GP G GP GP G PSEN1 BACE1 12901838, 23023127, 21836163 hprd,i2d exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G PSEN1 STX5 21836163 i2d,bci exp, pred GP GP G G GP GP G G G G GP GP GP GP G G GP G GP G GP GP GP G G G GP GP G PSEN1 SEC61A1 ortho G GP G G GP GP G G G G GP GP G G G GP GP G GP G GP G G G GP G GP GP G PSEN1 PEMT ortho GP GP G P GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP G PSEN1 PLD1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP P GP GP GP GP G PSEN1 GRIN2A ortho G G G G GP G G G G P GP GP G P G P P G CALR PSEN1 ortho GP G G G GP GP G G G G G GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G PSEN1 GRIN1 ortho P P G P GP G P G P G P P P GP P P P P G P P P P PSEN1 ARC ortho P P G P P P P P P P P P P P G P P P P P P P PSEN1 ATP6V0A1 25402006 ortho, pred G GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 STT3B 25402006 ortho, pred GP GP G G G GP G GP GP G G G GP G G G GP G GP G GP G G GP G G GP GP G NGFR PSEN1 25402006 ortho, pred GP G G P P G G G G G G P G G G PSEN1 EFNB1 25402006 ortho, pred GP GP G GP P G GP GP GP GP GP GP G P P G P GP P GP P GP GP GP P G PSEN1 KIAA1109 25402006 pred GP G G G G G G GP GP G GP G GP G G GP G G GP G GP GP G G GP G GP GP G PSEN1 MAP3K5 25402006 pred G GP G G GP GP G G GP G GP G GP GP G G GP G GP G G GP G G G GP GP GP G PSEN1 CSNK2A1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G HSP90AA1 PSEN1 25402006 pred GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G PSEN1 STXBP1 25402006 pred G G G G G GP G G GP G G G G G G G GP G GP G G G G G G G G G G CDH5 PSEN1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 PKP3 25402006 pred GP GP G G G G G G GP G GP GP GP G G GP G G GP G GP GP GP G GP GP G G EGFR PSEN1 25402006 pred GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP GP G PSEN1 ERBB2IP 25402006 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP G G GP GP GP GP G G HSPA8 PSEN1 25402006 pred P P P P P P P P P P P P P P P P CAPN2 PSEN1 25402006 pred GP GP G G GP GP G G G G GP GP GP G G G GP G GP G G GP GP G G G GP GP G ETS1 PSEN1 21836163 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP G G G PSEN1 HIF1A 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP G PSEN1 PLEKHA7 25402006 pred GP P P P G GP GP G GP GP GP P G GP GP G P GP P GP GP P GP GP PSEN1 BMF 25402006 pred GP GP G GP P P GP GP GP GP GP G GP P G GP G GP GP GP P GP GP GP P G CDK1 PSEN1 25402006 pred GP G GP G GP P P P GP G GP G GP P GP GP GP GP PSEN1 PKP2 25402006 pred G P G G P G GP GP GP G P G GP P G GP G GP G GP GP GP GP GP PSEN1 TCF7L1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SRC PSEN1 25402006 pred GP GP G GP GP G G GP G G G G GP GP G G G GP GP G GP GP GP GP G PSEN1 DAZAP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ACTN4 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PECAM1 PSEN1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 MAP3K14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 LRRC7 25402006 pred P P G P GP P G P P P P P GP P P P P P P P P P CASK PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIO PSEN1 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 ACTG1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 EP300 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 PARL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G PSEN1 FBXW11 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYC PSEN1 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP P G GP GP GP GP GP GP GP GP GP G CDH3 PSEN1 25402006 pred GP P P P P P P G P G P P GP P P GP P P G CDH2 PSEN1 25402006 pred GP G GP G GP GP G GP GP G G GP G P G G G G GP GP G BCL2L11 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CSNK1D PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 CDK5R1 25402006 pred G G G G G G G G G PSEN1 APLP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ERBB2 PSEN1 25402006 pred GP G G G G G G G GP G GP G G G G GP G G G G GP GP G G GP G G G G PSEN1 JAG1 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G FOS PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 TRAF2 25402006 pred P P P P P P P P P P P P P P P P P P GP GP P PSEN1 LIMA1 25402006 pred GP GP G G GP G G G GP G GP G GP G G GP G G GP G GP GP GP GP GP G GP GP G SRI PSEN1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 LEF1 25402006 pred G G G G GP GP G GP G GP GP GP G G GP G G G G G G GP G G G PSEN1 TP53BP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 BIK 25402006 pred P P P P P P P P GP P P P GP GP P GP P GP P PSEN1 APBA2 25402006 pred P P G G GP GP G P P G P P P GP P GP P P P P P P GP P P PSEN1 FLNC 25402006 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G MET PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 MAGI2 25402006 pred G GP G P GP G GP GP G GP GP GP G G G GP G GP G P G GP GP G GP G GP G PSEN1 YWHAZ 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 SMC5 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G POR PSEN1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P G P G P G P GP GP GP GP G PSEN1 TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 RCN2 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP GP G PSEN1 APLP1 25402006 pred GP G GP G P G G GP GP G P GP PSEN1 BRCA2 25402006 pred P P G GP P P P P P P P P P P P P P P P P GP G PSEN1 CHD3 21836163 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PSEN1 PSMD4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PSEN1 ATP5E 21836163 pred G G G G G G G GP GP G G G G G G GP G G GP G G G G G GP G G G G NFKB1 PSEN1 25402006 pred GP G G G GP G G G GP G G G GP GP G GP G G G G GP GP GP G GP GP G GP G MAP3K7 PSEN1 25402006 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G MAPK8 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G LCK PSEN1 25402006 pred G G GP G G G G G G GP G G G G G GP G PRKACB PSEN1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 TRAF4 25402006 pred G GP G GP G P GP G GP GP GP G G GP GP G GP G GP G GP P GP G GP GP G PSEN1 PIN1 25402006 pred G GP G G GP GP G G GP G G G G GP G G GP G P G P GP G G G G GP GP G APBA3 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G PRKACG PSEN1 21836163 pred P P G GP P P P P P P P P G GP G P P P P P P P GP YES1 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PSEN1 PPP3R1 25402006 pred GP GP G G G GP G GP GP G GP G G GP G GP GP G GP G G G GP GP GP GP GP GP G AXIN1 PSEN1 25402006 pred GP GP G GP GP G P GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SLC9A3R1 PSEN1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 BAX 25402006 pred P P G GP P P GP GP P GP P GP P G P G P GP P P GP GP GP P G PARP1 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 GSK3A 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G AKT1 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 RUNX3 25402006 pred G G G G G G G G G GP G G G G G G G G G PTPN6 PSEN1 25402006 pred G G G G GP G G G G G G G GP GP G G G G G G GP G G G G GP G G G PSEN1 SMAD2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MUC1 PSEN1 25402006 pred GP P GP GP P GP P G GP GP GP GP GP GP GP GP G PSEN1 BAK1 25402006 pred GP GP G G GP G G GP GP G GP GP GP GP G GP G G GP G GP GP GP G GP GP GP GP G NF1 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G EPS15 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ARRB1 PSEN1 25402006 pred GP G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G XRCC5 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MTOR PSEN1 25402006 pred G GP G G G GP G G G G G G GP G G G GP G G G G GP G G G G GP G G PSEN1 PPA1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SMAD7 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP P G CHUK PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 APBB2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G IKBKB PSEN1 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PARK2 PSEN1 25402006 pred P GP G P GP G GP GP G GP P P G P GP G P G P GP GP GP P GP G PSEN1 PPP1CA 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PTPRF PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP G PSEN1 HM13 21836163 pred GP GP G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 XIAP 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G ARRB2 PSEN1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 MAPK14 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G APBB1 PSEN1 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP GP G GP GP GP G CFLAR PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G C2 PSEN1 21836163, 21836163 pred G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G PSMB5 PSEN1 21836163 pred G GP G G G GP G G GP G GP G G G G G GP G GP G G G GP G G G GP GP G APC PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP PSEN1 DIO2 21836163 pred G GP G G GP GP G G G GP P GP G G G GP G G G GP G GP G G GP GP G PSEN1 NDRG1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TUBB PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 CREM 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G GP G PSEN1 PTPRJ 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RCVRN PSEN1 21836163 pred G G ITGB7 PSEN1 25402006 pred P P G GP P GP GP P P GP GP G GP P GP P P GP GP GP GP GP P CTSD PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PRKCA PSEN1 25402006 pred G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G G GP GP G GP GP G PSEN1 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSEN1 BNIP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G GP G GP G PSEN1 CALM1, CALM2, CALM3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 TMED2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G JUN PSEN1 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G PSEN1 PSMC1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 MAP3K3 25402006 pred G G G G GP GP G GP G G GP G GP GP G GP GP G G G GP G G G GP GP GP G G CYP26A1 PSEN1 21836163 pred G G G G G PSEN1 CTNNBIP1 25402006 pred G G G G G GP G G GP G G G G G G G GP G GP G GP GP GP G G G G GP G PSEN1 CASP9 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 CTBP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 ROCK1 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP GP G GP GP GP GP G PSEN1 MAP3K1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PTPRM PSEN1 25402006 pred GP GP G P GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G PDZD2 PSEN1 25402006 pred GP GP G GP G GP G G GP P GP G GP GP G G G G GP GP GP GP GP G PSEN1 MALT1 25402006 pred G G GP G G G G G G GP G G G G G G G G G G G G GP G PSEN1 AXIN2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NUMB PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G CSNK1A1 PSEN1 25402006 pred G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G PSEN1 EIF2AK3 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PIK3CA PSEN1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G P GP G GP G P GP GP GP GP GP GP GP AR PSEN1 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G GP G PSEN1 CREBBP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSEN1 FHL2 25402006 pred GP GP G G GP GP G GP GP GP GP GP G G GP GP G G G GP GP G GP GP G GP GP G PSEN1 DLG1 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CAPN1 PSEN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PSEN1 APH1A MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation) 12297508,12471034,14572442,15474363 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|-|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0468(hprd)|(intact) BIOGRID_102354|BIOGRID_244422|BIOGRID_87772|UniProt_70628|BIOGRID_244426|BIOGRID_103224|BIOGRID_102351|BIOGRID_102350|HPRD_36752|BIOGRID_87780|HPRD_39389|UniProt_70629 prey|prey|bait|-|bait|prey|bait|prey|-|prey|-|- bait|bait|prey|-|prey|bait|prey|bait|-|bait|-|- PIK3R1 PSEN1 MI:0492(in vitro) 15192701 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36441 - - ERN1 PSEN1 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10587643 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_36655|BIOGRID_109353 -|bait -|prey CTNND1 PSEN1 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10208590,11226248 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_31601|BIOGRID_109355|BIOGRID_109356|BIOGRID_109354 -|prey|prey|prey -|bait|bait|bait PSEN1 FBXW7 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12354302 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_36732|BIOGRID_101926 -|bait -|prey JUP PSEN1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16306047 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0468(hprd)|(intact)|(intact) UniProt_166553|UniProt_82288|HPRD_31578|UniProt_82284|UniProt_82279 bait|bait|-|bait|bait prey|prey|-|prey|prey CLSTN1 PSEN1 MI:0004(affinity chromatography technology) 15037614 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_86829 bait prey PSEN1 PRAM1 MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229835|UniProt_111152 bait|bait prey|prey PSEN1 FAM82A2 MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229969|UniProt_111000 bait|bait prey|prey PSMA5 PSEN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10527805 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_190201|BIOGRID_190203|BIOGRID_190199|BIOGRID_309279 prey|bait|prey|bait bait|prey|bait|prey PSEN1 YME1L1 MI:0018(two hybrid)|MI:0018(two hybrid) 12214059 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_116503|HPRD_36784 bait|- prey|- PSEN1 APBA1 MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 11083918,12196555,16007100 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0468(hprd)|(intact)|(intact)|(intact)|(intact) MINT_78247|UniProt_68317|UniProt_81156|UniProt_181118|MINT_48779|HPRD_36612|UniProt_160519|UniProt_68319|UniProt_68321|UniProt_160521 bait|prey|bait|prey|bait|-|prey|prey|bait|bait prey|bait|prey|bait|prey|-|bait|bait|prey|prey PSEN1 CASP8 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36580 - - CFL1 PSEN1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111009|BIOGRID_229972 prey|prey bait|bait APP PSEN1 MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 10593990,11083918,21163940,9223340 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_110963|UniProt_134430|UniProt_134428|BIOGRID_229722|UniProt_134435|BIOGRID_230118|HPRD_36354|UniProt_134431|UniProt_110965|UniProt_111039|UniProt_134434|UniProt_68322|UniProt_160522|UniProt_68321|UniProt_160521 bait|prey|prey|bait|null|bait|-|bait|prey|bait|null|null|null|null|null prey|bait|bait|prey|bait|prey|-|prey|bait|prey|bait|bait|bait|bait|bait PSEN1 STAMBPL1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229923 bait prey FLNB PSEN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9437013 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint) MINT_56901|MINT_56902|UniProt_135984|HPRD_36633|UniProt_135988|BIOGRID_97067|BIOGRID_97069|MINT_86015|MINT_86014 prey|prey|prey|-|prey|prey|bait|prey|prey bait|bait|bait|-|bait|bait|prey|bait|bait PSEN1 EFNB2 MI:0493(in vivo) 16511561 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_32538 - - PSEN1 DAG1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_54393|DIP_54449 -|- -|- PSEN1 DSG2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_54395|DIP_54447 -|- -|- NOTCH1 PSEN1 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10077672 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_36473|BIOGRID_108828 -|prey -|bait NPR1 PSEN1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_54391|DIP_54443 -|- -|- PSEN1 TUBA1B MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_230011 bait prey UMPS PSEN1 MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229973|UniProt_111014 prey|prey bait|bait CASP1 PSEN1 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36408 - - UBC PSEN1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 10527805,21139048,21906983,23000965,23707529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_168000|BIOGRID_281236|BIOGRID_177427|BIOGRID_309281|BIOGRID_270108 bait|prey|bait|prey|bait prey|bait|prey|bait|prey PSEN1 VASN MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0465(dip) DIP_54439|DIP_54389 -|- -|- HTRA2 PSEN1 MI:0018(two hybrid) 10971580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_67935 prey bait SCN1A PSEN1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_230010 prey bait GFAP PSEN1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 12058025 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_95889|HPRD_36397|BIOGRID_95891 prey|-|prey bait|-|bait APOE PSEN1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111148|BIOGRID_229831 prey|prey bait|bait PSEN1 RAB11A MI:0493(in vivo)|MI:0018(two hybrid) 10369872 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|MI:0465(dip) HPRD_36722|DIP_52687 -|- -|- CASP3 PSEN1 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36536 - - PSEN1 APH1B MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12471034,15474363 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_244436|HPRD_36762 prey|- bait|- PSEN1 CIB1 MI:0493(in vivo)|MI:0018(two hybrid) 10366599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_17569|BIOGRID_111023 -|bait -|prey PSEN1 DHX9 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239334 prey bait BCL2 PSEN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 10521466 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_102990|BIOGRID_102989|HPRD_36419 bait|prey|- prey|bait|- MAPT PSEN1 MI:0493(in vivo)|MI:0401(biochemical) 9689133 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0403(colocalization) MI:0468(hprd)|(biogrid) HPRD_36430|BIOGRID_109357 -|prey -|bait PSEN1 NOTCH4 MI:0493(in vivo) 11518718 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24393 - - PSEN1 CDC37 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(intact)|(biogrid) UniProt_110971|UniProt_110970|BIOGRID_230124|UniProt_111150|BIOGRID_229833 prey|bait|prey|bait|bait bait|prey|bait|prey|prey PSEN1 SCAF11 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36644 - - PSEN1 PKP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0018(two hybrid) 10092585 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(intact)|MI:0471(mint) MINT_85520|MINT_85521|MINT_56480|MINT_85522|MINT_56481|BIOGRID_98039|BIOGRID_98038|UniProt_66863|UniProt_66862|HPRD_36667|BIOGRID_98040|UniProt_66861|MINT_56482 bait|bait|bait|bait|bait|bait|bait|bait|bait|-|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|-|prey|prey|prey PSEN1 CDK5 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12056836,21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_111155|BIOGRID_229838|HPRD_36387 bait|bait|- prey|prey|- PSEN1 ST13 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(intact)|(biogrid) UniProt_111011|UniProt_110980|BIOGRID_230018|UniProt_110979|BIOGRID_229970 bait|prey|bait|bait|bait prey|bait|prey|prey|prey RAB3A PSEN1 MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229834|UniProt_111151 prey|prey bait|bait PSEN1 RNF32 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229940 prey bait ACTN1 PSEN1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111003|BIOGRID_229966 prey|prey bait|bait PSEN1 HERPUD1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 11799129,14550564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_216748|BIOGRID_216749|BIOGRID_109351|HPRD_36802 bait|prey|bait|- prey|bait|prey|- ENSA PSEN1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111010|BIOGRID_229971 prey|prey bait|bait CYP2C8 PSEN1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229916 prey bait PSEN1 PDCD4 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229919 bait prey DLL1 PSEN1 MI:0492(in vitro) 12794186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36743 - - PSEN1 PLXDC2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0465(dip) DIP_54445|DIP_54396 -|- -|- FLNA PSEN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9437013 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) UniProt_135987|MINT_77449|UniProt_135990|HPRD_36494|MINT_48388|MINT_77443|MINT_48387 prey|prey|prey|-|prey|prey|prey bait|bait|bait|-|bait|bait|bait PSEN1 DTNA MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239481 prey bait PSEN1 TRAF6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18996842,19012753,23707529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_281233|BIOGRID_213371|BIOGRID_281232|BIOGRID_116309|BIOGRID_213370 bait|prey|prey|prey|bait prey|bait|bait|bait|prey PSEN1 KCNIP3 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0493(in vivo) 10854253,12207970,9771752 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_109346|BIOGRID_101646|HPRD_36678 prey|prey|- bait|bait|- PSEN1 EPB41L3 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111004|BIOGRID_229965 bait|bait prey|prey PSEN1 RHEB MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229922 bait prey PSEN1 BCL2L1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10446169 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(biogrid) UniProt_66749|HPRD_36515|MINT_86076|MINT_56959|BIOGRID_109350 prey|-|prey|prey|bait bait|-|bait|bait|prey PSEN1 DNER MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0465(dip) DIP_54441|DIP_54394 -|- -|- PSEN1 AP1M2 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229914 bait prey DSP PSEN1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238575 bait prey CASP4 PSEN1 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_25881 - - CTNNB1 PSEN1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0493(in vivo) 10341227,16126725,16306047,17360711,9738936,9852041 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd) BIOGRID_126481|BIOGRID_109352|BIOGRID_84108|BIOGRID_118989|BIOGRID_118988|UniProt_82283|BIOGRID_85438|UniProt_82278|BIOGRID_118990|HPRD_36376 bait|bait|prey|bait|bait|bait|prey|bait|prey|- prey|prey|bait|prey|prey|prey|bait|prey|bait|- PSEN1 NCSTN MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0416(fluorescence microscopy)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0007(anti tag coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0029(cosedimentation through density gradient)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 10993067,12297508,12471034,14572442,15257293,15474363,16641999,18201567,18942891,20515039 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|-|-|-|-|-|-|MI:0915(physical association)|-|MI:0403(colocalization)|-|-|- (intact)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip)|(intact)|(intact)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|(intact)|MI:0468(hprd)|(intact)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip) UniProt_95634|BIOGRID_87770|BIOGRID_103228|MINT_60892|BIOGRID_102358|BIOGRID_244424|MINT_32063|BIOGRID_87775|HPRD_36711|BIOGRID_85969|BIOGRID_104579|BIOGRID_102353|DIP_54391|UniProt_70627|UniProt_70626|DIP_581|DIP_54392|DIP_54389|DIP_54394|DIP_54390|DIP_580|UniProt_83922|HPRD_39389|UniProt_106980|DIP_54396|DIP_54393|DIP_54395 bait|bait|prey|bait|prey|bait|bait|prey|-|prey|prey|bait|-|null|null|-|-|-|-|-|-|neutral component|-|null|-|-|- prey|prey|bait|prey|bait|prey|prey|bait|-|bait|bait|prey|-|bait|bait|-|-|-|-|-|-|neutral component|-|neutral component|-|-|- CDH1 PSEN1 MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 10635315,11953314,16126725 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid) BIOGRID_126480|HPRD_31326|MINT_57867|MINT_55202|UniProt_71341|BIOGRID_103943 bait|-|prey|prey|prey|bait prey|-|bait|bait|bait|prey PSEN1 GCDH MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_110972|BIOGRID_229836|UniProt_111153 prey|bait|bait bait|prey|prey PSEN1 FGF13 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_230007 bait prey IL1R1 PSEN1 MI:0004(affinity chromatography technology) 18996842 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_213375 prey bait NOS3 PSEN1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229918 prey bait PRKACA PSEN1 MI:0493(in vivo) 14576165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36559 - - PSEN1 ITSN2 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_230009 bait prey PSEN1 PSENEN MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12198112,12639958,14572442,15474363,16641999 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_83922|HPRD_39389|BIOGRID_87771|BIOGRID_105697|BIOGRID_244425|BIOGRID_87778|BIOGRID_90034|HPRD_36773 neutral component|-|bait|prey|bait|prey|bait|- neutral component|-|prey|bait|prey|bait|prey|- PSEN1 MTCH1 MI:0493(in vivo)|MI:0019(coimmunoprecipitation) 10551805,12377771 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(intact) HPRD_36846|UniProt_70349 -|prey -|bait PSEN1 PRKCZ MI:0493(in vivo) 14576165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36453 - - PSEN1 FBXL12 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229917 bait prey ETFA PSEN1 MI:0018(two hybrid) 10527805 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_309278 prey bait PSMB1 PSEN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10527805 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_190200|BIOGRID_190202|BIOGRID_190198|BIOGRID_309280 prey|bait|prey|bait bait|prey|bait|prey CYP2C18 PSEN1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229915 prey bait PSEN1 CTNND2 MI:0019(coimmunoprecipitation)|MI:0493(in vivo) 10208590,9223106 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- MI:0465(dip)|MI:0468(hprd) DIP_52688|HPRD_36813 -|- -|- PSEN1 TCF7L2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 11504726,16306047 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|-|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_82290|UniProt_166555|UniProt_166554|UniProt_82289|UniProt_82280|UniProt_82286|HPRD_36602|BIOGRID_109345|UniProt_166566|UniProt_166562|UniProt_82301|UniProt_82297 prey|prey|prey|prey|prey|prey|-|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|-|bait|prey|bait|prey|bait PSEN1 BACE1 MI:0493(in vivo) 12901838 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36795 - - GAPDH PSEN1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111001|BIOGRID_229968 prey|prey bait|bait IRAK2 PSEN1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18996842 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_213373|BIOGRID_213374 prey|bait bait|prey PSEN1 METTL2B MI:0018(two hybrid) 11738826 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36824 - - PSEN1 KANK2 MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229837|UniProt_111154 bait|bait prey|prey HMGB1 PSEN1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_230008 prey bait PSEN1 CASP7 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36570 - - PSEN1 CASP6 MI:0492(in vitro) 10069390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36547 - - PSEN1 KCNIP4 MI:0018(two hybrid) 11847232 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_110926 bait prey PSEN1 EFHD1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_111002|BIOGRID_229967 bait|bait prey|prey PSEN1 UBQLN1 MI:0096(pull down)|MI:0055(fluorescent resonance energy transfer)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11076969,16813565,16815845 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) UniProt_68863|BIOGRID_190327|UniProt_68861|BIOGRID_103890|HPRD_36700|UniProt_68859|BIOGRID_103888|MINT_86266|MINT_86265|MINT_86264|BIOGRID_194380|MINT_57126|MINT_57127|MINT_57125 neutral component|bait|prey|prey|-|prey|prey|neutral component|prey|prey|prey|prey|neutral component|prey neutral component|prey|bait|bait|-|bait|bait|neutral component|bait|bait|bait|bait|neutral component|bait PSEN1 ICAM5 MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11719200 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_36591|BIOGRID_97730|BIOGRID_97731|BIOGRID_97729 -|bait|bait|bait -|prey|prey|prey TDP2 PSEN1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286718|UniProt_118029 prey|unspecified role bait|unspecified role PSEN1 NOTCH3 MI:0493(in vivo) 11518718 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24396 - - RPL10 PSEN1 MI:0018(two hybrid) 10508860 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) MI:0465(dip) DIP_52685 - - PSEN1 ECSIT MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid) UniProt_110962|UniProt_110948|UniProt_111072|BIOGRID_229755|UniProt_110967|BIOGRID_230017|BIOGRID_230130 bait|bait|prey|prey|prey|bait|bait prey|prey|bait|bait|bait|prey|prey PSEN1 OXCT1 MI:0004(affinity chromatography technology)|MI:0096(pull down) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_229974|UniProt_111013 bait|bait prey|prey PRDX2 PSEN1 MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229920 prey bait PSEN1 NOTCH2 MI:0493(in vivo) 11518718 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24394 - - TMED10 PSEN1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16641999 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_83921|UniProt_83913|UniProt_83922|UniProt_83915|UniProt_83918 neutral component|bait|neutral component|prey|prey neutral component|prey|neutral component|bait|bait PSEN1 Npr3 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18942891 taxid:9606(Homo sapiens) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|-|- MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_54453|DIP_605|DIP_581|DIP_54392 -|-|-|- -|-|-|- PSEN1 GSK3B MI:0006(anti bait coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo) 11104755,16814287,17360711 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|MI:0468(hprd) MINT_49861|BIOGRID_118987|UniProt_86716|MINT_82089|HPRD_36689 bait|prey|bait|bait|- prey|bait|prey|prey|- PSEN1 PSEN2 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical) 12471034,15474363,21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_111149|BIOGRID_244432|BIOGRID_229832|BIOGRID_244428|BIOGRID_102352 bait|prey|bait|bait|bait prey|bait|prey|prey|prey PSEN1 DOCK3 MI:0492(in vitro) 10854253 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36835 - - CTNNA1 PSEN1 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10635315 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_36365|BIOGRID_103944 -|prey -|bait GDI1 PSEN1 MI:0492(in vitro) 15480879 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36504 - - PSEN1 RAD23A MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229921 bait prey NDUFS8 PSEN1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240051 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NDUFS8 PSEN1 22939629 0401 HT APP PSEN1 9223340,21163940,9223340,21163940,21163940,11083918,21163940 0019,0018,0006,0397,0006,0006,0004 LC CDH1 PSEN1 16126725,16126725,10635315 0004,0007,0004 LC DSP PSEN1 16306047,16306047,22939629 0004,0096,0401 LC,HT CTNNB1 PSEN1 16306047,9852041,16306047,9738936,16126725,17360711,17360711,16306047,10341227 0006,0004,0019,0004,0004,0096,0004,0004,0004 LC PSEN1 PSEN1 15474363,22036569,12297508 0004,0007,0006 LC PSEN1 PSEN2 12471034,15474363 0004,0004 LC PSEN1 APBA1 11083918,11083918,16007100,11083918 0006,0007,0096,0096 LC PSEN1 DHX9 22939629 0401 HT PSEN1 Q53FP9 14550564,11799129 0004,0004 LC PSEN1 NCSTN 15474363,10993067,15257293,17911105,12297508,17911105,10993067,12297508,14572442,16096062,18201567,12471034 0004,0019,0004,0004,0006,0401,0004,0004,0004,0004,0006,0004 LC PSEN1 APH1A 15474363,17911105,14572442,12471034,12297508,12297508,12297508,12471034 0004,0004,0004,0401,0004,0006,0007,0004 LC PSEN1 TCF7L2 11504726,16306047,16306047,16306047 0004,0096,0006,0019 LC PSEN1 PSENEN 12198112,12639958,22074918,14572442,15474363 0004,0004,0004,0004,0004 LC PSEN1 Q9UII7 10635315,16126725 0004,0004 LC PSEN1 UBQLN1 16813565,11076969,11076969,11076969 0096,0018,0416,0096 LC PSEN1 KCNIP3 9771752,10854253 0004,0004 LC PSEN1 DTNA 22939629 0401 HT PSEN1 TRAF6 24399296,19012753,18996842,23707529,24399296,18996842 0428,0004,0004,0004,0004,0007 LC NDUFS8 PSEN1 22939629 0401 HT DSP PSEN1 22939629 0401 HT PSEN1 DHX9 22939629 0401 HT PSEN1 DTNA 22939629 0401 HT APP PSEN1 9223340,21163940,9223340,21163940,21163940,11083918,21163940 0019,0018,0006,0397,0006,0006,0004 LC CDH1 PSEN1 16126725,16126725,10635315 0004,0007,0004 LC DSP PSEN1 16306047,16306047 0004,0096 LC CTNNB1 PSEN1 16306047,9852041,16306047,9738936,16126725,17360711,17360711,16306047,10341227 0006,0004,0019,0004,0004,0096,0004,0004,0004 LC PSEN1 PSEN1 15474363,22036569,12297508 0004,0007,0006 LC PSEN1 PSEN2 12471034,15474363 0004,0004 LC PSEN1 APBA1 11083918,11083918,16007100,11083918 0006,0007,0096,0096 LC PSEN1 Q53FP9 14550564,11799129 0004,0004 LC PSEN1 NCSTN 15474363,10993067,15257293,17911105,12297508,17911105,10993067,12297508,14572442,16096062,18201567,12471034 0004,0019,0004,0004,0006,0401,0004,0004,0004,0004,0006,0004 LC PSEN1 APH1A 15474363,17911105,14572442,12471034,12297508,12297508,12297508,12471034 0004,0004,0004,0401,0004,0006,0007,0004 LC PSEN1 TCF7L2 11504726,16306047,16306047,16306047 0004,0096,0006,0019 LC PSEN1 PSENEN 12198112,12639958,22074918,14572442,15474363 0004,0004,0004,0004,0004 LC PSEN1 Q9UII7 10635315,16126725 0004,0004 LC PSEN1 UBQLN1 16813565,11076969,11076969,11076969 0096,0018,0416,0096 LC PSEN1 KCNIP3 9771752,10854253 0004,0004 LC PSEN1 TRAF6 24399296,19012753,18996842,23707529,24399296,18996842 0428,0004,0004,0004,0004,0007 LC B7Z3K2 PSEN1 12901838 0018 LC NDUFS8 PSEN1 22939629 0401 LC HTRA2 PSEN1 10971580 0018 LC ENSA PSEN1 21163940 0018 HT CTNND1 PSEN1 10208590,10208590,10208590 0004,0096,0018 LC FLNB PSEN1 9437013,9437013,9437013 0019,0018,0096 LC TDP2 PSEN1 21988832,21988832 0397,0018 HT APOE PSEN1 21163940,21163940 0397,0018 HT GAPDH PSEN1 21163940 0018 HT APP PSEN1 9223340,21163940,9223340,14756819,15448688,21163940,21163940,10801777,21115843,10801777,10078972,21163940 0019,0018,0006,0019,0055,0397,0006,0019,0435,0029,0019,0004 LC,HT HMGB1 PSEN1 21163940 0018 HT BCL2 PSEN1 10521466,10521466,10521466 0018,0019,0004 LC CYP2C8 PSEN1 21163940 0018 HT MAPT PSEN1 9689133 0401 LC UMPS PSEN1 21163940 0018 HT ACTN1 PSEN1 21163940 0018 HT CDH1 PSEN1 11953314 0019 LC ETFA PSEN1 10527805 0018 LC GFAP PSEN1 12058025,12058025 0096,0018 LC JUP PSEN1 16306047,16306047,16306047 0096,0006,0019 LC DSP PSEN1 22939629 0401 LC RAB3A PSEN1 21163940,21163940 0397,0018 HT PSMB1 PSEN1 10527805,10527805,10527805 0096,0004,0018 LC FLNA PSEN1 9437013,9437013 0019,0018 LC CFL1 PSEN1 21163940 0018 HT RPL10 PSEN1 10508860,10508860 0019,0018 LC PSMA5 PSEN1 10527805,10527805,10527805 0096,0004,0018 LC CASP1 PSEN1 10069390 0045 LC NOS3 PSEN1 21163940 0018 HT CTNNB1 PSEN1 16306047,16306047,9632714,10037471,16306047 0006,0019,0019,0019,0004 LC SCN1A PSEN1 21163940 0018 HT CASP3 PSEN1 10069390 0045 LC CASP4 PSEN1 10069390 0045 LC PSEN1 PSEN1 12535650,9666482,9666482 0018,0030,0019 LC PSEN1 PSEN2 21163940,21163940 0397,0018 HT PSEN1 GSK3B 17360711 0415 LC PSEN1 ST13 21163940,21163940,21163940 0006,0004,0018 HT PSEN1 RAD23A 21163940 0018 HT PSEN1 CASP7 10069390 0045 LC PSEN1 OXCT1 21163940 0018 HT PSEN1 BACE1 12901838,12901838 0019,0018 LC PSEN1 RAB11A 10369872 0018 LC PSEN1 TUBA1B 21163940 0018 HT PSEN1 CDK5 21163940,21163940 0397,0018 HT PSEN1 BCL2L1 10446169 0018 LC PSEN1 DHX9 22939629 0401 LC PSEN1 STX5 15109302,15109302 0019,0029 LC PSEN1 RHEB 21163940 0018 HT PSEN1 CDC37 21163940,21163940,21163940,21163940 0397,0006,0004,0018 HT PSEN1 STX1A 10891589,10891589,10891589 0018,0019,0004 LC PSEN1 NDUFA9 20515039 0029 LC PSEN1 PDCD4 21163940 0018 HT PSEN1 KANK2 21163940,21163940 0397,0018 HT PSEN1 METTL2B 11738826 0018 LC PSEN1 KCNIP4 11847232 0018 LC PSEN1 DKFZP686I24235 21163940 0018 HT PSEN1 DOCK3 10854253 0018 LC PSEN1 NCSTN 26280335,16641999,16641999,10993067,17911105,26623517,17911105,10993067 0114,0027,0276,0019,0004,0114,0401,0004 LC PSEN1 FGF13 21163940 0018 HT PSEN1 GCDH 21163940,21163940,21163940 0397,0006,0018 HT PSEN1 APH1A 26280335,12471034,26623517,12471034 0114,0401,0114,0004 LC PSEN1 STAMBPL1 21163940 0018 HT PSEN1 PRAM1 21163940,21163940 0397,0018 HT PSEN1 YME1L1 12214059 0018 LC PSEN1 RMDN3 21163940 0018 HT PSEN1 PKP4 10037471,10092585,10092585,10092585,10092585 0018,0019,0018,0004,0096 LC PSEN1 CIB1 10366599 0018 LC PSEN1 ECSIT 21163940,21163940,21163940,21163940,21163940 0096,0397,0006,0004,0018 HT PSEN1 EFHD1 21163940 0018 HT PSEN1 RNF32 21163940 0018 HT PSEN1 TCF7L2 16306047,16306047,16306047 0096,0006,0019 LC PSEN1 FBXL12 21163940 0018 HT PSEN1 PSENEN 26280335,15322109,26623517 0114,0019,0114 LC PSEN1 MTCH1 12377771 0019 LC PSEN1 ITSN2 21163940 0018 HT PSEN1 ICAM5 11719200,11719200,11719200 0096,0018,0004 LC PSEN1 UBQLN1 11076969,16815845,11076969,11076969 0018,0055,0416,0096 LC PSEN1 CTNND2 10037471,10037471,9223106,10208590,10208590,10037471,10037471 0018,0019,0018,0018,0019,0045,0004 LC PSEN1 EPB41L3 21163940 0018 HT PSEN1 DTNA 22939629 0401 LC PSEN1 AP1M2 21163940 0018 HT PSEN1 HEL-S-162EP 21163940 0018 HT PSEN1 HEL-S-2A 21163940 0018 HT PSEN1 HEL-S-15 21163940 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P49768 O43464 PSEN1 HTRA2 0.309 10971580 P49768 P15924 PSEN1 DSP 0.498 22939629,16306047 Q9H0A6 P49768 RNF32 PSEN1 0.183 21163940 P49768 O70248 PSEN1 APBA3 0.21 12196555 Q9WV31 P49768 ARC PSEN1 0.21 22036569 P49768 O35431 PSEN1 APBA2 0.21 12196555 P49768 O75460 PSEN1 ERN1 0.21 10587643 Q9Y4J8 P49768 DTNA PSEN1 0.081 22939629 Q6EMK4 P49768 VASN PSEN1 0.21 18942891 P49768 O94985 PSEN1 CLSTN1 0.21 15037614 P49768 P09055 PSEN1 ITGB1 0.21 18942891 Q9Y2W7 P49768 KCNIP3 PSEN1 0.376 9771752,10854253 Q9BQ95 P49768 ECSIT PSEN1 0.554 21163940 Q16543 P49768 CDC37 PSEN1 0.523 21163940 Q63053 P49768 ARC PSEN1 0.671 22036569 P49768 P20618 PSEN1 PSMB1 0.702 10527805 P49768 P27635 PSEN1 RPL10 0.065 10508860 P49768 P28066 PSEN1 PSMA5 0.702 10527805 P49841 P49768 GSK3B PSEN1 0.454 16814287,17360711 Q9BUP0 P49768 EFHD1 PSEN1 0.332 21163940 P49768 P15884 PSEN1 TCF4 0.454 16306047 P49768 O43768 PSEN1 ENSA 0.332 21163940 P49768 P12814 PSEN1 ACTN1 0.332 21163940 P49768 P02649 PSEN1 APOE 0.286 21163940 P49768 P21333 PSEN1 FLNA 0.454 9437013 P49768 P23528 PSEN1 CFL1 0.332 21163940 Q00535 P49768 CDK5 PSEN1 0.286 21163940 Q63ZY3 P49768 KANK2 PSEN1 0.286 21163940 Q9Y2J2 P49768 EPB41L3 PSEN1 0.332 21163940 Q9UMX0 P49768 UBQLN1 PSEN1 0.905 11076969,16813565,16815845 Q9UQB3 P49768 CTNND2 PSEN1 0.065 10208590 P49810 P49768 PSEN2 PSEN1 0.648 15474363,21163940,12471034 P62493 P49768 RAB11A PSEN1 0.454 10369872 P57716 P49768 NCSTN PSEN1 0.236 26496610 P49768 O60716 PSEN1 CTNND1 0.623 10208590 P49768 P05067 PSEN1 APP 0.765 11083918,9223340,21163940 Q9Y4K3 P49768 TRAF6 PSEN1 0.787 19012753,18996842,23707529,24399296 Q9UMF0 P49768 ICAM5 PSEN1 0.623 11719200 P49768 P12830 PSEN1 CDH1 0.507 11953314,16126725,10635315 Q9NZ42 P49768 PSENEN PSEN1 0.814 12198112,15474363,14572442,unassigned1304,12639958,22074918 Q9NQB0 P49768 TCF7L2 PSEN1 0.61 16306047,11504726 P49768 P49768 PSEN1 PSEN1 0.772 12297508,22036569,15474363,12535650 Q96BI3 P49768 APH1A PSEN1 0.928 15474363,14572442,12471034,12297508,17911105 P49768 P14923 PSEN1 JUP 0.61 16306047 P49768 P35222 PSEN1 CTNNB1 0.934 9738936,16306047,16126725,10341227,9852041,17360711 Q92542 P49768 NCSTN PSEN1 0.959 15474363,15257293,16641999,12471034,12297508,17911105,18201567,10993067,14572442 P49768 P36897 PSEN1 TGFBR1 0.454 24399296 Q92947 P49768 GCDH PSEN1 0.376 21163940 Q8WW43 P49768 APH1B PSEN1 0.21 15474363 P49768 P35408 PSEN1 PTGER4 0.21 19407341 Q96QH2 P49768 PRAM1 PSEN1 0.286 21163940 Q96TC7 P49768 RMDN3 PSEN1 0.332 21163940 Q9C0B0 P49768 UNK PSEN1 0.126 25737280 Q99569 P49768 PKP4 PSEN1 0.858 10092585 Q9QXT8 P49768 KCNIP3 PSEN1 0.309 27009418 Q14118 P49768 DAG1 PSEN1 0.21 18942891 Q14126 P49768 DSG2 PSEN1 0.21 18942891 P49768 A4D1B5 PSEN1 GSAP 0.21 20811458 P98084 P49768 APBA2 PSEN1 0.376 11083918 P49768 P49755 PSEN1 TMED10 0.376 16641999 P49768 E9Q9F5 PSEN1 E9Q9F5 0.126 27036734 P49768 F6RWR5 PSEN1 F6RWR5 0.126 27036734 P49768 F8WIS9 PSEN1 F8WIS9 0.126 27036734 P49768 G3UW68 PSEN1 G3UW68 0.126 27036734 P49768 O08553 PSEN1 DPYSL2 0.126 27036734 P49768 O35430 PSEN1 APBA1 0.376 12196555 P49768 O35927 PSEN1 CTNND2 0.126 27036734 P49768 O43187 PSEN1 IRAK2 0.376 18996842 P49768 O75369 PSEN1 FLNB 0.74 9437013 P49768 O88935 PSEN1 SYN1 0.126 27036734 P49768 O89112 PSEN1 LANCL1 0.126 27036734 P49768 O94905 PSEN1 ERLIN2 0.21 22771797 P49768 O95551 PSEN1 TDP2 0.286 21988832 P49768 P04370 PSEN1 MBP 0.126 27036734 P49768 P04406 PSEN1 GAPDH 0.332 21163940 P49768 P08551 PSEN1 NEFL 0.126 27036734 P49768 P09429 PSEN1 HMGB1 0.183 21163940 P49768 P0CG48 PSEN1 UBC 0.126 24399296 P49768 P10126 PSEN1 EEF1A1 0.126 27036734 P49768 P10415 PSEN1 BCL2 0.454 10521466 P49768 P10632 PSEN1 CYP2C8 0.183 21163940 P49768 P10636 PSEN1 MAPT 0.126 9689133 P49768 P10637 PSEN1 MAPT 0.126 27036734 P49768 P10649 PSEN1 GSTM1 0.126 27036734 P49768 P11172 PSEN1 UMPS 0.332 21163940 P49768 P11798 PSEN1 CAMK2A 0.126 27036734 P49768 P13804 PSEN1 ETFA 0.309 10527805 P49768 P14094 PSEN1 ATP1B1 0.126 27036734 P49768 P14131 PSEN1 RPS16 0.126 27036734 P49768 P15626 PSEN1 GSTM2 0.126 27036734 P49768 P16066 PSEN1 NPR1 0.21 18942891 P49768 P16330 PSEN1 CNP 0.126 27036734 P49768 P16627 PSEN1 HSPA1L 0.126 27036734 P49768 P16858 PSEN1 GAPDH 0.126 27036734 P49768 P17182 PSEN1 ENO1 0.126 27036734 P49768 P19157 PSEN1 GSTP1 0.126 27036734 P49768 P20029 PSEN1 HSPA5 0.126 27036734 P49768 P20336 PSEN1 RAB3A 0.286 21163940 P49768 P20357 PSEN1 MAP2 0.126 27036734 P49768 P24410 PSEN1 RAB11A 0.033 10369872 P49768 P29474 PSEN1 NOS3 0.183 21163940 P49768 P30999 PSEN1 CTNND1 0.126 27036734 P49768 P32119 PSEN1 PRDX2 0.183 21163940 P49768 P33260 PSEN1 CYP2C18 0.183 21163940 P49768 P35221 PSEN1 CTNNA1 0.21 10635315 P49768 P35498 PSEN1 SCN1A 0.183 21163940 P49768 P38647 PSEN1 HSPA9 0.126 27036734 P49768 P43006 PSEN1 SLC1A2 0.126 27036734 P49768 P46096 PSEN1 SYT1 0.126 27036734 P49768 P46425 PSEN1 GSTP2 0.126 27036734 P49768 P46460 PSEN1 NSF 0.126 27036734 P49768 P46531 PSEN1 NOTCH1 0.21 10077672 P49768 P46660 PSEN1 INA 0.126 27036734 P49768 P47708 PSEN1 RPH3A 0.126 27036734 P49768 P48318 PSEN1 GAD1 0.126 27036734 P49768 P48774 PSEN1 GSTM5 0.126 27036734 P49768 P48962 PSEN1 SLC25A4 0.126 27036734 P49769 P49768 PSEN1 PSEN1 0.126 27036734 P51881 P49768 SLC25A5 PSEN1 0.126 27036734 P52480 P49768 PKM PSEN1 0.126 27036734 P54725 P49768 RAD23A PSEN1 0.183 21163940 P55809 P49768 OXCT1 PSEN1 0.332 21163940 P56480 P49768 ATP5B PSEN1 0.126 27036734 P60710 P49768 ACTB PSEN1 0.126 27036734 P61979 P49768 HNRNPK PSEN1 0.126 27036734 P62631 P49768 EEF1A2 PSEN1 0.126 27036734 P62908 P49768 RPS3 PSEN1 0.126 27036734 P63017 P49768 HSPA8 PSEN1 0.126 27036734 P68134 P49768 ACTA1 PSEN1 0.126 27036734 P68363 P49768 TUBA1B PSEN1 0.183 21163940 P68368 P49768 TUBA4A PSEN1 0.126 27036734 P68369 P49768 TUBA1A PSEN1 0.126 27036734 P70180 P49768 NPR3 PSEN1 0.21 18942891 P99024 P49768 TUBB5 PSEN1 0.126 27036734 Q02410 P49768 APBA1 PSEN1 0.659 16007100,11083918 Q03265 P49768 ATP5A1 PSEN1 0.126 27036734 Q07817 P49768 BCL2L1 PSEN1 0.523 10446169 Q15382 P49768 RHEB PSEN1 0.183 21163940 Q3UHL1 P49768 CAMKV PSEN1 0.126 27036734 Q3ULA2 P49768 BTRC PSEN1 0.126 27036734 Q53EL6 P49768 PDCD4 PSEN1 0.183 21163940 Q5RJI5 P49768 BRSK1 PSEN1 0.126 27036734 Q61301 P49768 CTNNA2 PSEN1 0.126 27036734 Q62188 P49768 DPYSL3 PSEN1 0.126 27036734 Q64467 P49768 GAPDHS PSEN1 0.126 27036734 Q6P1J1 P49768 Q6P1J1 PSEN1 0.126 27036734 Q6PHZ2 P49768 CAMK2D PSEN1 0.126 27036734 Q6PIC6 P49768 ATP1A3 PSEN1 0.126 27036734 Q6PIL6 P49768 KCNIP4 PSEN1 0.309 11847232 Q6UX71 P49768 PLXDC2 PSEN1 0.21 18942891 Q76MZ3 P49768 PPP2R1A PSEN1 0.126 27036734 Q7TSJ2 P49768 MAP6 PSEN1 0.126 27036734 Q80W21 P49768 GSTM7 PSEN1 0.126 27036734 Q8BFR5 P49768 TUFM PSEN1 0.126 27036734 Q8BH59 P49768 SLC25A12 PSEN1 0.126 27036734 Q8BLR2 P49768 CPNE4 {ECO:0000312|MGI:MGI:1921270} PSEN1 0.126 27036734 Q8BRJ7 P49768 Q8BRJ7 PSEN1 0.126 27036734 Q8C0C7 P49768 FARSA PSEN1 0.126 27036734 Q8CBW4 P49768 DCAF12L1 PSEN1 0.126 27036734 Q8K0U4 P49768 HSPA12A PSEN1 0.126 27036734 Q8NFT8 P49768 DNER PSEN1 0.21 18942891 Q8VEM8 P49768 SLC25A3 PSEN1 0.126 27036734 Q91V61 P49768 SFXN3 PSEN1 0.126 27036734 Q91VA7 P49768 IDH3B PSEN1 0.126 27036734 Q91VR2 P49768 ATP5C1 PSEN1 0.126 27036734 Q91VZ6 P49768 SMAP1 PSEN1 0.126 27036734 Q922A0 P49768 ENO2 {ECO:0000313|EMBL:AAH09018.1, ECO:0000313|MGI:MGI:95394} PSEN1 0.126 27036734 Q92913 P49768 FGF13 PSEN1 0.183 21163940 Q969H0 P49768 FBXW7 PSEN1 0.21 12354302 Q96FJ0 P49768 STAMBPL1 PSEN1 0.183 21163940 Q96TA2 P49768 YME1L1 PSEN1 0.309 12214059 Q99828 P49768 CIB1 PSEN1 0.309 10366599 Q99LP6 P49768 GRPEL1 PSEN1 0.126 27036734 Q9CR62 P49768 SLC25A11 PSEN1 0.126 27036734 Q9CWF2 P49768 TUBB2B PSEN1 0.126 27036734 Q9D6F9 P49768 TUBB4A PSEN1 0.126 27036734 Q9D6M3 P49768 SLC25A22 PSEN1 0.126 27036734 Q9DB20 P49768 ATP5O PSEN1 0.126 27036734 Q9ERD7 P49768 TUBB3 PSEN1 0.126 27036734 Q9NXK8 P49768 FBXL12 PSEN1 0.183 21163940 Q9NZJ7 P49768 MTCH1 PSEN1 0.21 12377771 Q9NZM3 P49768 ITSN2 PSEN1 0.183 21163940 Q9R0N5 P49768 SYT5 PSEN1 0.126 27036734 Q9WV60 P49768 GSK3B PSEN1 0.126 27036734 Q9Y6Q5 P49768 AP1M2 PSEN1 0.183 21163940 Q9Z140 P49768 CPNE6 PSEN1 0.126 27036734 Q15011 P49768 HERPUD1 PSEN1 0.507 11799129,14550564 P50502 P49768 ST13 PSEN1 0.49 21163940 Q02248 P49768 CTNNB1 PSEN1 0.454 12070348,27036734,16306047 P49768 O00217 PSEN1 NDUFS8 0.081 22939629 P49768 P15253 PSEN1 CALR 0.21 23585889 Q08211 P49768 DHX9 PSEN1 0.081 22939629 Q16795 P49768 NDUFA9 PSEN1 0.126 20515039

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 GSAP PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SYT5 PSEN1 MI:0362 inference MI:0461 interaction database DLL1 PSEN1 MI:0362 inference MI:0461 interaction database GAPDHS PSEN1 MI:0362 inference MI:0461 interaction database IRAK2 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA12A PSEN1 MI:0362 inference MI:0461 interaction database HTRA2 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database ENSA PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database LANCL1 PSEN1 MI:0362 inference MI:0461 interaction database IDH3B PSEN1 MI:0362 inference MI:0461 interaction database CTNND1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database FLNB PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database ERN1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A12 PSEN1 MI:0362 inference MI:0461 interaction database ERLIN2 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database CLSTN1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database TDP2 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database CPNE6 PSEN1 MI:0362 inference MI:0461 interaction database APBA3 PSEN1 MI:0362 inference MI:0461 interaction database APOE PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database MBP PSEN1 MI:0362 inference MI:0461 interaction database TUBB4A PSEN1 MI:0362 inference MI:0461 interaction database GAPDH PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database ATP1B1 PSEN1 MI:0362 inference MI:0461 interaction database APP PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A5 PSEN1 MI:0362 inference MI:0461 interaction database ITGB1 PSEN1 MI:0362 inference MI:0461 interaction database ATP5B PSEN1 MI:0362 inference MI:0461 interaction database ENO1 PSEN1 MI:0362 inference MI:0461 interaction database NEFL PSEN1 MI:0362 inference MI:0461 interaction database TUBB PSEN1 MI:0362 inference MI:0461 interaction database NGFR PSEN1 MI:0362 inference MI:0461 interaction database GSTP1 PSEN1 MI:0362 inference MI:0461 interaction database HMGB1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database GSTM1 PSEN1 MI:0362 inference MI:0461 interaction database CNP PSEN1 MI:0362 inference MI:0461 interaction database UBC PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B PSEN1 MI:0362 inference MI:0461 interaction database BCL2 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database CYP2C8 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database MAPT PSEN1 MI:0362 inference MI:0461 interaction database HSPA5 PSEN1 MI:0362 inference MI:0461 interaction database MAP2 PSEN1 MI:0362 inference MI:0461 interaction database HSPA8 PSEN1 MI:0362 inference MI:0461 interaction database UMPS PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A4 PSEN1 MI:0362 inference MI:0461 interaction database ACTN1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database CDH1 PSEN1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ATP1A3 PSEN1 MI:0362 inference MI:0461 interaction database ETFA PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database GFAP PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database PKM PSEN1 MI:0362 inference MI:0461 interaction database JUP PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database TCF4 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database DSP PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database NPR1 PSEN1 MI:0362 inference MI:0461 interaction database HSPA6 PSEN1 MI:0362 inference MI:0461 interaction database NPR3 PSEN1 MI:0362 inference MI:0461 interaction database SYN1 PSEN1 MI:0362 inference MI:0461 interaction database RAB3A PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database PSMB1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database GSTM3 PSEN1 MI:0362 inference MI:0461 interaction database FLNA PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SYT1 PSEN1 MI:0362 inference MI:0461 interaction database VDAC1 PSEN1 MI:0362 inference MI:0461 interaction database RPS3 PSEN1 MI:0362 inference MI:0461 interaction database CFL1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database ATP5A1 PSEN1 MI:0362 inference MI:0461 interaction database CTNNA2 PSEN1 MI:0362 inference MI:0461 interaction database CALR PSEN1 MI:0362 inference MI:0461 interaction database PIK3R1 PSEN1 MI:0362 inference MI:0461 interaction database PSMA5 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database GSTM2 PSEN1 MI:0362 inference MI:0461 interaction database CASP1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database NOS3 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R1A PSEN1 MI:0362 inference MI:0461 interaction database PPP2R1B PSEN1 MI:0362 inference MI:0461 interaction database PRDX2 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database CYP2C18 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L PSEN1 MI:0362 inference MI:0461 interaction database CTNNA1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database CTNNB1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SCN1A PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database ATP5C1 PSEN1 MI:0362 inference MI:0461 interaction database TGFBR1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA9 PSEN1 MI:0362 inference MI:0461 interaction database CASP3 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database SLC1A2 PSEN1 MI:0362 inference MI:0461 interaction database GSTM5 PSEN1 MI:0362 inference MI:0461 interaction database NSF PSEN1 MI:0362 inference MI:0461 interaction database NOTCH1 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database STT3A PSEN1 MI:0362 inference MI:0461 interaction database ATP5O PSEN1 MI:0362 inference MI:0461 interaction database TUFM PSEN1 MI:0362 inference MI:0461 interaction database CASP4 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database TMED10 PSEN1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 PSEN2 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 GSK3B MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 IDH3A MI:0362 inference MI:0461 interaction database PSEN1 ST13 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 DNM2 MI:0362 inference MI:0461 interaction database PSEN1 IDH3G MI:0362 inference MI:0461 interaction database PSEN1 EFNB2 MI:0362 inference MI:0461 interaction database PSEN1 HSPA2 MI:0362 inference MI:0461 interaction database PSEN1 RAD23A MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 CASP7 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 OXCT1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 BACE1 MI:0362 inference MI:0461 interaction database PSEN1 ACTB MI:0362 inference MI:0461 interaction database PSEN1 SEC61A1 MI:0362 inference MI:0461 interaction database PSEN1 HNRNPK MI:0362 inference MI:0461 interaction database PSEN1 RPS16 MI:0362 inference MI:0461 interaction database PSEN1 RAB11A MI:0362 inference MI:0461 interaction database PSEN1 EEF1A1 MI:0362 inference MI:0461 interaction database PSEN1 ACTA1 MI:0362 inference MI:0461 interaction database PSEN1 TUBA1B MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 TUBA4A MI:0362 inference MI:0461 interaction database PSEN1 TUBB4B MI:0362 inference MI:0461 interaction database PSEN1 EFNB1 MI:0362 inference MI:0461 interaction database PSEN1 SLC25A3 MI:0362 inference MI:0461 interaction database PSEN1 CDK5 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 APBA1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 SLC25A11 MI:0362 inference MI:0461 interaction database PSEN1 GSTM4 MI:0362 inference MI:0461 interaction database PSEN1 NOTCH2 MI:0362 inference MI:0461 interaction database PSEN1 GAD2 MI:0362 inference MI:0461 interaction database PSEN1 GRIN1 MI:0362 inference MI:0461 interaction database PSEN1 EEF1A2 MI:0362 inference MI:0461 interaction database PSEN1 BCL2L1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 GRIN2A MI:0362 inference MI:0461 interaction database PSEN1 STX5 MI:0362 inference MI:0461 interaction database PSEN1 PLD1 MI:0362 inference MI:0461 interaction database PSEN1 TUBB3 MI:0362 inference MI:0461 interaction database PSEN1 CAMK2D MI:0362 inference MI:0461 interaction database PSEN1 TUBA3C MI:0362 inference MI:0461 interaction database PSEN1 TUBB2A MI:0362 inference MI:0461 interaction database PSEN1 DAG1 MI:0362 inference MI:0461 interaction database PSEN1 DSG2 MI:0362 inference MI:0461 interaction database PSEN1 CRMP1 MI:0362 inference MI:0461 interaction database PSEN1 DPYSL3 MI:0362 inference MI:0461 interaction database PSEN1 FLOT2 MI:0362 inference MI:0461 interaction database PSEN1 HERPUD1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 TMED2 MI:0362 inference MI:0461 interaction database PSEN1 RHEB MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 EFNB3 MI:0362 inference MI:0461 interaction database PSEN1 INA MI:0362 inference MI:0461 interaction database PSEN1 CDC37 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 DPYSL2 MI:0362 inference MI:0461 interaction database PSEN1 STX1A MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 PDCD4 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 DCAF12L1 MI:0362 inference MI:0461 interaction database PSEN1 DCAF12L2 MI:0362 inference MI:0461 interaction database PSEN1 KANK2 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 VASN MI:0362 inference MI:0461 interaction database PSEN1 TUBA3E MI:0362 inference MI:0461 interaction database PSEN1 KCNIP4 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 PLXDC2 MI:0362 inference MI:0461 interaction database PSEN1 TUBA1A MI:0362 inference MI:0461 interaction database PSEN1 ARC MI:0362 inference MI:0461 interaction database PSEN1 SMAP1 MI:0362 inference MI:0461 interaction database PSEN1 DOCK3 MI:0362 inference MI:0461 interaction database PSEN1 CAMKV MI:0362 inference MI:0461 interaction database PSEN1 DNER MI:0362 inference MI:0461 interaction database PSEN1 STT3B MI:0362 inference MI:0461 interaction database PSEN1 BRSK1 MI:0362 inference MI:0461 interaction database PSEN1 SMAP2 MI:0362 inference MI:0461 interaction database PSEN1 APH1B MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 NCSTN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSEN1 FGF13 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 GCDH MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 ATP6V0A1 MI:0362 inference MI:0461 interaction database PSEN1 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 CPNE4 MI:0362 inference MI:0461 interaction database PSEN1 APH1A MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 STAMBPL1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 MAP6 MI:0362 inference MI:0461 interaction database PSEN1 PRAM1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 YME1L1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 RMDN3 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 GAD1 MI:0362 inference MI:0461 interaction database PSEN1 NOTCH4 MI:0362 inference MI:0461 interaction database PSEN1 PKP4 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 APBA2 MI:0362 inference MI:0461 interaction database PSEN1 CIB1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 SH3GL1 MI:0362 inference MI:0461 interaction database PSEN1 SH3GL2 MI:0362 inference MI:0461 interaction database PSEN1 SH3GL3 MI:0362 inference MI:0461 interaction database PSEN1 ECSIT MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 EFHD1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 TUBB2B MI:0362 inference MI:0461 interaction database PSEN1 SFXN3 MI:0362 inference MI:0461 interaction database PSEN1 UNK MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 RNF32 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 SLC25A31 MI:0362 inference MI:0461 interaction database PSEN1 SLC25A22 MI:0362 inference MI:0461 interaction database PSEN1 GRPEL1 MI:0362 inference MI:0461 interaction database PSEN1 ATP6V0A4 MI:0362 inference MI:0461 interaction database PSEN1 TCF7L2 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 FBXL12 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 PSENEN MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 MTCH1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 ITSN2 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 CTNNA3 MI:0362 inference MI:0461 interaction database PSEN1 SLC25A13 MI:0362 inference MI:0461 interaction database PSEN1 FBXW11 MI:0362 inference MI:0461 interaction database PSEN1 NOTCH3 MI:0362 inference MI:0461 interaction database PSEN1 ICAM5 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 UBQLN1 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 ATP1B4 MI:0362 inference MI:0461 interaction database PSEN1 CTNND2 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 CAMK2A MI:0362 inference MI:0461 interaction database PSEN1 FARSA MI:0362 inference MI:0461 interaction database PSEN1 BTRC MI:0362 inference MI:0461 interaction database PSEN1 RPH3A MI:0362 inference MI:0461 interaction database PSEN1 EPB41L3 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 KCNIP3 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 ATP6V0A2 MI:0362 inference MI:0461 interaction database PSEN1 TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database PSEN1 AP1M2 MI:0045 experimental interaction detection MI:0461 interaction database