PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LIG4 OSTM1 22990118 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP P G P GP P GP GP GP GP GP ELAVL1 OSTM1 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G OSTM1 RGS17 12826607 hprd,biogrid exp P P G GP G P P G P P GP GP G P GP P GP P GP GP G LGALS8 OSTM1 26186194 biogrid exp GP P G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP P GP GP GP GP LGALS3 OSTM1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G OSTM1 FAM177A1 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G OSTM1 GPSM1 12826607 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G LGALS9 OSTM1 26186194 biogrid exp GP GP G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP P GP GP GP P OSTM1 BIRC7 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP P GP GP GP GP GP GP G RGS19 OSTM1 12826607 hprd,biogrid exp GP GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G GP GP GP G ATP6AP2 OSTM1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G RGS20 OSTM1 12826607, 21836163 hprd,biogrid exp, pred G G G G G CLCN3 OSTM1 16525474, 21836163 hprd exp, pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G LAMP1 OSTM1 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G CLCN7 OSTM1 25402006, 21836163 ortho, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G CSNK2A1 OSTM1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G CLCN6 OSTM1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP GP G GP G TCIRG1 OSTM1 21836163 pred GP GP G GP P GP GP GP G GP G G GP P G GP GP GP GP P GP GP GP P G OSTM1 PITX2 21836163 pred G G G G G G GNAZ OSTM1 25402006 pred G GP G G GP GP G GP GP G GP GP G G G GP GP G GP G GP G G G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86WC4 P49795 pull down 12826607 direct interaction X 2 Q86WC4 P49795 two hybrid 12826607 direct interaction X 2 Q86WC4 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q86WC4 A0A024RE06 two hybrid 22990118 direct interaction X 2 Q86WC4 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q86WC4 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q86WC4 Q9UGC6 two hybrid 12826607 direct interaction X 2 Q86WC4 O76081-3 two hybrid 12826607 direct interaction X 2 Q86WC4 Q86YR5 pull down 12826607 direct interaction X 2 Q86WC4 P0CG48 affinity chromatography technology 21987572 physical association X 2 Q86WC4 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q86WC4 P51798-2 in vivo 16525474 - X 2 Q86WC4 P49795 in vitro 12826607 - X 2 Q86WC4 P49795 two hybrid 12826607 - X 2 Q86WC4 P49795 in vitro 12826607 - X 2 Q86WC4 P49795 two hybrid 12826607 - X 2 Q86WC4 P51798-2 in vivo 16525474 - X 2 Q86WC4 Q9UGC6 two hybrid 12826607 - X 2 Q86WC4 H9NIM5 two hybrid 12826607 - X 2 Q86WC4 Q9UGC6 two hybrid 12826607 - X 2 Q86WC4 H9NIM5 two hybrid 12826607 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RGS19 OSTM1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 12826607 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_88951|HPRD_13494|BIOGRID_88953 prey|-|prey bait|-|bait OSTM1 GPSM1 MI:0018(two hybrid) 12826607 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_88952 bait prey RGS20 OSTM1 MI:0018(two hybrid)|MI:0492(in vitro) 12826607 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_78020|HPRD_14139 prey|- bait|- CLCN7 OSTM1 MI:0493(in vivo) 16525474 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_32328 - - ELAVL1 OSTM1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186974 bait prey LIG4 OSTM1 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_246017 bait prey OSTM1 RGS17 MI:0492(in vitro)|MI:0018(two hybrid) 12826607 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_14137|BIOGRID_78019 -|bait -|prey UBC OSTM1 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,21963094,21987572,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_265144|BIOGRID_163688|BIOGRID_223969|BIOGRID_179184 bait|bait|bait|bait prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality LGALS9 OSTM1 26186194 0004 HT LGALS8 OSTM1 26186194 0004 HT LGALS3 OSTM1 26186194 0004 HT OSTM1 FAM177A1 26186194 0004 HT OSTM1 SIDT2 26496610,26496610 0007,0004 HT OSTM1 BIRC7 26186194 0004 HT LGALS9 OSTM1 26186194 0004 HT LGALS8 OSTM1 26186194 0004 HT LGALS3 OSTM1 26186194 0004 HT OSTM1 FAM177A1 26186194 0004 HT OSTM1 SIDT2 26496610,26496610 0007,0004 HT OSTM1 BIRC7 26186194 0004 HT RGS20 OSTM1 12826607 0018 LC RGS19 OSTM1 12826607,12826607 0018,0096 LC LIG4 OSTM1 22990118 0018 LC OSTM1 RGS17 12826607 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N128 Q86WC4 FAM177A1 OSTM1 0.126 26186194 Q86WC4 O75787 OSTM1 ATP6AP2 0.126 26496610 Q86WC4 P0CK58 OSTM1 P0CK58 0.126 22810586 Q86WC4 O76081 OSTM1 RGS20 0.309 12826607 Q9UGC6 Q86WC4 RGS17 OSTM1 0.309 12826607 Q96CA5 Q86WC4 BIRC7 OSTM1 0.126 26186194 Q86WC4 P17931 OSTM1 LGALS3 0.126 26186194 Q86WC4 P49917 OSTM1 LIG4 0.183 22990118 Q86WC4 Q15717 OSTM1 ELAVL1 0.126 19322201 Q86WC4 O00182 OSTM1 LGALS9 0.126 26186194 Q86WC4 O00214 OSTM1 LGALS8 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LGALS9 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database LGALS8 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database ATP6AP2 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database RGS20 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database UBC OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database LGALS3 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database POLR2A OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database RGS19 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database LIG4 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database CLCN7 OSTM1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database ELAVL1 OSTM1 MI:0045 experimental interaction detection MI:0461 interaction database OSTM1 GPSM1 MI:0045 experimental interaction detection MI:0461 interaction database OSTM1 FAM177A1 MI:0045 experimental interaction detection MI:0461 interaction database OSTM1 BIRC7 MI:0045 experimental interaction detection MI:0461 interaction database OSTM1 RGS17 MI:0045 experimental interaction detection MI:0461 interaction database