PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus BZRAP1 CADPS2 24722188 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 MEGF10 12421765,unassigned5 hprd,intact exp G G G G G G G G G G G G G CADPS2 UBE2E3 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N CADPS2 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 CADPS2 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 ASB12 24337577 biogrid exp G G UBE2E1 CADPS2 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D3 CADPS2 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 UBE2W 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DRD2 CADPS2 15857609 hprd exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2U CADPS2 19690564 biogrid,intact exp G CADPS2 UBE2D4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 ASB6 24337577 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G SRPK2 CADPS2 26167880 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 CADPS2 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DMD CADPS2 12659812, 25402006 hprd exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G BDNF CADPS2 14715936, 21836163 hprd exp, pred G G G G G G G G G G G G G G G G STX6 CADPS2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GOLGA2 CADPS2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VAMP4 CADPS2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARF4 CADPS2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARF5 CADPS2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RALB CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 PLEKHA1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARHGEF7 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDH13 CADPS2 23023127 pred G G G G G G G G G G CADPS2 SYT4 23023127 pred G G G G G G G G G G G G G G G G G G SYK CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 RAB3C 23023127 pred G G G G G G CADPS2 IRS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 COL4A3BP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SYT7 CADPS2 23023127 pred G G G G G G G G G G G CADPS2 EXOC8 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 G3BP2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PLEKHM3 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 GAB2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CACNA1A CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RIMS1 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G RAB27B CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 SYTL1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 APBA2 23023127 pred G G G G G G G G G DOC2B CADPS2 23023127 pred G G G G G G G SPTBN1 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 UNC13A 23023127 pred G G G G G G STX1A CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G PLEK CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VTN CADPS2 23023127 pred DNM2 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PTPN3 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 RIMS3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G APBA1 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G CADPS2 UNC13C 23023127 pred G G G G G G G PARK2 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G DOC2A CADPS2 23023127 pred G G G G G G G G KALRN CADPS2 23023127 pred G G G G G G CADPS2 RAB26 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 PACSIN1 23023127 pred G G G G G G G CADPS2 HOMER1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G CADPS2 DNM3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G SYT9 CADPS2 23023127 pred G G G G SYT1 CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAB3D CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CADPS2 NGEF 23023127 pred G G G G G G G G G G G G G G G G G G G SPTBN2 CADPS2 23023127 pred G G G G G G G G G G G G G G CADPS2 PLEKHA6 23023127 pred G G G G G G G G G G G G G G G G G G G RAB3A CADPS2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86UW7 A0A024R2K3 two hybrid array 19690564 physical association X 2 Q86UW7 Q5VVX9 two hybrid array 19690564 physical association X 2 Q8D0S2 Q86UW7 two hybrid pooling approach 20711500 physical association X 2 Q969T4 Q86UW7 two hybrid array 19690564 physical association X 2 Q86UW7 A0A024RDH2 two hybrid array 19690564 physical association X 2 Q86UW7 A0A024RA90 two hybrid array 19690564 physical association X 2 Q86UW7 P62837 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q86UW7 two hybrid array 19690564 physical association X 2 Q8D0H0 Q86UW7 two hybrid pooling approach 20711500 physical association X 2 P61088 Q86UW7 two hybrid array 19690564 physical association X 2 Q9WMX2 Q86UW7 two hybrid prey pooling approach 18985028 physical association X 2 Q96KG7 Q86UW7 two hybrid - physical association X 2 Q96B02 Q86UW7 two hybrid array 19690564 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2U CADPS2 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102632|BIOGRID_123643 bait|bait prey|prey UBE2N CADPS2 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102597|BIOGRID_123608 bait|bait prey|prey CADPS2 ASB12 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309891 prey bait CADPS2 UBE2E3 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102549|BIOGRID_123559 prey|prey bait|bait DRD2 CADPS2 MI:0493(in vivo) 15857609 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_19056 - - CADPS2 MEGF10 MI:0018(two hybrid)|MI:0018(two hybrid) 12421765 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (intact)|MI:0468(hprd) UniProt_136099|HPRD_16028 prey|- bait|- UBE2D1 CADPS2 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102404|BIOGRID_123415 bait|bait prey|prey CADPS2 UBE2W MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102683|BIOGRID_123694 prey|prey bait|bait DMD CADPS2 MI:0018(two hybrid) 12659812 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_5649 - - CADPS2 ASB6 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309714 prey bait UBE2E1 CADPS2 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123539|UniProt_102527 bait|bait prey|prey CADPS2 UBE2D4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102497|BIOGRID_123508 prey|prey bait|bait UBE2D2 CADPS2 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102430|BIOGRID_123442 bait|bait prey|prey UBE2D3 CADPS2 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102466|BIOGRID_123476 bait|bait prey|prey BDNF CADPS2 MI:0493(in vivo) 14715936 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24458 - -

PPI - HINT Gene A Gene B PMID Method Quality BZRAP1 CADPS2 24722188 0018 HT DMD CADPS2 12659812 0018 LC DRD2 CADPS2 15857609 0018 LC UBE2D1 CADPS2 19690564,19690564 0397,0018 HT UBE2E1 CADPS2 19690564,19690564 0397,0018 HT UBE2D3 CADPS2 19690564,19690564 0397,0018 HT UBE2N CADPS2 19690564,19690564 0397,0018 HT UBE2D2 CADPS2 19690564,19690564 0397,0018 HT SRPK2 CADPS2 26167880 0415 LC UBE2U CADPS2 19690564,19690564 0397,0018 HT CADPS2 UBE2E3 19690564,19690564 0397,0018 HT CADPS2 UBE2W 19690564,19690564 0397,0018 HT CADPS2 MEGF10 12421765 0018 HT CADPS2 UBE2D4 19690564,19690564 0397,0018 HT CADPS2 HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86UW7 P61077 CADPS2 UBE2D3 0.286 19690564 Q86UW7 Q5VVX9 CADPS2 UBE2U 0.286 19690564 Q8D0H0 Q86UW7 RSTB CADPS2 0.126 20711500 Q8D0S2 Q86UW7 Q8D0S2 CADPS2 0.126 20711500 Q9NWX5 Q86UW7 ASB6 CADPS2 0.126 24337577 Q86UW7 O95153 CADPS2 BZRAP1 0.183 24722188 Q969T4 Q86UW7 UBE2E3 CADPS2 0.376 19690564 Q96KG7 Q86UW7 MEGF10 CADPS2 0.309 unassigned5 Q9Y2X8 Q86UW7 UBE2D4 CADPS2 0.376 19690564 Q86UW7 P51668 CADPS2 UBE2D1 0.286 19690564 Q86UW7 P51965 CADPS2 UBE2E1 0.286 19690564 Q86UW7 P61088 CADPS2 UBE2N 0.286 19690564 Q96B02 Q86UW7 UBE2W CADPS2 0.286 19690564 Q8WXK4 Q86UW7 ASB12 CADPS2 0.126 24337577 Q86UW7 P78362 CADPS2 SRPK2 0.183 26167880 Q86UW7 P62837 CADPS2 UBE2D2 0.286 19690564

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TSPOAP1 CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database DMD CADPS2 MI:0362 inference MI:0461 interaction database ARF4 CADPS2 MI:0362 inference MI:0461 interaction database UBE2D1 CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database SRPK2 CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database ARF5 CADPS2 MI:0362 inference MI:0461 interaction database UBE2U CADPS2 MI:0045 experimental interaction detection MI:0461 interaction database CADPS2 ASB12 MI:0045 experimental interaction detection MI:0461 interaction database CADPS2 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database CADPS2 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database CADPS2 ASB6 MI:0045 experimental interaction detection MI:0461 interaction database CADPS2 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database