PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RBPJ WDR70 26186194,25609649 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZC3H18 WDR70 22939629 biogrid exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G WDR48 WDR70 19615732 biogrid,intact exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G SIRT1 WDR70 23382074 biogrid exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G WDR70 CHORDC1 26496610 biogrid,intact exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G NTRK1 WDR70 25921289 biogrid exp P G P UBTF WDR70 22939629 biogrid exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G CDC37 WDR70 25036637 intact exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G LMNA WDR70 22412018 biogrid exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G SRPK2 WDR70 26167880 biogrid exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G WDR70 TSSC4 22939629 biogrid exp G P G G G G G G G G G G G G G G G GP G XPO1 WDR70 26673895 biogrid exp G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G YWHAH WDR70 ortho G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G VPS39 WDR70 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G GP G RAB3IL1 WDR70 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR70 INO80 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DLAT WDR70 ortho G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G GNB4 WDR70 23023127 pred G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G PDC WDR70 23023127 pred P P GNAI3 WDR70 23023127 pred G GP G G G G G G G G G G G G G G G G G G G G G G G G G GP G WDR5 WDR70 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86VM9 Q9NW82 biochemical 22939629 colocalization X 2 P0CG48 Q9NW82 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9NW82 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9NW82 affinity chromatography technology 21906983 physical association X 2 Q9NW82 P17480 biochemical 22939629 colocalization X 2 Q9NW82 B0QZ35 affinity chromatography technology 23382074 physical association X 2 Q8TAF3 Q9NW82 affinity chromatography technology 19615732 physical association X 2 Q9Y5U2 Q9NW82 biochemical 22939629 colocalization X 2 Q9NW82 P02545-5 proximity labelling technology 22412018 physical association X 2 Q9NW82 anti tag coimmunoprecipitation 19615732 physical association C 59 Q9NW82 A0A024R7B7 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LMNA WDR70 - 22412018 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_280389 bait prey WDR48 WDR70 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100725|BIOGRID_120509 bait|bait prey|prey ZC3H18 WDR70 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241927 prey bait WDR70 TSSC4 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242850 prey bait UBTF WDR70 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240660 bait prey SIRT1 WDR70 MI:0004(affinity chromatography technology) 23382074 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249677 bait prey

PPI - HINT Gene A Gene B PMID Method Quality UBTF WDR70 22939629 0401 HT RBPJ WDR70 26186194,25609649,25609649 0004,0676,0004 HT ZC3H18 WDR70 22939629 0401 HT WDR48 WDR70 19615732,19615732 0004,0007 HT WDR70 CHORDC1 26496610,26496610 0007,0004 HT WDR70 TSSC4 22939629 0401 HT UBTF WDR70 22939629 0401 HT RBPJ WDR70 26186194,25609649,25609649 0004,0676,0004 HT ZC3H18 WDR70 22939629 0401 HT WDR48 WDR70 19615732,19615732 0004,0007 HT WDR70 CHORDC1 26496610,26496610 0007,0004 HT WDR70 TSSC4 22939629 0401 HT UBTF WDR70 22939629 0401 LC SRPK2 WDR70 26167880 0415 LC CDC37 WDR70 25036637 0729 HT ZC3H18 WDR70 22939629 0401 LC WDR70 TSSC4 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NW82 Q8NAV1 WDR70 PRPF38A 0.126 unassigned1312 Q9NW82 Q86VM9 WDR70 ZC3H18 0.081 22939629 Q9Y5U2 Q9NW82 TSSC4 WDR70 0.081 22939629 Q9NW82 Q6P5F9 WDR70 XPO1 0.126 26673895 Q9NW82 P02545 WDR70 LMNA 0.126 22412018 Q9NW82 P04629 WDR70 NTRK1 0.126 25921289 Q9NW82 Q91W40 WDR70 KLC3 0.236 26496610 Q9NW82 Q8R344 WDR70 CCDC12 0.236 26496610 Q9NW82 Q8TAF3 WDR70 WDR48 0.236 19615732 Q9NW82 Q06330 WDR70 RBPJ 0.332 25609649,26186194 Q9NW82 Q96EB6 WDR70 SIRT1 0.21 23382074 Q9UHD1 Q9NW82 CHORDC1 WDR70 0.126 26496610 Q9NW82 P17480 WDR70 UBTF 0.081 22939629 Q9NW82 P78362 WDR70 SRPK2 0.183 26167880 Q9NW82 Q16543 WDR70 CDC37 0.126 25036637 Q9NW82 Q3UH45 WDR70 Q3UH45 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 WDR70 MI:0045 experimental interaction detection MI:0461 interaction database TECPR2 WDR70 MI:0362 inference MI:0461 interaction database LMNA WDR70 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 WDR70 MI:0045 experimental interaction detection MI:0461 interaction database UBC WDR70 MI:0045 experimental interaction detection MI:0461 interaction database DLAT WDR70 MI:0362 inference MI:0461 interaction database SRPK2 WDR70 MI:0045 experimental interaction detection MI:0461 interaction database CYCS WDR70 MI:0362 inference MI:0461 interaction database RPL18A WDR70 MI:0362 inference MI:0461 interaction database RBPJ WDR70 MI:0045 experimental interaction detection MI:0461 interaction database CDC37 WDR70 MI:0045 experimental interaction detection MI:0461 interaction database KLC3 WDR70 MI:0362 inference MI:0461 interaction database WDR48 WDR70 MI:0045 experimental interaction detection MI:0461 interaction database RAB3IL1 WDR70 MI:0362 inference MI:0461 interaction database CCDC12 WDR70 MI:0362 inference MI:0461 interaction database SIRT1 WDR70 MI:0045 experimental interaction detection MI:0461 interaction database VPS39 WDR70 MI:0362 inference MI:0461 interaction database RAB3IP WDR70 MI:0362 inference MI:0461 interaction database BTBD10 WDR70 MI:0362 inference MI:0461 interaction database WDR70 CHORDC1 MI:0045 experimental interaction detection MI:0461 interaction database WDR70 INO80 MI:0362 inference MI:0461 interaction database