PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FAM219A WDFY1 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP G G G GP GP G P G GP GP GP GP GP GP GP GP G WDFY1 LHX6 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP GP G ALDOC WDFY1 26344197 biogrid exp G G G G G GP G G G G G G G G G G GP G G G G G G G G G G GP G WDFY1 TMEM123 26186194 biogrid exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP GP GP GP G GP GP GP G WDFY1 HACL1 26344197 biogrid exp GP GP G G G G G GP GP G GP GP GP GP G GP G G GP G GP GP GP G GP G GP GP G STBD1 WDFY1 26186194 biogrid exp G G FH WDFY1 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TXNL4A WDFY1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 WDFY1 19322201 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G GDI1 WDFY1 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SNX1 WDFY1 26344197 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G WDFY1 UBQLN1 22939629 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G WDFY1 FAHD2A 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TPD52L2 WDFY1 26344197 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G COX5B WDFY1 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G WDFY1 L3HYPDH 22939629 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP G G G G G GP G GP G GP GP G SNX2 WDFY1 26344197 biogrid exp G GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G WDFY1 EHD1 26344197, 21836163 biogrid exp, pred G G G G G GP G GP GP G GP G GP GP G G GP G G G GP G G G G GP G GP G TLR4 WDFY1 ortho G GP G G G GP G G G G G GP G GP G G G GP G GP G TLR3 WDFY1 ortho GP GP P G P GP GP GP GP G GP P G GP GP GP G GP G GP GP G WDFY1 ANKRD27 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G WDFY1 EHBP1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G GOLIM4 WDFY1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G WDFY1 EHD4 21836163 pred G G G G G GP G GP GP G GP G GP GP G G GP G G G GP G G G G GP G GP G GOLGB1 WDFY1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ARPC4 WDFY1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G AP1G2 WDFY1 21836163 pred GP GP G G G GP GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP GP GP GP G WDFY1 RIN2 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP P G VAC14 WDFY1 21836163 pred GP G GP G P P G GP GP GP GP G GP GP G P G P GP GP G GP G GP GP WDFY1 EHD3 21836163 pred G G G G G GP G GP GP G GP G GP GP G G GP G G GP G G GP G P G WDFY1 RUFY1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G WDFY1 CHMP5 21836163 pred G GP G G G GP G GP GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G WDFY1 STAMBPL1 21836163 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G P GP GP GP GP GP GP GP SNX4 WDFY1 21836163 pred G GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP G G G GP GP GP GP G WDFY1 WDFY2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IWB7 A0A024R3Z2 affinity chromatography technology 24654937 physical association X 2 Q8IWB7 P83876 biochemical 22939629 colocalization X 2 Q8IWB7 Q96EM0 biochemical 22939629 colocalization X 2 Q8IWB7 A0A024R284 biochemical 22939629 colocalization X 2 Q8IWB7 Q15843 affinity chromatography technology 24654937 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N131 Q8IWB7 TMEM123 WDFY1 0.126 26186194 Q8IWB7 O15455 WDFY1 TLR3 0.21 25736436 Q8IWB7 Q8IW50 WDFY1 FAM219A 0.126 26186194 Q8IWB7 P10606 WDFY1 COX5B 0.081 26344197 Q8IWB7 P09972 WDFY1 ALDOC 0.081 26344197 Q8IWB7 O43399 WDFY1 TPD52L2 0.081 26344197 Q8IWB7 P31150 WDFY1 GDI1 0.081 26344197 Q96GK7 Q8IWB7 FAHD2A WDFY1 0.081 26344197 Q8IWB7 P07954 WDFY1 FH 0.081 26344197 Q8IWB7 O95210 WDFY1 STBD1 0.126 26186194 Q96EM0 Q8IWB7 L3HYPDH WDFY1 0.081 22939629 Q9UJ83 Q8IWB7 HACL1 WDFY1 0.081 26344197 Q9UMX0 Q8IWB7 UBQLN1 WDFY1 0.081 22939629 Q9UPM6 Q8IWB7 LHX6 WDFY1 0.126 26186194 Q8IWB7 P83876 WDFY1 TXNL4A 0.081 22939629 Q8IWB7 Q15717 WDFY1 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TLR4 WDFY1 MI:0362 inference MI:0461 interaction database TLR3 WDFY1 MI:0045 experimental interaction detection MI:0461 interaction database STBD1 WDFY1 MI:0045 experimental interaction detection MI:0461 interaction database PAK4 WDFY1 MI:0362 inference MI:0461 interaction database BTF3 WDFY1 MI:0362 inference MI:0461 interaction database SUMO1 WDFY1 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 WDFY1 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 WDFY1 MI:0045 experimental interaction detection MI:0461 interaction database TICAM1 WDFY1 MI:0362 inference MI:0461 interaction database FAM219A WDFY1 MI:0045 experimental interaction detection MI:0461 interaction database WDFY1 TMEM123 MI:0045 experimental interaction detection MI:0461 interaction database WDFY1 BTF3L4 MI:0362 inference MI:0461 interaction database WDFY1 PAK7 MI:0362 inference MI:0461 interaction database WDFY1 LHX6 MI:0045 experimental interaction detection MI:0461 interaction database