PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HNRNPA3 ZFAND6 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G GSS ZFAND6 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ZFAND6 USP3 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC ZFAND6 23314748,19285159 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PPP2R1A ZFAND6 23443559 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CIRBP ZFAND6 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZFAND6 CDV3 26344197 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G G GP G GP G GP GP G G G GP GP GP G DNM2 ZFAND6 16169070 hprd,i2d,mint,intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TRAF5 ZFAND6 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NONO ZFAND6 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PKN1 ZFAND6 11054541 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ZFAND6 WIPI2 22939629 biogrid exp G GP G G G GP G G GP G GP G G G G G GP G GP G GP GP GP GP G G GP GP G ZFAND6 TXLNG 26344197 biogrid exp GP GP G G GP G G G GP G GP GP G GP G GP G G GP G GP GP GP G GP GP GP GP G TRAF2 ZFAND6 16189514,21810480 hprd,biogrid,mint,intact exp P P P P P P P P P P P P P P P P P P GP GP P CDC34 ZFAND6 11054541, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SMAD1 ZFAND6 ortho G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6FIF0 A0A024R8H5 two hybrid 16189514 - X 2 Q6FIF0 A0A024R8H5 two hybrid 16189514 - X 2 Q16512 Q6FIF0 in vivo 11054541 - X 2 Q16512 Q6FIF0 in vivo 11054541 - X 2 P50570-2 Q6FIF0 two hybrid 16169070 - X 2 P50570-2 Q6FIF0 two hybrid 16169070 - X 2 Q6FIF0 A0A024R1Z1 two hybrid 11054541 - X 2 Q6FIF0 A0A024R1Z1 in vitro 11054541 - X 2 Q6FIF0 A0A024R1Z1 two hybrid 11054541 - X 2 Q6FIF0 A0A024R1Z1 in vitro 11054541 - X 2 Q6FIF0 A0A024R8H5 two hybrid pooling approach 16189514 physical association X 2 Q6FIF0 A0A024R8H5 anti bait coimmunoprecipitation 21810480 physical association X 2 Q6FIF0 A0A024R8H5 anti bait coimmunoprecipitation 21810480 physical association X 2 Q6FIF0 A0A024R8H5 two hybrid 21810480 physical association X 2 Q6FIF0 A0A024R8H5 two hybrid 21810480 physical association X 2 Q6FIF0 A0A024R8H5 anti tag coimmunoprecipitation 21810480 physical association X 2 Q6FIF0 P50570 two hybrid pooling approach 16169070 physical association X 2 Q6FIF0 O00463 two hybrid prey pooling approach 25416956 physical association X 2 Q6FIF0 O00463 two hybrid array 25416956 physical association X 2 Q6FIF0 O00463 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZFAND6 TRAF2 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_67431|MINT_38248 prey|prey bait|bait UBC ZFAND6 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19285159,21890473,21963094,22505724,23314748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_200680|BIOGRID_264230|BIOGRID_248086|BIOGRID_200661|BIOGRID_224441|BIOGRID_174799 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey ZFAND6 uniprotkb:(gene name) MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_64076|MINT_35099 prey|prey bait|bait CDC34 ZFAND6 MI:0493(in vivo)|MI:0018(two hybrid) 11054541 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_16920|BIOGRID_209957 -|bait -|prey TRAF2 ZFAND6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514,21810480 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact) UniProt_115379|HPRD_21882|BIOGRID_80010|UniProt_152854|UniProt_115377|UniProt_115378|BIOGRID_142366|BIOGRID_142367|UniProt_115375|BIOGRID_142368|UniProt_115376 prey|-|bait|unspecified role|bait|prey|bait|prey|bait|prey|bait bait|-|prey|unspecified role|prey|bait|prey|bait|prey|bait|prey DNM2 ZFAND6 MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(intact) HPRD_29036|UniProt_156829 -|bait -|prey PKN1 ZFAND6 MI:0493(in vivo) 11054541 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_8317 - - ZFAND6 WIPI2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243614 prey bait ZFAND6 USP3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240556 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBC ZFAND6 23314748,19285159,19285159 0096,0096,0004 LC PPP2R1A ZFAND6 23443559 0004 HT HNRNPA3 ZFAND6 26344197 0401 HT CIRBP ZFAND6 26344197 0401 HT NONO ZFAND6 26344197 0401 HT ZFAND6 TXLNG 26344197 0401 HT ZFAND6 CDV3 26344197 0401 HT ZFAND6 WIPI2 22939629 0401 HT ZFAND6 USP3 22939629 0401 HT ZFAND6 HEL-S-64P 26344197 0401 HT PPP2R1A ZFAND6 23443559 0004 HT HNRNPA3 ZFAND6 26344197 0401 HT CIRBP ZFAND6 26344197 0401 HT NONO ZFAND6 26344197 0401 HT ZFAND6 TXLNG 26344197 0401 HT ZFAND6 CDV3 26344197 0401 HT ZFAND6 WIPI2 22939629 0401 HT ZFAND6 USP3 22939629 0401 HT ZFAND6 HEL-S-64P 26344197 0401 HT UBC ZFAND6 23314748,19285159,19285159 0096,0096,0004 LC TRAF5 ZFAND6 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CDC34 ZFAND6 11054541 0018 LC DNM2 ZFAND6 16169070,16169070 0018,0398 HT HNRNPA3 ZFAND6 26344197 0401 LC TRAF2 ZFAND6 21810480,16189514,21810480,21810480,16189514,21810480,21810480 0007,0398,0006,0018,0018,0096,0004 LC,HT CIRBP ZFAND6 26344197 0401 LC NONO ZFAND6 26344197 0401 LC ZFAND6 Q8N1K8 16169070 0018 HT ZFAND6 TXLNG 26344197 0401 LC ZFAND6 CDV3 26344197 0401 LC ZFAND6 WIPI2 22939629 0401 LC ZFAND6 USP3 22939629 0401 LC ZFAND6 HEL-S-64P 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y4P8 Q6FIF0 WIPI2 ZFAND6 0.081 22939629 Q9Y6I4 Q6FIF0 USP3 ZFAND6 0.081 22939629 Q9UKY7 Q6FIF0 CDV3 ZFAND6 0.081 26344197 Q9NUQ3 Q6FIF0 TXLNG ZFAND6 0.081 26344197 Q6FIF0 P48637 ZFAND6 GSS 0.081 26344197 Q6FIF0 Q14011 ZFAND6 CIRBP 0.081 26344197 Q6FIF0 P51991 ZFAND6 HNRNPA3 0.081 26344197 Q6FIF0 P50570 ZFAND6 DNM2 0.126 16169070 Q6FIF0 Q15233 ZFAND6 NONO 0.081 26344197 Q6FIF0 Q12933 ZFAND6 TRAF2 0.731 16189514,21810480 Q6FIF0 P0CG48 ZFAND6 UBC 0.554 19285159,23314748 Q6FIF0 O00463 ZFAND6 TRAF5 0.454 25416956 Q6FIF0 P30153 ZFAND6 PPP2R1A 0.126 23443559 Q6FIF0 P49427 ZFAND6 CDC34 0.309 11054541

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRAF5 ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database UBC ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R1A ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database CDC34 ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database DNM2 ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 ZFAND6 MI:0045 experimental interaction detection MI:0461 interaction database PKN1 ZFAND6 MI:0362 inference MI:0461 interaction database ZFAND6 PKN3 MI:0362 inference MI:0461 interaction database ZFAND6 SIAH1 MI:0362 inference MI:0461 interaction database