PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM23 KLHL42 25416956 biogrid,intact exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G GSTM3 KLHL42 26186194 biogrid exp G G G G G GP G G G G GP G G G G G GP G G G G G G G G G G GP G DCUN1D1 KLHL42 21145461 biogrid exp G G G GP G P G P P GP G GP G GP G G G GP G UBQLN4 KLHL42 16713569 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAK4 KLHL42 26186194 biogrid exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G KLHL42 COPS3 19295130 biogrid exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G KATNA1 KLHL42 19261606 biogrid exp G G G G GP GP G G GP G GP G GP G G G GP G GP G GP G G G G G G GP G CUL5 KLHL42 21145461 biogrid exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G COPS6 KLHL42 19615732,21145461 biogrid,intact exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G COPS4 KLHL42 19295130 biogrid exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G DDI1 KLHL42 25416956 biogrid,intact exp P P P G GP GP G GP RFWD2 KLHL42 19295130 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G UBE2E3 KLHL42 19256485 biogrid exp G G G G G GP G G GP G GP G G G G G GP GP G G GP G G G G G G GP G STXBP4 KLHL42 25416956 biogrid,intact exp G G GP P P GP P G P GP GP G GP G G P G PCMT1 KLHL42 26186194 biogrid exp G G G G GP GP G G G G GP G GP G G G GP GP GP G GP G G G G G G GP G KLHL42 SERTAD1 16189514 hprd,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RCN3 KLHL42 16189514 hprd,biogrid,intact exp G G G GP P G G GP GP G GP G G G GP G GP G P G G G G G GP G GAS2L1 KLHL42 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAM2 KLHL42 25416956 biogrid,intact exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G USHBP1 KLHL42 16189514 hprd,biogrid,intact exp P P P P P P P RNF126 KLHL42 26186194 biogrid exp G G G G GP GP G G GP G GP G GP G G G GP GP P G GP G G G G G G GP G CUL3 KLHL42 19295130,19256485,19261606,25011449,21145461 innatedb,biogrid exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G KLHL42 SSX2IP 25416956 biogrid,intact exp G G G G GP G G GP G GP G GP G G GP G GP G GP G G G G G GP G KLHL42 UBQLN1 25416956,16189514 hprd,biogrid,intact exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G COPS5 KLHL42 18850735,21145461 biogrid,intact exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G COIL KLHL42 16713569 hprd,biogrid,mint,intact exp G G G G G GP G G GP G GP G GP G G G GP G GP G GP G G G G G G GP G FAM168A KLHL42 25416956 biogrid,intact exp G G G G G GP G G G G G G G G G G GP GP G G G G G G G G G GP G CALCOCO2 KLHL42 25416956 biogrid,intact exp G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G KLHL42 TEKT2 26186194 biogrid exp P P P P P P P G P GP PLS3 KLHL42 21836163 pred G G G G GP GP G G GP G GP G GP G G G GP GP GP G GP G G G G G G GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RCN3 KLHDC5 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_24001|UniProt_153209|BIOGRID_80367 -|unspecified role|bait -|unspecified role|prey COPS6 KLHDC5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_205722|BIOGRID_120600|UniProt_100633 bait|bait|bait prey|prey|prey UBQLN4 KLHDC5 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) BIOGRID_215192|UniProt_85681|MINT_83083|MINT_50795|HPRD_35180 bait|prey|bait|bait|- prey|bait|prey|prey|- UBE2E3 KLHDC5 MI:0096(pull down) 19256485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_214478 bait prey KLHDC5 UBQLN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact) BIOGRID_80691|HPRD_22531|UniProt_153520 prey|-|unspecified role bait|-|unspecified role KLHDC5 COPS3 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221749 prey bait COIL KLHDC5 MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(intact)|(biogrid) MINT_50796|MINT_83084|HPRD_29413|UniProt_85777|BIOGRID_215338 bait|bait|-|prey|bait prey|prey|-|bait|prey KLHDC5 SERTAD1 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_23933|UniProt_152842|BIOGRID_79997 -|unspecified role|prey -|unspecified role|bait COPS4 KLHDC5 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221771 bait prey CUL5 KLHDC5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203496 bait prey KATNA1 KLHDC5 MI:0018(two hybrid) 19261606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_146655 prey bait COPS5 KLHDC5 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 18850735,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_205307|UniProt_96542 bait|bait prey|prey USHBP1 KLHDC5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact) HPRD_24002|BIOGRID_78609|UniProt_151467 -|prey|unspecified role -|bait|unspecified role RFWD2 KLHDC5 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221732 bait prey CUL3 KLHDC5 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0018(two hybrid) 19256485,19261606,19295130,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_221278|BIOGRID_146652|BIOGRID_201912|BIOGRID_214474|BIOGRID_146658 bait|bait|bait|bait|bait prey|prey|prey|prey|prey DCUN1D1 KLHDC5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205987 bait prey UBC KLHDC5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_180430|BIOGRID_265806|BIOGRID_171253|BIOGRID_176084 bait|bait|bait|bait prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PAK4 KLHL42 26186194 0004 HT GSTM3 KLHL42 26186194 0004 HT PCMT1 KLHL42 26186194 0004 HT CUL3 KLHL42 25011449,21145461,19256485,19261606,19295130,19261606 0004,0004,0096,0004,0004,0018 LC,HT COPS6 KLHL42 19615732,21145461,19615732 0004,0004,0007 HT COPS5 KLHL42 18850735,21145461 0676,0004 LC,HT CUL5 KLHL42 21145461 0004 HT DCUN1D1 KLHL42 21145461 0004 HT GAS2L1 KLHL42 26186194 0004 HT RNF126 KLHL42 26186194 0004 HT KLHL42 TEKT2 26186194 0004 HT PAK4 KLHL42 26186194 0004 HT GSTM3 KLHL42 26186194 0004 HT PCMT1 KLHL42 26186194 0004 HT CUL3 KLHL42 21145461 0004 HT COPS6 KLHL42 19615732,21145461,19615732 0004,0004,0007 HT COPS5 KLHL42 21145461 0004 HT CUL5 KLHL42 21145461 0004 HT DCUN1D1 KLHL42 21145461 0004 HT GAS2L1 KLHL42 26186194 0004 HT RNF126 KLHL42 26186194 0004 HT KLHL42 TEKT2 26186194 0004 HT CUL3 KLHL42 25011449,19256485,19261606,19295130,19261606 0004,0096,0004,0004,0018 LC COPS5 KLHL42 18850735 0676 LC STAM2 KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM23 KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT COIL KLHL42 16713569,16713569 0397,0018 HT CALCOCO2 KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CUL3 KLHL42 19261606,19261606 0004,0018 LC STXBP4 KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT USHBP1 KLHL42 16189514,16189514 0398,0018 HT DDI1 KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FAM168A KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RCN3 KLHL42 16189514,16189514 0398,0018 HT UBQLN4 KLHL42 16713569,16713569 0397,0018 HT KLHL42 SERTAD1 16189514,16189514 0398,0018 HT KLHL42 UBQLN1 16189514,25416956,25416956,25416956,16189514,25416956 0398,1112,0397,0018,0018,1356 HT KLHL42 SSX2IP 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9P2K6 Q8NHY2 KLHL42 RFWD2 0.126 19295130 Q9P2K6 O96013 KLHL42 PAK4 0.126 26186194 Q9P2K6 P15173 KLHL42 MYOG 0.236 unassigned1304 Q9P2K6 P36406 KLHL42 TRIM23 0.583 25416956,unassigned1304 Q9P2K6 Q13137 KLHL42 CALCOCO2 0.454 25416956 Q9P2K6 Q8N1B4 KLHL42 VPS52 0.236 unassigned1304 Q9P2K6 Q99471 KLHL42 PFDN5 0.236 unassigned1304 Q9P2K6 P01189 KLHL42 POMC 0.236 unassigned1304 Q9P2K6 Q8WTU0 KLHL42 DDI1 0.583 25416956,unassigned1304 Q9UHD9 Q9P2K6 UBQLN2 KLHL42 0.236 unassigned1304 Q9UJW9 Q9P2K6 SERTAD3 KLHL42 0.236 unassigned1304 Q9P2K6 Q92905 KLHL42 COPS5 0.236 18850735,21145461 Q9P2K6 Q9BXL8 KLHL42 CDCA4 0.236 unassigned1304 Q9P2K6 Q15038 KLHL42 DAZAP2 0.236 unassigned1304 Q9P2K6 Q9BYV2 KLHL42 TRIM54 0.236 unassigned1304 Q9P2K6 Q3LI73 KLHL42 KRTAP19-4 0.236 unassigned1304 Q9P2K6 Q04864 KLHL42 REL 0.236 unassigned1304 Q9P2K6 Q7L5N1 KLHL42 COPS6 0.332 19615732,21145461 Q9P2K6 O75886 KLHL42 STAM2 0.583 25416956,unassigned1304 Q9P2K6 Q08AL9 KLHL42 STXBP4 {ECO:0000313|EMBL:AAI25117.1} 0.332 25416956 Q9UMX0 Q9P2K6 UBQLN1 KLHL42 0.702 25416956,16189514,unassigned1304 Q9Y2D8 Q9P2K6 SSX2IP KLHL42 0.454 25416956 Q9P2K6 Q9JLV5 KLHL42 CUL3 0.416 26496610,20360068 Q9P2K6 Q92567 KLHL42 FAM168A 0.454 25416956 Q9P2K6 Q13618 KLHL42 CUL3 0.772 21145461,19295130,19256485,25011449,19261606 Q9P2K6 Q93034 KLHL42 CUL5 0.126 21145461 Q9P2K6 Q969T4 KLHL42 UBE2E3 0.309 19256485 Q9P2K6 Q96D15 KLHL42 RCN3 0.286 16189514 Q9P2K6 Q96GG9 KLHL42 DCUN1D1 0.126 21145461 Q9P2K6 Q9BT78 KLHL42 COPS4 0.126 19295130 Q9P2K6 Q9BV68 KLHL42 RNF126 0.126 26186194 Q9P2K6 Q99501 KLHL42 GAS2L1 0.126 26186194 Q9P2K6 O75449 KLHL42 KATNA1 0.21 19261606 Q9P2K6 Q8N6Y0 KLHL42 USHBP1 0.286 16189514 Q9P2K6 P38432 KLHL42 COIL 0.376 16713569 Q9P2K6 Q6ZWJ1 KLHL42 STXBP4 0.183 25416956 Q9UHV2 Q9P2K6 SERTAD1 KLHL42 0.454 16189514,unassigned1304 Q9P2K6 Q9NRR5 KLHL42 UBQLN4 0.376 16713569 Q9UIF3 Q9P2K6 TEKT2 KLHL42 0.126 26186194 Q9UNS2 Q9P2K6 COPS3 KLHL42 0.126 19295130 Q9P2K6 P21266 KLHL42 GSTM3 0.126 26186194 Q9P2K6 P22061 KLHL42 PCMT1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 KATNA1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database STAM2 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database PAK4 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database GSTM3 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database PCMT1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database COIL KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 KLHL42 MI:0362 inference MI:1106 pathways database CALCOCO2 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KLHL42 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NEDD8 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database STXBP4 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database USHBP1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database RFWD2 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database FAM168A KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database COPS5 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E3 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database RCN3 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database GAS2L1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database COPS4 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database RNF126 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database UBQLN4 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database KLHL42 SERTAD1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL42 TEKT2 MI:0045 experimental interaction detection MI:0461 interaction database KLHL42 UBQLN1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL42 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database KLHL42 SSX2IP MI:0045 experimental interaction detection MI:0461 interaction database