PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus BRAP ZNF479 25820252 intact exp G G G G G G G IKBKB BRAP 21670849 biogrid exp P P G GP P G P P P P G GP P P G GP P GP G GP P P GP UBE2H BRAP 19549727 biogrid,intact exp P P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP CENPF BRAP 9497340 hprd,bci exp P P G GP P GP P P P P P GP P P GP P GP GP GP P P GP BRAP ZNF526 26496610 biogrid,intact exp P P G GP P GP P P P P P G GP P P G P P GP P P P GP ATMIN BRAP 25820252 intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP TWIST1 BRAP 21983900 biogrid,intact exp G G G G G G G NEDD8 BRAP 23554956 biogrid exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP TRIM8 22493164 biogrid,intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP CUL2 BRAP 21145461 biogrid exp P P G G P G P P P P P G G P P G GP P GP G G P GP Tex35 BRAP 25820252 intact exp P P P G P P G GP P P G P P P P GP P GP BRAP TRIM55 22493164 biogrid,intact exp P P GP P P P P P P P P P GP GP P GP APOA1 BRAP 25820252 intact exp G P P G G G CDKN1A BRAP 15340083 biogrid exp P P G GP G P P G GP G GP G G GP GP BRAP C5orf42 25820252 intact exp P P P P P P P P P G P P P P P P P BRAP SMARCE1 25820252 intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP USP15 23105109 biogrid exp P G GP P G P P P P P G GP P P G GP P GP GP GP P P GP BRAP FAM184A 25820252 intact exp G G P GP P P G G P G G G P G P GP BRAP KLHDC3 26186194 biogrid exp P P G GP P GP P P P G GP P P G GP GP GP GP P GP USP4 BRAP 23105109 biogrid exp P G GP P GP P P P P P G GP P P G GP GP GP GP P GP BRAP CCDC105 25820252 intact exp P G GP G P P GP G P G G P P GP BRAP TANC2 25820252 intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP ZNF382 25820252 intact exp P P P GP P P P P P P P G P P P P P P P BRAP TRIM41 22493164 biogrid,intact exp P P G GP P G P P P P G GP P P G GP P GP GP GP P P GP UBB BRAP 25820252 intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP ZNF521 25820252 intact exp P P P P GP P P P P G GP P P G P P GP GP GP P P GP DDB1 BRAP 10777491 hprd,intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP FBXO28 25820252 intact exp G G G G G G G G G G G NFKBIB BRAP 21670849 biogrid exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP SPRTN 26496610 biogrid,intact exp P G GP P P G P G G GP LGALS2 BRAP 19198608 innatedb exp P P P P P GP P P GP BRAP RBM12 25820252 intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP BRK1 25820252 intact exp G G G G G G G G G G G BRAP SHCBP1L 25820252 intact exp P G G GP UBC BRAP 17550899,25820252 biogrid,intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP CUL1 BRAP 23554956 biogrid exp P G G P GP P P P P G GP P P G GP P GP GP GP P P GP EFHC1 BRAP 25820252 intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP CCDC30 BRAP 25820252 intact exp G G P GP P P P G P P G G GP G GP P NUMA1 BRAP 23707952,25820252 biogrid,intact exp, ortho P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP PHLPP1 BRAP 25820252 intact exp, ortho P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP DNMT1 BRAP 25820252 intact exp, ortho G GP G P P G GP G GP G G GP P GP BRAP BRAP 23554956,25820252,14724641 hprd,biogrid,i2d,intact exp, ortho P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP AKAP3 BRAP 25820252 intact exp, ortho G P P P GP MAP2K1 BRAP 18332145 innatedb,biogrid exp, ortho P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP HMG20A 23707952,25820252 biogrid,intact exp, ortho P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP SYNE2 23707952,25820252 biogrid,intact exp, ortho P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP BRAP KSR1 18332145,14724641, 21836163 innatedb,biogrid,intact,bci exp, ortho, pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP RAF1 BRAP 18332145, 23023127 biogrid exp, ortho, pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP HRAS BRAP 14724641, 25402006 hprd,biogrid,i2d,intact,bci exp, ortho, pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRCA1 BRAP 9497340,8955125, 25402006 hprd,biogrid,mint,intact,bci exp, pred P P G GP P P P P P P P GP P P P P P P P P P GP BRAF BRAP 18332145, 25402006 biogrid exp, pred P P G GP P GP P P P P P P P P G GP P GP GP P P P GP BRAP CNKSR1 14724641, 21836163 hprd,bci exp, pred P P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP BRAP CDC14A 19152073, 21836163 biogrid exp, pred P P P P P P P P P P P P P P P P P P P P GP RANGAP1 BRAP ortho P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP YPEL3 BRAP ortho P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP INO80 ortho G G G G G G G G G G G NOTCH1 BRAP ortho P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP GLTSCR2 ortho P P P P P P P P P P P P P P P GP P P P P P BRAP NUP93 ortho P P G GP P GP P P P P G GP P P P P GP P P GP BRAP OARD1 ortho P G GP P G P P P P G GP P P G G P G G GP P GP BRAP LNX1 21836163 pred P P GP P P P P P G GP P P G GP P GP G GP P P GP NT5C2 BRAP 21836163 pred P G GP P GP P P P P G GP P G GP P GP GP GP P P GP BRAP BRIP1 25402006 pred P G GP P P P P P P P GP P P P P P P P P P GP BRAP PURG 21836163 pred P P G GP P GP P P P P P G GP P P G P P GP GP GP P P GP BRAP IGF2BP2 21836163 pred P P G GP P GP P P P P P G GP P P G GP GP P GP P P GP PIK3R1 BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP RNF25 21836163 pred P P P P P P P P P P P P P P P P P RGL2 BRAP 25402006 pred P P G G P GP P P P G GP P P G G P G GP GP P GP BRAP TOPBP1 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP ARL3 BRAP 23023127 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP WWOX 23023127 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP SHOC2 25402006 pred P G GP P G P P P P G G P G GP G GP G P P GP BRAP CHFR 21836163 pred G G G G G G G G G G G BRAP TRIM5 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP P GP P P P RNF20 BRAP 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP TNMD 21836163 pred P P P P P P P P P G P P P P P P P P P P BRAP ZNF350 25402006 pred P P P P P P G P P P G GP P G GP P P P GP BRAP TRIM11 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP P GP P P GP AMPD1 BRAP 21836163 pred P G GP P P P P P P GP P P G P P GP GP GP P P PPP1CB BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP IMPDH1 BRAP 21836163 pred P P G G P GP P P P P P G GP P P G GP P GP GP P P GP CSTF1 BRAP 25402006 pred P P G GP P P P P P P P G GP P P P P P GP GP P P GP RASIP1 BRAP 25402006 pred G G G G G G G G G G G BRAP CHD8 23023127 pred G G G G G G G G G G G BRAP UHRF1 21836163 pred G G G G G G G IRAK1 BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP G GP P P GP BRAP NT5C1A 21836163 pred P G G P GP P G G P P G GP P G GP G GP RLF BRAP 25402006 pred P G G GP P P P G GP G G G GP GP GP SUMO1 BRAP 25402006 pred P P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP BRAP SMURF1 23023127 pred P G GP P G P P P G G P G GP G G G P GP COASY BRAP 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP ADK BRAP 21836163 pred P P G G P GP P P P P P G GP P P G GP P GP GP GP P P GP AMPD3 BRAP 21836163 pred P G GP GP P P P P G GP G G GP GP GP P P G BRAP PDSS2 21836163 pred P P G GP P GP P P P P P G GP P P G P P GP GP GP P P P AMPD2 BRAP 21836163 pred P G G P G P P P P G GP P P G GP GP G GP P P GP RAP1GDS1 BRAP 25402006 pred P P G G P GP P P P P G GP P P G GP G GP GP P P GP UBE2D1 BRAP 25402006 pred P G GP P G P P P P P G G P P G GP P G GP G P P GP LRSAM1 BRAP 21836163 pred P P P P P P P P P P P P P G P P P P P P P P UBC BRAP 23023127 pred PPP1CC BRAP 25402006 pred P P G G P GP P P P P G GP P P G GP P GP GP GP P P GP BRAP NUFIP1 25402006 pred P G G P G P P P P G P P P G P G GP GP P GP BRAP RASSF1 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP IMPDH2 BRAP 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP PIK3CA BRAP 25402006 pred P P P P GP P P P P P G P P P G P P GP GP GP P P GP RALGDS BRAP 23023127 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP RPL31 BRAP 25402006 pred G G G G G G G G G G G BRAP CCNB1IP1 21836163 pred G G G G G G G G G G G ABL2 BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP FAM175A BRAP 25402006 pred P G G G P G GP G G G G GP P GP PIAS1 BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP ARHGEF6 BRAP 23023127 pred P G GP P G P P P P P G GP P P G G G G GP P G CNOT4 BRAP 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP ITPA 21836163 pred P P G GP P GP P P P P P G GP P P G GP P G GP GP P P GP BRAP AMFR 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP UBE2D3 BRAP 25402006 pred P G GP P G P P P P P G G P P G GP P G GP G P P GP PFAS BRAP 21836163 pred P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP SOS2 BRAP 25402006 pred P P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP IRAK2 BRAP 25402006 pred P P G GP P P P P P P P GP P G G GP GP GP P P BRAP MIB1 21836163 pred P P G GP P G P P P P G GP P P G GP P GP G GP P GP RALA BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP RNF144B BRAP 21836163 pred P G G P GP P P P P G GP P P G GP G G GP GP BRAP MYLIP 21836163 pred G G G G G G G G G G G TERF1 BRAP 21836163 pred G G G G G G G G G G G GNAL BRAP 21836163 pred P P P P GP P P P P P G P P P G P P GP GP GP P P GP BRAP PIAS4 25402006 pred G G G G G G G BRAP IGF2BP1 21836163 pred GP BRAP BRE 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP RGL4 25402006 pred P G G P P P P P P P P P P P ACSM3 BRAP 21836163 pred G G P P P P P GP P P G GP P P NFX1 BRAP 21836163 pred G G G G G G G G G G G NEDD4 BRAP 23023127 pred P P G GP P GP P P P P G GP P P G GP P GP GP GP P P P BRAP FANCL 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP RGL1 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP TRAF7 BRAP 21836163 pred P P G G P GP P P P P G GP P G G GP GP GP P GP BRAP ARIH1 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP ATIC BRAP 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP PJA1 21836163 pred P P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP UBE3C BRAP 21836163 pred P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP RNF8 BRAP 25402006 pred P P G G P GP P P G GP P P G G GP G GP P GP BRAP TTC1 25402006 pred P P G GP P GP P P P P P G GP P G GP P GP GP GP P GP IMPA1 BRAP 21836163 pred P P G G P GP P P P P P G GP P P G G P GP GP GP P P GP CANX BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP BRAP HM13 21836163 pred P P G GP P G P P P G GP P P G GP P GP G GP P P GP KPNA2 BRAP 25402006 pred P P G GP P GP P P P P P G GP P P G GP GP GP GP P P GP BRAP VRK2 25402006 pred P P G G GP P P P P G GP P G GP P GP GP GP P GP BRAP WWC1 23023127 pred P P G G P G P P P P G GP P P G GP P GP GP GP P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A090N7U0 Q7Z569 affinity chromatography technology 23554956 physical association X 2 A0A090N7U0 Q7Z569 affinity chromatography technology 23554956 physical association X 2 L7RRS6 Q7Z569 affinity chromatography technology 18332145 physical association X 2 Q8IVT5-4 Q7Z569 affinity chromatography technology 18332145 physical association X 2 Q7Z569 Q15653-2 affinity chromatography technology 21670849 physical association X 2 Q7Z569 Q15653-2 affinity chromatography technology 21670849 physical association X 2 Q7Z569 P15056 affinity chromatography technology 18332145 physical association X 2 Q7Z569 Q8WV44-2 two hybrid 22493164 direct interaction X 2 Q7Z569 Q8WXH0 two hybrid 23707952 direct interaction X 2 Q7Z569 two hybrid 9497340 direct interaction X 2 Q7Z569 pull down 9497340 direct interaction X 2 Q7Z569 two hybrid 8955125 direct interaction X 2 Q13617 Q7Z569 affinity chromatography technology 21145461 physical association X 2 Q14980 Q7Z569 two hybrid 23707952 direct interaction X 2 P0CG48 Q7Z569 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 17550899 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 25015289 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 20639865 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 18781797 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q7Z569 affinity chromatography technology 21906983 physical association X 2 A0A024RCX5 Q7Z569 affinity chromatography technology 15340083 physical association X 2 Q9BZR9 Q7Z569 two hybrid 22493164 direct interaction X 2 P01112 Q7Z569 affinity chromatography technology 14724641 physical association X 2 Q9NP66 Q7Z569 two hybrid 23707952 direct interaction X 2 Q9NP66 Q7Z569 affinity chromatography technology 23707952 physical association X 2 Q7Z569 affinity chromatography technology 21670849 physical association X 2 Q7Z569 affinity chromatography technology 21670849 physical association X 2 Q7Z569 A4QPA9 affinity chromatography technology 18332145 physical association X 2 Q7Z569 Q13107-3 two hybrid 23105109 direct interaction X 2 Q7Z569 Q9Y4E8-2 two hybrid 23105109 direct interaction X 2 Q7Z569 Q13107-3 affinity chromatography technology 23105109 physical association X 2 Q7Z569 Q9Y4E8-2 affinity chromatography technology 23105109 physical association X 2 Q7Z569 Q13107-3 two hybrid 23105109 direct interaction X 2 Q7Z569 Q9Y4E8-2 two hybrid 23105109 direct interaction X 2 Q7Z569 Q15843 affinity chromatography technology 23554956 physical association X 2 Q7Z569 Q15843 affinity chromatography technology 23554956 physical association X 2 Q7Z569 Q7Z569 affinity chromatography technology 23554956 physical association X 2 Q7Z569 Q9BYV6-4 two hybrid 22493164 direct interaction X 2 Q7Z569 two hybrid 19152073 direct interaction X 2 Q7Z569 affinity chromatography technology 19152073 physical association X 2 Q7Z569 pull down 19152073 direct interaction X 2 Q7Z569 two hybrid 19549727 direct interaction X 2 Q15672 Q7Z569 affinity chromatography technology 21983900 physical association X 2 Q7Z569 in vitro 9497340 - X 2 Q7Z569 two hybrid 9497340 - X 2 Q7Z569 two hybrid 9497340 - X 2 Q7Z569 in vitro 9497340 - X 2 Q53GM7 Q7Z569 in vivo 14724641 - X 2 Q53GM7 Q7Z569 in vivo 14724641 - X 2 P01112-2 Q7Z569 in vitro 14724641 - X 2 P01112-2 Q7Z569 in vivo 14724641 - X 2 P01112-2 Q7Z569 in vivo 14724641 - X 2 P01112-2 Q7Z569 in vitro 14724641 - X 2 Q7Z569 in vitro 9497340 - X 2 Q7Z569 in vitro 9497340 - X 2 Q7Z569 Q7Z569 in vivo 14724641 - X 2 Q7Z569 two hybrid 10777491 - X 2 Q7Z569 two hybrid 10777491 - X 2 Q7Z569 pull down 21983900 association C 6 P38398 Q7Z569 two hybrid 9497340 physical association X 2 P38398 Q7Z569 two hybrid 9497340 physical association X 2 P38398 Q7Z569 pull down 9497340 physical association X 2 Q7Z569 Q16531 two hybrid 10777491 physical association X 2 Q9BZR9 Q7Z569 two hybrid array 22493164 physical association X 2 Q8WV44 Q7Z569 two hybrid array 22493164 physical association X 2 P01112 Q7Z569 coimmunoprecipitation 14724641 physical association X 2 P01112 Q7Z569 pull down 14724641 physical association X 2 P01112 Q7Z569 coimmunoprecipitation 14724641 physical association X 2 Q8IVT5 Q7Z569 coimmunoprecipitation 14724641 physical association X 2 Q7Z569 Q7Z569 coimmunoprecipitation 14724641 physical association X 2 A4D1L5 Q7Z569 two hybrid array 19549727 physical association X 2 Q9BYV6 Q7Z569 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B IKBKB BRAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21670849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_207474|BIOGRID_207476 prey|bait bait|prey BRAP CDC14A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19152073 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_116162|BIOGRID_116160|BIOGRID_116161 bait|prey|prey prey|bait|bait CUL1 BRAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23554956 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272198|BIOGRID_272199 bait|prey prey|bait BRAP KSR1 MI:0096(pull down) 14724641 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_74065 bait prey UBC BRAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18781797,20639865,21139048,21890473,21906983,21963094,22053931,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_162208|BIOGRID_222205|BIOGRID_225242|BIOGRID_177310|BIOGRID_264579|BIOGRID_173506|BIOGRID_268286|BIOGRID_167881|BIOGRID_160131 bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey TWIST1 BRAP MI:0004(affinity chromatography technology)|MI:0071(molecular sieving) 21983900 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_189795|UniProt_116432 bait|bait prey|prey HRAS BRAP MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 14724641 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(intact) UniProt_74061|UniProt_74062|BIOGRID_199721|UniProt_74063 prey|bait|bait|bait bait|prey|prey|prey UBE2H BRAP MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101336|BIOGRID_124341 bait|bait prey|prey BRAP USP15 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_248152|BIOGRID_248201|BIOGRID_248150 bait|prey|bait prey|bait|prey CUL2 BRAP MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203747 bait prey DDB1 BRAP MI:0018(two hybrid) 10777491 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_66174 bait prey RAF1 BRAP MI:0004(affinity chromatography technology) 18332145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_207834 bait prey CDKN1A BRAP MI:0004(affinity chromatography technology) 15340083 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_194828 bait prey NEDD8 BRAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23554956 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272195|BIOGRID_272194 bait|prey prey|bait MAP2K1 BRAP MI:0004(affinity chromatography technology) 18332145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_207827 prey bait NFKBIB BRAP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21670849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_207475|BIOGRID_207477 prey|bait bait|prey BRAF BRAP MI:0004(affinity chromatography technology) 18332145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_207828 prey bait BRAP TRIM41 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122509|BIOGRID_284041 prey|bait bait|prey USP4 BRAP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_248151|BIOGRID_248149|BIOGRID_248186 prey|prey|bait bait|bait|prey BRCA1 BRAP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 8955125,9497340 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(intact)|(intact) MINT_86038|MINT_86039|BIOGRID_111520|MINT_86037|MINT_56923|BIOGRID_111521|MINT_56924|MINT_56925|BIOGRID_117015|UniProt_134926|UniProt_134923|UniProt_134924 prey|prey|bait|prey|prey|prey|prey|prey|bait|prey|bait|bait bait|bait|prey|bait|bait|bait|bait|bait|prey|bait|prey|prey BRAP TRIM55 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122508|BIOGRID_284038 prey|bait bait|prey BRAP TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122507|BIOGRID_284056 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality UBC BRAP 17550899,20639865 0004,0004 LC CUL2 BRAP 21145461 0004 HT BRAP KSR1 18332145,14724641,14724641 0004,0007,0019 LC BRAP ZNF526 26496610,26496610 0007,0004 HT BRAP KLHDC3 26186194 0004 HT BRAP SPRTN 26496610,26496610 0007,0004 HT CUL2 BRAP 21145461 0004 HT BRAP ZNF526 26496610,26496610 0007,0004 HT BRAP KLHDC3 26186194 0004 HT BRAP SPRTN 26496610,26496610 0007,0004 HT UBC BRAP 17550899,20639865 0004,0004 LC BRAP KSR1 18332145,14724641,14724641 0004,0007,0019 LC ATMIN BRAP 25820252 0018 LC PHLPP1 BRAP 25820252,25820252,25820252,25820252 0663,0018,0007,0096 LC AKAP3 BRAP 25820252,25820252 0018,0007 LC HRAS BRAP 14724641,14724641,14724641,14724641 0096,0018,0019,0004 LC APOA1 BRAP 25820252 0018 LC UBB BRAP 25820252 0018 LC UBC BRAP 25820252 0018 LC DNMT1 BRAP 25820252 0018 LC BRCA1 BRAP 9497340,9497340,8955125,9497340 0018,0019,0018,0096 LC UBE2H BRAP 19549727,19549727 0397,0018 HT USP4 BRAP 23105109,23105109 0018,0004 LC NUMA1 BRAP 23707952,25820252 0018,0018 LC DDB1 BRAP 10777491 0018 LC Q59FP7 BRAP 25820252,25820252 0018,0096 LC EFHC1 BRAP 25820252 0018 LC TEX35 BRAP 25820252 0018 LC CCDC30 BRAP 25820252 0018 LC BRAP BRAP 14724641,25820252,14724641 0045,0018,0019 LC BRAP KSR1 14724641,14724641 0007,0019 LC BRAP CCDC105 25820252 0018 LC BRAP FAM184A 25820252 0018 LC BRAP BRK1 25820252 0018 LC BRAP TRIM41 22493164,22493164 0018,0397 HT BRAP SYNE2 23707952,25820252 0018,0018 LC BRAP SMARCE1 25820252 0018 LC BRAP ZNF479 25820252 0018 LC BRAP ZNF521 25820252 0018 LC BRAP ZNF382 25820252 0018 LC BRAP TRIM55 22493164,22493164 0018,0397 HT BRAP SHCBP1L 25820252 0018 LC BRAP TRIM8 22493164,22493164 0018,0397 HT BRAP C5ORF42 25820252 0018 LC BRAP TANC2 25820252 0018 LC BRAP HMG20A 23707952,25820252,23707952 0018,0018,0004 LC BRAP RBM12 25820252 0018 LC BRAP FBXO28 25820252 0018 LC BRAP FBXO2 25820252 0018 LC BRAP CDC14A 19152073,19152073,19152073 0018,0004,0096 LC BRAP USP15 23105109,23105109 0018,0004 LC BRAP HEL159 25820252,25820252 0018,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7Z569 O14920 BRAP IKBKB 0.376 21670849 Q7Z569 Q5JVL4 BRAP EFHC1 0.332 25820252 Q7Z569 Q5T0J7 BRAP TEX35 0.332 25820252 Q7Z569 O43313 BRAP ATMIN 0.332 25820252 Q7Z569 Q5VVM6 BRAP CCDC30 0.332 25820252 Q8IYK2 Q7Z569 CCDC105 BRAP 0.332 25820252 Q9H799 Q7Z569 C5ORF42 BRAP 0.183 25820252 Q9HCD6 Q7Z569 TANC2 BRAP 0.332 25820252 Q8NB25 Q7Z569 FAM184A BRAP 0.332 25820252 Q7Z569 O60346 BRAP PHLPP1 0.561 25820252 Q9NP66 Q7Z569 HMG20A BRAP 0.636 25820252,23707952 Q9NTZ6 Q7Z569 RBM12 BRAP 0.332 25820252 Q9NVF7 Q7Z569 FBXO28 BRAP 0.183 25820252 Q8IVT5 Q7Z569 KSR1 BRAP 0.376 14724641,18332145 Q9Y4E8 Q7Z569 USP15 BRAP 0.416 23105109 Q7Z569 P0CG47 BRAP UBB 0.332 25820252 Q7Z569 P01112 BRAP HRAS 0.61 14724641 Q7Z569 P02647 BRAP APOA1 0.332 25820252 Q7Z569 P0CG48 BRAP UBC 0.416 25820252,17550899 Q7Z569 P15056 BRAP BRAF 0.21 18332145 Q7Z569 Q02750 BRAP MAP2K1 0.21 18332145 Q7Z569 Q16531 BRAP DDB1 0.309 10777491 Q9UK22 Q7Z569 FBXO2 BRAP 0.183 25820252 Q9UNH5 Q7Z569 CDC14A BRAP 0.623 19152073 Q7Z569 P04049 BRAP RAF1 0.21 18332145 Q7Z569 P13864 BRAP DNMT1 0.126 25820252 Q8TF50 Q7Z569 ZNF526 BRAP 0.236 26496610 Q9H040 Q7Z569 SPRTN BRAP 0.236 26496610 Q9CQ49 Q7Z569 NCBP2 BRAP 0.236 26496610 Q7Z569 Q15672 BRAP TWIST1 0.376 21983900 Q7Z569 P24668 BRAP M6PR 0.236 26496610 Q7Z569 Q60862 BRAP ORC2 0.236 26496610 Q7Z569 O08586 BRAP PTEN 0.236 26496610 Q7Z569 P51954 BRAP NEK1 0.236 26496610 Q7Z569 O75969 BRAP AKAP3 0.523 25820252 Q7Z569 P38398 BRAP BRCA1 0.82 9497340,8955125 Q7Z569 P62256 BRAP UBE2H 0.286 19549727 Q7Z569 Q7Z569 BRAP BRAP 0.636 25820252,23554956,14724641 Q8WUW1 Q7Z569 BRK1 BRAP 0.332 25820252 Q8WV44 Q7Z569 TRIM41 BRAP 0.286 22493164 Q969G3 Q7Z569 SMARCE1 BRAP 0.332 25820252 Q8WXH0 Q7Z569 SYNE2 BRAP 0.539 23707952,25820252 Q7Z569 P26358 BRAP DNMT1 0.454 25820252 Q96JC4 Q7Z569 ZNF479 BRAP 0.332 25820252 Q96K83 Q7Z569 ZNF521 BRAP 0.332 25820252 Q9BQ90 Q7Z569 KLHDC3 BRAP 0.126 26186194 Q96SR6 Q7Z569 ZNF382 BRAP 0.332 25820252 Q9BYV6 Q7Z569 TRIM55 BRAP 0.286 22493164 Q9BZQ2 Q7Z569 SHCBP1L BRAP 0.332 25820252 Q9BZR9 Q7Z569 TRIM8 BRAP 0.286 22493164 Q7Z569 P38936 BRAP CDKN1A 0.21 15340083 Q7Z569 Q13616 BRAP CUL1 0.376 23554956 Q7Z569 Q13617 BRAP CUL2 0.126 21145461 Q7Z569 Q14980 BRAP NUMA1 0.539 23707952,25820252 Q7Z569 Q13107 BRAP USP4 0.416 23105109 Q7Z569 Q15653 BRAP NFKBIB 0.376 21670849 Q7Z569 Q15843 BRAP NEDD8 0.376 23554956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IKBKB BRAP MI:0045 experimental interaction detection MI:0461 interaction database PLD2 BRAP MI:0362 inference MI:0461 interaction database ATMIN BRAP MI:0045 experimental interaction detection MI:0461 interaction database PHLPP1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database YPEL1 BRAP MI:0362 inference MI:0461 interaction database SOAT2 BRAP MI:0362 inference MI:0461 interaction database AKAP3 BRAP MI:0045 experimental interaction detection MI:0461 interaction database MTA2 BRAP MI:0362 inference MI:0461 interaction database NRAS BRAP MI:0362 inference MI:1106 pathways database HRAS BRAP MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KRAS BRAP MI:0362 inference MI:1106 pathways database APOA1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database RAF1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database UBB BRAP MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBC BRAP MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HSPA1A BRAP MI:0362 inference MI:0461 interaction database HSPA1B BRAP MI:0362 inference MI:0461 interaction database HSPA8 BRAP MI:0362 inference MI:0461 interaction database BRAF BRAP MI:0045 experimental interaction detection MI:0461 interaction database HSPA6 BRAP MI:0362 inference MI:0461 interaction database RCC1 BRAP MI:0362 inference MI:0461 interaction database M6PR BRAP MI:0362 inference MI:0461 interaction database TUBG1 BRAP MI:0362 inference MI:0461 interaction database DNMT1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database MARK3 BRAP MI:0362 inference MI:1106 pathways database HSPA1L BRAP MI:0362 inference MI:0461 interaction database SOAT1 BRAP MI:0362 inference MI:0461 interaction database BRCA1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database CDKN1A BRAP MI:0045 experimental interaction detection MI:0461 interaction database HNF4A BRAP MI:0045 experimental interaction detection MI:0461 interaction database RANGAP1 BRAP MI:0362 inference MI:0461 interaction database NOTCH1 BRAP MI:0362 inference MI:0461 interaction database NCBP2 BRAP MI:0362 inference MI:0461 interaction database HSPA2 BRAP MI:0362 inference MI:0461 interaction database PTEN BRAP MI:0362 inference MI:0461 interaction database YPEL3 BRAP MI:0362 inference MI:0461 interaction database RPS15A BRAP MI:0362 inference MI:0461 interaction database UBE2H BRAP MI:0045 experimental interaction detection MI:0461 interaction database HIST1H4A BRAP MI:0362 inference MI:0461 interaction database RPS27A BRAP MI:0362 inference MI:1106 pathways database UBA52 BRAP MI:0362 inference MI:1106 pathways database PPP2CA BRAP MI:0362 inference MI:0461 interaction database MAP2K1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database RELA BRAP MI:0362 inference MI:0461 interaction database NOTCH2 BRAP MI:0362 inference MI:0461 interaction database USP4 BRAP MI:0045 experimental interaction detection MI:0461 interaction database ORC2 BRAP MI:0362 inference MI:0461 interaction database HDAC1 BRAP MI:0362 inference MI:0461 interaction database CUL1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database CUL2 BRAP MI:0045 experimental interaction detection MI:0461 interaction database DYNC1H1 BRAP MI:0362 inference MI:0461 interaction database NUMA1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database NFKBIB BRAP MI:0045 experimental interaction detection MI:0461 interaction database TWIST1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 BRAP MI:0045 experimental interaction detection MI:0461 interaction database DDB1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database EFHC1 BRAP MI:0045 experimental interaction detection MI:0461 interaction database Tex35 BRAP MI:0045 experimental interaction detection MI:0461 interaction database CCDC30 BRAP MI:0045 experimental interaction detection MI:0461 interaction database CHMP1B BRAP MI:0362 inference MI:0461 interaction database BRAP KSR1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BRAP CCDC105 MI:0045 experimental interaction detection MI:0461 interaction database BRAP NUP93 MI:0362 inference MI:0461 interaction database BRAP FAM184A MI:0045 experimental interaction detection MI:0461 interaction database BRAP OSR1 MI:0362 inference MI:0461 interaction database BRAP ZNF526 MI:0045 experimental interaction detection MI:0461 interaction database BRAP BRK1 MI:0045 experimental interaction detection MI:0461 interaction database BRAP TRIM41 MI:0045 experimental interaction detection MI:0461 interaction database BRAP SYNE2 MI:0045 experimental interaction detection MI:0461 interaction database BRAP SMARCE1 MI:0045 experimental interaction detection MI:0461 interaction database BRAP HES6 MI:0362 inference MI:0461 interaction database BRAP ZNF479 MI:0045 experimental interaction detection MI:0461 interaction database BRAP ZNF521 MI:0045 experimental interaction detection MI:0461 interaction database BRAP YPEL4 MI:0362 inference MI:0461 interaction database BRAP NEK1 MI:0362 inference MI:0461 interaction database BRAP YPEL2 MI:0362 inference MI:0461 interaction database BRAP ZNF382 MI:0045 experimental interaction detection MI:0461 interaction database BRAP KLHDC3 MI:0045 experimental interaction detection MI:0461 interaction database BRAP KIFC1 MI:0362 inference MI:0461 interaction database BRAP TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database BRAP SHCBP1L MI:0045 experimental interaction detection MI:0461 interaction database BRAP TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database BRAP SPRTN MI:0045 experimental interaction detection MI:0461 interaction database BRAP C5orf42 MI:0045 experimental interaction detection MI:0461 interaction database BRAP TANC2 MI:0045 experimental interaction detection MI:0461 interaction database BRAP CHMP1A MI:0362 inference MI:0461 interaction database BRAP HMG20A MI:0045 experimental interaction detection MI:0461 interaction database BRAP KMT5A MI:0362 inference MI:0461 interaction database BRAP TUBG2 MI:0362 inference MI:0461 interaction database BRAP RBM12 MI:0045 experimental interaction detection MI:0461 interaction database BRAP FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database BRAP GLTSCR2 MI:0362 inference MI:0461 interaction database BRAP FBXO2 MI:0045 experimental interaction detection MI:0461 interaction database BRAP INO80 MI:0362 inference MI:0461 interaction database BRAP NOTCH3 MI:0362 inference MI:0461 interaction database BRAP CDC14A MI:0045 experimental interaction detection MI:0461 interaction database BRAP USP15 MI:0045 experimental interaction detection MI:0461 interaction database BRAP ARIH1 MI:0362 inference MI:0461 interaction database