PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2E3 MUL1 19690564,25224329 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP G G G GP G G GP GP G GP GP G UBE2U MUL1 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P GP SUMO1 MUL1 19407830 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G MUL1 MUL1 18213395 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBC MUL1 19407830 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G ULK1 MUL1 26018823 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AKT1 MUL1 22410793 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G MUL1 VPS35 20619655 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G SLC39A4 MUL1 26186194 biogrid exp P GP G P P P GP GP G GP G GP P G GP P GP GP P GP GP GP G ATG13 MUL1 26018823 biogrid exp GP G G G G GP G GP GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G IQCF1 MUL1 26186194 biogrid exp G G G G G G G G G G UBE2D1 MUL1 19690564,26018823,21597459 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G G GP G GP G GP GP G GP G G GP GP G MUL1 UBE2D4 19690564 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G G GP G GP G GP GP G GP G G GP GP G PEX19 MUL1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2G2 MUL1 25224329 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G MUL1 UBE2W 19690564 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G MUL1 TRIM9 25416956 biogrid,intact exp G G G G G G G G G G G UBE2L3 MUL1 25224329 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G VPS26A MUL1 20619655 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G TP53 MUL1 21597459 biogrid exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G TANK MUL1 24841215 intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G APPBP2 MUL1 19060904,16189514 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G MUL1 HAUS7 26186194 biogrid exp G GP G G G GP G G GP G GP G GP G G GP GP G GP G G GP G G GP G G GP G UBE2D3 MUL1 19690564,21597459 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G G GP G GP G GP GP G GP G G GP GP G UBE2E1 MUL1 19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP G G G GP G G GP GP G GP GP G MUL1 UBE2E2 25224329 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G GABARAP MUL1 25224329 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAP1 MUL1 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G DNM1L MUL1 19407830 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2D2 MUL1 19407830,18213395,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G G GP G GP G GP GP G GP G G GP GP G UBE2I MUL1 19407830 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G UBE2L6 MUL1 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G TRAF2 MUL1 24841215 biogrid exp P P P P P P P P P P P P P P P P P G GP P MAVS MUL1 23399697 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G NR6A1 MUL1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G RASSF5 MUL1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G GP9 MUL1 25402006 pred P G GP P G G P G G P G SLC22A6 MUL1 25402006 pred G FSTL1 MUL1 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP G GP G GP G GP GP G KIF6 MUL1 25402006 pred P P G P GP GP P G GP P P GP GP G P P GP GP GP GP GP NFYA MUL1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G MUL1 SYT11 25402006 pred GP GP G G G GP G G GP G GP G G G G GP GP G G G G G G GP G G G G FAM92A1 MUL1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B MAVS MUL1 MI:0004(affinity chromatography technology) 23399697 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_250803 bait prey MUL1 VPS35 MI:0004(affinity chromatography technology) 20619655 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196957 bait prey MUL1 UBE2W MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102682|BIOGRID_123693 prey|prey bait|bait UBE2E3 MUL1 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102548|BIOGRID_123558 bait|bait prey|prey UBE2D1 MUL1 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 19690564,21597459 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_102403|BIOGRID_123414|BIOGRID_225987 bait|bait|prey prey|prey|bait APPBP2 MUL1 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0397(two hybrid array) 16189514,19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(intact) BIOGRID_262313|UniProt_99384|HPRD_22587|MINT_66447|MINT_37266|BIOGRID_79044|UniProt_151895|UniProt_97209 prey|prey|-|bait|bait|bait|unspecified role|prey bait|bait|-|prey|prey|prey|unspecified role|bait UBE2D2 MUL1 MI:0397(two hybrid array)|MI:0415(enzymatic study)|MI:0018(two hybrid) 19407830,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_102431|BIOGRID_225841|BIOGRID_123441 bait|prey|bait prey|bait|prey UBE2E1 MUL1 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102528|BIOGRID_123538 bait|bait prey|prey AKT1 MUL1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 22410793 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_208415|BIOGRID_208414|BIOGRID_208413 prey|bait|prey bait|prey|bait UBE2L6 MUL1 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102586|BIOGRID_123597 bait|bait prey|prey p53 MUL1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21597459 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_208935|BIOGRID_208934|BIOGRID_208933|BIOGRID_208931|BIOGRID_208932 prey|prey|bait|bait|prey bait|bait|prey|prey|bait UBE2D3 MUL1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 19690564,21597459 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_102463|BIOGRID_225988|BIOGRID_123475 bait|prey|bait prey|bait|prey UBC MUL1 MI:0096(pull down)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 10,19407830,21139048,21890473,21906983,21987572,23399697 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) MINT_41957|MINT_71938|BIOGRID_198745|BIOGRID_170261|UniProt_99787|BIOGRID_250808|BIOGRID_179501|BIOGRID_174452|BIOGRID_162984 prey|prey|prey|bait|prey|prey|bait|bait|bait bait|bait|bait|prey|bait|bait|prey|prey|prey TAP1 MUL1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286924|UniProt_118147 prey|unspecified role bait|unspecified role MUL1 UBE2D4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102495|BIOGRID_123507 prey|prey bait|bait UBE2U MUL1 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102631|BIOGRID_123642 bait|bait prey|prey VPS26A MUL1 MI:0004(affinity chromatography technology) 20619655 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196958 prey bait SUMO1 MUL1 MI:0096(pull down)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0096(pull down) 10,19407830 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact) MINT_41956|MINT_71937|BIOGRID_198746|UniProt_99786 prey|prey|prey|prey bait|bait|bait|bait UBE2I MUL1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 10,19407830 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|(intact)|MI:0471(mint) MINT_41959|MINT_71942|UniProt_99789|BIOGRID_198747|MINT_41961|UniProt_99788|MINT_71940 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PEX19 MUL1 26186194 0004 HT UBE2D1 MUL1 26018823,21597459 0096,0096 LC UBE2D2 MUL1 19407830,18213395 0096,0096 LC IQCF1 MUL1 26186194 0004 HT MUL1 HAUS7 26186194 0004 HT MUL1 Q9NX22 26186194 0004 HT PEX19 MUL1 26186194 0004 HT IQCF1 MUL1 26186194 0004 HT MUL1 HAUS7 26186194 0004 HT MUL1 Q9NX22 26186194 0004 HT UBE2D1 MUL1 26018823,21597459 0096,0096 LC UBE2D2 MUL1 19407830,18213395 0096,0096 LC DNM1L MUL1 19407830 0415 LC UBE2L6 MUL1 19690564,19690564 0397,0018 HT TP73 MUL1 26435500,26435500 0004,0415 LC HTRA2 MUL1 24709290 0415 LC ULK1 MUL1 26018823,26018823,26018823 0096,0415,0004 LC UBC MUL1 19407830,19407830 0415,0096 LC AKT1 MUL1 22410793,22410793,22410793 0415,0096,0004 LC UBE2D1 MUL1 19690564,19690564 0397,0018 HT UBE2E1 MUL1 19690564,19690564 0397,0018 HT UBE2G2 MUL1 25224329 0018 LC UBE2D3 MUL1 19690564,19690564 0397,0018 HT UBE2D2 MUL1 19690564,19690564 0397,0018 HT SUMO1 MUL1 19407830,19407830 0415,0096 LC UBE2L3 MUL1 25224329 0018 LC TAP1 MUL1 21988832,21988832 0397,0018 HT Q53GA5 MUL1 21597459,21597459,21597459 0004,0415,0096 LC UBE2U MUL1 19690564,19690564 0397,0018 HT APPBP2 MUL1 19060904,16189514,16189514,19060904,19060904 0018,0398,0018,0397,0398 HT UBE2E3 MUL1 25224329,19690564,19690564 0018,0397,0018 LC,HT MUL1 MUL1 18213395 0415 LC MUL1 UBE2W 19690564,19690564 0397,0018 HT MUL1 UBE2E2 25224329 0018 LC MUL1 TRIM9 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MUL1 UBE2D4 19690564,19690564 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q969V5 O43464 MUL1 HTRA2 0.309 24709290 Q969V5 Q8N6M8 MUL1 IQCF1 0.126 26186194 Q969V5 O75143 MUL1 ATG13 0.21 26018823 Q969V5 O75385 MUL1 ULK1 0.702 26018823 Q969V5 Q7Z434 MUL1 MAVS 0.21 23399697 Q969V5 Q6P5W5 MUL1 SLC39A4 0.126 26186194 Q969V5 O95166 MUL1 GABARAP 0.21 25224329 Q969V5 P04637 MUL1 TP53 0.794 21597459 Q969V5 Q969T4 MUL1 UBE2E3 0.569 19690564,25224329 Q969V5 P63165 MUL1 SUMO1 0.454 19407830 Q969V5 P0CG48 MUL1 UBC 0.454 19407830 Q969V5 P62837 MUL1 UBE2D2 0.659 19690564,18213395,19407830 Q969V5 P51668 MUL1 UBE2D1 0.569 19690564,26018823 Q969V5 P60410 MUL1 KRTAP10-8 0.236 unassigned1304 Q969V5 O14933 MUL1 UBE2L6 0.286 19690564 Q969V5 Q92624 MUL1 APPBP2 0.659 19060904,16189514,unassigned1304 Q969V5 O00429 MUL1 DNM1L 0.309 19407830 Q969V5 O15350 MUL1 TP73 0.454 26435500 Q969V5 O75436 MUL1 VPS26A 0.21 20619655 Q969V5 P51965 MUL1 UBE2E1 0.376 19690564 Q969V5 P60604 MUL1 UBE2G2 0.309 25224329 Q969V5 P61077 MUL1 UBE2D3 0.376 19690564 Q969V5 P68036 MUL1 UBE2L3 0.309 25224329 Q969V5 Q03518 MUL1 TAP1 0.286 21988832 Q969V5 Q5VVX9 MUL1 UBE2U 0.376 19690564 Q969V5 Q92844 MUL1 TANK 0.21 24841215 Q969V5 Q969V5 MUL1 MUL1 0.332 18213395 Q96B02 Q969V5 UBE2W MUL1 0.376 19690564 Q96LR5 Q969V5 UBE2E2 MUL1 0.309 25224329 Q96QK1 Q969V5 VPS35 MUL1 0.21 20619655 Q9Y2X8 Q969V5 UBE2D4 MUL1 0.376 19690564 Q969V5 P31749 MUL1 AKT1 0.623 22410793 Q99871 Q969V5 HAUS7 MUL1 0.126 26186194 Q9C026 Q969V5 TRIM9 MUL1 0.454 25416956 Q969V5 P40855 MUL1 PEX19 0.126 26186194 Q969V5 Q12933 MUL1 TRAF2 0.21 24841215 Q969V5 P63279 MUL1 UBE2I 0.507 19407830

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DNM1L MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L6 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database TP73 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database HTRA2 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database ATG13 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database ULK1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database VPS26A MUL1 MI:0045 experimental interaction detection MI:0461 interaction database GABARAP MUL1 MI:0045 experimental interaction detection MI:0461 interaction database TP53 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBC MUL1 MI:0045 experimental interaction detection MI:0461 interaction database AKT1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database PEX19 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2I MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L3 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database TAP1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database NR6A1 MUL1 MI:0362 inference MI:0461 interaction database UBE2U MUL1 MI:0045 experimental interaction detection MI:0461 interaction database ATL3 MUL1 MI:0362 inference MI:0461 interaction database SLC39A4 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database MAVS MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 MUL1 MI:0362 inference MI:0461 interaction database IQCF1 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database ATL2 MUL1 MI:0362 inference MI:0461 interaction database ATL1 MUL1 MI:0362 inference MI:0461 interaction database APPBP2 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database TANK MUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E3 MUL1 MI:0045 experimental interaction detection MI:0461 interaction database MUL1 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database MUL1 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database MUL1 VPS35 MI:0045 experimental interaction detection MI:0461 interaction database MUL1 HAUS7 MI:0045 experimental interaction detection MI:0461 interaction database MUL1 TRIM9 MI:0045 experimental interaction detection MI:0461 interaction database MUL1 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database