PTM - CPLM Gene Name UniProt ID Type Position Code DTX2; KIAA1528; RNF58 Q86UW9 Acetylation 249 K DTX2; KIAA1528; RNF58 Q86UW9 Acetylation 553 K DTX2; KIAA1528; RNF58 Q86UW9 Acetylation 557 K DTX2; KIAA1528; RNF58 Q86UW9 Ubiquitination 249 K DTX2; KIAA1528; RNF58 Q86UW9 Ubiquitination 553 K DTX2; KIAA1528; RNF58 Q86UW9 Ubiquitination 479 K

PTM - dbPAF Gene Name UniProt ID Position Type Species DTX2; KIAA1528; RNF58 Q86UW9 153 T Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 156 Y Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 236 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 247 Y Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 251 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 253 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 257 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 280 Y Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 360 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 364 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 368 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 373 S Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 386 T Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 425 Y Homo sapiens(Human) DTX2; KIAA1528; RNF58 Q86UW9 75 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q86UW9 K249-ac Acetylation QAFAPyNkPsLsGAr Q86UW9 K379-ac Acetylation GsVKRLRkMSVkGAt Q86UW9 K383-ac Acetylation RLRkMSVkGAtPKPE Q86UW9 K553-ac Acetylation RKVLELLkVAWkRRL Q86UW9 K557-ac Acetylation ELLkVAWkRRLIFTV Q86UW9 R213-m2 Methylation RTGPVSGrYrHsMTN Q86UW9 R213-m1 Methylation RTGPVSGrYrHsMTN Q86UW9 R215-m1 Methylation GPVSGrYrHsMTNLP Q86UW9 R215-m2 Methylation GPVSGrYrHsMTNLP Q86UW9 R233-m2 Methylation VPQHPPHrTAsVFGT Q86UW9 R256-m1 Methylation kPsLsGArsAPRLNT Q86UW9 R281-m1 Methylation LGSQPLyrSSLSHLG Q86UW9 Y75-p Phosphorylation ADPSLAPyIIDLPSW Q86UW9 T153-p Phosphorylation APLGYNYtVNyTTHT Q86UW9 Y156-p Phosphorylation GYNYtVNyTTHTQTN Q86UW9 S217-p Phosphorylation VSGrYrHsMTNLPAY Q86UW9 S236-p Phosphorylation HPPHrTAsVFGTHQA Q86UW9 Y247-p Phosphorylation THQAFAPyNkPsLsG Q86UW9 S251-p Phosphorylation FAPyNkPsLsGArsA Q86UW9 S253-p Phosphorylation PyNkPsLsGArsAPR Q86UW9 S257-p Phosphorylation PsLsGArsAPRLNTT Q86UW9 Y280-p Phosphorylation SLGSQPLyrSSLSHL Q86UW9 S360-p Phosphorylation SRAPQPTsPPAsRLA Q86UW9 S364-p Phosphorylation QPTsPPAsRLAsKSH Q86UW9 S368-p Phosphorylation PPAsRLAsKSHGsVK Q86UW9 S373-p Phosphorylation LAsKSHGsVKRLRkM Q86UW9 T386-p Phosphorylation kMSVkGAtPKPEPEP Q86UW9 K249-ub Ubiquitination QAFAPyNkPsLsGAr Q86UW9 K553-ub Ubiquitination RKVLELLkVAWkRRL

PTM - dbPTM UniProt ID Position Code Type Resources References Q86UW9 249 K Acetylation Swiss-Prot 1010711 19608861 Q86UW9 360 S Phosphorylation Swiss-Prot 1010711 18669648 Q86UW9 360 S Phosphorylation PhosphoELM.10011 18669648 Q86UW9 249 K Ubiquitylation Phosphositeplus.1010730 21890473 Q86UW9 553 K Ubiquitylation Phosphositeplus.1010730 21890473 Q86UW9 249 K Acetylation Phosphositeplus.1010730 19608861 Q86UW9 553 K Acetylation Phosphositeplus.1010730 20167786 Q86UW9 557 K Acetylation Phosphositeplus.1010730 20167786 Q86UW9 360 S Phosphorylation Phosphositeplus.1010730 18669648 Q86UW9 156 Y Phosphorylation Phosphositeplus.1010730 20736484 Q86UW9 249 K Acetylation HPRD 9.0 19608861 Q86UW9 360 S Phosphorylation HPRD 9.0 18669648 Q86UW9 425 Y Phosphorylation HPRD 9.0 18083107 Q86UW9 360 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References DTX2 249 K Acetylation 19608861 DTX2 360 S Phosphorylation 18669648 DTX2 425 Y Phosphorylation 18083107

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q86UW9 360 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q86UW9 213 Asymmetric dimethylarginine 24129315 Q86UW9 215 Asymmetric dimethylarginine 24129315 Q86UW9 233 Asymmetric dimethylarginine 24129315 Q86UW9 249 N6-acetyllysine 19608861 Q86UW9 256 Omega-N-methylarginine 24129315 Q86UW9 360 Phosphoserine 18669648

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type DTX2 IPI00292746 K 249 AFAPYNaKPSLSGA acetylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 113878 125266 - K Ubiquitination 21987572 113878 125266 - K Ubiquitination 21139048 113878 125266 - K Ubiquitination 21890473 113878 125266 - K Ubiquitination 23000965 113878 125266 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID DTX2 Homo sapiens (Human) 462; 158 "462,KVLELLKVAWKRR; 158,AFAPYNKPSLSGA" 462:21890473; 158:21890473 DTX2 Homo sapiens (Human) 506; 249 "506,KVLELLKVAWKRR; 249,AFAPYNKPSLSGA" 506:21890473; 249:21890473 DTX2 Homo sapiens (Human) 462; 158 "462,KVLELLKVAWKRR; 158,AFAPYNKPSLSGA" 462:21890473; 158:21890473 DTX2 Homo sapiens (Human) 462; 158 "462,KVLELLKVAWKRR; 158,AFAPYNKPSLSGA" 462:21890473; 158:21890473 DTX2 Homo sapiens (Human) 249; 553 "249,AFAPYNKPSLSGA; 553,KVLELLKVAWKRR" 249:21890473; 553:21890473 DTX2 Homo sapiens (Human) 506; 249 "506,KVLELLKVAWKRR; 249,AFAPYNKPSLSGA" 506:21890473; 249:21890473 DTX2 Homo sapiens (Human) 249; 553 "249,AFAPYNKPSLSGA; 553,KVLELLKVAWKRR" 249:21890473; 553:21890473 DTX2 Homo sapiens (Human) 462; 158 "462,KVLELLKVAWKRR; 158,AFAPYNKPSLSGA" 462:21890473; 158:21890473 DTX2 Homo sapiens (Human) 506; 249 "506,KVLELLKVAWKRR; 249,AFAPYNKPSLSGA" 506:21890473; 249:21890473