PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PITX1 RNF31 24722188 biogrid exp P P P P P P P P GP P P G P P P GP GP P P P PPARD RNF31 26186194 biogrid exp P P G G GP GP P G GP G GP P GP GP P GP G GP P G GP GP P GP TNFAIP3 RNF31 23032187,23032186 biogrid,intact exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP G P GP NR0B2 RNF31 19237537 biogrid exp G G G G G G G G G G G ENDOV RNF31 26186194 biogrid exp G G G G G G G G G G G G G G G G G DDX58 RNF31 21292167 biogrid exp P P G G GP GP P G GP GP GP P GP GP P P G GP P P GP GP GP P GP GFI1B RNF31 16713569 hprd,biogrid,intact exp P P G GP P P P P P P P P P P P P P P P LIPF RNF31 26186194 biogrid exp G P G G G G P P LDLRAD4 RNF31 26186194 biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G P P P GP GP GP P P TRIM25 RNF31 21292167 biogrid exp P G G GP GP P G GP G GP P GP GP P GP G GP P P G GP GP P GP RNF31 NOD2 23818254,22607974 biogrid exp P G GP P P P GP P P P P P P P P P GP P ESR1 RNF31 24441041 biogrid exp P G G G G G G G G G G G G G G G G G NOS3 RNF31 21163940 biogrid,intact exp P P G GP G CCDC24 RNF31 25416956 biogrid,intact exp P G P G G P G P P P P G NTRK1 RNF31 25921289 biogrid exp P P P P P P P P P P P P P P P P P P ATXN7 RNF31 21078624 biogrid,intact exp P G G GP GP P G GP GP GP G GP P GP G GP P P GP G G P G RNF31 AZI2 21903422 innatedb,biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP AES RNF31 25416956 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G UBA52 RNF31 21455181 dip exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 TSSC4 25416956 biogrid,intact exp P P P P G P G GP P GP P GP G GP P P GP GP G P GP ARHGEF10 RNF31 26186194 biogrid exp P P G P GP G GP G G GP P P G P P GP G GP GP PRKCA RNF31 25118570 biogrid exp P G G GP GP P P G GP G G P GP GP GP G GP GP GP G P GP RNF31 AKAP8L 24726327 biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP BIRC3 RNF31 23524849 biogrid,intact exp P G GP P P GP G P GP GP P P GP GP P GP RIPK2 RNF31 22607974 biogrid exp P P G G GP GP P P G GP G GP P GP GP P GP G GP P P GP GP G GP ATN1 RNF31 16713569 hprd,biogrid,intact exp P P G G GP GP P P G GP GP G GP GP P GP G GP P P GP GP GP P GP RNF31 KRTAP9-2 25416956 biogrid,intact exp P P P P P P P P P P P NDUFA8 RNF31 24726327 biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP SNRPC RNF31 25416956 biogrid,intact exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 RNF31 24726323 biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP LTBR RNF31 26186194 biogrid exp P G GP P GP G GP P GP P G G GP P G GP GP P GP KIF1A RNF31 24722188 biogrid exp P G P GP P P G P P P P GP GP GP G P P P P GP P P P UBC RNF31 17006537,21455180,24726327,24469399,20005846,23986494,23727886 biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP SMAD3 RNF31 21988832 innatedb,biogrid,intact exp P P G G G GP G G G GP P G GP GP G GP G G G G NR0B1 RNF31 19237537 biogrid exp G G G UBE2D2 RNF31 17006537 biogrid exp P G G GP GP P G GP GP GP P G GP P GP G GP P GP G GP P GP ATXN1 RNF31 16713569 hprd,biogrid,intact exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 WRNIP1 24726327 biogrid exp P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP CCDC14 RNF31 24726327 biogrid exp P P G G GP GP P P G GP GP GP GP GP GP G GP P P GP GP G P GP SOCS3 RNF31 21988832 biogrid,intact exp P P G G GP GP P P G GP GP GP GP GP P GP G GP P GP GP G P GP VASN RNF31 25416956 biogrid,intact exp P G GP P P G GP GP GP G GP P GP G GP P G G G P GP VCP RNF31 24726327,24461064,24726323 innatedb,biogrid exp, ortho P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP TNF RNF31 24726327,23746843,23732909,23032187,20005846,23032186,23955153 biogrid,intact,dip exp, ortho G G G GP P G G G GP GP GP GP G G G GP G P G RNF31 SHARPIN 24726327,21455180,23746843,23104095,23032186 biogrid,intact,dip exp, ortho P P G G G GP P P G GP GP GP P GP GP P P G P P P GP GP GP P GP OTULIN RNF31 24726327,24461064,24726323,23708998 innatedb,biogrid exp, ortho P P G G G GP P P G GP GP GP P GP GP P GP G GP P P G GP GP P GP TRAF1 RNF31 21903422 innatedb,biogrid exp, ortho G G GP GP P G GP G G P G GP G G G G GP G CD40 RNF31 20614026, 23023127 biogrid exp, ortho, pred G G G G G G G G P G G G G G G G GP G RNF31 IKBKG 19675569,21455180,24469399,23732909,23032187,21811235,23986494,23032186, 25402006 biogrid,intact,dip exp, ortho, pred G G G G G G G G G G G G G G G G G RNF31 RBCK1 24726327,17006537,doi:10.1038/embor.2012.105,19136968,23708998,17069764,22791023,22430200,21455180,doi:10.1038/embor.2012.24,23032187,20005846, 25402006 innatedb,hprd,biogrid,mint,intact,dip exp, ortho, pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP UBE2D3 RNF31 17006537,21455180,21292167, 23023127 biogrid exp, ortho, pred P G G GP GP P G GP GP GP P G GP P GP G GP P GP G GP P GP RNF31 CYLD 24461064, 23023127 innatedb exp, ortho, pred P P G G GP GP P P G GP GP GP P GP GP P P G GP P P GP GP GP P GP IRAK1 RNF31 24491438, 23023127 biogrid exp, pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P G GP GP P GP UBE2L3 RNF31 17006537, 23023127 biogrid exp, pred P G G G GP P P G GP G G GP GP GP G G P GP GP G P GP UBE2D1 RNF31 17006537,17069764, 23023127 biogrid exp, pred P G G GP GP P G GP GP GP P G GP P GP G GP P GP G GP P GP PRKCB RNF31 17069764, 23023127 biogrid exp, pred P P G G GP GP P G GP G GP P G GP P GP G G P P G G GP P GP TRAF2 RNF31 24726327, 23023127 biogrid exp, pred P P P P P P P P P P P P P P P P P P P GP P P RNF31 MALT1 24491438, 23023127 biogrid exp, pred G GP G G G P G G G G G G G GP BIRC2 RNF31 24726327,23524849, 25402006, 23023127 biogrid,intact exp, pred P P G G GP GP P P G GP GP GP P GP GP GP G GP P GP GP GP P GP CHUK RNF31 ortho P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP MUSK RNF31 ortho G G G G IKBKB RNF31 23023127 ortho, pred P P G G GP GP P G GP G GP P GP GP P GP G GP P P G GP GP P GP TNFRSF1A RNF31 23023127 ortho, pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP IREB2 RNF31 25402006 pred P P G G G GP P P G GP GP G P GP GP GP G GP P P GP GP GP P GP CDC34 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP ICAM1 RNF31 23023127 pred G G GP GP P G GP G GP P G GP G G G G G GP GP RNF31 ASAP1 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P G GP GP P GP CD46 RNF31 23023127 pred P G G G GP P G GP GP GP P GP GP GP G GP P P G GP GP P GP IRF3 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P G GP GP P GP RNF151 RNF31 23023127 pred P G G GP GP P P GP G P GP G P GP G P GP IRF7 RNF31 21836163 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 RNF115 23023127 pred G G G G G G G G G G G G G G G G G ZBTB7A RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP GP G GP P P GP GP GP P GP GRB10 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP TRIM21 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP SH3RF1 RNF31 23023127 pred G G G G G G G G G G G G G G G G G TRAF7 RNF31 23023127 pred P P G G G GP P P G GP GP GP GP GP G G G P GP GP G P GP RNF182 RNF31 23023127 pred P G G GP GP P G P GP P P GP P G G GP P P P GP WWC1 RNF31 23023127 pred P P G G G GP P G GP GP GP GP GP P GP G GP P P GP GP G P GP CTSG RNF31 23023127 pred G GP G G G P G G G G G P G BCL2 RNF31 23023127 pred G G GP GP P G GP G G P G GP P G G GP P G G GP G RIPK1 RNF31 25402006, 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP GTF2A2 RNF31 23023127 pred G G G G G G G G G G G G G G G G G MIB2 RNF31 23023127 pred P P G GP P P G GP P P P P GP P GP G GP P P GP GP P P P RNF31 C1RL 23023127 pred G GP P P P GP G G GP P G G P GP GP P P RNF31 PLEKHA1 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP WWP2 RNF31 23023127 pred P P G G G GP P P G GP GP GP P GP GP GP G GP P P GP GP G P GP RNF31 S100A14 23023127 pred P G G G GP P G GP GP GP P GP GP G G GP P G GP G P G RNF31 MOSPD1 21836163 pred P P G G GP GP P P G GP GP GP P GP GP GP G GP P P GP GP GP P GP USP33 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP GP G GP P P GP GP G P GP RNF135 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP GP G GP P P GP GP G P GP NFKBID RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G P P P P GP GP P GP RNF31 TRIM33 23023127 pred P P G G GP GP P P G GP G GP P GP GP P GP G GP P P G GP GP P GP RNF31 RNF24 23023127 pred P P G G GP GP P P G GP GP GP GP GP P GP G GP P P GP GP GP P GP RNF31 TLR7 23023127 pred P P P P P P P P P RNF31 VAPA 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP S100A3 RNF31 23023127 pred G G G G G G G G G G G G RBBP6 RNF31 23023127 pred P G G G GP P P G GP GP GP GP GP G G GP P G GP GP P GP RNF4 RNF31 23023127 pred P G G G GP P P G GP G G G GP P G G GP P P GP G G P GP RNF31 EGLN1 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF25 RNF31 23023127 pred P G P P P P P P P P P P P P P GP P P UBE2V1 RNF31 23023127 pred RNF31 CADM1 23023127 pred P P G GP P G GP GP GP GP GP GP G GP P P G GP G P GP SKI RNF31 23023127 pred P P G G GP GP P P G GP G GP GP GP P GP G GP P P GP GP GP P GP UBOX5 RNF31 23023127 pred P P G G G GP P P G G G GP P P GP G G G P P GP GP P G TNFRSF10B RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP CBLB RNF31 23023127 pred P P G G G GP P G GP GP GP P GP GP P GP G GP P G GP GP P GP RNF31 RLIM 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP FLT1 RNF31 23023127 pred G GP P P G G G G G GP G G GP GP G G G LRSAM1 RNF31 23023127 pred P P G P GP P P G GP GP P P P GP P GP G P P P P P GP P P PVR RNF31 23023127 pred P P G G G GP P P G GP GP GP P GP GP P GP G GP P G GP G P GP SMARCA4 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP TRAF5 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP GP G GP P P GP GP GP P GP THY1 RNF31 23023127 pred G G G GP G GP G G G GP G G G GP G G G C4BPA RNF31 23023127 pred G G GP GP P G G GP G GP G G G G G G TAB3 RNF31 25402006 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP KRAS RNF31 23023127 pred G G GP GP P G GP G G P GP GP GP G G P P GP GP G P GP RNF31 FAF1 23023127 pred P P G G GP GP P P G GP G GP P GP GP P GP G GP P P GP GP GP P GP RNF144B RNF31 23023127 pred P G G G GP P P G GP GP GP GP GP P GP G GP G GP G GP RNF31 NEK6 23023127 pred P G G GP GP P G GP G GP GP GP GP G GP P P GP G P GP C3 RNF31 23023127 pred P G G G GP GP G P G G G G GP G G G P G AXIN1 RNF31 23023127 pred P P G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP TGFB1 RNF31 23023127 pred G G GP G G G G G GP G G G GP G GP GP P G RNF31 TRAF4 23023127 pred P G GP P P G GP GP GP GP GP GP G GP P P GP G P GP EP300 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RHOC RNF31 23023127 pred P G P G P P SH2B2 RNF31 23023127 pred P P G G GP GP P G GP GP GP GP GP GP G GP P P G GP GP P GP RNF31 ITCH 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP NCK1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P G GP GP P GP RNF31 RNF5 23023127 pred P P G G GP GP P G GP GP GP P GP GP GP G GP P P GP GP G P GP FASLG RNF31 23023127 pred P P G G GP GP P G GP G P P GP P GP G GP P P GP P GP P GP EDA RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP P P P GP RNF31 NKIRAS2 23023127 pred G G G G G G G G G G G G G G G G G JAG1 RNF31 23023127 pred P P G G G GP P P G GP GP GP GP GP P GP G GP P P GP GP G P GP PPIL2 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP MIER1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP BCAR1 RNF31 23023127 pred P P G P GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP EEF1D RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP FLNA RNF31 23023127 pred G G GP GP P G GP GP GP P G GP P GP G GP G G G P GP RNF31 EDA2R 23023127 pred P P P P P G P P P G G GP P P P P NFKBIB RNF31 23023127 pred P P G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 TRAF6 23023127 pred P P G G GP G P P G GP GP GP GP G P G G GP P P G GP GP P GP SP100 RNF31 23023127 pred P P G GP P P P GP GP GP P GP P P P G GP P P GP GP GP P P RNF31 FBXO4 23023127 pred G G G G G G G G G G G G G G NFAM1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP BIRC7 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 RNF41 23023127 pred P P G G G GP P P G GP P GP GP P P G P P GP GP GP P P RNF31 SLA2 23023127 pred G G G G G G G G G RNF31 AMFR 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP BRCA1 RNF31 23023127 pred P P G GP P P P P P P P GP P P P P P P P P P P GP NHLRC1 RNF31 23023127 pred UBASH3A RNF31 23023127 pred P P P P P G UBE2B RNF31 23023127 pred G G G G G G G G G G G G G G G G G KIR2DL1 RNF31 23023127 pred RNF31 SMURF1 23023127 pred P G G GP GP P G GP G GP G GP P G G GP G G GP GP BACH1 RNF31 25402006 pred P P G G GP GP P G GP G GP P GP GP GP G GP P P GP GP GP P GP RNF31 CBX8 23023127 pred P P P P P P P P P P P P P P P P P P P P ILK RNF31 23023127 pred P P G G GP GP P P G GP G GP P GP GP P GP G GP P P GP GP GP P GP RNF31 KLHL20 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP C8B RNF31 23023127 pred P G G GP GP P P GP GP GP G G G G GP RNF31 S100A13 23023127 pred P P G G G GP P G GP G GP P G GP P GP G GP GP G GP GP PVRL2 RNF31 23023127 pred P P G G GP G P P G GP GP GP P GP G P GP G GP P P GP GP GP P GP MAPK1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 RNF167 23023127 pred P P G G G GP P P G GP GP GP GP GP P GP G GP P G GP G P GP RNF31 BARD1 23023127 pred P G GP P P P P P P P GP P P P P P GP P GP P GP TFG RNF31 23023127 pred P G G GP GP P P G GP G G P GP GP P GP G GP P P G GP G P GP CD3E RNF31 23023127 pred G GP G G G G G P G G G G G G G GP C4B, C4B_2 RNF31 23023127 pred P P P P TRIP6 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF220 RNF31 23023127 pred P G G GP GP P G GP GP GP G GP GP G GP P P GP G G P G RNF31 MAPK8IP1 23023127 pred P P G P GP P P G P P P P P GP P G P P P P P P P GP RFWD3 RNF31 23023127 pred G G G G G G G G G G G C1S RNF31 23023127 pred G G G G G G G G G G G G G G G G G PLCG2 RNF31 23023127 pred P G G GP GP P P G GP G GP P GP GP P G G GP GP GP GP P GP RNF31 UHRF2 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RNF31 OSMR 23023127 pred P P P P P P P GP P P P GP GP P P P P P P NFKBIA RNF31 23023127 pred P G G GP GP P P G G G GP P GP GP GP G GP P P GP GP GP P GP RNF31 TNFRSF19 23023127 pred P P G G P P P G GP P GP P GP GP P GP G P P P GP GP GP P GP RNF31 TNFRSF11A 23023127 pred P P G GP P P P P P P GP P P G P P GP P P RNF31 LMCD1 23023127 pred P G G G GP P G GP GP GP GP GP P GP G GP P P GP GP GP P GP RNF31 CLEC7A 23023127 pred G G G GP P P G GP GP G P GP GP GP G G P GP GP P P RNF31 CHFR 23023127 pred G G G G G G G G G G G G G G G G G PLA2G1B RNF31 23023127 pred G G GP G LCK RNF31 23023127 pred G GP G G G P G G GP EREG RNF31 23023127 pred P G G P P P P P P P P P P P P P P P P P P MID1 RNF31 23023127 pred G GP P P G GP G G GP GP GP G GP GP GP G P GP RNF31 STUB1 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP SORBS3 RNF31 23023127 pred G G G GP P P G GP GP G GP GP GP G GP P P GP GP G P G DCC RNF31 23023127 pred P P P GP P P G P P P P P GP P P P P P P P P P ELF1 RNF31 23023127 pred P P G G GP GP P G GP GP GP P GP GP P GP G GP P P G GP GP P GP PKN1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP ZAP70 RNF31 23023127 pred G GP G G P G GP AGER RNF31 23023127 pred P P G GP P P P P P GP P P P P G P P P GP P GP P P PARK2 RNF31 23023127 pred P P G P GP P P G GP P P P GP P P G P P GP GP P GP RNF31 VSIG4 23023127 pred G G G GP G G G GP P G GP G G GP G G G P GP STAT2 RNF31 21836163 pred P P G G GP GP P G GP G GP P GP GP GP G GP P P GP GP G P GP BTLA RNF31 23023127 pred G GP P P P GP RNF31 PRPF19 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP ARHGEF2 RNF31 23023127 pred P P G G GP GP P P G GP G GP P GP GP P GP G GP P P GP GP GP P GP SUMO2 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP SKAP1 RNF31 23023127 pred G G GP G G G G GP P G G G G G G G GP G C1R RNF31 23023127 pred G G GP GP G GP GP GP P GP GP P GP G G P G GP GP GP TRIM38 RNF31 23023127 pred P P G GP P P P GP GP GP P GP GP P GP GP P P GP GP GP P P RNF31 HBEGF 23023127 pred G P GP P P G GP G GP GP GP G P GP GP G P G RNF31 CAMK2A 23023127 pred P P G GP P P G GP P GP G G P P GP G GP SQSTM1 RNF31 23023127 pred P P G G GP G P G GP GP GP P GP G P GP G GP P P GP GP GP P GP KLHL6 RNF31 23023127 pred P P G GP P P P P P GP P GP P P P P P P GP GP P P ARIH2 RNF31 23023127 pred G G G G G G G G G G G G G G G G G STAT1 RNF31 21836163 pred G G GP GP P G GP G GP P GP GP GP G GP P G GP GP GP MAP3K1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP RELA RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P P GP GP GP P GP TRADD RNF31 23023127 pred P P G G GP GP P G GP G GP P G GP G G GP P P G G GP P GP MASP1 RNF31 23023127 pred P G G G G P G G GP GP G G G G G G G GP FYN RNF31 23023127 pred P G G GP GP P G GP GP G P G GP G G G G G GP G TGFB1I1 RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P GP G GP P GP GP GP P GP ZDHHC13 RNF31 23023127 pred G G GP G G G GP G G G GP G G G GP P GP DTX3L RNF31 23023127 pred P P G G GP GP P P G GP GP GP P GP GP P G G GP P GP GP GP P GP CFI RNF31 23023127 pred P GP GP G G G G G G G G G MAP3K7 RNF31 23023127 pred P P G G G GP P G G GP GP G GP GP G GP P G G G P GP DZIP3 RNF31 23023127 pred P P G G GP GP P P G GP G GP P GP GP P GP G P P P GP GP G P GP RHEBL1 RNF31 23023127 pred P P G G GP GP P P G P P GP P P GP P GP G GP P P GP P GP P GP SYK RNF31 23023127 pred P G G GP GP P G GP G GP P GP GP GP G G G GP GP P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P21580 Q96EP0 affinity chromatography technology 23032187 physical association X 2 P21580 Q96EP0 affinity chromatography technology 23032186 physical association X 2 P01375 Q96EP0 affinity chromatography technology 23032187 physical association X 2 P01375 Q96EP0 affinity chromatography technology 23032186 physical association X 2 P01375 Q96EP0 affinity chromatography technology 23746843 physical association X 2 P01375 Q96EP0 affinity chromatography technology 23732909 physical association X 2 P01375 Q96EP0 affinity chromatography technology 24726327 physical association X 2 P01375 Q96EP0 affinity chromatography technology 20005846 physical association X 2 Q8N4L8 Q96EP0 two hybrid 25416956 direct interaction X 2 Q96EP0 O43353 affinity chromatography technology 22607974 physical association X 2 Q96EP0 F1D8P4 two hybrid 19237537 direct interaction X 2 Q96EP0 F1D8P4 two hybrid 19237537 direct interaction X 2 Q96EP0 Q15466 two hybrid 19237537 direct interaction X 2 Q96EP0 F1D8P4 affinity chromatography technology 19237537 physical association X 2 Q96EP0 O60508 affinity chromatography technology 20614026 physical association X 2 Q96EP0 O60508 affinity chromatography technology 20614026 physical association X 2 Q96EP0 Q86V38 two hybrid 16713569 direct interaction X 2 Q96EP0 Q96FF1 two hybrid 16713569 direct interaction X 2 Q96EP0 A0A024R8F3 two hybrid 16713569 direct interaction X 2 Q96EP0 affinity chromatography technology 23032187 physical association X 2 Q96EP0 affinity chromatography technology 23032186 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q96EP0 A0A0A0MTA6 two hybrid 21163940 direct interaction X 2 Q96EP0 P0CG48 affinity chromatography technology 17006537 physical association X 2 Q96EP0 two hybrid 18985028 direct interaction X 2 Q96EP0 affinity chromatography technology 21811235 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q96EP0 Q13490 affinity chromatography technology 23524849 physical association X 2 Q96EP0 Q13489 affinity chromatography technology 23524849 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 23727886 physical association X 2 Q96EP0 P0CG48 pull down 23727886 direct interaction X 2 Q96EP0 Q96BN8 affinity chromatography technology 23708998 physical association X 2 Q96EP0 Q96BN8 affinity chromatography technology 23708998 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 23986494 physical association X 2 Q96EP0 affinity chromatography technology 23986494 physical association X 2 Q96EP0 affinity chromatography technology 23986494 physical association X 2 Q96EP0 enzymatic study 24469399 direct interaction X 2 Q96EP0 P0CG48 pull down 24469399 direct interaction X 2 Q96EP0 Q96BN8 affinity chromatography technology 24726327 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 24726327 physical association X 2 Q96EP0 P55072 affinity chromatography technology 24726327 physical association X 2 Q96EP0 P51970 affinity chromatography technology 24726327 physical association X 2 Q96EP0 Q13490 affinity chromatography technology 24726327 physical association X 2 Q96EP0 Q49A88-6 affinity chromatography technology 24726327 physical association X 2 Q96EP0 Q96BN8 affinity chromatography technology 24726327 physical association X 2 Q96EP0 Q96BN8 pull down 24726327 direct interaction X 2 Q96EP0 P55072 pull down 24726327 direct interaction X 2 Q96EP0 Q96BN8 x-ray crystallography 24726327 association X 2 Q96EP0 P55072 x-ray crystallography 24726327 association X 2 Q96EP0 Q96BN8 pull down 24726327 direct interaction X 2 Q96EP0 affinity chromatography technology 24441041 physical association X 2 Q96EP0 affinity chromatography technology 24441041 physical association X 2 Q96EP0 Q96BN8 affinity chromatography technology 24726323 physical association X 2 Q96EP0 Q96EP0 affinity chromatography technology 24726323 physical association X 2 Q96EP0 Q96BN8 pull down 24726323 direct interaction X 2 Q96EP0 Q96BN8 unspecified method 24726323 direct interaction X 2 Q96EP0 P55072 unspecified method 24726323 direct interaction X 2 Q96EP0 Q96BN8 pull down 24726323 direct interaction X 2 Q96EP0 Q96BN8 x-ray crystallography 24726323 association X 2 Q96EP0 Q96BN8 affinity chromatography technology 24726323 physical association X 2 Q96EP0 P0CG48 enzymatic study 21455180 direct interaction X 2 Q96EP0 P78337 two hybrid 24722188 direct interaction X 2 Q96EP0 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q96EP0 enzymatic study 25118570 direct interaction X 2 Q96EP0 P09234 two hybrid 25416956 direct interaction X 2 Q96EP0 Q9BYQ4 two hybrid 25416956 direct interaction X 2 Q96EP0 enzymatic study 21455180 direct interaction X 2 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q96EP0 enzymatic study 19675569 direct interaction X 2 Q96EP0 O15265 two hybrid 21078624 direct interaction X 2 Q96EP0 Q13077-2 affinity chromatography technology 21903422 physical association X 2 Q96EP0 Q13077-2 pull down 21903422 direct interaction X 2 Q96EP0 O95786 affinity chromatography technology 21292167 physical association X 2 Q96EP0 O95786 affinity chromatography technology 21292167 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 21987572 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q96EP0 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 23032186 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 23746843 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 24726327 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 24726327 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q9ULX6 Q96EP0 affinity chromatography technology 24726327 physical association X 2 Q96EP0 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q96EP0 x-ray crystallography 22430200 association X 2 Q96EP0 pull down 22430200 direct interaction X 2 Q96EP0 affinity chromatography technology 22430200 physical association X 2 Q96EP0 P05771 affinity chromatography technology 17069764 physical association X 2 Q96EP0 P05771 enzymatic study 17069764 direct interaction X 2 Q96EP0 P05771 affinity chromatography technology 17069764 physical association X 2 Q96EP0 affinity chromatography technology 17069764 physical association X 2 Q96EP0 affinity chromatography technology 23032187 physical association X 2 Q96EP0 A0A087WW00 pull down 17069764 direct interaction X 2 Q96EP0 P61077-3 pull down 21292167 direct interaction X 2 Q96EP0 biochemical 17006537 colocalization X 2 Q96EP0 affinity chromatography technology 17006537 physical association X 2 Q96EP0 affinity chromatography technology 23708998 physical association X 2 Q96EP0 Q9HC29 affinity chromatography technology 23818254 physical association X 2 Q96EP0 affinity chromatography technology 21988832 physical association X 2 Q96EP0 two hybrid 21988832 direct interaction X 2 Q96EP0 O14543 two hybrid 21988832 direct interaction X 2 Q96EP0 O88522 x-ray crystallography 24469399 association X 2 Q96EP0 affinity chromatography technology 24726327 physical association X 2 Q96EP0 A0A024R8H5 affinity chromatography technology 24726327 physical association X 2 Q96EP0 Q96S55-2 affinity chromatography technology 24726327 physical association X 2 Q96EP0 P51617-3 affinity chromatography technology 24491438 physical association X 2 Q96EP0 affinity chromatography technology 24491438 physical association X 2 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q96EP0 two hybrid 24722188 direct interaction X 2 Q96EP0 Q08117 two hybrid 25416956 direct interaction X 2 Q96EP0 Q6EMK4 two hybrid 25416956 direct interaction X 2 Q96EP0 P61077-3 pull down 21455180 direct interaction X 2 Q96EP0 Q9EQL9 affinity chromatography technology 22253853 physical association X 2 Q96EP0 Q9EQL9 affinity chromatography technology 22253853 physical association X 2 Q96EP0 affinity chromatography technology 20005846 physical association X 2 Q96EP0 Q9H6S1 affinity chromatography technology 21903422 physical association X 2 Q96EP0 Q9H6S1 pull down 21903422 direct interaction X 2 Q96EP0 Q14258 affinity chromatography technology 21292167 physical association X 2 Q96EP0 Q14258 imaging technique 21292167 colocalization X 2 Q96EP0 Q14258 enzymatic study 21292167 direct interaction X 2 Q9Y5U2 Q96EP0 two hybrid 25416956 direct interaction X 2 Q96EP0 pull down 23955153 - C 8 Q96EP0 anti tag coimmunoprecipitation 21455180 - C 4 Q96EP0 anti bait coimmunoprecipitation 21455180 - C 4 Q96EP0 anti tag coimmunoprecipitation 21455180 - C 3 P01375 Q96EP0 pull down 23955153 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 24141947 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q96EP0 Q9BYM8 pull down 21455180 physical association X 2 Q96EP0 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9BYM8 pull down 21455180 physical association X 2 Q96EP0 Q9BYM8 pull down 21455180 physical association X 2 Q96EP0 P62987 pull down 21455181 direct interaction X 2 Q96EP0 P62987 pull down 21455181 direct interaction X 2 Q96EP0 P62987 pull down 22158122 direct interaction X 2 Q96EP0 P62987 isothermal titration calorimetry 21455181 direct interaction X 2 Q96EP0 P62987 pull down 22158122 direct interaction X 2 Q96EP0 Q9Y6K9 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9Y6K9 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9Y6K9 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 Q9Y6K9 anti tag coimmunoprecipitation 21455180 physical association X 2 Q96EP0 P63048 x-ray crystallography 24141947 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 two hybrid 22158122 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 24141947 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 pull down 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 pull down 21455180 direct interaction X 2 Q9H0F6 Q96EP0 pull down 21455180 direct interaction X 2 Q96EP0 anti bait coimmunoprecipitation 21455180 - C 5 Q96EP0 anti tag coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 pull down 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455181 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455181 physical association C 3 Q96EP0 molecular sieving 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455180 physical association C 3 Q96EP0 pull down 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 molecular sieving 21455180 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 24141947 physical association C 3 Q96EP0 pull down 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455181 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q96EP0 anti tag coimmunoprecipitation 21455180 - C 3 Q96EP0 anti bait coimmunoprecipitation 21455180 - C 5 Q96EP0 anti bait coimmunoprecipitation 21455180 - C 6 Q96EP0 P54253 two hybrid 16713569 - X 2 Q96EP0 P54253 two hybrid 16713569 - X 2 Q96EP0 Q5VTD9-2 two hybrid 16713569 - X 2 Q96EP0 P54259 two hybrid 16713569 - X 2 Q96EP0 Q9BYM8-4 in vivo 17006537 - X 2 Q96EP0 Q9BYM8-4 in vitro 17006537 - X 2 Q96EP0 Q5VTD9-2 two hybrid 16713569 - X 2 Q96EP0 P54259 two hybrid 16713569 - X 2 Q96EP0 Q9BYM8-4 in vivo 17006537 - X 2 Q96EP0 Q9BYM8-4 in vitro 17006537 - X 2 Q96EP0 anti bait coimmunoprecipitation 23032186 association C 4 Q96EP0 anti bait coimmunoprecipitation 23032186 association C 5 Q96EP0 anti tag coimmunoprecipitation 23032186 association C 6 Q96EP0 anti tag coimmunoprecipitation 21903422 association C 6 Q96EP0 two hybrid 18985028 physical association C 3 Q96EP0 anti bait coimmunoprecipitation 21811235 association C 3 Q96EP0 P54253 two hybrid 16713569 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 17006537 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 17006537 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 17006537 physical association X 2 Q96EP0 Q9BYM8 molecular sieving 17006537 association X 2 Q96EP0 Q9BYM8 pull down 17006537 direct interaction X 2 Q96EP0 P0C706 two hybrid 17446270 physical association X 2 Q96EP0 O15265 two hybrid 21078624 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 22430200 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 22430200 physical association X 2 Q96EP0 Q9BYM8 surface plasmon resonance 22430200 direct interaction X 2 Q96EP0 Q9BYM8 surface plasmon resonance 22430200 direct interaction X 2 Q96EP0 Q9BYM8 surface plasmon resonance 22430200 direct interaction X 2 Q96EP0 Q9BYM8 surface plasmon resonance 22430200 direct interaction X 2 Q96EP0 Q9BYM8 surface plasmon resonance 22430200 direct interaction X 2 Q96EP0 Q9BYM8 x-ray crystallography 22430200 direct interaction X 2 Q96EP0 Q9BYM8 nuclear magnetic resonance 22430200 direct interaction X 2 Q96EP0 Q9BYM8 molecular sieving 22430200 direct interaction X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 22430200 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 22430200 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 22430200 physical association X 2 Q96EP0 Q9BYM8 anti tag coimmunoprecipitation 22430200 physical association X 2 Q96EP0 Q9BYM8 isothermal titration calorimetry 22791023 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 23104095 physical association X 2 Q4VA12 Q96EP0 anti tag coimmunoprecipitation 21903422 physical association X 2 Q9WMX2 Q96EP0 two hybrid 18985028 physical association X 2 Q9WMX2 Q96EP0 two hybrid 18985028 physical association X 2 Q96EP0 anti tag coimmunoprecipitation 23032186 association C 4 Q96EP0 anti bait coimmunoprecipitation 23032186 association C 4 Q96EP0 anti tag coimmunoprecipitation 23524849 association C 20 Q96EP0 anti tag coimmunoprecipitation 23524849 association C 18 Q96EP0 anti bait coimmunoprecipitation 23032186 association C 3 A0A024R5Z3 Q96EP0 anti tag coimmunoprecipitation 21988832 physical association X 2 Q96EP0 P54259 two hybrid 16713569 physical association X 2 Q96EP0 Q81S59 two hybrid pooling approach 20711500 physical association X 2 Q96EP0 Q0WJY2 two hybrid pooling approach 20711500 physical association X 2 Q96EP0 Q7ARD3 two hybrid pooling approach 20711500 physical association X 2 Q96EP0 P29474 two hybrid 21163940 physical association X 2 Q96EP0 Q9QYP6 anti tag coimmunoprecipitation 21903422 physical association X 2 Q5VTD9 Q96EP0 two hybrid 16713569 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SMAD3 RNF31 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact) BIOGRID_285333|UniProt_119809|BIOGRID_288362|UniProt_120290 prey|unspecified role|prey|unspecified role bait|unspecified role|bait|unspecified role BIRC2 RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 23524849,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|(intact) BIOGRID_310378|BIOGRID_272903|UniProt_130011 prey|bait|bait bait|prey|prey DDX58 RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21292167 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_158747|BIOGRID_158748 prey|bait bait|prey RNF31 WRNIP1 MI:0004(affinity chromatography technology) 24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310381 bait prey TRIM25 RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21292167 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_158751|BIOGRID_158745|BIOGRID_158758 bait|bait|prey prey|prey|bait UBE2D1 RNF31 MI:0004(affinity chromatography technology) 17069764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_221533 prey bait RNF31 NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22607974,23818254 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_282694|BIOGRID_187979 prey|prey bait|bait RIPK2 RNF31 MI:0004(affinity chromatography technology) 22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187985 bait prey BIRC3 RNF31 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23524849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_130010|BIOGRID_272922 bait|bait prey|prey SOCS3 RNF31 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119880|BIOGRID_288452 unspecified role|prey unspecified role|bait CCDC14 RNF31 MI:0004(affinity chromatography technology) 24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310380 prey bait RNF31 RBCK1 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0065(isothermal titration calorimetry)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0401(biochemical)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0401(biochemical)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography) 17006537,17069764,20005846,22430200,22791023,23032187,23708998,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0468(hprd)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(biogrid)|MI:0471(mint)|(intact)|(intact)|(biogrid)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact) UniProt_123318|UniProt_123319|HPRD_31264|UniProt_123331|MINT_51680|UniProt_123330|UniProt_88175|UniProt_88174|BIOGRID_218372|MINT_84085|UniProt_88178|UniProt_88177|BIOGRID_200615|UniProt_88176|UniProt_125808|MINT_84082|MINT_84081|MINT_84084|MINT_84083|BIOGRID_253588|UniProt_123329|BIOGRID_199047|BIOGRID_253587|BIOGRID_199048|BIOGRID_199049|BIOGRID_282397|UniProt_123320|MINT_51678|UniProt_123322|UniProt_123321|MINT_51679|MINT_51676|UniProt_123324|UniProt_123323|MINT_51677|UniProt_123326|BIOGRID_141247|UniProt_123325|UniProt_123328|BIOGRID_310373|UniProt_123327 neutral component|prey|-|neutral component|bait|bait|bait|neutral component|bait|bait|bait|prey|bait|bait|prey|neutral component|bait|prey|bait|bait|bait|bait|prey|bait|bait|bait|prey|bait|prey|prey|prey|bait|neutral component|prey|neutral component|prey|bait|prey|bait|bait|prey neutral component|bait|-|neutral component|prey|prey|prey|neutral component|prey|prey|prey|bait|prey|prey|bait|neutral component|prey|bait|prey|prey|prey|prey|bait|prey|prey|prey|bait|prey|bait|bait|bait|prey|neutral component|bait|neutral component|bait|prey|bait|prey|prey|bait TRAF2 RNF31 MI:0004(affinity chromatography technology) 24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310379 prey bait TRAF1 RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_156002|BIOGRID_155839 bait|bait prey|prey FAM105B RNF31 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23708998,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_282398|BIOGRID_310389|BIOGRID_282396|BIOGRID_310387|BIOGRID_310383|BIOGRID_310372|BIOGRID_310391 bait|prey|prey|prey|bait|prey|bait prey|bait|bait|bait|prey|bait|prey VCP RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid)|(biogrid) BIOGRID_310376|BIOGRID_310388|BIOGRID_310390 prey|prey|prey bait|bait|bait TNF RNF31 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 20005846,23032186,23032187,23732909,23746843,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_141245|BIOGRID_281131|BIOGRID_219090|BIOGRID_218366|BIOGRID_310392|BIOGRID_281384|UniProt_125831 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey NOS3 RNF31 MI:0096(pull down)|MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_110996|BIOGRID_229953 bait|bait prey|prey ATXN7 RNF31 MI:0018(two hybrid)|MI:0018(two hybrid) 21078624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_147548|UniProt_110037 bait|bait prey|prey TNFAIP3 RNF31 MI:0004(affinity chromatography technology)|MI:0096(pull down) 23032186,23032187 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_219127|BIOGRID_218370 bait|prey prey|bait NR0B2 RNF31 MI:0018(two hybrid) 19237537 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_194384 prey bait PRKCB RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17069764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_200613|BIOGRID_200611|BIOGRID_200614 prey|bait|prey bait|prey|bait UBE2D3 RNF31 MI:0004(affinity chromatography technology) 21292167 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226129 prey bait UBC RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17006537,21139048,21890473,21906983,21963094,21987572,22505724,23000965,23727886,23986494,24141947,24469399,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_310375|BIOGRID_224499|BIOGRID_281372|BIOGRID_281371|BIOGRID_310214|BIOGRID_270413|BIOGRID_173907|BIOGRID_172632|BIOGRID_297008|BIOGRID_297007|BIOGRID_266454|BIOGRID_253590|BIOGRID_163081|BIOGRID_289202|BIOGRID_181717 prey|bait|prey|prey|prey|bait|bait|bait|prey|prey|bait|prey|bait|prey|bait bait|prey|bait|bait|bait|prey|prey|prey|bait|bait|prey|bait|prey|bait|prey ATN1 RNF31 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_86109|BIOGRID_215559|HPRD_38126 bait|bait|- prey|prey|- RNF31 IKBKG MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 21811235,23032186,23032187,23986494,24469399 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_125829|UniProt_116441|UniProt_125827|BIOGRID_289209|BIOGRID_310212|BIOGRID_256686|BIOGRID_219083|BIOGRID_218371|BIOGRID_289206|UniProt_125825 prey|prey|prey|prey|bait|prey|prey|bait|prey|prey bait|bait|bait|bait|prey|bait|bait|prey|bait|bait NDUFA8 RNF31 MI:0004(affinity chromatography technology) 24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310377 prey bait RNF31 AZI2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_155950|BIOGRID_155642 prey|prey bait|bait RNF31 SHARPIN MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 22253853,23032186,23104095,23746843,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_201083|UniProt_124323|BIOGRID_201082|BIOGRID_310385|BIOGRID_281123|BIOGRID_219087|BIOGRID_310374|UniProt_125826|UniProt_125832 bait|bait|prey|prey|prey|prey|bait|prey|prey prey|prey|bait|bait|bait|bait|prey|bait|prey RNF31 AKAP8L MI:0004(affinity chromatography technology) 24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310382 bait prey NR0B1 RNF31 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19237537 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_194382|BIOGRID_194383|BIOGRID_194385 bait|prey|bait prey|bait|prey ATXN1 RNF31 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(intact)|MI:0468(hprd) BIOGRID_215582|UniProt_86134|HPRD_18825 bait|bait|- prey|prey|- CDC40 RNF31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20614026 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_200977|BIOGRID_200989 bait|bait prey|prey GFI1B RNF31 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact) BIOGRID_215857|HPRD_32521|UniProt_86422 bait|-|bait prey|-|prey NFKBIA RNF31 MI:0004(affinity chromatography technology) 22605335 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_192126 prey bait

PPI - HINT Gene A Gene B PMID Method Quality ARHGEF10 RNF31 26186194 0004 HT LDLRAD4 RNF31 26186194 0004 HT TNF RNF31 26670046,23032187,23032186,23032186,20005846,23955153,23732909,24726327,23746843 0004,0004,0007,0004,0004,0096,0004,0004,0004 LC LIPF RNF31 26186194 0004 HT UBC RNF31 23986494,22158122,21455181,21455181,23727886,24469399,20005846,24726327 0096,0096,0096,0065,0096,0096,0096,0004 LC TNFAIP3 RNF31 23032186,23032187,23032186 0004,0004,0007 LC LTBR RNF31 26186194 0004 HT UBE2D1 RNF31 17006537,17069764 0096,0096 LC UBE2D3 RNF31 21292167,17006537,21455180 0096,0096,0096 LC UBE2D2 RNF31 26789245,26789245,17006537 0114,0096,0096 LC UBE2L3 RNF31 25996949,17006537 0096,0096 LC PPARD RNF31 26186194 0004 HT TRAF1 RNF31 25996949,21903422,25996949,21903422 0415,0096,0004,0004 LC BIRC2 RNF31 24726327,23524849,23524849 0004,0007,0004 LC ENDOV RNF31 26186194 0004 HT OTULIN RNF31 26670046,24726327,24726323,24726323,24726327,23708998,24726323,24726327 0004,0114,0004,0114,0096,0004,0096,0004 LC RNF31 RNF31 24726323,24726323 0004,0114 LC RNF31 RBCK1 17006537,22430200,17069764,21455180,23708998,21455180,24726327,22430200,26670046,23032187,26525107,22791023,17006537,22791023,17006537,21455180,26577923,22430200,24141947,22430200,17006537,22430200,22430200,22430200,20005846,17006537,21455180,21455181 0401,0071,0004,0096,0004,0007,0004,0004,0004,0004,0004,0065,0071,0096,0096,0004,0004,0114,0007,0107,0004,0007,0096,0077,0004,0007,0006,0007 LC RNF31 SHARPIN 26670046,24141947,26600301,21455181,26600301,23032186,21455181,21455180,21455180,23032186,22791023,21455180,26600301,24726327,21455180,23746843,23104095 0004,0007,0096,0096,0047,0006,0007,0007,0096,0004,0096,0006,0004,0004,0004,0004,0006 LC RNF31 NOD2 26670046,22607974,23818254 0004,0004,0004 LC RNF31 IKBKG 23986494,23032187,21811235,21455180,26577923,23032186,21455180,23732909,21455180,23032186,21811235 0096,0004,0004,0415,0004,0004,0007,0004,0004,0006,0006 LC ARHGEF10 RNF31 26186194 0004 HT LDLRAD4 RNF31 26186194 0004 HT LIPF RNF31 26186194 0004 HT LTBR RNF31 26186194 0004 HT PPARD RNF31 26186194 0004 HT ENDOV RNF31 26186194 0004 HT TNF RNF31 26670046,23032187,23032186,23032186,20005846,23955153,23732909,24726327,23746843 0004,0004,0007,0004,0004,0096,0004,0004,0004 LC UBC RNF31 23986494,22158122,21455181,21455181,23727886,24469399,20005846,24726327 0096,0096,0096,0065,0096,0096,0096,0004 LC TNFAIP3 RNF31 23032186,23032187,23032186 0004,0004,0007 LC UBE2D1 RNF31 17006537,17069764 0096,0096 LC UBE2D3 RNF31 21292167,17006537,21455180 0096,0096,0096 LC UBE2D2 RNF31 26789245,26789245,17006537 0114,0096,0096 LC UBE2L3 RNF31 25996949,17006537 0096,0096 LC TRAF1 RNF31 25996949,21903422,25996949,21903422 0415,0096,0004,0004 LC BIRC2 RNF31 24726327,23524849,23524849 0004,0007,0004 LC OTULIN RNF31 26670046,24726327,24726323,24726323,24726327,23708998,24726323,24726327 0004,0114,0004,0114,0096,0004,0096,0004 LC RNF31 RNF31 24726323,24726323 0004,0114 LC RNF31 RBCK1 17006537,22430200,17069764,21455180,23708998,21455180,24726327,22430200,26670046,23032187,26525107,22791023,17006537,22791023,17006537,21455180,26577923,22430200,24141947,22430200,17006537,22430200,22430200,22430200,20005846,17006537,21455180,21455181 0401,0071,0004,0096,0004,0007,0004,0004,0004,0004,0004,0065,0071,0096,0096,0004,0004,0114,0007,0107,0004,0007,0096,0077,0004,0007,0006,0007 LC RNF31 SHARPIN 26670046,24141947,26600301,21455181,26600301,23032186,21455181,21455180,21455180,23032186,22791023,21455180,26600301,24726327,21455180,23746843,23104095 0004,0007,0096,0096,0047,0006,0007,0007,0096,0004,0096,0006,0004,0004,0004,0004,0006 LC RNF31 NOD2 26670046,22607974,23818254 0004,0004,0004 LC RNF31 IKBKG 23986494,23032187,21811235,21455180,26577923,23032186,21455180,23732909,21455180,23032186,21811235 0096,0004,0004,0415,0004,0004,0007,0004,0004,0006,0006 LC SOCS3 RNF31 21988832 0018 HT ATXN7 RNF31 21078624 0018 HT PRKCB RNF31 17069764,17069764 0415,0004 LC SNRPC RNF31 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBC RNF31 21455181,22791023,21455181,21455180,26789245,17006537,26789245,25494483 0096,0415,0065,0415,0415,0415,0114,0415 LC PRKCA RNF31 25118570 0415 LC NFKBIA RNF31 22605335 0415 LC NOS3 RNF31 21163940 0018 HT NR0B1 RNF31 19237537,19237537 0018,0004 LC ATXN1 RNF31 16713569 0018 HT ATN1 RNF31 16713569 0018 HT UBE2D2 RNF31 26789245,26789245 0114,0096 LC UBA52 RNF31 21455181,21455181 0065,0096 LC PITX1 RNF31 24722188 0018 HT SMAD3 RNF31 21988832,21988832 0007,0018 HT AES RNF31 25416956,25416956,25416956 1112,0397,1356 HT KIF1A RNF31 24722188 0018 HT TRAF1 RNF31 25996949,25996949 0415,0004 LC TRIM25 RNF31 21292167,21292167,21292167 0415,0428,0004 LC NR0B2 RNF31 19237537 0018 LC GFI1B RNF31 16713569 0018 HT VASN RNF31 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CCDC24 RNF31 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PP2150 RNF31 25416956 0018 HT OTULIN RNF31 24726327,24726323,24726323,24726327,24726323,24726327 0114,0004,0114,0096,0096,0004 LC RNF31 RNF31 27591049,24726323,PDB_4JUY,24726323,24141947,24726327 0114,0004,0114,0114,0114,0114 LC RNF31 RBCK1 17006537,22430200,22430200,22791023,17006537,22791023,17006537,22430200,22430200,17006537,22430200,22430200,22430200,17006537 0401,0071,0004,0065,0071,0096,0096,0114,0107,0004,0007,0096,0077,0007 LC RNF31 KRTAP9-2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RNF31 SHARPIN 26600301,26600301,22158122,26600301 0096,0047,0018,0004 LC RNF31 Q9P0T0 21988832,21988832 0004,0018 HT RNF31 SPATA2 27591049 0114 LC RNF31 TSSC4 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RNF31 IKBKG 24469399,21455180,21455180,19675569,21455180 0415,0415,0007,0415,0004 LC RNF31 HEL-S-70 24726327,24726327,24726327 0004,0114,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96EP0 O15013 RNF31 ARHGEF10 0.126 26186194 Q96EP0 Q5TAL4 RNF31 Q5TAL4 0.332 25416956 Q96EP0 O43353 RNF31 RIPK2 0.21 22607974 Q96EP0 O15165 RNF31 LDLRAD4 0.126 26186194 Q96EP0 Q0WJY2 RNF31 RHAM 0.126 20711500 Q96EP0 Q8N8Q3 RNF31 ENDOV 0.126 26186194 Q96EP0 P0C706 RNF31 P0C706 0.183 17446270 Q96EP0 Q7ARD3 RNF31 Q7ARD3 0.126 20711500 Q96EP0 P0CG48 RNF31 UBC 0.959 17006537,20005846,23727886,24469399,26789245,25494483,24726327,22791023 Q96EP0 Q6EMK4 RNF31 VASN 0.454 25416956 Q96EP0 Q81S59 RNF31 Q81S59 0.126 20711500 Q96EP0 P09234 RNF31 SNRPC 0.183 25416956 Q96EP0 P04629 RNF31 NTRK1 0.126 25921289 Q96EP0 P05771 RNF31 PRKCB 0.569 17069764 Q96EP0 P07098 RNF31 LIPF 0.126 26186194 Q9Y5U2 Q96EP0 TSSC4 RNF31 0.454 25416956 Q9H6S1 Q96EP0 AZI2 RNF31 0.286 21903422 Q96EP0 Q8N4L8 RNF31 CCDC24 0.454 25416956 Q96EP0 Q08117 RNF31 AES 0.454 25416956 Q96EP0 P68036 RNF31 UBE2L3 0.523 17006537,25996949 Q96EP0 O14543 RNF31 SOCS3 0.332 21988832 Q96EP0 P51668 RNF31 UBE2D1 0.523 17006537,17069764 Q9BYQ4 Q96EP0 KRTAP9-2 RNF31 0.454 25416956 Q96EP0 Q13489 RNF31 BIRC3 0.236 23524849 Q96EP0 P29474 RNF31 NOS3 0.332 21163940 Q96EP0 Q5VTD9 RNF31 GFI1B 0.332 16713569 Q96EP0 P62837 RNF31 UBE2D2 0.671 26789245,17006537 Q96EP0 P61077 RNF31 UBE2D3 0.671 21455180,17006537,21292167 Q9HC29 Q96EP0 NOD2 RNF31 0.507 26670046,22607974,23818254 Q96EP0 P55072 RNF31 VCP 0.74 24726327,24726323 Q9H0F6 Q96EP0 SHARPIN RNF31 0.96 23746843,26670046,23032186,26600301,24726327,22791023 Q9Y6K9 Q96EP0 IKBKG RNF31 0.95 23032186,23032187,24469399,26577923,21811235,23732909,19675569,21455180 Q96EP0 Q96BN8 RNF31 OTULIN 0.989 26670046,23708998,24726327,24726323 Q96EP0 P01375 RNF31 TNF 0.848 23746843,26670046,23032186,20005846,23032187,24726327,23732909 Q9BYM8 Q96EP0 RBCK1 RNF31 1 26670046,17006537,20005846,26525107,22430200,26577923,17069764,23708998,22791023,24726327,23032187 Q96EP0 P36941 RNF31 LTBR 0.126 26186194 Q96EP0 P25942 RNF31 CD40 0.21 20614026 Q96EP0 O15265 RNF31 ATXN7 0.332 21078624 Q96EP0 O88522 RNF31 IKBKG 0.523 24469399 Q96EP0 O95786 RNF31 DDX58 0.376 21292167 Q96EP0 P03372 RNF31 ESR1 0.376 24441041 Q96EP0 P17252 RNF31 PRKCA 0.309 25118570 Q96EP0 P19438 RNF31 TNFRSF1A 0.21 26670046 Q96EP0 P21580 RNF31 TNFAIP3 0.507 23032186,23032187 Q96EP0 P51843 RNF31 NR0B1 0.623 19237537 Q96EP0 P51970 RNF31 NDUFA8 0.21 24726327 Q96EP0 P54253 RNF31 ATXN1 0.454 16713569 Q96EP0 P54259 RNF31 ATN1 0.454 16713569 Q96EP0 Q12933 RNF31 TRAF2 0.21 24726327 Q96EP0 Q13077 RNF31 TRAF1 0.61 21903422,25996949 Q96EP0 Q13490 RNF31 BIRC2 0.396 24726327,23524849 Q96EP0 Q13546 RNF31 RIPK1 0.21 26670046 Q96EP0 Q14258 RNF31 TRIM25 0.523 21292167 Q96EP0 Q15466 RNF31 NR0B2 0.309 19237537 Q96EP0 Q49A88 RNF31 CCDC14 0.21 24726327 Q96EP0 Q4VA12 RNF31 TRAF1 0.236 21903422 Q96EP0 Q96EP0 RNF31 RNF31 0.236 24726323 Q96S55 Q96EP0 WRNIP1 RNF31 0.21 24726327 Q9EQL9 Q96EP0 SHARPIN RNF31 0.376 22253853 Q9NQC7 Q96EP0 CYLD RNF31 0.376 26670046 Q9QYP6 Q96EP0 AZI2 RNF31 0.236 21903422 Q9ULX6 Q96EP0 AKAP8L RNF31 0.21 24726327 Q9UDY8 Q96EP0 MALT1 RNF31 0.21 24491438 Q96EP0 P78337 RNF31 PITX1 0.183 24722188 Q96EP0 Q12756 RNF31 KIF1A 0.183 24722188 Q96EP0 P84022 RNF31 SMAD3 0.49 21988832 Q96EP0 P51617 RNF31 IRAK1 0.21 24491438 Q96EP0 Q03181 RNF31 PPARD 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRAF5 RNF31 MI:0362 inference MI:0461 interaction database SOCS3 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database IKBKB RNF31 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database ARHGEF10 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database CHUK RNF31 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database MUSK RNF31 MI:0362 inference MI:0461 interaction database LDLRAD4 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database ATXN7 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database RIPK2 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database CDC40 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database DDX58 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database TNF RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ESR1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database PRKCB RNF31 MI:0045 experimental interaction detection MI:0461 interaction database LIPF RNF31 MI:0045 experimental interaction detection MI:0461 interaction database SNRPC RNF31 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF31 MI:0362 inference MI:0461 interaction database UBC RNF31 MI:0045 experimental interaction detection MI:0461 interaction database PRKCA RNF31 MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF1A RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TNFAIP3 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database CD40 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database NOS3 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database LTBR RNF31 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A RNF31 MI:0045 experimental interaction detection MI:0461 interaction database IRAK1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database NR0B1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF31 MI:0362 inference MI:0461 interaction database NDUFA8 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database ATXN1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database ATN1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database VCP RNF31 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A RNF31 MI:0362 inference MI:0461 interaction database UBA52 RNF31 MI:0362 inference MI:0461 interaction database UBE2L3 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database PITX1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database PPARD RNF31 MI:0045 experimental interaction detection MI:0461 interaction database AES RNF31 MI:0045 experimental interaction detection MI:0461 interaction database KIF1A RNF31 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRAF1 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database BIRC3 RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BIRC2 RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RIPK1 RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM25 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database NR0B2 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database TRADD RNF31 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CCDC14 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database GFI1B RNF31 MI:0045 experimental interaction detection MI:0461 interaction database VASN RNF31 MI:0045 experimental interaction detection MI:0461 interaction database ERC1 RNF31 MI:0362 inference MI:0461 interaction database CCDC24 RNF31 MI:0045 experimental interaction detection MI:0461 interaction database ENDOV RNF31 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E3 RNF31 MI:0362 inference MI:0461 interaction database OTULIN RNF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF31 UBE2E2 MI:0362 inference MI:0461 interaction database RNF31 WRNIP1 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 RBCK1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF31 KRTAP9-2 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF31 AZI2 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 CYLD MI:0045 experimental interaction detection MI:0461 interaction database RNF31 MALT1 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 AKAP8L MI:0045 experimental interaction detection MI:0461 interaction database RNF31 TSSC4 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 IKBKG MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database