PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSP90AA1 G2E3 22939624 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G G G G G G G G HSP90AB1 G2E3 22939624 intact exp G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G2E3 WDR6 16189514 hprd,biogrid,mint,intact exp G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G RPS15 G2E3 25416956 biogrid,intact exp G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G LST1 G2E3 14667819 hprd,i2d,intact exp G G G G G GP G G GP G P G G G G G GP G G G G G G G2E3 TRPM7 ortho G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G2E3 CNOT6 21836163 pred G G G G G GP G G GP G G G G G G G GP G G G G G G G G G G G2E3 GNL3 21836163 pred G P P P G G P G G G2E3 SENP7 21836163 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G2E3 GNL3L 21836163 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G2E3 USP28 21836163 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G RPS25 G2E3 21836163 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G2E3 UBXN4 21836163 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G2E3 NUP54 21836163 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G2E3 ANP32B 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G2E3 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7L622 - 14667819 - X 2 A0A087X295 Q7L622 two hybrid 16189514 direct interaction X 2 P0CG48 Q7L622 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q7L622 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q7L622 affinity chromatography technology 21890473 physical association X 2 Q7L622 P07900-2 affinity chromatography technology 22939624 physical association X 2 P62841 Q7L622 two hybrid 25416956 direct interaction X 2 A0A087X295 Q7L622 two hybrid 16189514 - X 2 A0A087X295 Q7L622 two hybrid 16189514 - X 2 A0A0A6YYA6 Q7L622 two hybrid 14667819 - X 2 A0A0A6YYA6 Q7L622 two hybrid 14667819 - X 2 Q6PKC6 Q7L622 two hybrid pooling approach 16189514 physical association X 2 A0A024RCT6 Q7L622 two hybrid 14667819 physical association X 2 Q7L622 Q7CKD3 two hybrid pooling approach 20711500 physical association X 2 Q7L622 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 P62841 Q7L622 two hybrid prey pooling approach 25416956 physical association X 2 P62841 Q7L622 two hybrid array 25416956 physical association X 2 P62841 Q7L622 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B G2E3 WDR6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(biogrid) MINT_40142|HPRD_22899|MINT_69515|BIOGRID_81053 prey|-|prey|prey bait|-|bait|bait HSP90AA1 G2E3 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255479 bait prey WDR6 G2E3 MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_153880 unspecified role unspecified role LST1 G2E3 MI:0018(two hybrid)|MI:0018(two hybrid) 14667819 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (intact)|MI:0468(hprd) UniProt_73645|HPRD_5726 bait|- prey|- HSP90AB1 G2E3 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125010 prey bait UBC G2E3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_170066|BIOGRID_269720|BIOGRID_174189 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality LST1 G2E3 14667819 0018 HT HSP90AB1 G2E3 22939624 0729 HT RPS15 G2E3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT G2E3 WDR6 16189514,16189514 0398,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NNW5 Q7L622 WDR6 G2E3 0.183 16189514 Q7L622 P07900 G2E3 HSP90AA1 0.126 22939624 Q7L622 O00453 G2E3 LST1 0.183 14667819 Q7L622 P08238 G2E3 HSP90AB1 0.126 22939624 Q7L622 P62841 G2E3 RPS15 0.454 25416956 Q7L622 Q6PKC6 G2E3 WDR6 0.126 16189514 Q7L622 Q7CKD3 G2E3 HTRA 0.126 20711500

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LST1 G2E3 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 G2E3 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 G2E3 MI:0045 experimental interaction detection MI:0461 interaction database UBC G2E3 MI:0045 experimental interaction detection MI:0461 interaction database RPS15 G2E3 MI:0045 experimental interaction detection MI:0461 interaction database G2E3 TRPM7 MI:0362 inference MI:0461 interaction database G2E3 WDR6 MI:0045 experimental interaction detection MI:0461 interaction database