PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ANKRD28 HECTD1 24255178 biogrid,intact exp G GP G G G GP G G GP G G G GP G G G GP G G G GP G G GP G G GP GP G ZNHIT3 HECTD1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TUBGCP3 HECTD1 23443559 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBC HECTD1 17550899 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G DYNLT1 HECTD1 26638075 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZRANB1 HECTD1 23277359,19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G APC HECTD1 23277359 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP G GP GP SMRP1 HECTD1 26186194 biogrid exp P G GP G G GP GP G GP G G G P G DDX56 HECTD1 17353931 intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP GP G GP GP G GEM HECTD1 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G PRDX1 HECTD1 22863883 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G BTF3L4 HECTD1 22863883 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UVRAG HECTD1 20562859 intact exp G G G G G GP G GP G G GP G GP G G G GP G G G GP G G G G G GP GP G YWHAB HECTD1 17353931 intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G AARSD1 HECTD1 25036637 biogrid,intact exp P P P P P P P P P P P P P P P SIRT7 HECTD1 22586326 biogrid exp GP GP G G G GP G GP GP G GP G G G G GP GP G GP G GP G GP GP GP G GP GP G HSPB1 HECTD1 25277244 biogrid,intact exp GP GP G G G G G GP GP G GP GP GP G G GP G G GP G GP GP GP GP GP G GP GP G TFCP2 HECTD1 20195357 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TPM2 HECTD1 22863883 biogrid exp G G G G G G G G G G G ZNF622 HECTD1 24778252 biogrid exp GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G RIOK2 HECTD1 23455922 biogrid,intact exp GP GP G GP G G GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP KIAA0101 HECTD1 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPGRIP1L HECTD1 26638075 biogrid,intact exp P P P P P P P P P P G P G P P P P P GP G TTLL1 HECTD1 26186194 biogrid exp GP GP G GP G GP P G GP P GP G GP GP G P G P GP GP GP GP GP G CAMKMT HECTD1 26186194 biogrid exp G G G G G G G G G G G G G G G G G YWHAQ HECTD1 23444366 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G NIN HECTD1 26638075 biogrid,intact exp GP G G G G G G GP GP G GP GP GP G G GP G G G GP GP GP GP GP G GP P G BMP15 HECTD1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHFM1 HECTD1 24811749 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP2R5D HECTD1 22863883 biogrid exp GP GP G G G GP G G GP G GP GP G G G GP GP G G G GP GP GP GP GP G GP GP G HECTD1 DNM3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G BMI1 HECTD1 20601937 intact exp P P P P P P P P P P P P P P P P P P FBXW11 HECTD1 25515538 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RASSF6 HECTD1 26186194 biogrid exp P P G GP G P G G P GP GP G G G GP P IGSF1 HECTD1 12421765 hprd,biogrid,i2d,intact exp P GP G G G GP G GP GP G GP P G G G GP GP G P G GP GP G G GP GP GP G TCTE1 HECTD1 26638075 intact exp P P P P P P P P P P P P P P P P P GP YWHAG HECTD1 15324660 hprd exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G HECTD1 AP1M2 26186194 biogrid exp G G G G G G G G G G G G G G G G G DIRAS3 HECTD1 26186194 biogrid exp P GP G GP GP P G GP P GP GP G GP G P GP P P GP GP P ATP6V1C2 HECTD1 26186194 biogrid exp P P P GP P P P G GP GP P P P P TCEAL4 HECTD1 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SETDB1 HECTD1 26186194, 23023127 biogrid exp, pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G G GP GP G GP GP G TP53 HECTD1 23443559, 23023127 biogrid exp, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G EGFR HECTD1 12577067, 23023127 i2d exp, pred GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP GP G DCTN6 HECTD1 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G NCAM1 HECTD1 ortho G GP G G G GP G GP GP G G G G G G G GP G G G G G G G G GP GP G INO80 HECTD1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAD54L HECTD1 ortho P P G G P P GP P P P GP P GP P P P GP P P GP PFN1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2L3 HECTD1 16082366 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G FEM1B HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TFAP2A HECTD1 23023127 pred GP G G G G G G G G GP G G G G G G G G GP G G G G G G G SMAD4 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G FYN HECTD1 23023127 pred G GP G G G GP G G GP G GP GP G G G G GP G G G G G G G G G G G G UBE2V2 HECTD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRB2 HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TULP3 HECTD1 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP GP G NOTCH2 HECTD1 23023127 pred G GP G G G G G G GP G G G G G G G G G G G G G G G G G GP G G MIB2 HECTD1 23023127 pred P P G GP G GP P G GP P P P GP G GP G GP GP GP GP GP P P G HECTD1 INVS 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G FCHSD2 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP P GP GP G GP G G DLC1 HECTD1 23023127 pred G G G G G GP G G GP G GP G G G G GP GP G G G G G G G GP G G GP G FEM1A HECTD1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP GP G DLL3 HECTD1 23023127 pred P G G G GP G P P G P P GP GP G P P G P P GP G SCRIB HECTD1 23023127 pred GP GP G G G G G GP GP G GP GP GP G G GP G G GP G GP GP GP G GP G GP GP G DVL2 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G RBBP6 HECTD1 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP G GP G GP GP G UBE2S HECTD1 16082366 pred G G G G G G G G GP G G G G G G G G G G G G G G G GP G USP33 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G HECTD1 TRIM33 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G CNOT4 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G T HECTD1 23023127 pred G G G G P G G G G G G G G HECTD1 TRAF6 23023127 pred GP GP G G G G G GP GP G GP GP GP G G GP G G G G GP GP GP G GP G GP GP G UBE2A HECTD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CEP350 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G MIB1 HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP G G G GP GP G GP G GP GP GP G GP G GP GP G NKX2-8 HECTD1 23023127 pred P P P P P P P P P P P P P P P P RUNX1 HECTD1 23023127 pred P P P P P P P P P P P P P P P P UBE2C HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G SKI HECTD1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2I HECTD1 16082366 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G SUMO2 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G BTK HECTD1 23023127 pred G G G G G GP G G G G G ANKRD13A HECTD1 23023127 pred G G G G G G G GP G G GP G GP G G G G G G G GP G G G G G G GP G SDF2 HECTD1 16082366 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G BIRC6 HECTD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2B HECTD1 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EVL HECTD1 23023127 pred G G G G G GP G G GP G G G GP G G G GP G G G G G G G G G G G G VAV2 HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP G GP GP G NOTCH4 HECTD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRSF1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G GDNF HECTD1 23023127 pred GP GP G G G GP GP GP G GP P P G G GP G GP G P GP GP G G GP GP G CYLD HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP ABL1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G HECTD1 USP3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC34 HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ZEB2 HECTD1 23023127 pred G G G G G GP G GP G G GP GP GP G G G GP G G G G G G G G G G BARD1 HECTD1 23023127 pred P G G P P GP P P P G G GP P G P P GP P GP P G GP GP G JAG1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G HECTD1 ROBO1 23023127 pred GP GP G GP G GP GP G GP P GP G G GP GP G P G P GP GP GP GP G GP GP G ALX4 HECTD1 23023127 pred G AKTIP HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G WWP2 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G SHH HECTD1 23023127 pred GP GP G G G GP G P GP G GP G GP G GP GP P G P GP P GP GP GP GP UBE2D3 HECTD1 23023127 pred GP G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP GP G HECTD1 UBE2D4 16082366 pred GP G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP GP G TP63 HECTD1 23023127 pred GP G G G G G G G G G G G G G G G G G G GP GP G G G G G ABL2 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G MAP3K7 HECTD1 23023127 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G RBPJ HECTD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2E3 HECTD1 16082366 pred GP GP G G G GP G G GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G UBE2N HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G CHRD HECTD1 23023127 pred GP GP G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP P G MYO15A HECTD1 23023127 pred GP G G G G GP G G GP G GP G G G G GP GP G GP G GP G G GP GP GP GP G DVL1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G PGF HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G UBE2D1 HECTD1 16082366 pred GP G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP GP G UBE2U HECTD1 16082366 pred P P P P P P P P P P P P P P P P P GP CHD8 HECTD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HECTD1 UBQLN1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G VAV3 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2M HECTD1 16082366 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G UBE2G1 HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBXN2A HECTD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKIL HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G UBE2R2 HECTD1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G G ZDHHC17 HECTD1 23023127 pred G GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBE2Z HECTD1 16082366 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TSG101 HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G RIMBP2 HECTD1 23023127 pred P P G GP G P P G GP P P G GP GP GP G P P P GP P GP P G ERBB2 HECTD1 23023127 pred GP G G G G G G G GP G GP G G G G GP G G G G GP GP G G GP G G G G UBE2L6 HECTD1 16082366 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G CELSR1 HECTD1 23023127 pred G G G G G G G G G G G G GNA13 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2E1 HECTD1 16082366 pred GP GP G G G GP G G GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G UBE2D2 HECTD1 16082366 pred GP G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP GP G GNA12 HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TRIO HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G HECTD1 UFC1 16082366 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G NOTCH1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G DEAF1 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2H HECTD1 16082366 pred GP GP G G G GP G GP G G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G BMP7 HECTD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CRKL HECTD1 23023127 pred GP G G G G GP G G GP G G G GP G G GP GP G GP G GP GP G G GP G GP G G RET HECTD1 23023127 pred P GP G G G GP G G P G GP GP GP G GP GP G GP G GP GP GP GP P P GP G UBE2T HECTD1 16082366 pred G G G GP G GP P P GP GP P GP P G GP P GP G PRRX1 HECTD1 23023127 pred GP G G G G GP G G GP G GP GP G G G GP GP G GP G G GP GP G GP G GP GP G EPHA2 HECTD1 23023127 pred GP GP G P G GP GP G GP GP GP G G GP GP GP G GP GP GP GP GP G GP GP G UBE2F HECTD1 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G STAB2 HECTD1 23023127 pred GP GP G G G GP G GP GP G G GP G G P GP G G GP GP G P G GP G G VASP HECTD1 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G HECTD1 16082366 pred GSC HECTD1 23023127 pred EPB41L5 HECTD1 23023127 pred G GP G G G GP G G G G GP GP G G G GP GP G GP G GP G G G GP GP GP G RELA HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ARHGAP35 HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9ULT8 P88991 two hybrid 22028648 direct interaction X 2 Q9ULT8 in vivo 15324660 - X 2 Q9ULT8 in vivo 15324660 - X 2 Q9ULT8 Q8N6C5 two hybrid 12421765 - X 2 Q9ULT8 Q8N6C5 two hybrid 12421765 - X 2 Q9ULT8 proximity-dependent biotin identification 24255178 colocalization C 39 Q9ULT8 anti tag coimmunoprecipitation 24811749 association C 66 Q9ULT8 anti tag coimmunoprecipitation 20562859 association C 31 Q9ULT8 tandem affinity purification 23455922 association C 14 Q9ULT8 P88991 two hybrid array 22028648 physical association X 2 Q9ULT8 P04792 reverse ras recruitment system 25277244 physical association X 2 Q9ULT8 tandem affinity purification 20601937 association C 16 Q9ULT8 anti tag coimmunoprecipitation 19615732 physical association C 21 Q9ULT8 anti tag coimmunoprecipitation 25036637 association C 7 Q9ULT8 Q8N6C5 two hybrid 12421765 physical association X 2 Q9ULT8 P31946 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9ULT8 Q9NY93 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9ULT8 A0A024R120 display technology 20195357 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality ANKRD28 HECTD1 24255178,24255178 1313,1314 HT DIRAS3 HECTD1 26186194 0004 HT TTLL1 HECTD1 26186194 0004 HT BMP15 HECTD1 26186194 0004 HT UBC HECTD1 17550899,20639865 0004,0004 LC YWHAB HECTD1 17353931 0006 HT GEM HECTD1 26186194 0004 HT DYNLT1 HECTD1 26638075 1313 HT PRDX1 HECTD1 22863883 0401 HT PPP2R5D HECTD1 22863883 0401 HT KIAA0101 HECTD1 22863883 0401 HT SETDB1 HECTD1 26186194 0004 HT ZNHIT3 HECTD1 26186194 0004 HT Q53GA5 HECTD1 23443559 0004 HT TCTE1 HECTD1 26638075 1314 HT RPGRIP1L HECTD1 26638075,26638075 1314,1313 HT RASSF6 HECTD1 26186194 0004 HT CAMKMT HECTD1 26186194 0004 HT NIN HECTD1 26638075,26638075 1314,1313 HT SMRP1 HECTD1 26186194 0004 HT ATP6V1C2 HECTD1 26186194 0004 HT TUBGCP3 HECTD1 23443559 0004 HT TCEAL4 HECTD1 22863883 0401 HT BTF3L4 HECTD1 22863883 0401 HT RIOK2 HECTD1 23455922,23455922 0004,0676 HT DDX56 HECTD1 17353931 0006 HT UVRAG HECTD1 20562859 0007 HT Q9UBT1 HECTD1 26389696,26166704 0004,0004 LC ZRANB1 HECTD1 19615732,23277359,19615732 0004,0004,0007 HT,LC HECTD1 DNM3 26186194 0004 HT HECTD1 AP1M2 26186194 0004 HT HECTD1 HEL-S-273 22863883 0401 HT ANKRD28 HECTD1 24255178,24255178 1313,1314 HT DIRAS3 HECTD1 26186194 0004 HT TTLL1 HECTD1 26186194 0004 HT BMP15 HECTD1 26186194 0004 HT YWHAB HECTD1 17353931 0006 HT GEM HECTD1 26186194 0004 HT DYNLT1 HECTD1 26638075 1313 HT PRDX1 HECTD1 22863883 0401 HT PPP2R5D HECTD1 22863883 0401 HT KIAA0101 HECTD1 22863883 0401 HT SETDB1 HECTD1 26186194 0004 HT ZNHIT3 HECTD1 26186194 0004 HT Q53GA5 HECTD1 23443559 0004 HT TCTE1 HECTD1 26638075 1314 HT RPGRIP1L HECTD1 26638075,26638075 1314,1313 HT RASSF6 HECTD1 26186194 0004 HT CAMKMT HECTD1 26186194 0004 HT NIN HECTD1 26638075,26638075 1314,1313 HT SMRP1 HECTD1 26186194 0004 HT ATP6V1C2 HECTD1 26186194 0004 HT TUBGCP3 HECTD1 23443559 0004 HT TCEAL4 HECTD1 22863883 0401 HT BTF3L4 HECTD1 22863883 0401 HT RIOK2 HECTD1 23455922,23455922 0004,0676 HT DDX56 HECTD1 17353931 0006 HT UVRAG HECTD1 20562859 0007 HT ZRANB1 HECTD1 19615732,19615732 0004,0007 HT HECTD1 DNM3 26186194 0004 HT HECTD1 AP1M2 26186194 0004 HT HECTD1 HEL-S-273 22863883 0401 HT UBC HECTD1 17550899,20639865 0004,0004 LC Q9UBT1 HECTD1 26389696,26166704 0004,0004 LC ZRANB1 HECTD1 23277359 0004 LC HSPB1 HECTD1 25277244 0097 LC MTNR1B HECTD1 26514267 0018 LC PRDX1 HECTD1 22863883 0401 LC TFCP2 HECTD1 20195357 0034 LC PPP2R5D HECTD1 22863883 0401 LC KIAA0101 HECTD1 22863883 0401 LC IGSF1 HECTD1 12421765 0018 HT TCEAL4 HECTD1 22863883 0401 LC BTF3L4 HECTD1 22863883 0401 LC HECTD1 HECTD1 26949039 0415 LC HECTD1 HEL-S-273 22863883 0401 LC HECTD1 HEL-S-102 25277244 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9ULT8 Q5JU00 HECTD1 TCTE1 0.126 26638075 Q9ULT8 B4URF5 HECTD1 PB1 {ECO:0000313|EMBL:ACF54606.1} 0.126 unassigned1333 Q9ULT8 Q8N4C6 HECTD1 NIN 0.126 26638075 Q9ULT8 P25054 HECTD1 APC 0.21 23277359 Q9ULT8 Q8NCR6 HECTD1 SMRP1 0.126 26186194 Q9ULT8 Q8NEY4 HECTD1 ATP6V1C2 0.126 26186194 Q9ULT8 Q9NRC8 HECTD1 SIRT7 0.126 22586326 Q9ULT8 Q9NTJ3 HECTD1 SMC4 0.21 26166704 Q9ULT8 Q9NWT6 HECTD1 HIF1AN 0.126 26972000 Q9ULT8 Q9NY93 HECTD1 DDX56 0.126 17353931 Q9Y6Q5 Q9ULT8 AP1M2 HECTD1 0.126 26186194 Q9ULT8 P07951 HECTD1 TPM2 0.081 22863883 Q9ULT8 Q6ZTQ3 HECTD1 RASSF6 0.126 26186194 Q9ULT8 P0CG48 HECTD1 UBC 0.126 17550899 Q9ULT8 Q7Z624 HECTD1 CAMKMT 0.126 26186194 Q9ULT8 Q6IBW4 HECTD1 NCAPH2 0.21 26166704 Q9ULT8 O95347 HECTD1 SMC2 0.21 26166704 Q9ULT8 P03431 HECTD1 PB1 0.126 unassigned1333 Q9ULT8 P04544 HECTD1 1C 0.126 22593156 Q9ULT8 O95661 HECTD1 DIRAS3 0.126 26186194 Q9ULT8 P04637 HECTD1 TP53 0.126 23443559 Q9ULT8 O95922 HECTD1 TTLL1 0.126 26186194 Q9ULT8 O95972 HECTD1 BMP15 0.126 26186194 Q9ULT8 P03372 HECTD1 ESR1 0.376 26166704,26389696 Q9ULT8 P04792 HECTD1 HSPB1 0.286 25277244 Q9ULT8 Q9BTE6 HECTD1 AARSD1 0.236 25036637 Q9ULT8 Q9BVS4 HECTD1 RIOK2 0.236 23455922 Q9ULT8 O15084 HECTD1 ANKRD28 0.196 24255178 Q9ULT8 Q68CZ1 HECTD1 RPGRIP1L 0.236 26638075 Q9ULT8 P60896 HECTD1 SHFM1 0.236 24811749 Q9ULT8 Q969H0 HECTD1 FBXW7 0.126 25720964 Q9ULT8 Q969S3 HECTD1 ZNF622 0.126 24778252 Q9ULT8 P35226 HECTD1 BMI1 0.126 20601937 Q9ULT8 Q96CW5 HECTD1 TUBGCP3 0.126 23443559 Q9ULT8 Q96EI5 HECTD1 TCEAL4 0.081 22863883 Q9ULT8 Q9BPX3 HECTD1 NCAPG 0.21 26166704 Q9ULT8 P27348 HECTD1 YWHAQ 0.21 23444366 Q9ULT8 Q9P2Y5 HECTD1 UVRAG 0.126 20562859 Q9ULT8 Q9UKB1 HECTD1 FBXW11 0.126 25515538 Q9ULT8 P31946 HECTD1 YWHAB 0.126 17353931 Q9ULT8 P61077 HECTD1 UBE2D3 0.309 26949039 Q9ULT8 Q14738 HECTD1 PPP2R5D 0.081 22863883 Q9ULT8 Q8N6C5 HECTD1 IGSF1 0.332 12421765 Q9ULT8 Q96K17 HECTD1 BTF3L4 0.081 22863883 Q9ULT8 Q9UGI0 HECTD1 ZRANB1 0.523 23277359,19615732 Q9ULT8 Q9ULT8 HECTD1 HECTD1 0.332 26949039 Q9UQ16 Q9ULT8 DNM3 HECTD1 0.126 26186194 Q9ULT8 Q12800 HECTD1 TFCP2 0.126 20195357 Q9ULT8 P49286 HECTD1 MTNR1B 0.183 26514267 Q9ULT8 P88991 HECTD1 BQRF1 0.126 22028648 Q9ULT8 Q15003 HECTD1 NCAPH 0.21 26166704 Q9ULT8 Q15004 HECTD1 KIAA0101 0.081 22863883 Q9ULT8 Q15021 HECTD1 NCAPD2 0.21 26166704 Q9ULT8 Q15047 HECTD1 SETDB1 0.126 26186194 Q9ULT8 Q15649 HECTD1 ZNHIT3 0.126 26186194 Q9ULT8 P55040 HECTD1 GEM 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DCTN6 HECTD1 MI:0362 inference MI:0461 interaction database ANKRD28 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database SMC2 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database DIRAS3 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database TTLL1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database BMP15 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database ESR1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database TP53 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database HSPB1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database UBC HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database APC HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database YWHAQ HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database YWHAB HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database BMI1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database ABCG1 HECTD1 MI:0362 inference MI:0461 interaction database MTNR1B HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database GEM HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database SHFM1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database DYNLT1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database TFCP2 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database NCAPH HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database WTAP HECTD1 MI:0362 inference MI:0461 interaction database NCAPD2 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database SETDB1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database ZNHIT3 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database TCTE1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database RPGRIP1L HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database NCAPH2 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database RASSF6 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database CAMKMT HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database NIN HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database IGSF1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database SMRP1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database ATP6V1C2 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database RAD54L HECTD1 MI:0362 inference MI:0461 interaction database FBXW7 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF622 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database TUBGCP3 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database NCAPG HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database AARSD1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database RIOK2 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database SIRT7 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database SMC4 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database DDX56 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database UVRAG HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database ZRANB1 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database OPN4 HECTD1 MI:0362 inference MI:0461 interaction database FBXW11 HECTD1 MI:0045 experimental interaction detection MI:0461 interaction database INO80 HECTD1 MI:0362 inference MI:0461 interaction database HECTD1 DNM3 MI:0045 experimental interaction detection MI:0461 interaction database HECTD1 AP1M2 MI:0045 experimental interaction detection MI:0461 interaction database