PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM29 FBXL19 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G TRIM27 FBXL19 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G RAC3 FBXL19 24684802 biogrid exp WDR44 FBXL19 24035498 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G FBXL19 SUGT1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G CTDSPL2 FBXL19 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G FBXL19 NSMAF 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G PSME3 FBXL19 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G FBXL19 DENND2D 26186194 biogrid exp G G G G G G G G G G G G G G G G CUL1 FBXL19 22660580 intact exp G G G G G G G G G G G G G G G G G G G G G G G G SKP1 FBXL19 22660580 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G COL11A1 FBXL19 22660580 biogrid exp G G G G G G G G G FBXL19 SORT1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G FGD1 FBXL19 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G FBXL19 STRADA 24035498 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G CBFA2T2 FBXL19 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G RHOA FBXL19 ortho G G G G G G G G G G G G G G G G G G G G G G G G FBXL19 CXXC1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G DNMT1 FBXL19 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G FBXL19 MBD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6PCT2 affinity chromatography technology 24035498 physical association X 2 A0A024R3J1 Q6PCT2 two hybrid 20211142 direct interaction X 2 P60763 Q6PCT2 affinity chromatography technology 24684802 physical association X 2 P60763 Q6PCT2 affinity chromatography technology 24684802 physical association X 2 Q5JSH3-2 Q6PCT2 affinity chromatography technology 24035498 physical association X 2 Q6PCT2 O43439-5 two hybrid 20211142 direct interaction X 2 P14373 Q6PCT2 two hybrid 20211142 direct interaction X 2 P12107-2 Q6PCT2 affinity chromatography technology 22660580 physical association X 2 P12107-2 Q6PCT2 affinity chromatography technology 22660580 physical association X 2 P63208 Q6PCT2 affinity chromatography technology 22660580 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B COL11A1 FBXL19 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22660580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_188042|BIOGRID_188040 prey|bait bait|prey CBFA2T2 FBXL19 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128804 bait prey SKP1 FBXL19 MI:0004(affinity chromatography technology) 22660580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_188041 bait prey FBXL19 ndhF MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:55380() MI:0915(physical association) (biogrid) BIOGRID_289818 bait prey RAC3 FBXL19 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24684802 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_310253|BIOGRID_310252 prey|bait bait|prey TRIM27 FBXL19 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128653 bait prey WDR44 FBXL19 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289817 prey bait FBXL19 STRAD alpha MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289816 bait prey TRIM29 FBXL19 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128881 bait prey

PPI - HINT Gene A Gene B PMID Method Quality FGD1 FBXL19 26496610,26496610 0007,0004 HT CTDSPL2 FBXL19 26496610,26496610 0007,0004 HT FBXL19 NSMAF 26496610,26496610 0007,0004 HT FBXL19 SORT1 26496610,26496610 0007,0004 HT FBXL19 DENND2D 26186194 0004 HT FBXL19 HEL-S-283 26186194 0004 HT FGD1 FBXL19 26496610,26496610 0007,0004 HT CTDSPL2 FBXL19 26496610,26496610 0007,0004 HT FBXL19 NSMAF 26496610,26496610 0007,0004 HT FBXL19 SORT1 26496610,26496610 0007,0004 HT FBXL19 DENND2D 26186194 0004 HT FBXL19 HEL-S-283 26186194 0004 HT B4DYC6 FBXL19 25036637 0729 HT CBFA2T2 FBXL19 20211142 0018 HT TRIM27 FBXL19 20211142 0018 HT CUL1 FBXL19 22660580 0997 LC TRIM29 FBXL19 20211142 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6PCT2 P60763 FBXL19 RAC3 0.376 24684802 Q6PCT2 O43439 FBXL19 CBFA2T2 0.183 20211142 Q9H6A0 Q6PCT2 DENND2D FBXL19 0.126 26186194 Q9Y4F3 Q6PCT2 KIAA0430 FBXL19 0.126 unassigned1312 Q6PCT2 Q5JSH3 FBXL19 WDR44 0.21 24035498 Q6PCT2 P12107 FBXL19 COL11A1 0.376 22660580 Q6PCT2 B4DYC6 FBXL19 B4DYC6 0.126 25036637 Q7RTN6 Q6PCT2 STRADA FBXL19 0.21 24035498 Q6PCT2 P14373 FBXL19 TRIM27 0.183 20211142 Q8VE37 Q6PCT2 RCC1 FBXL19 0.236 26496610 Q8IZP0 Q6PCT2 ABI1 FBXL19 0.236 unassigned1304 Q9NS64 Q6PCT2 RPRM FBXL19 0.236 unassigned1304 Q9NYB9 Q6PCT2 ABI2 FBXL19 0.236 unassigned1304 Q9WVM1 Q6PCT2 RACGAP1 FBXL19 0.236 26496610 Q8WW34 Q6PCT2 TMEM239 FBXL19 0.236 unassigned1304 Q92636 Q6PCT2 NSMAF FBXL19 0.236 26496610 Q99523 Q6PCT2 SORT1 FBXL19 0.236 26496610 Q6PCT2 P98174 FBXL19 FGD1 0.236 26496610 Q6PCT2 Q05D32 FBXL19 CTDSPL2 0.236 26496610 Q6PCT2 Q5JST6 FBXL19 EFHC2 0.236 unassigned1304 Q6ZPD8 Q6PCT2 DGAT2L6 FBXL19 0.236 unassigned1304 Q6PCT2 O60504 FBXL19 SORBS3 0.236 unassigned1304 Q8CAQ8 Q6PCT2 IMMT FBXL19 0.236 26496610 Q6PCT2 P61289 FBXL19 PSME3 0.332 unassigned1304,26186194 Q6PCT2 P63208 FBXL19 SKP1 0.472 22660580,27705803,unassigned1304 Q6PCT2 P42694 FBXL19 HELZ 0.126 unassigned1312 Q6PCT2 Q14134 FBXL19 TRIM29 0.183 20211142

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 FBXL19 MI:0362 inference MI:1106 pathways database CBFA2T2 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXL19 MI:0362 inference MI:1106 pathways database UBB FBXL19 MI:0362 inference MI:1106 pathways database UBC FBXL19 MI:0362 inference MI:1106 pathways database COL11A1 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database RCC1 FBXL19 MI:0362 inference MI:0461 interaction database TRIM21 FBXL19 MI:0362 inference MI:1106 pathways database TAF1 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 FBXL19 MI:0362 inference MI:0461 interaction database CCNF FBXL19 MI:0362 inference MI:1106 pathways database UBE2A FBXL19 MI:0362 inference MI:1106 pathways database UBE2D1 FBXL19 MI:0362 inference MI:0461 interaction database FBXW4 FBXL19 MI:0362 inference MI:1106 pathways database RAC3 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database PSME3 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database RHOA FBXL19 MI:0362 inference MI:0461 interaction database UBE2G1 FBXL19 MI:0362 inference MI:0461 interaction database RBX1 FBXL19 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database RPS27A FBXL19 MI:0362 inference MI:1106 pathways database UBA52 FBXL19 MI:0362 inference MI:1106 pathways database SKP1 FBXL19 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FGD1 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database IL1RL1 FBXL19 MI:0362 inference MI:0461 interaction database CTDSPL2 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 FBXL19 MI:0362 inference MI:1106 pathways database CUL1 FBXL19 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM29 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXL19 MI:0362 inference MI:1106 pathways database IMMT FBXL19 MI:0362 inference MI:0461 interaction database LONRF1 FBXL19 MI:0362 inference MI:1106 pathways database WDR44 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database HECTD2 FBXL19 MI:0362 inference MI:1106 pathways database FBXO31 FBXL19 MI:0362 inference MI:1106 pathways database FBXW9 FBXL19 MI:0362 inference MI:1106 pathways database FBXW10 FBXL19 MI:0362 inference MI:1106 pathways database RNF213 FBXL19 MI:0362 inference MI:1106 pathways database FBXL22 FBXL19 MI:0362 inference MI:1106 pathways database FBXL19 FBXW12 MI:0362 inference MI:1106 pathways database FBXL19 RNF19B MI:0362 inference MI:1106 pathways database FBXL19 STRADA MI:0045 experimental interaction detection MI:0461 interaction database FBXL19 RNF144B MI:0362 inference MI:1106 pathways database FBXL19 RBBP6 MI:0362 inference MI:1106 pathways database FBXL19 HUWE1 MI:0362 inference MI:1106 pathways database FBXL19 TRIM69 MI:0362 inference MI:1106 pathways database FBXL19 SIAH1 MI:0362 inference MI:1106 pathways database FBXL19 HERC6 MI:0362 inference MI:1106 pathways database FBXL19 UBR2 MI:0362 inference MI:1106 pathways database FBXL19 FBXL14 MI:0362 inference MI:1106 pathways database FBXL19 FBXW8 MI:0362 inference MI:1106 pathways database FBXL19 FBXL16 MI:0362 inference MI:1106 pathways database FBXL19 FBXO15 MI:0362 inference MI:1106 pathways database FBXL19 ZNRF1 MI:0362 inference MI:1106 pathways database FBXL19 FBXL13 MI:0362 inference MI:1106 pathways database FBXL19 FBXO22 MI:0362 inference MI:1106 pathways database FBXL19 ZNRF2 MI:0362 inference MI:1106 pathways database FBXL19 FBXO27 MI:0362 inference MI:1106 pathways database FBXL19 FBXO30 MI:0362 inference MI:1106 pathways database FBXL19 RNF217 MI:0362 inference MI:1106 pathways database FBXL19 DTX3L MI:0362 inference MI:1106 pathways database FBXL19 FBXO41 MI:0362 inference MI:1106 pathways database FBXL19 LMO7 MI:0362 inference MI:1106 pathways database FBXL19 MYLIP MI:0362 inference MI:1106 pathways database FBXL19 NSMAF MI:0045 experimental interaction detection MI:0461 interaction database FBXL19 FBXW7 MI:0362 inference MI:1106 pathways database FBXL19 FBXO32 MI:0362 inference MI:1106 pathways database FBXL19 FBXW5 MI:0362 inference MI:1106 pathways database FBXL19 MIB2 MI:0362 inference MI:1106 pathways database FBXL19 SPSB1 MI:0362 inference MI:1106 pathways database FBXL19 FBXL8 MI:0362 inference MI:1106 pathways database FBXL19 FBXO17 MI:0362 inference MI:1106 pathways database FBXL19 FBXL20 MI:0362 inference MI:1106 pathways database FBXL19 FBXL18 MI:0362 inference MI:1106 pathways database FBXL19 NEDD4L MI:0362 inference MI:1106 pathways database FBXL19 SORT1 MI:0045 experimental interaction detection MI:0461 interaction database FBXL19 RBCK1 MI:0362 inference MI:1106 pathways database FBXL19 RACGAP1 MI:0362 inference MI:0461 interaction database FBXL19 RAB17 MI:0362 inference MI:0461 interaction database FBXL19 FBXL15 MI:0362 inference MI:1106 pathways database FBXL19 FBXO44 MI:0362 inference MI:1106 pathways database FBXL19 DENND2D MI:0045 experimental interaction detection MI:0461 interaction database FBXL19 UNKL MI:0362 inference MI:1106 pathways database FBXL19 SMURF2 MI:0362 inference MI:1106 pathways database FBXL19 TRIM36 MI:0362 inference MI:1106 pathways database FBXL19 FBXO6 MI:0362 inference MI:1106 pathways database FBXL19 RNF19A MI:0362 inference MI:1106 pathways database FBXL19 RLIM MI:0362 inference MI:1106 pathways database FBXL19 FBXL12 MI:0362 inference MI:1106 pathways database FBXL19 FBXO40 MI:0362 inference MI:1106 pathways database FBXL19 HERC5 MI:0362 inference MI:1106 pathways database FBXL19 FBXL7 MI:0362 inference MI:1106 pathways database FBXL19 FBXO2 MI:0362 inference MI:1106 pathways database FBXL19 FBXO10 MI:0362 inference MI:1106 pathways database FBXL19 FBXO9 MI:0362 inference MI:1106 pathways database FBXL19 FBXL5 MI:0362 inference MI:1106 pathways database FBXL19 FBXL4 MI:0362 inference MI:1106 pathways database FBXL19 FBXW11 MI:0362 inference MI:1106 pathways database FBXL19 FBXO4 MI:0362 inference MI:1106 pathways database FBXL19 FBXL21 MI:0362 inference MI:1106 pathways database FBXL19 FBXL3 MI:0362 inference MI:1106 pathways database FBXL19 FBXW2 MI:0362 inference MI:1106 pathways database FBXL19 BTRC MI:0362 inference MI:1106 pathways database FBXL19 FBXO7 MI:0362 inference MI:1106 pathways database FBXL19 RNF115 MI:0362 inference MI:1106 pathways database FBXL19 RNF114 MI:0362 inference MI:1106 pathways database FBXL19 WSB1 MI:0362 inference MI:1106 pathways database